The Experts below are selected from a list of 321 Experts worldwide ranked by ideXlab platform
Varlamov A.v. - One of the best experts on this subject based on the ideXlab platform.
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Synthesis of pyridine bases from piperidine derivatives
'Springer Science and Business Media LLC', 2020Co-Authors: Prostakov N.s., Varlamov A.v., Vasil'ev G.a.Abstract:The corresponding substituted Pyridines are obtained in 40-90% yields when N-alkyl-substituted piperidines, gD4-piperideines, and secondary and tertiary γ-piperidols are heated at 240-270‡C with pyridine N-oxide. © 1978 Plenum Publishing Corporation
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Interaction of 4,5,7-trimethyl-4,5,6,7-tetrahydropyrrolo[3,2-c]Pyridines with acetic and trifluoroacetic anhydrides
'Springer Science and Business Media LLC', 2020Co-Authors: Borisova T.n., Voskressensky L.g., Soklakova T.a., Chernyshev A.i., Bonifas N., Borisov R.s., Varlamov A.v.Abstract:The reactions of NH- and N-vinyl-4,5,7-trimethyl-4,5,6,7-tetrahydropyrrolo- [3,2-c]Pyridines and their 2-substituted derivatives with acetic and trifluoroacetic anhydrides have been studied. Trifluoroacetylation of tetrahydropyrrolo-[3,2-c]Pyridines occurs at the α-position of the pyrrole ring, whereas cleavage of the tetrahydropyridine ring with formation of 3-vinylpyrroles occurs with acetic anhydride. 2-Acetyl-4,5,7-trimethyl-1-vinyl- 4,5,6,7-tetrahydropyrrolo[3,2-c]pyridine was synthesized by the Vilsmeier-Haack reaction. ©2005 Springer Science+Business Media, Inc
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Synthesis of 2-R-4,5,7-trimethyl-1-vinyl-4,5,6,7-tetrahydropyrrolo[3,2-c] Pyridines
Латвийский институт органического синтеза Латвийской академии наук Springer New York Consultants Bureau, 2020Co-Authors: Borisova T.n., Varlamov A.v., Chernyshev A.i., Bonifas N., Voskresenskii L.g., Krapivko A.p.Abstract:The synthesis of 1-vinyltetrahydropyrrolo[3,2-c]Pyridines substituted at C(2) has been accomplished, based on 4,5,7-trimethyl-1-vinyl-4,5,6,7- tetrahydropyrrolo[3,2-c]pyridine and its 2-formyl-substituted derivative. © 2004 Springer Science+Business Media, Inc
Christopher F Pigge - One of the best experts on this subject based on the ideXlab platform.
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alkylidene dihydroPyridines as synthetic intermediates model studies toward the synthesis of the bis piperidine alkaloid xestoproxamine c
Journal of Organic Chemistry, 2016Co-Authors: Ashabha I Lansakara, S Santhana V Mariappan, Christopher F PiggeAbstract:Results of model studies demonstrating a stereoselective synthetic route to tricyclic analogues of the bis(piperidine) alkaloid xestoproxamine C are presented. Dearomatization of a tricyclic pyridine derivative to afford an alkylidene dihydropyridine (anhydrobase) intermediate followed by catalytic heterogeneous hydrogenation was used to install the correct relative stereochemistry about the bis(piperidine) ring system. Other key features of these model studies include development of an efficient ring-closing metathesis procedure to prepare macrocyclic derivatives of 3,4-disusbstituted Pyridines, intramolecular cyclizations of alkylidene dihydroPyridines to establish pyridine-substituted pyrrolidines and piperidines, successful homologation of pyridine-4-carboxaldehydes using formaldehyde dimethyl thioacetal monoxide (FAMSO), and application of B-alkyl Suzuki coupling to assemble substituted Pyridines.
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Alkylidene DihydroPyridines As Synthetic Intermediates: Model Studies toward the Synthesis of the Bis(piperidine) Alkaloid Xestoproxamine C
2016Co-Authors: Ashabha I Lansakara, S Santhana V Mariappan, Christopher F PiggeAbstract:Results of model studies demonstrating a stereoselective synthetic route to tricyclic analogues of the bis(piperidine) alkaloid xestoproxamine C are presented. Dearomatization of a tricyclic pyridine derivative to afford an alkylidene dihydropyridine (anhydrobase) intermediate followed by catalytic heterogeneous hydrogenation was used to install the correct relative stereochemistry about the bis(piperidine) ring system. Other key features of these model studies include development of an efficient ring-closing metathesis procedure to prepare macrocyclic derivatives of 3,4-disusbstituted Pyridines, intramolecular cyclizations of alkylidene dihydroPyridines to establish pyridine-substituted pyrrolidines and piperidines, successful homologation of pyridine-4-carboxaldehydes using formaldehyde dimethyl thioacetal monoxide (FAMSO), and application of B-alkyl Suzuki coupling to assemble substituted Pyridines
Justo Cobo - One of the best experts on this subject based on the ideXlab platform.
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preparation of 6 chloropyrazolo 3 4 b pyridine 5 carbaldehydes by vilsmeier haack reaction and its use in the synthesis of heterocyclic chalcones and dipyrazoloPyridines
Tetrahedron Letters, 2010Co-Authors: Jairo Quiroga, Yurina Diaz, Braulio Insuasty, Rodrigo Abonia, Manuel Nogueras, Justo CoboAbstract:Abstract Novel 6-chloropyrazolo[3,4- b ]pyridine-5-carbaldehydes 5 have been synthesized from the 4,5-dihydropyrazolo[3,4- b ]pyridine-6-ones 4 via Vilsmeier–Haack reaction. Further treatment of carbaldehydes 5 with acetophenones 6 and hydrazine hydrate afforded chalcone analogues 7 and dipyrazolo[3,4- b :4′,3 ′ - e ]Pyridines 8 , respectively.
Steven De Jonghe - One of the best experts on this subject based on the ideXlab platform.
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structure activity relationship study of the pyridine moiety of isothiazolo 4 3 b Pyridines as antiviral agents targeting cyclin g associated kinase
Bioorganic & Medicinal Chemistry, 2020Co-Authors: Belen Martinezgualda, Piet Herdewijn, Mathy Froeyen, Shirit Einav, Steven De JongheAbstract:Previously, we reported the discovery of 3,6-disubstituted isothiazolo[4,3-b]Pyridines as potent and selective cyclin G-associated kinase (GAK) inhibitors with promising antiviral activity. In this manuscript, the structure-activity relationship study was expanded to synthesis of isothiazolo[4,3-b]Pyridines with modifications of the pyridine moiety. This effort led to the discovery of an isothiazolo[4,3-b]pyridine derivative with a 3,4-dimethoxyphenyl residue at position 5 that displayed low nanomolar GAK binding affinity and antiviral activity against dengue virus.
Borisova T.n. - One of the best experts on this subject based on the ideXlab platform.
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Interaction of 4,5,7-trimethyl-4,5,6,7-tetrahydropyrrolo[3,2-c]Pyridines with acetic and trifluoroacetic anhydrides
'Springer Science and Business Media LLC', 2020Co-Authors: Borisova T.n., Voskressensky L.g., Soklakova T.a., Chernyshev A.i., Bonifas N., Borisov R.s., Varlamov A.v.Abstract:The reactions of NH- and N-vinyl-4,5,7-trimethyl-4,5,6,7-tetrahydropyrrolo- [3,2-c]Pyridines and their 2-substituted derivatives with acetic and trifluoroacetic anhydrides have been studied. Trifluoroacetylation of tetrahydropyrrolo-[3,2-c]Pyridines occurs at the α-position of the pyrrole ring, whereas cleavage of the tetrahydropyridine ring with formation of 3-vinylpyrroles occurs with acetic anhydride. 2-Acetyl-4,5,7-trimethyl-1-vinyl- 4,5,6,7-tetrahydropyrrolo[3,2-c]pyridine was synthesized by the Vilsmeier-Haack reaction. ©2005 Springer Science+Business Media, Inc
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Synthesis of 2-R-4,5,7-trimethyl-1-vinyl-4,5,6,7-tetrahydropyrrolo[3,2-c] Pyridines
Латвийский институт органического синтеза Латвийской академии наук Springer New York Consultants Bureau, 2020Co-Authors: Borisova T.n., Varlamov A.v., Chernyshev A.i., Bonifas N., Voskresenskii L.g., Krapivko A.p.Abstract:The synthesis of 1-vinyltetrahydropyrrolo[3,2-c]Pyridines substituted at C(2) has been accomplished, based on 4,5,7-trimethyl-1-vinyl-4,5,6,7- tetrahydropyrrolo[3,2-c]pyridine and its 2-formyl-substituted derivative. © 2004 Springer Science+Business Media, Inc
