The Experts below are selected from a list of 1482 Experts worldwide ranked by ideXlab platform
Audrey Thomasschoemann - One of the best experts on this subject based on the ideXlab platform.
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identification of baseline parameters associated with the inter individual variability in cytidine deaminase serum activity a key enzyme in the metabolism of Pyrimidine Analogue
Journal of Clinical Oncology, 2016Co-Authors: Romain Cohen, Laurehelene Preta, Aurelia Bessone, Celine Narjoz, Ioannis Nicolis, D Desaulle, Emmanuel Curis, Anatole Cessot, Olivier Huillard, Audrey ThomasschoemannAbstract:e14096Background: Cytidine deaminase (CDA) catabolizes gemcitabine and cytosine arabinoside and its serum activity (CDA-A) has been associated with efficacy and toxicity of both treatment. CDA is also involved in the conversion of prodrug capecitabine into active 5-fluorouracil. CDA is mainly produced by hepatocytes. Our objective was to identify pretreatment patients (pts) characteristics that may contribute to the large inter-individual variability in CDA-A. Methods: From December 2014 to November 2015, all consecutive pts were prospectively included into this single-center study. CDA-A in serum was assayed using a standardized spectrophotometric method. Biological, clinical characteristics and 5 common single nucleotide polymorphisms in the CDA gene (-451G > A, -92A > G, -33delC, 79A > C, 435T > C) were analyzed according to pretreatment CDA-A. Written consent was obtained from all patients. Univariate and multivariate statistical analysis were performed on log-transformed CDA with significance level o...
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identification of baseline parameters associated with the inter individual variability in cytidine deaminase serum activity a key enzyme in the metabolism of Pyrimidine Analogue
Journal of Clinical Oncology, 2016Co-Authors: Romain Cohen, Laurehelene Preta, Aurelia Bessone, Celine Narjoz, Ioannis Nicolis, D Desaulle, Emmanuel Curis, Anatole Cessot, Olivier Huillard, Audrey ThomasschoemannAbstract:e14096Background: Cytidine deaminase (CDA) catabolizes gemcitabine and cytosine arabinoside and its serum activity (CDA-A) has been associated with efficacy and toxicity of both treatment. CDA is a...
Gottfried Kohler - One of the best experts on this subject based on the ideXlab platform.
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phase separation in phosphatidylcholine membrane caused by the presence of a Pyrimidine Analogue of fluphenazine with high anti multidrug resistance activity
Journal of Physical Chemistry B, 2014Co-Authors: Katarzyna Cieślikboczula, Piotr Swiątek, Agata Jaszczyszyn, Patrycja Zawilska, Kazimierz Gąsiorowski, Wieslaw Malinka, Gottfried KohlerAbstract:Phenothiazine compounds are known as effective inhibitors of a multidrug resistance (MDR) of tumor cells to chemotherapeutic agents. This group consists of many important substances used in human medicine such as antipsychotic drugs in the case of fluphenazine (FPh) or chlorpromazine (CPZ). Fluphenazine was on the World Health Organization (WHO) list of Essential Medicines of 2009, and its new Pyrimidine analog (FPh-prm) presented in this work has been documented to have a high anti-MDR activity. In order to discover the character of alterations of the lipid bilayer structure caused by the presence of FPh-prm inside the lipid membrane, which is responsible for the essential increase of an anti-MDR activity of FPh-prm, microcalorimetric (differential scanning calorimetry), Laurdan fluorescence, 31P nuclear magnetic resonance spectroscopy (NMR), and attenuated total reflectance Fourier transfer infrared spectroscopy (FTIR-ATR) were used for dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) liposomes mixed with...
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phase separation in phosphatidylcholine membrane caused by the presence of a Pyrimidine Analogue of fluphenazine with high anti multidrug resistance activity
Journal of Physical Chemistry B, 2014Co-Authors: Katarzyna Cieślikboczula, Piotr Swiątek, Agata Jaszczyszyn, Patrycja Zawilska, Kazimierz Gąsiorowski, Wieslaw Malinka, Gottfried KohlerAbstract:Phenothiazine compounds are known as effective inhibitors of a multidrug resistance (MDR) of tumor cells to chemotherapeutic agents. This group consists of many important substances used in human medicine such as antipsychotic drugs in the case of fluphenazine (FPh) or chlorpromazine (CPZ). Fluphenazine was on the World Health Organization (WHO) list of Essential Medicines of 2009, and its new Pyrimidine analog (FPh-prm) presented in this work has been documented to have a high anti-MDR activity. In order to discover the character of alterations of the lipid bilayer structure caused by the presence of FPh-prm inside the lipid membrane, which is responsible for the essential increase of an anti-MDR activity of FPh-prm, microcalorimetric (differential scanning calorimetry), Laurdan fluorescence, (31)P nuclear magnetic resonance spectroscopy (NMR), and attenuated total reflectance Fourier transfer infrared spectroscopy (FTIR-ATR) were used for dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) liposomes mixed with a different concentration of amine Analogue. It was stated that the formation of domains with different content of FPh-prm/DPPC can be a reason for the membrane-related mechanism of chemoprevention associated with the inhibition of the outward transport of anticancer drugs by the glycoprotein P (Pgp) in cancer cells by the Pyrimidine analog of FPh. To our best knowledge, this report is the first to show the bilayer structure of domains formed by incomplete miscibility of fluphenazine-related compounds and phospholipid molecules. Our results provide a sound basis for the design of future modifications of anti-MDR drugs by providing very effective inhibitors of the pump activity of Pgp.
Romain Cohen - One of the best experts on this subject based on the ideXlab platform.
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identification of baseline parameters associated with the inter individual variability in cytidine deaminase serum activity a key enzyme in the metabolism of Pyrimidine Analogue
Journal of Clinical Oncology, 2016Co-Authors: Romain Cohen, Laurehelene Preta, Aurelia Bessone, Celine Narjoz, Ioannis Nicolis, D Desaulle, Emmanuel Curis, Anatole Cessot, Olivier Huillard, Audrey ThomasschoemannAbstract:e14096Background: Cytidine deaminase (CDA) catabolizes gemcitabine and cytosine arabinoside and its serum activity (CDA-A) has been associated with efficacy and toxicity of both treatment. CDA is also involved in the conversion of prodrug capecitabine into active 5-fluorouracil. CDA is mainly produced by hepatocytes. Our objective was to identify pretreatment patients (pts) characteristics that may contribute to the large inter-individual variability in CDA-A. Methods: From December 2014 to November 2015, all consecutive pts were prospectively included into this single-center study. CDA-A in serum was assayed using a standardized spectrophotometric method. Biological, clinical characteristics and 5 common single nucleotide polymorphisms in the CDA gene (-451G > A, -92A > G, -33delC, 79A > C, 435T > C) were analyzed according to pretreatment CDA-A. Written consent was obtained from all patients. Univariate and multivariate statistical analysis were performed on log-transformed CDA with significance level o...
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identification of baseline parameters associated with the inter individual variability in cytidine deaminase serum activity a key enzyme in the metabolism of Pyrimidine Analogue
Journal of Clinical Oncology, 2016Co-Authors: Romain Cohen, Laurehelene Preta, Aurelia Bessone, Celine Narjoz, Ioannis Nicolis, D Desaulle, Emmanuel Curis, Anatole Cessot, Olivier Huillard, Audrey ThomasschoemannAbstract:e14096Background: Cytidine deaminase (CDA) catabolizes gemcitabine and cytosine arabinoside and its serum activity (CDA-A) has been associated with efficacy and toxicity of both treatment. CDA is a...
Katarzyna Cieślikboczula - One of the best experts on this subject based on the ideXlab platform.
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phase separation in phosphatidylcholine membrane caused by the presence of a Pyrimidine Analogue of fluphenazine with high anti multidrug resistance activity
Journal of Physical Chemistry B, 2014Co-Authors: Katarzyna Cieślikboczula, Piotr Swiątek, Agata Jaszczyszyn, Patrycja Zawilska, Kazimierz Gąsiorowski, Wieslaw Malinka, Gottfried KohlerAbstract:Phenothiazine compounds are known as effective inhibitors of a multidrug resistance (MDR) of tumor cells to chemotherapeutic agents. This group consists of many important substances used in human medicine such as antipsychotic drugs in the case of fluphenazine (FPh) or chlorpromazine (CPZ). Fluphenazine was on the World Health Organization (WHO) list of Essential Medicines of 2009, and its new Pyrimidine analog (FPh-prm) presented in this work has been documented to have a high anti-MDR activity. In order to discover the character of alterations of the lipid bilayer structure caused by the presence of FPh-prm inside the lipid membrane, which is responsible for the essential increase of an anti-MDR activity of FPh-prm, microcalorimetric (differential scanning calorimetry), Laurdan fluorescence, 31P nuclear magnetic resonance spectroscopy (NMR), and attenuated total reflectance Fourier transfer infrared spectroscopy (FTIR-ATR) were used for dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) liposomes mixed with...
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phase separation in phosphatidylcholine membrane caused by the presence of a Pyrimidine Analogue of fluphenazine with high anti multidrug resistance activity
Journal of Physical Chemistry B, 2014Co-Authors: Katarzyna Cieślikboczula, Piotr Swiątek, Agata Jaszczyszyn, Patrycja Zawilska, Kazimierz Gąsiorowski, Wieslaw Malinka, Gottfried KohlerAbstract:Phenothiazine compounds are known as effective inhibitors of a multidrug resistance (MDR) of tumor cells to chemotherapeutic agents. This group consists of many important substances used in human medicine such as antipsychotic drugs in the case of fluphenazine (FPh) or chlorpromazine (CPZ). Fluphenazine was on the World Health Organization (WHO) list of Essential Medicines of 2009, and its new Pyrimidine analog (FPh-prm) presented in this work has been documented to have a high anti-MDR activity. In order to discover the character of alterations of the lipid bilayer structure caused by the presence of FPh-prm inside the lipid membrane, which is responsible for the essential increase of an anti-MDR activity of FPh-prm, microcalorimetric (differential scanning calorimetry), Laurdan fluorescence, (31)P nuclear magnetic resonance spectroscopy (NMR), and attenuated total reflectance Fourier transfer infrared spectroscopy (FTIR-ATR) were used for dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) liposomes mixed with a different concentration of amine Analogue. It was stated that the formation of domains with different content of FPh-prm/DPPC can be a reason for the membrane-related mechanism of chemoprevention associated with the inhibition of the outward transport of anticancer drugs by the glycoprotein P (Pgp) in cancer cells by the Pyrimidine analog of FPh. To our best knowledge, this report is the first to show the bilayer structure of domains formed by incomplete miscibility of fluphenazine-related compounds and phospholipid molecules. Our results provide a sound basis for the design of future modifications of anti-MDR drugs by providing very effective inhibitors of the pump activity of Pgp.
Anatole Cessot - One of the best experts on this subject based on the ideXlab platform.
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identification of baseline parameters associated with the inter individual variability in cytidine deaminase serum activity a key enzyme in the metabolism of Pyrimidine Analogue
Journal of Clinical Oncology, 2016Co-Authors: Romain Cohen, Laurehelene Preta, Aurelia Bessone, Celine Narjoz, Ioannis Nicolis, D Desaulle, Emmanuel Curis, Anatole Cessot, Olivier Huillard, Audrey ThomasschoemannAbstract:e14096Background: Cytidine deaminase (CDA) catabolizes gemcitabine and cytosine arabinoside and its serum activity (CDA-A) has been associated with efficacy and toxicity of both treatment. CDA is also involved in the conversion of prodrug capecitabine into active 5-fluorouracil. CDA is mainly produced by hepatocytes. Our objective was to identify pretreatment patients (pts) characteristics that may contribute to the large inter-individual variability in CDA-A. Methods: From December 2014 to November 2015, all consecutive pts were prospectively included into this single-center study. CDA-A in serum was assayed using a standardized spectrophotometric method. Biological, clinical characteristics and 5 common single nucleotide polymorphisms in the CDA gene (-451G > A, -92A > G, -33delC, 79A > C, 435T > C) were analyzed according to pretreatment CDA-A. Written consent was obtained from all patients. Univariate and multivariate statistical analysis were performed on log-transformed CDA with significance level o...
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identification of baseline parameters associated with the inter individual variability in cytidine deaminase serum activity a key enzyme in the metabolism of Pyrimidine Analogue
Journal of Clinical Oncology, 2016Co-Authors: Romain Cohen, Laurehelene Preta, Aurelia Bessone, Celine Narjoz, Ioannis Nicolis, D Desaulle, Emmanuel Curis, Anatole Cessot, Olivier Huillard, Audrey ThomasschoemannAbstract:e14096Background: Cytidine deaminase (CDA) catabolizes gemcitabine and cytosine arabinoside and its serum activity (CDA-A) has been associated with efficacy and toxicity of both treatment. CDA is a...
