The Experts below are selected from a list of 252 Experts worldwide ranked by ideXlab platform
Geoffrey Heinzl - One of the best experts on this subject based on the ideXlab platform.
-
base catalyzed one step synthesis of 5 7 disubstituted 1 2 4 triazolo 1 5 a Pyrimidines
Tetrahedron Letters, 2015Co-Authors: Xinhua He, Shaymaa E Kassab, Geoffrey HeinzlAbstract:We report a practical high-yield synthesis of 5,7-disubstituted-1,2,4-triazolo[1,5-a]Pyrimidines using a base-assisted cyclocondensation of chalcone and 1,2,4-triazol-3-amine in an open reaction vessel. The same conditions can also be used for the preparation of novel imidazo[1,2-a]pyrimidine derivatives.
Xinhua He - One of the best experts on this subject based on the ideXlab platform.
-
base catalyzed one step synthesis of 5 7 disubstituted 1 2 4 triazolo 1 5 a Pyrimidines
Tetrahedron Letters, 2015Co-Authors: Xinhua He, Shaymaa E Kassab, Geoffrey HeinzlAbstract:We report a practical high-yield synthesis of 5,7-disubstituted-1,2,4-triazolo[1,5-a]Pyrimidines using a base-assisted cyclocondensation of chalcone and 1,2,4-triazol-3-amine in an open reaction vessel. The same conditions can also be used for the preparation of novel imidazo[1,2-a]pyrimidine derivatives.
Hongbin Tu - One of the best experts on this subject based on the ideXlab platform.
-
regiospecific synthesis of 3 substituted imidazo 1 2 a pyridines imidazo 1 2 a Pyrimidines and imidazo 1 2 c pyrimidine
Journal of Organic Chemistry, 2003Co-Authors: Alan R Katritzky, Yongjiang Xu, Hongbin TuAbstract:3-Substituted imidazo[1,2-a]pyridines, imidazo[1,2-a]Pyrimidines, and imidazo[1,2-c]pyrimidine were obtained regiospecifically in yields of 35−92% in one pot by reaction of 2-aminopyridines or 2-(or 4-)aminoPyrimidines, respectively, with 1,2-bis(benzotriazolyl)-1,2-(dialkylamino)ethanes.
Shaymaa E Kassab - One of the best experts on this subject based on the ideXlab platform.
-
base catalyzed one step synthesis of 5 7 disubstituted 1 2 4 triazolo 1 5 a Pyrimidines
Tetrahedron Letters, 2015Co-Authors: Xinhua He, Shaymaa E Kassab, Geoffrey HeinzlAbstract:We report a practical high-yield synthesis of 5,7-disubstituted-1,2,4-triazolo[1,5-a]Pyrimidines using a base-assisted cyclocondensation of chalcone and 1,2,4-triazol-3-amine in an open reaction vessel. The same conditions can also be used for the preparation of novel imidazo[1,2-a]pyrimidine derivatives.
Javier Forn - One of the best experts on this subject based on the ideXlab platform.
-
synthesis and sar of a new series of cox 2 selective inhibitors pyrazolo 1 5 a Pyrimidines
Journal of Medicinal Chemistry, 2001Co-Authors: Carmen Almansa, Alberto Fernandez De Arriba, Fernando L Cavalcanti, Luis A Gomez, Agusti Miralles, Manuel Merlos, Julian Garciarafanell, Javier FornAbstract:The synthesis and pharmacological activity of a series of bicyclic pyrazolo[1,5-a]Pyrimidines as potent and selective cyclooxygenase-2 (COX-2) inhibitors are described. The new compounds were evaluated both in vitro (COX-1 and COX-2 inhibition in human whole blood) and in vivo (carrageenan-induced paw edema and air-pouch model). Modification of the pyrimidine substituents showed that 6,7-disubstitution provided the best activity and led to the identification of 3-(4-fluorophenyl)-6,7-dimethyl-2-(4-methylsulfonylphenyl)pyrazolo[1,5-a]pyrimidine (10f) as one of the most potent and selective COX-2 inhibitor in this series.
