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Isabel Vidal-tato - One of the best experts on this subject based on the ideXlab platform.
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Surface Tension of Aqueous Solutions of Short N-Alkyl-2-Pyrrolidinones
Journal of Chemical & Engineering Data, 2008Co-Authors: Alicia García-abuín, José M. Navaza, Diego Gómez-díaz, Isabel Vidal-tatoAbstract:The surface tension of aqueous solutions of 2-Pyrrolidinone, 1-methyl-2-Pyrrolidinone, and 1-ethyl-2-Pyrrolidinone has been measured at temperatures from (20 to 50) °C over the whole range of concentrations. The surface tensions of these aqueous binary mixtures show more concentration dependence on the water-rich side. The addition of a small amount of N-alkyl-2-Pyrrolidinone drastically reduces the surface tension of water. This effect is related to not only the presence of hydrophobic groups that tend to remain at the air−water interface but also the influence of the complex interactions between N-alkyl-2-Pyrrolidinones molecules on the surface tension.
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Surface Tension of Aqueous Solutions of Short N-Alkyl-2-Pyrrolidinones
Journal of Chemical & Engineering Data, 2008Co-Authors: Alicia García-abuín, José M. Navaza, Diego Gómez-díaz, Isabel Vidal-tatoAbstract:The surface tension of aqueous solutions of 2-Pyrrolidinone, 1-methyl-2-Pyrrolidinone, and 1-ethyl-2-Pyrrolidinone has been measured at temperatures from (20 to 50) °C over the whole range of conce...
José M. Navaza - One of the best experts on this subject based on the ideXlab platform.
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influence of temperature and composition upon density viscosity speed of sound and refractive index of aqueous solutions of 1 ethyl 2 Pyrrolidinone
Journal of Chemical & Engineering Data, 2010Co-Authors: Antonio Blanco, Alicia Garciaabuin, José M. Navaza, Diego Gomezdiaz, Isabel VidaltatoAbstract:Experimental density, viscosity, speed of sound, and refractive index for aqueous solutions of 1-ethyl-2-Pyrrolidinone were measured over the entire composition range and at different temperatures (293 to 323) K. Excess properties and deviations have been calculated, and their dependence on composition was mathematically represented by a Redlich−Kister-type equation. The hydration of Pyrrolidinone molecules plays an important role in the thermophysical behavior of this mixture.
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Surface Tension of Aqueous Solutions of Short N-Alkyl-2-Pyrrolidinones
Journal of Chemical & Engineering Data, 2008Co-Authors: Alicia García-abuín, José M. Navaza, Diego Gómez-díaz, Isabel Vidal-tatoAbstract:The surface tension of aqueous solutions of 2-Pyrrolidinone, 1-methyl-2-Pyrrolidinone, and 1-ethyl-2-Pyrrolidinone has been measured at temperatures from (20 to 50) °C over the whole range of concentrations. The surface tensions of these aqueous binary mixtures show more concentration dependence on the water-rich side. The addition of a small amount of N-alkyl-2-Pyrrolidinone drastically reduces the surface tension of water. This effect is related to not only the presence of hydrophobic groups that tend to remain at the air−water interface but also the influence of the complex interactions between N-alkyl-2-Pyrrolidinones molecules on the surface tension.
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Surface Tension of Aqueous Solutions of Short N-Alkyl-2-Pyrrolidinones
Journal of Chemical & Engineering Data, 2008Co-Authors: Alicia García-abuín, José M. Navaza, Diego Gómez-díaz, Isabel Vidal-tatoAbstract:The surface tension of aqueous solutions of 2-Pyrrolidinone, 1-methyl-2-Pyrrolidinone, and 1-ethyl-2-Pyrrolidinone has been measured at temperatures from (20 to 50) °C over the whole range of conce...
Alicia García-abuín - One of the best experts on this subject based on the ideXlab platform.
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Surface Tension of Aqueous Solutions of Short N-Alkyl-2-Pyrrolidinones
Journal of Chemical & Engineering Data, 2008Co-Authors: Alicia García-abuín, José M. Navaza, Diego Gómez-díaz, Isabel Vidal-tatoAbstract:The surface tension of aqueous solutions of 2-Pyrrolidinone, 1-methyl-2-Pyrrolidinone, and 1-ethyl-2-Pyrrolidinone has been measured at temperatures from (20 to 50) °C over the whole range of concentrations. The surface tensions of these aqueous binary mixtures show more concentration dependence on the water-rich side. The addition of a small amount of N-alkyl-2-Pyrrolidinone drastically reduces the surface tension of water. This effect is related to not only the presence of hydrophobic groups that tend to remain at the air−water interface but also the influence of the complex interactions between N-alkyl-2-Pyrrolidinones molecules on the surface tension.
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Surface Tension of Aqueous Solutions of Short N-Alkyl-2-Pyrrolidinones
Journal of Chemical & Engineering Data, 2008Co-Authors: Alicia García-abuín, José M. Navaza, Diego Gómez-díaz, Isabel Vidal-tatoAbstract:The surface tension of aqueous solutions of 2-Pyrrolidinone, 1-methyl-2-Pyrrolidinone, and 1-ethyl-2-Pyrrolidinone has been measured at temperatures from (20 to 50) °C over the whole range of conce...
Guan-hu Bao - One of the best experts on this subject based on the ideXlab platform.
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Flavoalkaloids with a Pyrrolidinone Ring from Chinese Ancient Cultivated Tea Xi-Gui.
Journal of agricultural and food chemistry, 2018Co-Authors: Jian Cheng, Pu Wang, Xiaochun Wan, Ming-hua Qiu, Guan-hu BaoAbstract:Chinese Xi-Gui tea is one ancient cultivated variety of Camellia sinensis var. assamica. At present, it is used for producing expensive and elite tea in China. Five new flavoalkaloids, (−)-6-(5′′′S)-N-ethyl-2-Pyrrolidinone-epicatechin-3-O-gallate (ester-type catechins Pyrrolidinone E, etc-Pyrrolidinone E, 1), (−)-6-(5′′′R)-N-ethyl-2-Pyrrolidinone-epicatechin-3-O-gallate (etc-Pyrrolidinone F, 2) (−)-8-(5′′′S)-N-ethyl-2-Pyrrolidinone-epicatechin-3-O-gallate (etc-Pyrrolidinone G, 3a), (−)-8-(5′′′S)-N-ethyl-2-Pyrrolidinone-catechin-3-O-gallate (etc-Pyrrolidinone I, 4a), (−)-8-(5′′′R)-N-ethyl-2-Pyrrolidinone-catechin-3-O-gallate (etc-Pyrrolidinone J, 4b), and one new naturally occurring natural product (−)-8-(5′′′R)-N-ethyl-2-Pyrrolidinone-epicatechin-3-O-gallate (etc-Pyrrolidinone H, 3b) together with the known flavoalkaloids etc-Pyrrolidinones A–D (5, 6, 7a, and 7b) were detected and isolated from Xi-Gui green tea. Their structures were identified by comprehensive NMR spectroscopic analyses. Absolute configu...
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Flavoalkaloids with a Pyrrolidinone Ring from Chinese Ancient Cultivated Tea Xi-Gui
2018Co-Authors: Jian Cheng, Pu Wang, Xiaochun Wan, Ming-hua Qiu, Guan-hu BaoAbstract:Chinese Xi-Gui tea is one ancient cultivated variety of Camellia sinensis var. assamica. At present, it is used for producing expensive and elite tea in China. Five new flavoalkaloids, (−)-6-(5′′′S)-N-ethyl-2-Pyrrolidinone-epicatechin-3-O-gallate (ester-type catechins Pyrrolidinone E, etc-Pyrrolidinone E, 1), (−)-6-(5′′′R)-N-ethyl-2-Pyrrolidinone-epicatechin-3-O-gallate (etc-Pyrrolidinone F, 2) (−)-8-(5′′′S)-N-ethyl-2-Pyrrolidinone-epicatechin-3-O-gallate (etc-Pyrrolidinone G, 3a), (−)-8-(5′′′S)-N-ethyl-2-Pyrrolidinone-catechin-3-O-gallate (etc-Pyrrolidinone I, 4a), (−)-8-(5′′′R)-N-ethyl-2-Pyrrolidinone-catechin-3-O-gallate (etc-Pyrrolidinone J, 4b), and one new naturally occurring natural product (−)-8-(5′′′R)-N-ethyl-2-Pyrrolidinone-epicatechin-3-O-gallate (etc-Pyrrolidinone H, 3b) together with the known flavoalkaloids etc-Pyrrolidinones A–D (5, 6, 7a, and 7b) were detected and isolated from Xi-Gui green tea. Their structures were identified by comprehensive NMR spectroscopic analyses. Absolute configurations of 1–3 were established by comparison of the CD analyses with epicatechin-3-O-gallate (ECG). Compounds 1–4 were evaluated for their protection against high glucose induced cell senescence on human umbilical vein endothelia cells (HUVECs) and showed significant protection effects (p < 0.01) at both 1.0 and 10 μM. A discussion on the possible evolution of tea plants divergent from related food plants on the basis of phytochemical view is also provided
Joelle Pérard-viret - One of the best experts on this subject based on the ideXlab platform.
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In silico studies, synthesis and binding evaluation of substituted 2-Pyrrolidinones as peptidomimetics of RGD tripeptide sequence
Tetrahedron, 2015Co-Authors: Valérie Toum, Julie Bolley, Yoann Lalatonne, Carole Barbey, Laurence Motte, Marc Lecouvey, Jacques Royer, Nathalie Dupont, Joelle Pérard-viretAbstract:In silico optimisation, synthesis and binding evaluation of αvβ3 integrin's affinity for precursors of a new RGD peptidomimetics family are presented. The 2-Pyrrolidinone building block was obtained by condensation of L-lysine with dimethoxydihydrofuran followed by reduction. The ring was functionalised functionalized with a carboxylic acid and a guanidinium appendage. On the Pyrrolidinone heterocycle, the effects on affinity of position, length and relative .geometry of the two acid or basic functionalized side chains introduced on the Pyrrolidinone ring have been previously evaluated by docking studies. Peptidomimetics have finally been evaluated by competition binding assays for αvβ3 integrin's affinity using radio-ligands.
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In silico studies, synthesis and binding evaluation of substituted 2-Pyrrolidinones as peptidomimetics of RGD tripeptide sequence
European journal of medicinal chemistry, 2015Co-Authors: Valérie Toum, Julie Bolley, Yoann Lalatonne, Carole Barbey, Laurence Motte, Marc Lecouvey, Jacques Royer, Nathalie Dupont, Joelle Pérard-viretAbstract:In silico optimisation, synthesis and binding evaluation of αvβ3 integrin's affinity for precursors of a new RGD peptidomimetics family are presented. The 2-Pyrrolidinone building block was obtained by condensation of l-lysine with dimethoxydihydrofuran followed by reduction. The ring was functionalized with a carboxylic acid and a guanidinium appendage. On the Pyrrolidinone heterocycle, the effects on affinity of position, length and relative geometry of the two acid or basic functionalized side chains introduced on the Pyrrolidinone ring have been previously evaluated by docking studies. Peptidomimetics have finally been evaluated by competition binding assays for αvβ3 integrin's affinity using radio-ligands.
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An expeditiousAn expeditious total synthesis of (±)-jamtine using condensation between imine and acid anhydride total synthesis of (±)-jamtine using condensation between imines and acid anhydride
Tetrahedron Letters, 2010Co-Authors: Joelle Pérard-viret, Florence Souquet, Marie-line Manisse, Jacques RoyerAbstract:In silico optimisation, synthesis and binding evaluation of avb3 integrin's affinity for precursors of a new RGD peptidomimetics family are presented. The 2-Pyrrolidinone building block was obtained by condensation of L-lysine with dimethoxydihydrofuran followed by reduction. The ring was functionalized with a carboxylic acid and a guanidinium appendage. On the Pyrrolidinone heterocycle, the effects on affinity of position, length and relative geometry of the two acid or basic functionalized side chains introduced on the Pyrrolidinone ring have been previously evaluated by docking studies. Peptidomimetics have finally been evaluated by competition binding assays for avb3 integrin's affinity using radioligands
