The Experts below are selected from a list of 3078 Experts worldwide ranked by ideXlab platform
M Gourven - One of the best experts on this subject based on the ideXlab platform.
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emerging therapy for improving wound repair of severe Radiation Burns using local bone marrow derived stem cell administrations
Wound Repair and Regeneration, 2010Co-Authors: Marie Prat, Francois Trompier, Pierre Battaglini, Isabelle Ernou, Laetitia Boutin, M Gourven, Marc Benderitter, Marc Brachet, Pierre Duhamel, Frederique TissedreAbstract:The therapeutic management of severe Radiation Burns remains a challenging issue today. Conventional surgical treatment including excision, skin autograft, or flap often fails to prevent unpredictable and uncontrolled extension of the Radiation-induced necrotic process. In a recent very severe accidental Radiation Burn, we demonstrated the efficiency of a new therapeutic approach combining surgery and local cellular therapy using autologous mesenchymal stem cells (MSC), and we confirmed the crucial place of the dose assessment in this medical management. The patient presented a very significant Radiation lesion located on the arm, which was first treated by several surgical procedures: iterative excisions, skin graft, latissimus muscle dorsi flap, and forearm radial flap. This conventional surgical therapy was unfortunately inefficient, leading to the use of an innovative cell therapy strategy. Autologous MSC were obtained from three bone marrow collections and were expanded according to a clinical-grade protocol using platelet-derived growth factors. A total of five local MSC administrations were performed in combination with skin autograft. After iterative local MSC administrations, the clinical evolution was favorable and no recurrence of Radiation inflammatory waves occurred during the patient's 8-month follow-up. The benefit of this local cell therapy could be linked to the “drug cell” activity of MSC by modulating the Radiation inflammatory processes, as suggested by the decrease in the C-reactive protein level observed after each MSC administration. The success of this combined treatment leads to new prospects in the medical management of severe Radiation Burns and more widely in the improvement of wound repair.
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new approach to Radiation Burn treatment by dosimetry guided surgery combined with autologous mesenchymal stem cell therapy
Regenerative Medicine, 2007Co-Authors: Jean Jacques Lataillade, H Carsin, Alain Chapel, Isabelle Ernou, M Gourven, C Huet, I Clairand, Christelle Doucet, J F Bottollierdepois, Laetitia BoutinAbstract:The therapeutic management of severe Radiation Burns remains a challenging issue. Conventional surgical treatment (excision and skin autograft or rotation flap) often fails to prevent unpredictable and uncontrolled extension of the Radiation necrotic process. We report here an innovative therapeutic strategy applied to the victim of a Radiation accident (December 15, 2005) with an iridium gammagraphy radioactive source (192Ir, 3.3 TBq). The approach combined numerical dosimetry-guided surgery with cellular therapy using mesenchymal stem cells. A very severe buttock Radiation Burn (2000 Gy at the center of the skin surface lesion) of a 27-year-old Chilean victim was widely excised (10 cm in diameter) using a physical and anatomical dose reconstruction in order to better define the limit of the surgical excision in apparently healthy tissues. A secondary extension of the Radiation necrosis led to a new excision of fibronecrotic tissues associated with a local cellular therapy using autologous expanded mesen...
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New approach to Radiation Burn treatment by dosimetry-guided surgery combined with autologous mesenchymal stem cell therapy
Regenerative Medicine, 2007Co-Authors: Jean Jacques Lataillade, Jean Francois Bottollier-depois, H Carsin, Alain Chapel, Isabelle Ernou, Cedric Doucet, C Huet, Erik Bey, I Clairand, M GourvenAbstract:The therapeutic management of severe Radiation Burns remains a challenging issue. Conventional surgical treatment (excision and skin autograft or rotation flap) often fails to prevent unpredictable and uncontrolled extension of the Radiation necrotic process. We report here an innovative therapeutic strategy applied to the victim of a Radiation accident (December 15, 2005) with an iridium gammagraphy radioactive source (192Ir, 3.3 TBq). The approach combined numerical dosimetry-guided surgery with cellular therapy using mesenchymal stem cells. A very severe buttock Radiation Burn (2000 Gy at the center of the skin surface lesion) of a 27-year-old Chilean victim was widely excised (10 cm in diameter) using a physical and anatomical dose reconstruction in order to better define the limit of the surgical excision in apparently healthy tissues. A secondary extension of the Radiation necrosis led to a new excision of fibronecrotic tissues associated with a local cellular therapy using autologous expanded mesenchymal stem cells as a source of trophic factors to promote tissue regeneration. Bone marrow-derived mesenchymal stem cells were expanded according to a clinical-grade technique using closed culture devices and serum-free medium enriched in human platelet lysate. The clinical evolution (Radiation pain and healing progression) was favorable and no recurrence of Radiation inflammatory waves was observed during the 11 month patient's follow-up. This novel multidisciplinary therapeutic approach combining physical techniques, surgical procedures and cellular therapy with adult stem cells may be of clinical relevance for improving the medical management of severe localized irRadiations. It may open new prospects in the field of radiotherapy complications.
Laetitia Boutin - One of the best experts on this subject based on the ideXlab platform.
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emerging therapy for improving wound repair of severe Radiation Burns using local bone marrow derived stem cell administrations
Wound Repair and Regeneration, 2010Co-Authors: Marie Prat, Francois Trompier, Pierre Battaglini, Isabelle Ernou, Laetitia Boutin, M Gourven, Marc Benderitter, Marc Brachet, Pierre Duhamel, Frederique TissedreAbstract:The therapeutic management of severe Radiation Burns remains a challenging issue today. Conventional surgical treatment including excision, skin autograft, or flap often fails to prevent unpredictable and uncontrolled extension of the Radiation-induced necrotic process. In a recent very severe accidental Radiation Burn, we demonstrated the efficiency of a new therapeutic approach combining surgery and local cellular therapy using autologous mesenchymal stem cells (MSC), and we confirmed the crucial place of the dose assessment in this medical management. The patient presented a very significant Radiation lesion located on the arm, which was first treated by several surgical procedures: iterative excisions, skin graft, latissimus muscle dorsi flap, and forearm radial flap. This conventional surgical therapy was unfortunately inefficient, leading to the use of an innovative cell therapy strategy. Autologous MSC were obtained from three bone marrow collections and were expanded according to a clinical-grade protocol using platelet-derived growth factors. A total of five local MSC administrations were performed in combination with skin autograft. After iterative local MSC administrations, the clinical evolution was favorable and no recurrence of Radiation inflammatory waves occurred during the patient's 8-month follow-up. The benefit of this local cell therapy could be linked to the “drug cell” activity of MSC by modulating the Radiation inflammatory processes, as suggested by the decrease in the C-reactive protein level observed after each MSC administration. The success of this combined treatment leads to new prospects in the medical management of severe Radiation Burns and more widely in the improvement of wound repair.
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new approach to Radiation Burn treatment by dosimetry guided surgery combined with autologous mesenchymal stem cell therapy
Regenerative Medicine, 2007Co-Authors: Jean Jacques Lataillade, H Carsin, Alain Chapel, Isabelle Ernou, M Gourven, C Huet, I Clairand, Christelle Doucet, J F Bottollierdepois, Laetitia BoutinAbstract:The therapeutic management of severe Radiation Burns remains a challenging issue. Conventional surgical treatment (excision and skin autograft or rotation flap) often fails to prevent unpredictable and uncontrolled extension of the Radiation necrotic process. We report here an innovative therapeutic strategy applied to the victim of a Radiation accident (December 15, 2005) with an iridium gammagraphy radioactive source (192Ir, 3.3 TBq). The approach combined numerical dosimetry-guided surgery with cellular therapy using mesenchymal stem cells. A very severe buttock Radiation Burn (2000 Gy at the center of the skin surface lesion) of a 27-year-old Chilean victim was widely excised (10 cm in diameter) using a physical and anatomical dose reconstruction in order to better define the limit of the surgical excision in apparently healthy tissues. A secondary extension of the Radiation necrosis led to a new excision of fibronecrotic tissues associated with a local cellular therapy using autologous expanded mesen...
Isabelle Ernou - One of the best experts on this subject based on the ideXlab platform.
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emerging therapy for improving wound repair of severe Radiation Burns using local bone marrow derived stem cell administrations
Wound Repair and Regeneration, 2010Co-Authors: Marie Prat, Francois Trompier, Pierre Battaglini, Isabelle Ernou, Laetitia Boutin, M Gourven, Marc Benderitter, Marc Brachet, Pierre Duhamel, Frederique TissedreAbstract:The therapeutic management of severe Radiation Burns remains a challenging issue today. Conventional surgical treatment including excision, skin autograft, or flap often fails to prevent unpredictable and uncontrolled extension of the Radiation-induced necrotic process. In a recent very severe accidental Radiation Burn, we demonstrated the efficiency of a new therapeutic approach combining surgery and local cellular therapy using autologous mesenchymal stem cells (MSC), and we confirmed the crucial place of the dose assessment in this medical management. The patient presented a very significant Radiation lesion located on the arm, which was first treated by several surgical procedures: iterative excisions, skin graft, latissimus muscle dorsi flap, and forearm radial flap. This conventional surgical therapy was unfortunately inefficient, leading to the use of an innovative cell therapy strategy. Autologous MSC were obtained from three bone marrow collections and were expanded according to a clinical-grade protocol using platelet-derived growth factors. A total of five local MSC administrations were performed in combination with skin autograft. After iterative local MSC administrations, the clinical evolution was favorable and no recurrence of Radiation inflammatory waves occurred during the patient's 8-month follow-up. The benefit of this local cell therapy could be linked to the “drug cell” activity of MSC by modulating the Radiation inflammatory processes, as suggested by the decrease in the C-reactive protein level observed after each MSC administration. The success of this combined treatment leads to new prospects in the medical management of severe Radiation Burns and more widely in the improvement of wound repair.
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new approach to Radiation Burn treatment by dosimetry guided surgery combined with autologous mesenchymal stem cell therapy
Regenerative Medicine, 2007Co-Authors: Jean Jacques Lataillade, H Carsin, Alain Chapel, Isabelle Ernou, M Gourven, C Huet, I Clairand, Christelle Doucet, J F Bottollierdepois, Laetitia BoutinAbstract:The therapeutic management of severe Radiation Burns remains a challenging issue. Conventional surgical treatment (excision and skin autograft or rotation flap) often fails to prevent unpredictable and uncontrolled extension of the Radiation necrotic process. We report here an innovative therapeutic strategy applied to the victim of a Radiation accident (December 15, 2005) with an iridium gammagraphy radioactive source (192Ir, 3.3 TBq). The approach combined numerical dosimetry-guided surgery with cellular therapy using mesenchymal stem cells. A very severe buttock Radiation Burn (2000 Gy at the center of the skin surface lesion) of a 27-year-old Chilean victim was widely excised (10 cm in diameter) using a physical and anatomical dose reconstruction in order to better define the limit of the surgical excision in apparently healthy tissues. A secondary extension of the Radiation necrosis led to a new excision of fibronecrotic tissues associated with a local cellular therapy using autologous expanded mesen...
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New approach to Radiation Burn treatment by dosimetry-guided surgery combined with autologous mesenchymal stem cell therapy
Regenerative Medicine, 2007Co-Authors: Jean Jacques Lataillade, Jean Francois Bottollier-depois, H Carsin, Alain Chapel, Isabelle Ernou, Cedric Doucet, C Huet, Erik Bey, I Clairand, M GourvenAbstract:The therapeutic management of severe Radiation Burns remains a challenging issue. Conventional surgical treatment (excision and skin autograft or rotation flap) often fails to prevent unpredictable and uncontrolled extension of the Radiation necrotic process. We report here an innovative therapeutic strategy applied to the victim of a Radiation accident (December 15, 2005) with an iridium gammagraphy radioactive source (192Ir, 3.3 TBq). The approach combined numerical dosimetry-guided surgery with cellular therapy using mesenchymal stem cells. A very severe buttock Radiation Burn (2000 Gy at the center of the skin surface lesion) of a 27-year-old Chilean victim was widely excised (10 cm in diameter) using a physical and anatomical dose reconstruction in order to better define the limit of the surgical excision in apparently healthy tissues. A secondary extension of the Radiation necrosis led to a new excision of fibronecrotic tissues associated with a local cellular therapy using autologous expanded mesenchymal stem cells as a source of trophic factors to promote tissue regeneration. Bone marrow-derived mesenchymal stem cells were expanded according to a clinical-grade technique using closed culture devices and serum-free medium enriched in human platelet lysate. The clinical evolution (Radiation pain and healing progression) was favorable and no recurrence of Radiation inflammatory waves was observed during the 11 month patient's follow-up. This novel multidisciplinary therapeutic approach combining physical techniques, surgical procedures and cellular therapy with adult stem cells may be of clinical relevance for improving the medical management of severe localized irRadiations. It may open new prospects in the field of radiotherapy complications.
Jean Jacques Lataillade - One of the best experts on this subject based on the ideXlab platform.
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new approach to Radiation Burn treatment by dosimetry guided surgery combined with autologous mesenchymal stem cell therapy
Regenerative Medicine, 2007Co-Authors: Jean Jacques Lataillade, H Carsin, Alain Chapel, Isabelle Ernou, M Gourven, C Huet, I Clairand, Christelle Doucet, J F Bottollierdepois, Laetitia BoutinAbstract:The therapeutic management of severe Radiation Burns remains a challenging issue. Conventional surgical treatment (excision and skin autograft or rotation flap) often fails to prevent unpredictable and uncontrolled extension of the Radiation necrotic process. We report here an innovative therapeutic strategy applied to the victim of a Radiation accident (December 15, 2005) with an iridium gammagraphy radioactive source (192Ir, 3.3 TBq). The approach combined numerical dosimetry-guided surgery with cellular therapy using mesenchymal stem cells. A very severe buttock Radiation Burn (2000 Gy at the center of the skin surface lesion) of a 27-year-old Chilean victim was widely excised (10 cm in diameter) using a physical and anatomical dose reconstruction in order to better define the limit of the surgical excision in apparently healthy tissues. A secondary extension of the Radiation necrosis led to a new excision of fibronecrotic tissues associated with a local cellular therapy using autologous expanded mesen...
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New approach to Radiation Burn treatment by dosimetry-guided surgery combined with autologous mesenchymal stem cell therapy
Regenerative Medicine, 2007Co-Authors: Jean Jacques Lataillade, Jean Francois Bottollier-depois, H Carsin, Alain Chapel, Isabelle Ernou, Cedric Doucet, C Huet, Erik Bey, I Clairand, M GourvenAbstract:The therapeutic management of severe Radiation Burns remains a challenging issue. Conventional surgical treatment (excision and skin autograft or rotation flap) often fails to prevent unpredictable and uncontrolled extension of the Radiation necrotic process. We report here an innovative therapeutic strategy applied to the victim of a Radiation accident (December 15, 2005) with an iridium gammagraphy radioactive source (192Ir, 3.3 TBq). The approach combined numerical dosimetry-guided surgery with cellular therapy using mesenchymal stem cells. A very severe buttock Radiation Burn (2000 Gy at the center of the skin surface lesion) of a 27-year-old Chilean victim was widely excised (10 cm in diameter) using a physical and anatomical dose reconstruction in order to better define the limit of the surgical excision in apparently healthy tissues. A secondary extension of the Radiation necrosis led to a new excision of fibronecrotic tissues associated with a local cellular therapy using autologous expanded mesenchymal stem cells as a source of trophic factors to promote tissue regeneration. Bone marrow-derived mesenchymal stem cells were expanded according to a clinical-grade technique using closed culture devices and serum-free medium enriched in human platelet lysate. The clinical evolution (Radiation pain and healing progression) was favorable and no recurrence of Radiation inflammatory waves was observed during the 11 month patient's follow-up. This novel multidisciplinary therapeutic approach combining physical techniques, surgical procedures and cellular therapy with adult stem cells may be of clinical relevance for improving the medical management of severe localized irRadiations. It may open new prospects in the field of radiotherapy complications.
H Carsin - One of the best experts on this subject based on the ideXlab platform.
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new approach to Radiation Burn treatment by dosimetry guided surgery combined with autologous mesenchymal stem cell therapy
Regenerative Medicine, 2007Co-Authors: Jean Jacques Lataillade, H Carsin, Alain Chapel, Isabelle Ernou, M Gourven, C Huet, I Clairand, Christelle Doucet, J F Bottollierdepois, Laetitia BoutinAbstract:The therapeutic management of severe Radiation Burns remains a challenging issue. Conventional surgical treatment (excision and skin autograft or rotation flap) often fails to prevent unpredictable and uncontrolled extension of the Radiation necrotic process. We report here an innovative therapeutic strategy applied to the victim of a Radiation accident (December 15, 2005) with an iridium gammagraphy radioactive source (192Ir, 3.3 TBq). The approach combined numerical dosimetry-guided surgery with cellular therapy using mesenchymal stem cells. A very severe buttock Radiation Burn (2000 Gy at the center of the skin surface lesion) of a 27-year-old Chilean victim was widely excised (10 cm in diameter) using a physical and anatomical dose reconstruction in order to better define the limit of the surgical excision in apparently healthy tissues. A secondary extension of the Radiation necrosis led to a new excision of fibronecrotic tissues associated with a local cellular therapy using autologous expanded mesen...
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New approach to Radiation Burn treatment by dosimetry-guided surgery combined with autologous mesenchymal stem cell therapy
Regenerative Medicine, 2007Co-Authors: Jean Jacques Lataillade, Jean Francois Bottollier-depois, H Carsin, Alain Chapel, Isabelle Ernou, Cedric Doucet, C Huet, Erik Bey, I Clairand, M GourvenAbstract:The therapeutic management of severe Radiation Burns remains a challenging issue. Conventional surgical treatment (excision and skin autograft or rotation flap) often fails to prevent unpredictable and uncontrolled extension of the Radiation necrotic process. We report here an innovative therapeutic strategy applied to the victim of a Radiation accident (December 15, 2005) with an iridium gammagraphy radioactive source (192Ir, 3.3 TBq). The approach combined numerical dosimetry-guided surgery with cellular therapy using mesenchymal stem cells. A very severe buttock Radiation Burn (2000 Gy at the center of the skin surface lesion) of a 27-year-old Chilean victim was widely excised (10 cm in diameter) using a physical and anatomical dose reconstruction in order to better define the limit of the surgical excision in apparently healthy tissues. A secondary extension of the Radiation necrosis led to a new excision of fibronecrotic tissues associated with a local cellular therapy using autologous expanded mesenchymal stem cells as a source of trophic factors to promote tissue regeneration. Bone marrow-derived mesenchymal stem cells were expanded according to a clinical-grade technique using closed culture devices and serum-free medium enriched in human platelet lysate. The clinical evolution (Radiation pain and healing progression) was favorable and no recurrence of Radiation inflammatory waves was observed during the 11 month patient's follow-up. This novel multidisciplinary therapeutic approach combining physical techniques, surgical procedures and cellular therapy with adult stem cells may be of clinical relevance for improving the medical management of severe localized irRadiations. It may open new prospects in the field of radiotherapy complications.
