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K P Wong - One of the best experts on this subject based on the ideXlab platform.
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muir torre syndrome associated pleomorphic liposarcoma arising in a previous Radiation Field
Virchows Archiv, 2013Co-Authors: Masato Yozu, Pennie J Symmans, Michael Dray, Jennifer Griffin, Catherine H Han, Susan Parry, K P WongAbstract:Muir-Torre syndrome is a variant of Lynch syndrome, characterised by sebaceous neoplasia and/or keratoacanthomas associated with visceral malignancies. Muir-Torre syndrome is caused by germline mutations of one of the mismatch repair genes, frequently MSH2 and less frequently MLH1 and MSH6. Visceral malignancies associated with Muir-Torre syndrome and Lynch syndrome include colorectal, endometrial and other gastrointestinal, urological and gynaecological malignancies. Small numbers of Lynch syndrome-associated soft tissue sarcomas have been reported, but there are no reported cases of soft tissue sarcomas in Muir-Torre syndrome. In this study, we report a 74-year-old man with known Muir-Torre syndrome with confirmed MSH2 germline mutation, diagnosed with pleomorphic liposarcoma of the right buttock in a previous Radiation Field. The tumour showed loss of expression of MSH2 and MSH6 on immunohistochemistry. Immunohistochemistry on another pleomorphic liposarcoma in a different patient with no previous history of Muir-Torre syndrome or Lynch syndrome showed no loss of expression of mismatch repair proteins. This is the first report of Muir-Torre syndrome-associated sarcoma and the first case of post-Radiation sarcoma in Lynch syndrome.
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muir torre syndrome associated pleomorphic liposarcoma arising in a previous Radiation Field
Pathology, 2013Co-Authors: Masato Yozu, Pennie J Symmans, Michael Dray, Jennifer Griffin, Catherine H Han, Susan Parry, K P WongAbstract:Background Muir–Torre syndrome is a variant of Lynch syndrome, characterised by sebaceous neoplasia and/or keratoacan-thomas associated with visceral malignancies. Muir–Torre syndrome is caused by germline mutations of one of the mismatch repair genes, frequently MSH2 and less frequently MLH1 and MSH6. Visceral malignancies associated with Muir–Torre syndrome and Lynch syndrome include colorectal, endometrial and other gastrointestinal, urological and gynaecological malignancies. Small numbers of Lynch syndrome-associated soft tissue sarcomas have been reported but there are no reported cases of soft tissue sarcomas in Muir–Torre syndrome. Aim and Methods In this study, we report a 74-year-old man with known Muir–Torre syndrome with confirmed MSH2 germ-line mutation, diagnosed with pleomorphic liposarcoma of the right buttock in a previous Radiation Field. The tumour showed loss of expression of MSH2 and MSH6 on immunohistochemistry. Results Immunohistochemistry on another pleomorphic liposar-coma in a different patient with no previous history of Muir–Torre syndrome or Lynch syndrome showed no loss of expression of mismatch repair proteins. Discussion This is the first report of Muir–Torre syndrome-associated sarcoma and the first case of post-Radiation sarcoma in Lynch syndrome.
Susan Parry - One of the best experts on this subject based on the ideXlab platform.
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muir torre syndrome associated pleomorphic liposarcoma arising in a previous Radiation Field
Virchows Archiv, 2013Co-Authors: Masato Yozu, Pennie J Symmans, Michael Dray, Jennifer Griffin, Catherine H Han, Susan Parry, K P WongAbstract:Muir-Torre syndrome is a variant of Lynch syndrome, characterised by sebaceous neoplasia and/or keratoacanthomas associated with visceral malignancies. Muir-Torre syndrome is caused by germline mutations of one of the mismatch repair genes, frequently MSH2 and less frequently MLH1 and MSH6. Visceral malignancies associated with Muir-Torre syndrome and Lynch syndrome include colorectal, endometrial and other gastrointestinal, urological and gynaecological malignancies. Small numbers of Lynch syndrome-associated soft tissue sarcomas have been reported, but there are no reported cases of soft tissue sarcomas in Muir-Torre syndrome. In this study, we report a 74-year-old man with known Muir-Torre syndrome with confirmed MSH2 germline mutation, diagnosed with pleomorphic liposarcoma of the right buttock in a previous Radiation Field. The tumour showed loss of expression of MSH2 and MSH6 on immunohistochemistry. Immunohistochemistry on another pleomorphic liposarcoma in a different patient with no previous history of Muir-Torre syndrome or Lynch syndrome showed no loss of expression of mismatch repair proteins. This is the first report of Muir-Torre syndrome-associated sarcoma and the first case of post-Radiation sarcoma in Lynch syndrome.
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muir torre syndrome associated pleomorphic liposarcoma arising in a previous Radiation Field
Pathology, 2013Co-Authors: Masato Yozu, Pennie J Symmans, Michael Dray, Jennifer Griffin, Catherine H Han, Susan Parry, K P WongAbstract:Background Muir–Torre syndrome is a variant of Lynch syndrome, characterised by sebaceous neoplasia and/or keratoacan-thomas associated with visceral malignancies. Muir–Torre syndrome is caused by germline mutations of one of the mismatch repair genes, frequently MSH2 and less frequently MLH1 and MSH6. Visceral malignancies associated with Muir–Torre syndrome and Lynch syndrome include colorectal, endometrial and other gastrointestinal, urological and gynaecological malignancies. Small numbers of Lynch syndrome-associated soft tissue sarcomas have been reported but there are no reported cases of soft tissue sarcomas in Muir–Torre syndrome. Aim and Methods In this study, we report a 74-year-old man with known Muir–Torre syndrome with confirmed MSH2 germ-line mutation, diagnosed with pleomorphic liposarcoma of the right buttock in a previous Radiation Field. The tumour showed loss of expression of MSH2 and MSH6 on immunohistochemistry. Results Immunohistochemistry on another pleomorphic liposar-coma in a different patient with no previous history of Muir–Torre syndrome or Lynch syndrome showed no loss of expression of mismatch repair proteins. Discussion This is the first report of Muir–Torre syndrome-associated sarcoma and the first case of post-Radiation sarcoma in Lynch syndrome.
Masato Yozu - One of the best experts on this subject based on the ideXlab platform.
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muir torre syndrome associated pleomorphic liposarcoma arising in a previous Radiation Field
Virchows Archiv, 2013Co-Authors: Masato Yozu, Pennie J Symmans, Michael Dray, Jennifer Griffin, Catherine H Han, Susan Parry, K P WongAbstract:Muir-Torre syndrome is a variant of Lynch syndrome, characterised by sebaceous neoplasia and/or keratoacanthomas associated with visceral malignancies. Muir-Torre syndrome is caused by germline mutations of one of the mismatch repair genes, frequently MSH2 and less frequently MLH1 and MSH6. Visceral malignancies associated with Muir-Torre syndrome and Lynch syndrome include colorectal, endometrial and other gastrointestinal, urological and gynaecological malignancies. Small numbers of Lynch syndrome-associated soft tissue sarcomas have been reported, but there are no reported cases of soft tissue sarcomas in Muir-Torre syndrome. In this study, we report a 74-year-old man with known Muir-Torre syndrome with confirmed MSH2 germline mutation, diagnosed with pleomorphic liposarcoma of the right buttock in a previous Radiation Field. The tumour showed loss of expression of MSH2 and MSH6 on immunohistochemistry. Immunohistochemistry on another pleomorphic liposarcoma in a different patient with no previous history of Muir-Torre syndrome or Lynch syndrome showed no loss of expression of mismatch repair proteins. This is the first report of Muir-Torre syndrome-associated sarcoma and the first case of post-Radiation sarcoma in Lynch syndrome.
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muir torre syndrome associated pleomorphic liposarcoma arising in a previous Radiation Field
Pathology, 2013Co-Authors: Masato Yozu, Pennie J Symmans, Michael Dray, Jennifer Griffin, Catherine H Han, Susan Parry, K P WongAbstract:Background Muir–Torre syndrome is a variant of Lynch syndrome, characterised by sebaceous neoplasia and/or keratoacan-thomas associated with visceral malignancies. Muir–Torre syndrome is caused by germline mutations of one of the mismatch repair genes, frequently MSH2 and less frequently MLH1 and MSH6. Visceral malignancies associated with Muir–Torre syndrome and Lynch syndrome include colorectal, endometrial and other gastrointestinal, urological and gynaecological malignancies. Small numbers of Lynch syndrome-associated soft tissue sarcomas have been reported but there are no reported cases of soft tissue sarcomas in Muir–Torre syndrome. Aim and Methods In this study, we report a 74-year-old man with known Muir–Torre syndrome with confirmed MSH2 germ-line mutation, diagnosed with pleomorphic liposarcoma of the right buttock in a previous Radiation Field. The tumour showed loss of expression of MSH2 and MSH6 on immunohistochemistry. Results Immunohistochemistry on another pleomorphic liposar-coma in a different patient with no previous history of Muir–Torre syndrome or Lynch syndrome showed no loss of expression of mismatch repair proteins. Discussion This is the first report of Muir–Torre syndrome-associated sarcoma and the first case of post-Radiation sarcoma in Lynch syndrome.
Jurg Frohlich - One of the best experts on this subject based on the ideXlab platform.
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infrared finite algorithms in qed ii the expansion of the groundstate of an atom interacting with the quantized Radiation Field
Advances in Mathematics, 2009Co-Authors: Volker Bach, Jurg Frohlich, Alessandro PizzoAbstract:Abstract In this paper, we present an explicit and constructive algorithm enabling us to calculate the groundstate and the groundstate energy of a non-relativistic atom minimally coupled to the quantized Radiation Field up to an error of arbitrary finite order in the fine structure constant. Because of infrared divergences, which invalidate a straightforward Taylor expansion, an iterative construction is employed to remove the infrared cut-off in photon momentum space and to produce a convergent algorithm.
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infrared finite algorithms in qed the groundstate of an atom interacting with the quantized Radiation Field
Communications in Mathematical Physics, 2006Co-Authors: Volker Bach, Jurg Frohlich, Alessandro PizzoAbstract:In this paper, the groundstate of a nonrelativistic atom, minimally coupled to the quantized Radiation Field, and its groundstate energy are constructed by an iteration scheme inspired by [10]. This scheme successively removes an infrared cutoff in momentum space and yields a convergent algorithm enabling us to calculate the groundstate and the groundstate energy, to arbitrary order in the feinstructure constant α ~ 1/137. In forthcoming papers, we will use our result to re-expand the groundstate and, eventually, scattering amplitudes in terms of bare quantities.
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asymptotic electromagnetic Fields in models of quantum mechanical matter interacting with the quantized Radiation Field
Advances in Mathematics, 2001Co-Authors: Jurg Frohlich, Marcel Griesemer, Benjamin SchleinAbstract:In models of (non-relativistic and pseudo-relativistic) electrons interacting with static nuclei and with the (ultraviolet-cutoff) quantized Radiation Field, the existence of asymptotic electromagnetic Fields is established. Our results yield some mathematically rigorous understanding of Rayleigh scattering and of the phenomenon of relaxation of isolated atoms to their ground states. Our proofs are based on propagation estimates for electrons inspired by similar estimates known from N-body scattering theory. I Introduction In this paper we study the scattering of light at non-relativistic and pseudo-relativistic, quantum mechanical electrons moving under the influence of an external potential and minimally coupled to the soft modes of the quantized electromagnetic Field. The external potential may be the Coulomb potential generated by a configuration of static nuclei. Our goal is to establish the existence of asymptotic electromagnetic Fields on states of the system with the property that the velocities of all electrons present are smaller than the velocity of light, (in a sense to be made mathematically precise). This property is automatically satisfied if one chooses relativistic kinematics in the description of electrons, because the propagation velocity of a massive relativistic particle is smaller than the velocity of light. In contrast, if the kinematics of electrons is non-relativistic these particles can propagate arbitrarily fast, and the condition that the propagation velocities of electrons in a state of the system are smaller than the velocity of light is a very stringent one. It is satisfied if all electrons remain bound to nuclei. But, in realistic models, such “bound states” are not dense in the Hilbert space of the system.
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spectral analysis for systems of atoms and molecules coupled to the quantized Radiation Field
Communications in Mathematical Physics, 1999Co-Authors: Volker Bach, Jurg Frohlich, I M SigalAbstract:We consider systems of static nuclei and electrons – atoms and molecules – coupled to the quantized Radiation Field. The interactions between electrons and the soft modes of the quantized electromagnetic Field are described by minimal coupling, p→p−e A (x), where A(x) is the electromagnetic vector potential with an ultraviolet cutoff. If the interactions between the electrons and the quantized Radiation Field are turned off, the atom or molecule is assumed to have at least one bound state. We prove that, for sufficiently small values of the fine structure constant α, the interacting system has a ground state corresponding to the bottom of its energy spectrum. For an atom, we prove that its excited states above the ground state turn into metastable states whose life-times we estimate. Furthermore the energy spectrum is absolutely continuous, except, perhaps, in a small interval above the ground state energy and around the threshold energies of the atom or molecule.
Jennifer Griffin - One of the best experts on this subject based on the ideXlab platform.
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muir torre syndrome associated pleomorphic liposarcoma arising in a previous Radiation Field
Virchows Archiv, 2013Co-Authors: Masato Yozu, Pennie J Symmans, Michael Dray, Jennifer Griffin, Catherine H Han, Susan Parry, K P WongAbstract:Muir-Torre syndrome is a variant of Lynch syndrome, characterised by sebaceous neoplasia and/or keratoacanthomas associated with visceral malignancies. Muir-Torre syndrome is caused by germline mutations of one of the mismatch repair genes, frequently MSH2 and less frequently MLH1 and MSH6. Visceral malignancies associated with Muir-Torre syndrome and Lynch syndrome include colorectal, endometrial and other gastrointestinal, urological and gynaecological malignancies. Small numbers of Lynch syndrome-associated soft tissue sarcomas have been reported, but there are no reported cases of soft tissue sarcomas in Muir-Torre syndrome. In this study, we report a 74-year-old man with known Muir-Torre syndrome with confirmed MSH2 germline mutation, diagnosed with pleomorphic liposarcoma of the right buttock in a previous Radiation Field. The tumour showed loss of expression of MSH2 and MSH6 on immunohistochemistry. Immunohistochemistry on another pleomorphic liposarcoma in a different patient with no previous history of Muir-Torre syndrome or Lynch syndrome showed no loss of expression of mismatch repair proteins. This is the first report of Muir-Torre syndrome-associated sarcoma and the first case of post-Radiation sarcoma in Lynch syndrome.
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muir torre syndrome associated pleomorphic liposarcoma arising in a previous Radiation Field
Pathology, 2013Co-Authors: Masato Yozu, Pennie J Symmans, Michael Dray, Jennifer Griffin, Catherine H Han, Susan Parry, K P WongAbstract:Background Muir–Torre syndrome is a variant of Lynch syndrome, characterised by sebaceous neoplasia and/or keratoacan-thomas associated with visceral malignancies. Muir–Torre syndrome is caused by germline mutations of one of the mismatch repair genes, frequently MSH2 and less frequently MLH1 and MSH6. Visceral malignancies associated with Muir–Torre syndrome and Lynch syndrome include colorectal, endometrial and other gastrointestinal, urological and gynaecological malignancies. Small numbers of Lynch syndrome-associated soft tissue sarcomas have been reported but there are no reported cases of soft tissue sarcomas in Muir–Torre syndrome. Aim and Methods In this study, we report a 74-year-old man with known Muir–Torre syndrome with confirmed MSH2 germ-line mutation, diagnosed with pleomorphic liposarcoma of the right buttock in a previous Radiation Field. The tumour showed loss of expression of MSH2 and MSH6 on immunohistochemistry. Results Immunohistochemistry on another pleomorphic liposar-coma in a different patient with no previous history of Muir–Torre syndrome or Lynch syndrome showed no loss of expression of mismatch repair proteins. Discussion This is the first report of Muir–Torre syndrome-associated sarcoma and the first case of post-Radiation sarcoma in Lynch syndrome.
