The Experts below are selected from a list of 15534 Experts worldwide ranked by ideXlab platform
Matthew C Good - One of the best experts on this subject based on the ideXlab platform.
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comparison of computed tomographic angiography with digital subtraction angiography in the diagnosis of cerebral aneurysms a meta analysis
Neurosurgery, 2003Co-Authors: Thomas E Chappell, Federico Castro Moure, Matthew C GoodAbstract:Objective To compare a novel diagnostic Radiological Technique, computed tomographic angiography (CTA), with the standard method, namely digital subtraction angiography (DSA), in the diagnosis of cerebral aneurysms. Methods A comprehensive search of the world literature on CTA was performed. Articles that reported on prospective comparisons of CTA and DSA in the evaluation of patients suspected of harboring cerebral aneurysms were selected for data extraction. Suitable statistical methods were applied to the extracted data for meta-analysis. Results Twenty-one references met the criteria for use in the meta-analysis. Unweighted calculations based on data for 1251 patients resulted in a sensitivity of 0.933 (93.3%; range, 75.4-100%) and a specificity of 0.878 (87.8%; range, 0-100%). When the studies were weighted for the number of patients in each study, the sensitivity decreased slightly, to 0.927 (92.7%), and the specificity decreased more substantially, to 0.772 (77.2%). Conclusion On the basis of this meta-analysis, DSA remains the standard method. However, many who use CTA have reported it to be as good as or better than DSA in the diagnosis and treatment of cerebral aneurysms, as well as being of less risk and discomfort to their patients and easier and less expensive to perform.
Nathan Lawrentschuk - One of the best experts on this subject based on the ideXlab platform.
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sensitivity specificity and predictors of positive 68ga prostate specific membrane antigen positron emission tomography in advanced prostate cancer a systematic review and meta analysis
European Urology, 2016Co-Authors: Marlon Perera, Nathan Papa, Daniel Christidis, David Wetherell, Michael S Hofman, Declan Murphy, Damien M Bolton, Nathan LawrentschukAbstract:Abstract Context Positron emission tomography (PET) of 68 Ga-labelled prostate-specific membrane antigen ( 68 Ga-PSMA) is an emerging imaging modality introduced to assess the burden of prostate cancer, typically in biochemically recurrent or advanced disease. 68 Ga-PSMA PET provides the ability to selectively identify and localize metastatic prostate cancer cells and subsequently change patient management. Owing to its limited history, robust sensitivity and specificity data are not available for 68 Ga-PSMA PET–positive scans. Objective A systematic review and meta-analysis of reported predictors of positive 68 Ga-PSMA PET and corresponding sensitivity and specificity profiles. Evidence acquisition We performed critical reviews of MEDLINE, EMBASE, ScienceDirect, Cochrane Library, and Web of Science databases in April 2016 according to the Preferred Reporting Items for Systematic Review and Meta-analysis (PRISMA) statement. Quality was assessed using the Quality Assessment if Diagnostic Accuracy Studies-2 tool. Meta-analysis and meta-regression of proportions were performed using a random-effects model with pre-PET prostate-specific antigen (PSA) levels as the dependent variable. Summary sensitivity and specificity values were obtained by fitting bivariate hierarchical regression models. Evidence synthesis Sixteen articles involving 1309 patients were analysed. The overall percentage of positive 68 Ga-PSMA PET among patients was 40% (95% confidence interval [CI] 19–64%) for primary staging and 76% (95% CI 66–85%) for biochemical recurrence (BCR). Positive 68 Ga-PSMA PET scans for BCR patients increased with pre-PET PSA. For the PSA categories 0–0.2, 0.2–1, 1–2, and >2 ng/ml, 42%, 58%, 76%, and 95% scans, respectively, were positive. Shorter PSA doubling time increased 68 Ga-PSMA PET positivity. On per-patient analysis, the summary sensitivity and specificity were both 86%. On per-lesion analysis, the summary sensitivity and specificity were 80% and 97%, respectively. Conclusions In the setting of BCR prostate cancer, pre-PET PSA predicts the risk of positive 68 Ga-PSMA PET. Pooled data indicate favourable sensitivity and specificity profiles compared to choline-based PET imaging Techniques. Patient summary Positron emission tomography using 68 Ga-labelled prostate-specific membrane antigen is an emerging Radiological Technique developed to improve the characterisation of metastatic prostate cancer. We summarised the data available to date and found that this new test provides excellent rates of detection of cancer spread in late-stage prostate cancer.
Thomas E Chappell - One of the best experts on this subject based on the ideXlab platform.
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comparison of computed tomographic angiography with digital subtraction angiography in the diagnosis of cerebral aneurysms a meta analysis
Neurosurgery, 2003Co-Authors: Thomas E Chappell, Federico Castro Moure, Matthew C GoodAbstract:Objective To compare a novel diagnostic Radiological Technique, computed tomographic angiography (CTA), with the standard method, namely digital subtraction angiography (DSA), in the diagnosis of cerebral aneurysms. Methods A comprehensive search of the world literature on CTA was performed. Articles that reported on prospective comparisons of CTA and DSA in the evaluation of patients suspected of harboring cerebral aneurysms were selected for data extraction. Suitable statistical methods were applied to the extracted data for meta-analysis. Results Twenty-one references met the criteria for use in the meta-analysis. Unweighted calculations based on data for 1251 patients resulted in a sensitivity of 0.933 (93.3%; range, 75.4-100%) and a specificity of 0.878 (87.8%; range, 0-100%). When the studies were weighted for the number of patients in each study, the sensitivity decreased slightly, to 0.927 (92.7%), and the specificity decreased more substantially, to 0.772 (77.2%). Conclusion On the basis of this meta-analysis, DSA remains the standard method. However, many who use CTA have reported it to be as good as or better than DSA in the diagnosis and treatment of cerebral aneurysms, as well as being of less risk and discomfort to their patients and easier and less expensive to perform.
Manjing Deng - One of the best experts on this subject based on the ideXlab platform.
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The root canal morphology in mandibular first premolars: a comparative evaluation of cone-beam computed tomography and micro-computed tomography.
Clinical oral investigations, 2016Co-Authors: Dan Zhang, Junhong Chen, Guihua Lan, Xiujie Wen, Luchuan Liu, Manjing DengAbstract:This study evaluated the accuracy of cone-beam computed tomography (CBCT) in detecting the root canal morphology of mandibular first premolars using micro-computed tomography (micro-CT) as a reference standard. In total, 143 extracted human mandibular first premolars were selected and scanned using micro-CT and CBCT. The acquired images were used to evaluate the root canal morphology in each tooth, and evaluations were repeated after 2 weeks. The root canal configurations observed on the three-dimensional images were recorded, and the findings from both modalities were compared using chi-square tests. The actual agreement between the two modalities was assessed using kappa statistics. In total, the root morphologies in 136 mandibular first premolars were consistently identified by both CBCT and micro-CT: type I in 104, type III in five, type V in 20, and type IX in seven. Of the remaining seven teeth, the morphology in two, one, and four teeth was identified as type I, type VII, and type IX (type 1–3 in two and type 1-2-3 in two), respectively, by micro-CT and misdiagnosed as type III, type V, and type V, respectively, by CBCT. There were no significant differences between the two modalities with regard to the accurate detection of root canal configurations, with a kappa value of 0.886 for the actual agreement. Although CBCT may be accurate in detecting the root canal configuration in mandibular first premolars, it produces poorer image details compared with micro-CT. CBCT is a reliable Radiological Technique, but its accuracy in detecting details of the root canal morphology in mandibular first premolars, especially in some complex root canal configurations, needs to be improved.
Sae Young Kim - One of the best experts on this subject based on the ideXlab platform.
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detection rate of intravascular injections during cervical medial branch blocks a comparison of digital subtraction angiography and static images from conventional fluoroscopy
The Korean Journal of Pain, 2015Co-Authors: Younghoon Jeon, Sae Young KimAbstract:Background: The most definitive diagnosis of neck pain caused by facet joints can be obtained through cervical medial branch blocks (CMBBs). However, intravascular injections need to be carefully monitored, as they can increase the risk of false-negative blocks when diagnosing cervical facet joint syndrome. In addition, intravascular injections can cause neurologic deficits such as spinal infarction or cerebral infarction. Digital subtraction angiography (DSA) is a Radiological Technique that can be used to clearly visualize the blood vessels from surrounding bones or dense soft tissues. The purpose of this study was to compare the rate of detection of intravascular injections during CMBBs using DSA and static images obtained through conventional fluoroscopy. Methods: Seventy-two patients were included, and a total of 178 CMBBs were performed. The respective incidences of intravascular injections during CMBBs using DSA and static images from conventional fluoroscopy were measured. Results: A total of 178 CMBBs were performed on 72 patients. All cases of intravascular injections evidenced by the static images were detected by the DSAs. The detection rate of intravascular injections was higher from DSA images than from static images (10.7% vs. 1.7%, P ＜ 0.001). Conclusions: According to these findings, the use of DSA can improve the detection rate of intravascular injections during CMBBs. The use of DSA may therefore lead to an increase in the diagnostic and therapeutic value of CMBBs. In addition, it can decrease the incidence of potential side effects during CMBBs. (Korean J Pain 2015; 28: 105-108)