The Experts below are selected from a list of 42 Experts worldwide ranked by ideXlab platform
Robert G. Mckinnell - One of the best experts on this subject based on the ideXlab platform.
-
Genome sequences of two frog Herpesviruses
Journal of General Virology, 2006Co-Authors: Andrew J. Davison, Charles Cunningham, Walter Sauerbier, Robert G. MckinnellAbstract:The sequences of two frog Herpesviruses, Ranid Herpesvirus 1 and Ranid Herpesvirus 2, were determined. They are respectively 220 859 and 231 801 bp in size and contain 132 and 147 predicted genes. The genomes are related most closely in the central regions, where 40 genes are conserved convincingly. Nineteen of these genes are also conserved in a fish Herpesvirus, Ictalurid Herpesvirus 1. The terminal regions of the genomes are largely not conserved and contain many of the 15 families of related genes present in each genome. The frog Herpesviruses are unique among sequenced Herpesviruses in that the three exons of the gene encoding the putative ATPase subunit of terminase are not specified by the same DNA strand and in that they encode a putative DNA (cytosine-5-)-methyltransferase and have extensively methylated genomes.
-
Correspondence
2006Co-Authors: Walter Sauerbier, Charles Cunningham, Robert G. Mckinnell, Andrew J. DavisonAbstract:The sequences of two frog Herpesviruses, Ranid Herpesvirus 1 and Ranid Herpesvirus 2, were determined. They are respectively 220859 and 231801 bp in size and contain 132 and 147 predicted genes. The genomes are related most closely in the central regions, where 40 genes are conserved convincingly. Nineteen of these genes are also conserved in a fish Herpesvirus, Ictalurid Herpesvirus 1. The terminal regions of the genomes are largely not conserved and contain many of the 15 families of related genes present in each genome. The frog Herpesviruses are unique among sequenced Herpesviruses in that the three exons of the gene encoding the putative ATPase subunit of terminase are not specified by the same DNA strand and in that they encode a putative DNA (cytosine-5-)-methyltransferase and have extensively methylated genomes. Herpesviruses are defined morphologically by a T=16 icosahedral capsid and fall phylogenetically into three tenuously related groups corresponding to host class: those infecting Mammalia, Aves and Reptilia, those infecting Amphibia and Osteichthyes (bony fish) and a single virus that infects an invertebrate class, Bivalvia (Davison et al., 2005a; McGeoch et al., 2006). Two amphibian Herpesviruses have been classified: Ranid Herpesvirus 1 (RaHV-1; Lucke ́ tumour Herpesvirus) and Ranid Herpesvirus 2 (RaHV-2; frog virus 4). Analysis of 40 kbp of the genome has shown that RaHV-1 is related to Ictalurid Herpesvirus 1 (IcHV-1; channel catfish virus) (Davison, 1992; Davison et al., 1999). No sequence data are available for RaHV-2. The properties of RaHV-1 and RaHV-2 have been reviewed by Granoff (1999). RaHV-1 is the causative agent of a renal adenocarcinoma occurring in the leopard frog, Rana pipien
-
Genomic studies of the Lucké tumor Herpesvirus (RaHV-1)
Journal of Cancer Research and Clinical Oncology, 1999Co-Authors: Andrew J. Davison, Walter Sauerbier, Aidan Dolan, Clare Addison, Robert G. MckinnellAbstract:Ranid Herpesvirus 1 (RaHV-1) is the etiological agent of the Lucké renal adenocarcinoma of the North American leopard frog Rana pipiens. Construction of cosmid libraries containing RaHV-1 DNA inserts allowed the derivation of a Bam HI map for the viral genome. Summation of fragment sizes indicates that the genome is 217 kbp in size, a value in accordance with the most recent published estimate (220 kbp) obtained by field-inversion gel electrophoresis. The DNA sequence of the 39,757-bp insert in 1 cosmid (cos54) was determined and was predicted to contain 21 complete and 3 partial genes. In all, 12 genes have distant counterparts in a fish Herpesvirus (ictalurid Herpesvirus 1) and are present in 2 blocks, 1 of which is relatively inverted. This indicates that RaHV-1 belongs to the fish virus lineage of the Herpesvirus family rather than to the lineage populated by mammalian and avian viruses. The remainding 12 genes in cos54 lack counterparts in any other Herpesvirus. One of these encodes a putative DNA (cytosine-5) methyltransferase. This raises the possibility that biological processes induced in the host by RaHV-1 might involve methylation of cellular DNA by the viral enzyme.
-
Genomic studies of the Lucké tumor Herpesvirus (RaHV-1)
Journal of Cancer Research and Clinical Oncology, 1999Co-Authors: Andrew J. Davison, Walter Sauerbier, Aidan Dolan, Clare Addison, Robert G. MckinnellAbstract:Ranid Herpesvirus 1 (RaHV-1) is the etiological agent of the Lucke renal adenocarcinoma of the North American leopard frog Rana pipiens. Construction of cosmid libraries containing RaHV-1 DNA inserts allowed the derivation of a BamHI map for the viral genome. Summation of fragment sizes indicates that the genome is 217 kbp in size, a value in accordance with the most recent published estimate (220 kbp) obtained by field-inversion gel electrophoresis. The DNA sequence of the 39,757-bp insert in 1 cosmid (cos54) was determined and was predicted to contain 21 complete and 3 partial genes. In all, 12 genes have distant counterparts in a fish Herpesvirus (ictalurid Herpesvirus 1) and are present in 2 blocks, 1 of which is relatively inverted. This indicates that RaHV-1 belongs to the fish virus lineage of the Herpesvirus family rather than to the lineage populated by mammalian and avian viruses. The remainding 12 genes in cos54 lack counterparts in any other Herpesvirus. One of these encodes a putative DNA (cytosine-5) methyltransferase. This raises the possibility that biological processes induced in the host by RaHV-1 might involve methylation of cellular DNA by the viral enzyme.
Andrew J. Davison - One of the best experts on this subject based on the ideXlab platform.
-
Genome sequences of two frog Herpesviruses
Journal of General Virology, 2006Co-Authors: Andrew J. Davison, Charles Cunningham, Walter Sauerbier, Robert G. MckinnellAbstract:The sequences of two frog Herpesviruses, Ranid Herpesvirus 1 and Ranid Herpesvirus 2, were determined. They are respectively 220 859 and 231 801 bp in size and contain 132 and 147 predicted genes. The genomes are related most closely in the central regions, where 40 genes are conserved convincingly. Nineteen of these genes are also conserved in a fish Herpesvirus, Ictalurid Herpesvirus 1. The terminal regions of the genomes are largely not conserved and contain many of the 15 families of related genes present in each genome. The frog Herpesviruses are unique among sequenced Herpesviruses in that the three exons of the gene encoding the putative ATPase subunit of terminase are not specified by the same DNA strand and in that they encode a putative DNA (cytosine-5-)-methyltransferase and have extensively methylated genomes.
-
Correspondence
2006Co-Authors: Walter Sauerbier, Charles Cunningham, Robert G. Mckinnell, Andrew J. DavisonAbstract:The sequences of two frog Herpesviruses, Ranid Herpesvirus 1 and Ranid Herpesvirus 2, were determined. They are respectively 220859 and 231801 bp in size and contain 132 and 147 predicted genes. The genomes are related most closely in the central regions, where 40 genes are conserved convincingly. Nineteen of these genes are also conserved in a fish Herpesvirus, Ictalurid Herpesvirus 1. The terminal regions of the genomes are largely not conserved and contain many of the 15 families of related genes present in each genome. The frog Herpesviruses are unique among sequenced Herpesviruses in that the three exons of the gene encoding the putative ATPase subunit of terminase are not specified by the same DNA strand and in that they encode a putative DNA (cytosine-5-)-methyltransferase and have extensively methylated genomes. Herpesviruses are defined morphologically by a T=16 icosahedral capsid and fall phylogenetically into three tenuously related groups corresponding to host class: those infecting Mammalia, Aves and Reptilia, those infecting Amphibia and Osteichthyes (bony fish) and a single virus that infects an invertebrate class, Bivalvia (Davison et al., 2005a; McGeoch et al., 2006). Two amphibian Herpesviruses have been classified: Ranid Herpesvirus 1 (RaHV-1; Lucke ́ tumour Herpesvirus) and Ranid Herpesvirus 2 (RaHV-2; frog virus 4). Analysis of 40 kbp of the genome has shown that RaHV-1 is related to Ictalurid Herpesvirus 1 (IcHV-1; channel catfish virus) (Davison, 1992; Davison et al., 1999). No sequence data are available for RaHV-2. The properties of RaHV-1 and RaHV-2 have been reviewed by Granoff (1999). RaHV-1 is the causative agent of a renal adenocarcinoma occurring in the leopard frog, Rana pipien
-
Genomic studies of the Lucké tumor Herpesvirus (RaHV-1)
Journal of Cancer Research and Clinical Oncology, 1999Co-Authors: Andrew J. Davison, Walter Sauerbier, Aidan Dolan, Clare Addison, Robert G. MckinnellAbstract:Ranid Herpesvirus 1 (RaHV-1) is the etiological agent of the Lucké renal adenocarcinoma of the North American leopard frog Rana pipiens. Construction of cosmid libraries containing RaHV-1 DNA inserts allowed the derivation of a Bam HI map for the viral genome. Summation of fragment sizes indicates that the genome is 217 kbp in size, a value in accordance with the most recent published estimate (220 kbp) obtained by field-inversion gel electrophoresis. The DNA sequence of the 39,757-bp insert in 1 cosmid (cos54) was determined and was predicted to contain 21 complete and 3 partial genes. In all, 12 genes have distant counterparts in a fish Herpesvirus (ictalurid Herpesvirus 1) and are present in 2 blocks, 1 of which is relatively inverted. This indicates that RaHV-1 belongs to the fish virus lineage of the Herpesvirus family rather than to the lineage populated by mammalian and avian viruses. The remainding 12 genes in cos54 lack counterparts in any other Herpesvirus. One of these encodes a putative DNA (cytosine-5) methyltransferase. This raises the possibility that biological processes induced in the host by RaHV-1 might involve methylation of cellular DNA by the viral enzyme.
-
Genomic studies of the Lucké tumor Herpesvirus (RaHV-1)
Journal of Cancer Research and Clinical Oncology, 1999Co-Authors: Andrew J. Davison, Walter Sauerbier, Aidan Dolan, Clare Addison, Robert G. MckinnellAbstract:Ranid Herpesvirus 1 (RaHV-1) is the etiological agent of the Lucke renal adenocarcinoma of the North American leopard frog Rana pipiens. Construction of cosmid libraries containing RaHV-1 DNA inserts allowed the derivation of a BamHI map for the viral genome. Summation of fragment sizes indicates that the genome is 217 kbp in size, a value in accordance with the most recent published estimate (220 kbp) obtained by field-inversion gel electrophoresis. The DNA sequence of the 39,757-bp insert in 1 cosmid (cos54) was determined and was predicted to contain 21 complete and 3 partial genes. In all, 12 genes have distant counterparts in a fish Herpesvirus (ictalurid Herpesvirus 1) and are present in 2 blocks, 1 of which is relatively inverted. This indicates that RaHV-1 belongs to the fish virus lineage of the Herpesvirus family rather than to the lineage populated by mammalian and avian viruses. The remainding 12 genes in cos54 lack counterparts in any other Herpesvirus. One of these encodes a putative DNA (cytosine-5) methyltransferase. This raises the possibility that biological processes induced in the host by RaHV-1 might involve methylation of cellular DNA by the viral enzyme.
Walter Sauerbier - One of the best experts on this subject based on the ideXlab platform.
-
Genome sequences of two frog Herpesviruses
Journal of General Virology, 2006Co-Authors: Andrew J. Davison, Charles Cunningham, Walter Sauerbier, Robert G. MckinnellAbstract:The sequences of two frog Herpesviruses, Ranid Herpesvirus 1 and Ranid Herpesvirus 2, were determined. They are respectively 220 859 and 231 801 bp in size and contain 132 and 147 predicted genes. The genomes are related most closely in the central regions, where 40 genes are conserved convincingly. Nineteen of these genes are also conserved in a fish Herpesvirus, Ictalurid Herpesvirus 1. The terminal regions of the genomes are largely not conserved and contain many of the 15 families of related genes present in each genome. The frog Herpesviruses are unique among sequenced Herpesviruses in that the three exons of the gene encoding the putative ATPase subunit of terminase are not specified by the same DNA strand and in that they encode a putative DNA (cytosine-5-)-methyltransferase and have extensively methylated genomes.
-
Correspondence
2006Co-Authors: Walter Sauerbier, Charles Cunningham, Robert G. Mckinnell, Andrew J. DavisonAbstract:The sequences of two frog Herpesviruses, Ranid Herpesvirus 1 and Ranid Herpesvirus 2, were determined. They are respectively 220859 and 231801 bp in size and contain 132 and 147 predicted genes. The genomes are related most closely in the central regions, where 40 genes are conserved convincingly. Nineteen of these genes are also conserved in a fish Herpesvirus, Ictalurid Herpesvirus 1. The terminal regions of the genomes are largely not conserved and contain many of the 15 families of related genes present in each genome. The frog Herpesviruses are unique among sequenced Herpesviruses in that the three exons of the gene encoding the putative ATPase subunit of terminase are not specified by the same DNA strand and in that they encode a putative DNA (cytosine-5-)-methyltransferase and have extensively methylated genomes. Herpesviruses are defined morphologically by a T=16 icosahedral capsid and fall phylogenetically into three tenuously related groups corresponding to host class: those infecting Mammalia, Aves and Reptilia, those infecting Amphibia and Osteichthyes (bony fish) and a single virus that infects an invertebrate class, Bivalvia (Davison et al., 2005a; McGeoch et al., 2006). Two amphibian Herpesviruses have been classified: Ranid Herpesvirus 1 (RaHV-1; Lucke ́ tumour Herpesvirus) and Ranid Herpesvirus 2 (RaHV-2; frog virus 4). Analysis of 40 kbp of the genome has shown that RaHV-1 is related to Ictalurid Herpesvirus 1 (IcHV-1; channel catfish virus) (Davison, 1992; Davison et al., 1999). No sequence data are available for RaHV-2. The properties of RaHV-1 and RaHV-2 have been reviewed by Granoff (1999). RaHV-1 is the causative agent of a renal adenocarcinoma occurring in the leopard frog, Rana pipien
-
Genomic studies of the Lucké tumor Herpesvirus (RaHV-1)
Journal of Cancer Research and Clinical Oncology, 1999Co-Authors: Andrew J. Davison, Walter Sauerbier, Aidan Dolan, Clare Addison, Robert G. MckinnellAbstract:Ranid Herpesvirus 1 (RaHV-1) is the etiological agent of the Lucké renal adenocarcinoma of the North American leopard frog Rana pipiens. Construction of cosmid libraries containing RaHV-1 DNA inserts allowed the derivation of a Bam HI map for the viral genome. Summation of fragment sizes indicates that the genome is 217 kbp in size, a value in accordance with the most recent published estimate (220 kbp) obtained by field-inversion gel electrophoresis. The DNA sequence of the 39,757-bp insert in 1 cosmid (cos54) was determined and was predicted to contain 21 complete and 3 partial genes. In all, 12 genes have distant counterparts in a fish Herpesvirus (ictalurid Herpesvirus 1) and are present in 2 blocks, 1 of which is relatively inverted. This indicates that RaHV-1 belongs to the fish virus lineage of the Herpesvirus family rather than to the lineage populated by mammalian and avian viruses. The remainding 12 genes in cos54 lack counterparts in any other Herpesvirus. One of these encodes a putative DNA (cytosine-5) methyltransferase. This raises the possibility that biological processes induced in the host by RaHV-1 might involve methylation of cellular DNA by the viral enzyme.
-
Genomic studies of the Lucké tumor Herpesvirus (RaHV-1)
Journal of Cancer Research and Clinical Oncology, 1999Co-Authors: Andrew J. Davison, Walter Sauerbier, Aidan Dolan, Clare Addison, Robert G. MckinnellAbstract:Ranid Herpesvirus 1 (RaHV-1) is the etiological agent of the Lucke renal adenocarcinoma of the North American leopard frog Rana pipiens. Construction of cosmid libraries containing RaHV-1 DNA inserts allowed the derivation of a BamHI map for the viral genome. Summation of fragment sizes indicates that the genome is 217 kbp in size, a value in accordance with the most recent published estimate (220 kbp) obtained by field-inversion gel electrophoresis. The DNA sequence of the 39,757-bp insert in 1 cosmid (cos54) was determined and was predicted to contain 21 complete and 3 partial genes. In all, 12 genes have distant counterparts in a fish Herpesvirus (ictalurid Herpesvirus 1) and are present in 2 blocks, 1 of which is relatively inverted. This indicates that RaHV-1 belongs to the fish virus lineage of the Herpesvirus family rather than to the lineage populated by mammalian and avian viruses. The remainding 12 genes in cos54 lack counterparts in any other Herpesvirus. One of these encodes a putative DNA (cytosine-5) methyltransferase. This raises the possibility that biological processes induced in the host by RaHV-1 might involve methylation of cellular DNA by the viral enzyme.
Aidan Dolan - One of the best experts on this subject based on the ideXlab platform.
-
Genomic studies of the Lucké tumor Herpesvirus (RaHV-1)
Journal of Cancer Research and Clinical Oncology, 1999Co-Authors: Andrew J. Davison, Walter Sauerbier, Aidan Dolan, Clare Addison, Robert G. MckinnellAbstract:Ranid Herpesvirus 1 (RaHV-1) is the etiological agent of the Lucké renal adenocarcinoma of the North American leopard frog Rana pipiens. Construction of cosmid libraries containing RaHV-1 DNA inserts allowed the derivation of a Bam HI map for the viral genome. Summation of fragment sizes indicates that the genome is 217 kbp in size, a value in accordance with the most recent published estimate (220 kbp) obtained by field-inversion gel electrophoresis. The DNA sequence of the 39,757-bp insert in 1 cosmid (cos54) was determined and was predicted to contain 21 complete and 3 partial genes. In all, 12 genes have distant counterparts in a fish Herpesvirus (ictalurid Herpesvirus 1) and are present in 2 blocks, 1 of which is relatively inverted. This indicates that RaHV-1 belongs to the fish virus lineage of the Herpesvirus family rather than to the lineage populated by mammalian and avian viruses. The remainding 12 genes in cos54 lack counterparts in any other Herpesvirus. One of these encodes a putative DNA (cytosine-5) methyltransferase. This raises the possibility that biological processes induced in the host by RaHV-1 might involve methylation of cellular DNA by the viral enzyme.
-
Genomic studies of the Lucké tumor Herpesvirus (RaHV-1)
Journal of Cancer Research and Clinical Oncology, 1999Co-Authors: Andrew J. Davison, Walter Sauerbier, Aidan Dolan, Clare Addison, Robert G. MckinnellAbstract:Ranid Herpesvirus 1 (RaHV-1) is the etiological agent of the Lucke renal adenocarcinoma of the North American leopard frog Rana pipiens. Construction of cosmid libraries containing RaHV-1 DNA inserts allowed the derivation of a BamHI map for the viral genome. Summation of fragment sizes indicates that the genome is 217 kbp in size, a value in accordance with the most recent published estimate (220 kbp) obtained by field-inversion gel electrophoresis. The DNA sequence of the 39,757-bp insert in 1 cosmid (cos54) was determined and was predicted to contain 21 complete and 3 partial genes. In all, 12 genes have distant counterparts in a fish Herpesvirus (ictalurid Herpesvirus 1) and are present in 2 blocks, 1 of which is relatively inverted. This indicates that RaHV-1 belongs to the fish virus lineage of the Herpesvirus family rather than to the lineage populated by mammalian and avian viruses. The remainding 12 genes in cos54 lack counterparts in any other Herpesvirus. One of these encodes a putative DNA (cytosine-5) methyltransferase. This raises the possibility that biological processes induced in the host by RaHV-1 might involve methylation of cellular DNA by the viral enzyme.
Clare Addison - One of the best experts on this subject based on the ideXlab platform.
-
Genomic studies of the Lucké tumor Herpesvirus (RaHV-1)
Journal of Cancer Research and Clinical Oncology, 1999Co-Authors: Andrew J. Davison, Walter Sauerbier, Aidan Dolan, Clare Addison, Robert G. MckinnellAbstract:Ranid Herpesvirus 1 (RaHV-1) is the etiological agent of the Lucké renal adenocarcinoma of the North American leopard frog Rana pipiens. Construction of cosmid libraries containing RaHV-1 DNA inserts allowed the derivation of a Bam HI map for the viral genome. Summation of fragment sizes indicates that the genome is 217 kbp in size, a value in accordance with the most recent published estimate (220 kbp) obtained by field-inversion gel electrophoresis. The DNA sequence of the 39,757-bp insert in 1 cosmid (cos54) was determined and was predicted to contain 21 complete and 3 partial genes. In all, 12 genes have distant counterparts in a fish Herpesvirus (ictalurid Herpesvirus 1) and are present in 2 blocks, 1 of which is relatively inverted. This indicates that RaHV-1 belongs to the fish virus lineage of the Herpesvirus family rather than to the lineage populated by mammalian and avian viruses. The remainding 12 genes in cos54 lack counterparts in any other Herpesvirus. One of these encodes a putative DNA (cytosine-5) methyltransferase. This raises the possibility that biological processes induced in the host by RaHV-1 might involve methylation of cellular DNA by the viral enzyme.
-
Genomic studies of the Lucké tumor Herpesvirus (RaHV-1)
Journal of Cancer Research and Clinical Oncology, 1999Co-Authors: Andrew J. Davison, Walter Sauerbier, Aidan Dolan, Clare Addison, Robert G. MckinnellAbstract:Ranid Herpesvirus 1 (RaHV-1) is the etiological agent of the Lucke renal adenocarcinoma of the North American leopard frog Rana pipiens. Construction of cosmid libraries containing RaHV-1 DNA inserts allowed the derivation of a BamHI map for the viral genome. Summation of fragment sizes indicates that the genome is 217 kbp in size, a value in accordance with the most recent published estimate (220 kbp) obtained by field-inversion gel electrophoresis. The DNA sequence of the 39,757-bp insert in 1 cosmid (cos54) was determined and was predicted to contain 21 complete and 3 partial genes. In all, 12 genes have distant counterparts in a fish Herpesvirus (ictalurid Herpesvirus 1) and are present in 2 blocks, 1 of which is relatively inverted. This indicates that RaHV-1 belongs to the fish virus lineage of the Herpesvirus family rather than to the lineage populated by mammalian and avian viruses. The remainding 12 genes in cos54 lack counterparts in any other Herpesvirus. One of these encodes a putative DNA (cytosine-5) methyltransferase. This raises the possibility that biological processes induced in the host by RaHV-1 might involve methylation of cellular DNA by the viral enzyme.
