The Experts below are selected from a list of 4944 Experts worldwide ranked by ideXlab platform
Jennifer L. Stow - One of the best experts on this subject based on the ideXlab platform.
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Rorα deficiency and decreased adiposity are associated with induction of thermogenic gene expression in subcutaneous white adipose and brown adipose tissue.
American Journal of Physiology-Gastrointestinal and Liver Physiology, 2015Co-Authors: Patrick Lau, Zewen K. Tuong, Shu-ching Wang, Rebecca L. Fitzsimmons, Joel M. Goode, Gethin P. Thomas, Gary Cowin, Michael A. Pearen, Karine Mardon, Jennifer L. StowAbstract:The RAR-related Orphan Receptor-α (Rorα) is a nuclear Receptor that regulates adiposity and is a potential regulator of energy homeostasis. We have demonstrated that the Rorα-deficient staggerer (s...
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Rorα deficiency and decreased adiposity are associated with induction of thermogenic gene expression in subcutaneous white adipose and brown adipose tissue.
American journal of physiology. Endocrinology and metabolism, 2014Co-Authors: Patrick Lau, Zewen K. Tuong, Shu-ching Wang, Rebecca L. Fitzsimmons, Joel M. Goode, Gethin P. Thomas, Gary Cowin, Michael A. Pearen, Karine Mardon, Jennifer L. StowAbstract:The RAR-related Orphan Receptor-α (Rorα) is a nuclear Receptor that regulates adiposity and is a potential regulator of energy homeostasis. We have demonstrated that the Rorα-deficient staggerer (sg/sg) mice display a lean and obesity-resistant phenotype. Adaptive Ucp1-dependent thermogenesis in beige/brite and brown adipose tissue serves as a mechanism to increase energy expenditure and resist obesity. DEXA and MRI analysis demonstrated significantly decreased total fat mass and fat/lean mass tissue ratio in male chow-fed sg/sg mice relative to wt mice. In addition, we observed increased Ucp1 expression in brown adipose and subcutaneous white adipose tissue but not in visceral adipose tissue from Rorα-deficient mice. Moreover, this was associated with significant increases in the expression of the mRNAs encoding the thermogenic genes (i.e., markers of brown and beige adipose) Pparα, Errα, Dio2, Acot11/Bfit, Cpt1β, and Cidea in the subcutaneous adipose in the sg/sg relative to WT mice. These changes in thermogenic gene expression involved the significantly increased expression of the (cell-fate controlling) histone-lysine N-methyltransferase 1 (Ehmt1), which stabilizes the Prdm16 transcriptional complex. Moreover, primary brown adipocytes from sg/sg mice displayed a higher metabolic rate, and further analysis was consistent with increased uncoupling. Finally, core body temperature analysis and infrared thermography demonstrated that the sg/sg mice maintained greater thermal control and cold tolerance relative to the WT littermates. We suggest that enhanced Ucp1 and thermogenic gene expression/activity may be an important contributor to the lean, obesity-resistant phenotype in Rorα-deficient mice.
Patrick Lau - One of the best experts on this subject based on the ideXlab platform.
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Rorα deficiency and decreased adiposity are associated with induction of thermogenic gene expression in subcutaneous white adipose and brown adipose tissue.
American Journal of Physiology-Gastrointestinal and Liver Physiology, 2015Co-Authors: Patrick Lau, Zewen K. Tuong, Shu-ching Wang, Rebecca L. Fitzsimmons, Joel M. Goode, Gethin P. Thomas, Gary Cowin, Michael A. Pearen, Karine Mardon, Jennifer L. StowAbstract:The RAR-related Orphan Receptor-α (Rorα) is a nuclear Receptor that regulates adiposity and is a potential regulator of energy homeostasis. We have demonstrated that the Rorα-deficient staggerer (s...
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Rorα deficiency and decreased adiposity are associated with induction of thermogenic gene expression in subcutaneous white adipose and brown adipose tissue.
American journal of physiology. Endocrinology and metabolism, 2014Co-Authors: Patrick Lau, Zewen K. Tuong, Shu-ching Wang, Rebecca L. Fitzsimmons, Joel M. Goode, Gethin P. Thomas, Gary Cowin, Michael A. Pearen, Karine Mardon, Jennifer L. StowAbstract:The RAR-related Orphan Receptor-α (Rorα) is a nuclear Receptor that regulates adiposity and is a potential regulator of energy homeostasis. We have demonstrated that the Rorα-deficient staggerer (sg/sg) mice display a lean and obesity-resistant phenotype. Adaptive Ucp1-dependent thermogenesis in beige/brite and brown adipose tissue serves as a mechanism to increase energy expenditure and resist obesity. DEXA and MRI analysis demonstrated significantly decreased total fat mass and fat/lean mass tissue ratio in male chow-fed sg/sg mice relative to wt mice. In addition, we observed increased Ucp1 expression in brown adipose and subcutaneous white adipose tissue but not in visceral adipose tissue from Rorα-deficient mice. Moreover, this was associated with significant increases in the expression of the mRNAs encoding the thermogenic genes (i.e., markers of brown and beige adipose) Pparα, Errα, Dio2, Acot11/Bfit, Cpt1β, and Cidea in the subcutaneous adipose in the sg/sg relative to WT mice. These changes in thermogenic gene expression involved the significantly increased expression of the (cell-fate controlling) histone-lysine N-methyltransferase 1 (Ehmt1), which stabilizes the Prdm16 transcriptional complex. Moreover, primary brown adipocytes from sg/sg mice displayed a higher metabolic rate, and further analysis was consistent with increased uncoupling. Finally, core body temperature analysis and infrared thermography demonstrated that the sg/sg mice maintained greater thermal control and cold tolerance relative to the WT littermates. We suggest that enhanced Ucp1 and thermogenic gene expression/activity may be an important contributor to the lean, obesity-resistant phenotype in Rorα-deficient mice.
Rebecca L. Fitzsimmons - One of the best experts on this subject based on the ideXlab platform.
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Rorα deficiency and decreased adiposity are associated with induction of thermogenic gene expression in subcutaneous white adipose and brown adipose tissue.
American Journal of Physiology-Gastrointestinal and Liver Physiology, 2015Co-Authors: Patrick Lau, Zewen K. Tuong, Shu-ching Wang, Rebecca L. Fitzsimmons, Joel M. Goode, Gethin P. Thomas, Gary Cowin, Michael A. Pearen, Karine Mardon, Jennifer L. StowAbstract:The RAR-related Orphan Receptor-α (Rorα) is a nuclear Receptor that regulates adiposity and is a potential regulator of energy homeostasis. We have demonstrated that the Rorα-deficient staggerer (s...
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Rorα deficiency and decreased adiposity are associated with induction of thermogenic gene expression in subcutaneous white adipose and brown adipose tissue.
American journal of physiology. Endocrinology and metabolism, 2014Co-Authors: Patrick Lau, Zewen K. Tuong, Shu-ching Wang, Rebecca L. Fitzsimmons, Joel M. Goode, Gethin P. Thomas, Gary Cowin, Michael A. Pearen, Karine Mardon, Jennifer L. StowAbstract:The RAR-related Orphan Receptor-α (Rorα) is a nuclear Receptor that regulates adiposity and is a potential regulator of energy homeostasis. We have demonstrated that the Rorα-deficient staggerer (sg/sg) mice display a lean and obesity-resistant phenotype. Adaptive Ucp1-dependent thermogenesis in beige/brite and brown adipose tissue serves as a mechanism to increase energy expenditure and resist obesity. DEXA and MRI analysis demonstrated significantly decreased total fat mass and fat/lean mass tissue ratio in male chow-fed sg/sg mice relative to wt mice. In addition, we observed increased Ucp1 expression in brown adipose and subcutaneous white adipose tissue but not in visceral adipose tissue from Rorα-deficient mice. Moreover, this was associated with significant increases in the expression of the mRNAs encoding the thermogenic genes (i.e., markers of brown and beige adipose) Pparα, Errα, Dio2, Acot11/Bfit, Cpt1β, and Cidea in the subcutaneous adipose in the sg/sg relative to WT mice. These changes in thermogenic gene expression involved the significantly increased expression of the (cell-fate controlling) histone-lysine N-methyltransferase 1 (Ehmt1), which stabilizes the Prdm16 transcriptional complex. Moreover, primary brown adipocytes from sg/sg mice displayed a higher metabolic rate, and further analysis was consistent with increased uncoupling. Finally, core body temperature analysis and infrared thermography demonstrated that the sg/sg mice maintained greater thermal control and cold tolerance relative to the WT littermates. We suggest that enhanced Ucp1 and thermogenic gene expression/activity may be an important contributor to the lean, obesity-resistant phenotype in Rorα-deficient mice.
Zewen K. Tuong - One of the best experts on this subject based on the ideXlab platform.
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Rorα deficiency and decreased adiposity are associated with induction of thermogenic gene expression in subcutaneous white adipose and brown adipose tissue.
American Journal of Physiology-Gastrointestinal and Liver Physiology, 2015Co-Authors: Patrick Lau, Zewen K. Tuong, Shu-ching Wang, Rebecca L. Fitzsimmons, Joel M. Goode, Gethin P. Thomas, Gary Cowin, Michael A. Pearen, Karine Mardon, Jennifer L. StowAbstract:The RAR-related Orphan Receptor-α (Rorα) is a nuclear Receptor that regulates adiposity and is a potential regulator of energy homeostasis. We have demonstrated that the Rorα-deficient staggerer (s...
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Rorα deficiency and decreased adiposity are associated with induction of thermogenic gene expression in subcutaneous white adipose and brown adipose tissue.
American journal of physiology. Endocrinology and metabolism, 2014Co-Authors: Patrick Lau, Zewen K. Tuong, Shu-ching Wang, Rebecca L. Fitzsimmons, Joel M. Goode, Gethin P. Thomas, Gary Cowin, Michael A. Pearen, Karine Mardon, Jennifer L. StowAbstract:The RAR-related Orphan Receptor-α (Rorα) is a nuclear Receptor that regulates adiposity and is a potential regulator of energy homeostasis. We have demonstrated that the Rorα-deficient staggerer (sg/sg) mice display a lean and obesity-resistant phenotype. Adaptive Ucp1-dependent thermogenesis in beige/brite and brown adipose tissue serves as a mechanism to increase energy expenditure and resist obesity. DEXA and MRI analysis demonstrated significantly decreased total fat mass and fat/lean mass tissue ratio in male chow-fed sg/sg mice relative to wt mice. In addition, we observed increased Ucp1 expression in brown adipose and subcutaneous white adipose tissue but not in visceral adipose tissue from Rorα-deficient mice. Moreover, this was associated with significant increases in the expression of the mRNAs encoding the thermogenic genes (i.e., markers of brown and beige adipose) Pparα, Errα, Dio2, Acot11/Bfit, Cpt1β, and Cidea in the subcutaneous adipose in the sg/sg relative to WT mice. These changes in thermogenic gene expression involved the significantly increased expression of the (cell-fate controlling) histone-lysine N-methyltransferase 1 (Ehmt1), which stabilizes the Prdm16 transcriptional complex. Moreover, primary brown adipocytes from sg/sg mice displayed a higher metabolic rate, and further analysis was consistent with increased uncoupling. Finally, core body temperature analysis and infrared thermography demonstrated that the sg/sg mice maintained greater thermal control and cold tolerance relative to the WT littermates. We suggest that enhanced Ucp1 and thermogenic gene expression/activity may be an important contributor to the lean, obesity-resistant phenotype in Rorα-deficient mice.
Shu-ching Wang - One of the best experts on this subject based on the ideXlab platform.
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Rorα deficiency and decreased adiposity are associated with induction of thermogenic gene expression in subcutaneous white adipose and brown adipose tissue.
American Journal of Physiology-Gastrointestinal and Liver Physiology, 2015Co-Authors: Patrick Lau, Zewen K. Tuong, Shu-ching Wang, Rebecca L. Fitzsimmons, Joel M. Goode, Gethin P. Thomas, Gary Cowin, Michael A. Pearen, Karine Mardon, Jennifer L. StowAbstract:The RAR-related Orphan Receptor-α (Rorα) is a nuclear Receptor that regulates adiposity and is a potential regulator of energy homeostasis. We have demonstrated that the Rorα-deficient staggerer (s...
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Rorα deficiency and decreased adiposity are associated with induction of thermogenic gene expression in subcutaneous white adipose and brown adipose tissue.
American journal of physiology. Endocrinology and metabolism, 2014Co-Authors: Patrick Lau, Zewen K. Tuong, Shu-ching Wang, Rebecca L. Fitzsimmons, Joel M. Goode, Gethin P. Thomas, Gary Cowin, Michael A. Pearen, Karine Mardon, Jennifer L. StowAbstract:The RAR-related Orphan Receptor-α (Rorα) is a nuclear Receptor that regulates adiposity and is a potential regulator of energy homeostasis. We have demonstrated that the Rorα-deficient staggerer (sg/sg) mice display a lean and obesity-resistant phenotype. Adaptive Ucp1-dependent thermogenesis in beige/brite and brown adipose tissue serves as a mechanism to increase energy expenditure and resist obesity. DEXA and MRI analysis demonstrated significantly decreased total fat mass and fat/lean mass tissue ratio in male chow-fed sg/sg mice relative to wt mice. In addition, we observed increased Ucp1 expression in brown adipose and subcutaneous white adipose tissue but not in visceral adipose tissue from Rorα-deficient mice. Moreover, this was associated with significant increases in the expression of the mRNAs encoding the thermogenic genes (i.e., markers of brown and beige adipose) Pparα, Errα, Dio2, Acot11/Bfit, Cpt1β, and Cidea in the subcutaneous adipose in the sg/sg relative to WT mice. These changes in thermogenic gene expression involved the significantly increased expression of the (cell-fate controlling) histone-lysine N-methyltransferase 1 (Ehmt1), which stabilizes the Prdm16 transcriptional complex. Moreover, primary brown adipocytes from sg/sg mice displayed a higher metabolic rate, and further analysis was consistent with increased uncoupling. Finally, core body temperature analysis and infrared thermography demonstrated that the sg/sg mice maintained greater thermal control and cold tolerance relative to the WT littermates. We suggest that enhanced Ucp1 and thermogenic gene expression/activity may be an important contributor to the lean, obesity-resistant phenotype in Rorα-deficient mice.
