The Experts below are selected from a list of 294 Experts worldwide ranked by ideXlab platform
Hishashi Okamoto - One of the best experts on this subject based on the ideXlab platform.
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responses of elongation growth Rate turgor pressure and cell wall extensibility of stem cells of impatiens balsamina to lead cadmium and zinc
Biometals, 1993Co-Authors: Sharifah Barlian Aidid, Hishashi OkamotoAbstract:Elongation growth Rate of stem cells of Impatiens balsamina was inhibited by the heavy metals Pb2+, Cd2+ and Zn2+ due to their suppression on cell wall extensibility. Effective turgor was also inhibited by Pb2+ and Cd2+ but it played a secondary role in reducing the stem cell elongation growth Rate. The major Rate-Limiting Factor for cell elongation growth was the cell wall extensibility. Furthermore, Cd2+ was found to be more toxic than Pb2+, while Pb2+ was more toxic than Zn2+.
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responses of elongation growth Rate turgor pressure and cell wall extensibility of stem cells of impatiens balsamina to lead cadmium and zinc
Biometals, 1993Co-Authors: Sharifah Barlian Aidid, Hishashi OkamotoAbstract:Elongation growth Rate of stem cells of Impatiens balsamina was inhibited by the heavy metals Pb2+, Cd2+ and Zn2+ due to their suppression on cell wall extensibility. Effective turgor was also inhibited by Pb2+ and Cd2+ but it played a secondary role in reducing the stem cell elongation growth Rate. The major Rate-Limiting Factor for cell elongation growth was the cell wall extensibility. Furthermore, Cd2+ was found to be more toxic than Pb2+, while Pb2+ was more toxic than Zn2+.
Sharifah Barlian Aidid - One of the best experts on this subject based on the ideXlab platform.
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responses of elongation growth Rate turgor pressure and cell wall extensibility of stem cells of impatiens balsamina to lead cadmium and zinc
Biometals, 1993Co-Authors: Sharifah Barlian Aidid, Hishashi OkamotoAbstract:Elongation growth Rate of stem cells of Impatiens balsamina was inhibited by the heavy metals Pb2+, Cd2+ and Zn2+ due to their suppression on cell wall extensibility. Effective turgor was also inhibited by Pb2+ and Cd2+ but it played a secondary role in reducing the stem cell elongation growth Rate. The major Rate-Limiting Factor for cell elongation growth was the cell wall extensibility. Furthermore, Cd2+ was found to be more toxic than Pb2+, while Pb2+ was more toxic than Zn2+.
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responses of elongation growth Rate turgor pressure and cell wall extensibility of stem cells of impatiens balsamina to lead cadmium and zinc
Biometals, 1993Co-Authors: Sharifah Barlian Aidid, Hishashi OkamotoAbstract:Elongation growth Rate of stem cells of Impatiens balsamina was inhibited by the heavy metals Pb2+, Cd2+ and Zn2+ due to their suppression on cell wall extensibility. Effective turgor was also inhibited by Pb2+ and Cd2+ but it played a secondary role in reducing the stem cell elongation growth Rate. The major Rate-Limiting Factor for cell elongation growth was the cell wall extensibility. Furthermore, Cd2+ was found to be more toxic than Pb2+, while Pb2+ was more toxic than Zn2+.
Stefano Biffo - One of the best experts on this subject based on the ideXlab platform.
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translational control by 80s formation and 60s availability the central role of eif6 a Rate Limiting Factor in cell cycle progression and tumorigenesis
Cell Cycle, 2011Co-Authors: Daniela Brina, Stefano Grosso, Annarita Miluzio, Stefano BiffoAbstract:Ribosome biogenesis and translation can be simplified as the processes of generating ribosomes and their use for decoding mRNA into a protein. Ribosome biogenesis has been efficiently studied in unicellular organisms like the budding yeast, allowing us a deep and basic knowledge of this process in growing cells. Translation has been modeled in vitro and in unicellular organisms. These studies have given us an important insight into the mechanisms and evolutionarily conserved aspects of ribosome biology. However, we advocate the need of the direct study of these processes in multicellular organisms. Analysis of ribosome biogenesis and translation in vivo in Metazoa and mammalian models is emerging and unveils the unexpected consequences of perturbed ribosome biogenesis and translation. Here, we will describe how one Factor, eIF6, plays a crucial role both in the generation of the large ribosomal subunit and its availability for translation. From there, we will make specific conclusions on the physiological...
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the central role of eif6 a Rate Limiting Factor in cell cycle progression and tumorigenesis
2011Co-Authors: Daniela Brina, Stefano Grosso, Annarita Miluzio, Stefano BiffoAbstract:Ribosome biogenesis and translation can be simplified as the processes of generating ribosomes and their use for decoding mRNA into a protein. Ribosome biogenesis has been efficiently studied in unicellular organisms like the budding yeast, allowing us a deep and basic knowledge of this process in growing cells. Translation has been modeled in vitro and in unicellular organisms. These studies have given us an important insight into the mechanisms and evolutionarily conserved aspects of ribosome biology. However, we advocate the need of the direct study of these processes in multicellular organisms. Analysis of ribosome biogenesis and translation in vivo in Metazoa and mammalian models is emerging and unveils the unexpected consequences of perturbed ribosome biogenesis and translation. Here, we will describe how one Factor, eIF6, plays a crucial role both in the generation of the large ribosomal subunit and its availability for translation. From there, we will make specific conclusions on the physi ological relevance of eIF6 in 80S formation, cell cycle progression and disease, raising the point that the control of gene expression may occur at the unexpected level of the large ribosomal subunit. In the future, the modulation of eIF6 binding to the 60S may be pharmacologically exploited to reduce the growth of cancer cells or amelioRate the phenotype of SDS syndrome.
Ivan Topisirovic - One of the best experts on this subject based on the ideXlab platform.
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Translational control of the activation of transcription Factor NF-κB and production of type I interferon by phosphorylation of the translation Factor eIF4E.
Nature Immunology, 2012Co-Authors: Barbara Herdy, Maritza Jaramillo, Yuri V Svitkin, Amy B Rosenfeld, Mariko Kobayashi, Derek Walsh, Tommy Alain, Polen Sean, Nathaniel Robichaud, Ivan TopisirovicAbstract:Type I interferon is an integral component of the antiviral response, and its production is tightly controlled at the levels of transcription and translation. The eukaryotic translation-initiation Factor eIF4E is a Rate-Limiting Factor whose activity is regulated by phosphorylation of Ser209. Here we found that mice and fibroblasts in which eIF4E cannot be phosphorylated were less susceptible to virus infection. More production of type I interferon, resulting from less translation of Nfkbia mRNA (which encodes the inhibitor IκBα), largely explained this phenotype. The lower abundance of IκBα resulted in enhanced activity of the transcription Factor NF-κB, which promoted the production of interferon-β (IFN-β). Thus, regulated phosphorylation of eIF4E has a key role in antiviral host defense by selectively controlling the translation of an mRNA that encodes a critical suppressor of the innate antiviral response.
Richard A Berg - One of the best experts on this subject based on the ideXlab platform.
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correlation of the steady state rna levels among the α subunit of prolyl 4 hydroxylase and the α1 and α2 chains of type i collagen during growth of chicken embryo tendon fibroblasts
Biochemical and Biophysical Research Communications, 1991Co-Authors: James A Bassuk, Richard A BergAbstract:Abstract The relative steady-state levels of RNAs encoding type I collagen and prolyl 4-hydroxylase were examined in exponentially growing primary cultures of chicken embryo tendon fibroblasts. The RNA levels of the α1 and α2 chains of type I collagen were maximal when the fibroblasts reached the confluent state. The RNA levels of the α-subunit of prolyl 4-hydroxylase were also maximal at confluency and rose and fell with the RNA levels of the two collagen chains. The RNA levels of the β-subunit of prolyl 4-hydroxylase did not correlate with the changes observed for the α-subunit or for either chain of type I collagen. The RNA levels of the β-subunit were slightly higher than the RNA levels of the α-subunit. These results support our hypothesis that the synthesis of the α-subunit and thus the association of newly synthesized α-subunits with pre-existing β-subunits is the Rate-Limiting Factor in determining prolyl 4-hydroxylase activity in cultured cells.
