The Experts below are selected from a list of 75 Experts worldwide ranked by ideXlab platform
Qiuning Lin - One of the best experts on this subject based on the ideXlab platform.
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A strongly Adhesive hemostatic hydrogel for the repair of arterial and heart bleeds
Nature communications, 2019Co-Authors: Yi Hong, Xianzhu Zhang, Dihao Pan, Deming Jiang, Long Yang, Zhou Feifei, Hua Yujie, Zhang Yiqing, Qiuning LinAbstract:Uncontrollable bleeding is a major problem in surgical procedures and after major trauma. Existing hemostatic agents poorly control hemorrhaging from traumatic arterial and cardiac wounds because of their weak adhesion to wet and mobile tissues. Here we design a photo-Reactive Adhesive that mimics the extracellular matrix (ECM) composition. This biomacromolecule-based matrix hydrogel can undergo rapid gelling and fixation to adhere and seal bleeding arteries and cardiac walls after UV light irradiation. These repairs can withstand up to 290 mm Hg blood pressure, significantly higher than blood pressures in most clinical settings (systolic BP 60–160 mm Hg). Most importantly, the hydrogel can stop high-pressure bleeding from pig carotid arteries with 4~ 5 mm-long incision wounds and from pig hearts with 6 mm diameter cardiac penetration holes. Treated pigs survived after hemostatic treatments with this hydrogel, which is well-tolerated and appears to offer significant clinical advantage as a traumatic wound sealant. Uncontrollable bleeding is a major problem in surgery and after trauma. Here the authors design a photo-Reactive Adhesive that mimics the composition of connective tissue and is able to stop high pressure bleeding within half a minute.
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A strongly Adhesive hemostatic hydrogel for the repair of arterial and heart bleeds
Nature Publishing Group, 2019Co-Authors: Yi Hong, Feifei Zhou, Yujie Hua, Xianzhu Zhang, Dihao Pan, Yiqing Zhang, Deming Jiang, Long Yang, Qiuning LinAbstract:Uncontrollable bleeding is a major problem in surgery and after trauma. Here the authors design a photo-Reactive Adhesive that mimics the composition of connective tissue and is able to stop high pressure bleeding within half a minute
Yi Hong - One of the best experts on this subject based on the ideXlab platform.
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A strongly Adhesive hemostatic hydrogel for the repair of arterial and heart bleeds
Nature communications, 2019Co-Authors: Yi Hong, Xianzhu Zhang, Dihao Pan, Deming Jiang, Long Yang, Zhou Feifei, Hua Yujie, Zhang Yiqing, Qiuning LinAbstract:Uncontrollable bleeding is a major problem in surgical procedures and after major trauma. Existing hemostatic agents poorly control hemorrhaging from traumatic arterial and cardiac wounds because of their weak adhesion to wet and mobile tissues. Here we design a photo-Reactive Adhesive that mimics the extracellular matrix (ECM) composition. This biomacromolecule-based matrix hydrogel can undergo rapid gelling and fixation to adhere and seal bleeding arteries and cardiac walls after UV light irradiation. These repairs can withstand up to 290 mm Hg blood pressure, significantly higher than blood pressures in most clinical settings (systolic BP 60–160 mm Hg). Most importantly, the hydrogel can stop high-pressure bleeding from pig carotid arteries with 4~ 5 mm-long incision wounds and from pig hearts with 6 mm diameter cardiac penetration holes. Treated pigs survived after hemostatic treatments with this hydrogel, which is well-tolerated and appears to offer significant clinical advantage as a traumatic wound sealant. Uncontrollable bleeding is a major problem in surgery and after trauma. Here the authors design a photo-Reactive Adhesive that mimics the composition of connective tissue and is able to stop high pressure bleeding within half a minute.
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A strongly Adhesive hemostatic hydrogel for the repair of arterial and heart bleeds
Nature Publishing Group, 2019Co-Authors: Yi Hong, Feifei Zhou, Yujie Hua, Xianzhu Zhang, Dihao Pan, Yiqing Zhang, Deming Jiang, Long Yang, Qiuning LinAbstract:Uncontrollable bleeding is a major problem in surgery and after trauma. Here the authors design a photo-Reactive Adhesive that mimics the composition of connective tissue and is able to stop high pressure bleeding within half a minute
Long Yang - One of the best experts on this subject based on the ideXlab platform.
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A strongly Adhesive hemostatic hydrogel for the repair of arterial and heart bleeds
Nature communications, 2019Co-Authors: Yi Hong, Xianzhu Zhang, Dihao Pan, Deming Jiang, Long Yang, Zhou Feifei, Hua Yujie, Zhang Yiqing, Qiuning LinAbstract:Uncontrollable bleeding is a major problem in surgical procedures and after major trauma. Existing hemostatic agents poorly control hemorrhaging from traumatic arterial and cardiac wounds because of their weak adhesion to wet and mobile tissues. Here we design a photo-Reactive Adhesive that mimics the extracellular matrix (ECM) composition. This biomacromolecule-based matrix hydrogel can undergo rapid gelling and fixation to adhere and seal bleeding arteries and cardiac walls after UV light irradiation. These repairs can withstand up to 290 mm Hg blood pressure, significantly higher than blood pressures in most clinical settings (systolic BP 60–160 mm Hg). Most importantly, the hydrogel can stop high-pressure bleeding from pig carotid arteries with 4~ 5 mm-long incision wounds and from pig hearts with 6 mm diameter cardiac penetration holes. Treated pigs survived after hemostatic treatments with this hydrogel, which is well-tolerated and appears to offer significant clinical advantage as a traumatic wound sealant. Uncontrollable bleeding is a major problem in surgery and after trauma. Here the authors design a photo-Reactive Adhesive that mimics the composition of connective tissue and is able to stop high pressure bleeding within half a minute.
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A strongly Adhesive hemostatic hydrogel for the repair of arterial and heart bleeds
Nature Publishing Group, 2019Co-Authors: Yi Hong, Feifei Zhou, Yujie Hua, Xianzhu Zhang, Dihao Pan, Yiqing Zhang, Deming Jiang, Long Yang, Qiuning LinAbstract:Uncontrollable bleeding is a major problem in surgery and after trauma. Here the authors design a photo-Reactive Adhesive that mimics the composition of connective tissue and is able to stop high pressure bleeding within half a minute
Deming Jiang - One of the best experts on this subject based on the ideXlab platform.
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A strongly Adhesive hemostatic hydrogel for the repair of arterial and heart bleeds
Nature communications, 2019Co-Authors: Yi Hong, Xianzhu Zhang, Dihao Pan, Deming Jiang, Long Yang, Zhou Feifei, Hua Yujie, Zhang Yiqing, Qiuning LinAbstract:Uncontrollable bleeding is a major problem in surgical procedures and after major trauma. Existing hemostatic agents poorly control hemorrhaging from traumatic arterial and cardiac wounds because of their weak adhesion to wet and mobile tissues. Here we design a photo-Reactive Adhesive that mimics the extracellular matrix (ECM) composition. This biomacromolecule-based matrix hydrogel can undergo rapid gelling and fixation to adhere and seal bleeding arteries and cardiac walls after UV light irradiation. These repairs can withstand up to 290 mm Hg blood pressure, significantly higher than blood pressures in most clinical settings (systolic BP 60–160 mm Hg). Most importantly, the hydrogel can stop high-pressure bleeding from pig carotid arteries with 4~ 5 mm-long incision wounds and from pig hearts with 6 mm diameter cardiac penetration holes. Treated pigs survived after hemostatic treatments with this hydrogel, which is well-tolerated and appears to offer significant clinical advantage as a traumatic wound sealant. Uncontrollable bleeding is a major problem in surgery and after trauma. Here the authors design a photo-Reactive Adhesive that mimics the composition of connective tissue and is able to stop high pressure bleeding within half a minute.
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A strongly Adhesive hemostatic hydrogel for the repair of arterial and heart bleeds
Nature Publishing Group, 2019Co-Authors: Yi Hong, Feifei Zhou, Yujie Hua, Xianzhu Zhang, Dihao Pan, Yiqing Zhang, Deming Jiang, Long Yang, Qiuning LinAbstract:Uncontrollable bleeding is a major problem in surgery and after trauma. Here the authors design a photo-Reactive Adhesive that mimics the composition of connective tissue and is able to stop high pressure bleeding within half a minute
Dihao Pan - One of the best experts on this subject based on the ideXlab platform.
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A strongly Adhesive hemostatic hydrogel for the repair of arterial and heart bleeds
Nature communications, 2019Co-Authors: Yi Hong, Xianzhu Zhang, Dihao Pan, Deming Jiang, Long Yang, Zhou Feifei, Hua Yujie, Zhang Yiqing, Qiuning LinAbstract:Uncontrollable bleeding is a major problem in surgical procedures and after major trauma. Existing hemostatic agents poorly control hemorrhaging from traumatic arterial and cardiac wounds because of their weak adhesion to wet and mobile tissues. Here we design a photo-Reactive Adhesive that mimics the extracellular matrix (ECM) composition. This biomacromolecule-based matrix hydrogel can undergo rapid gelling and fixation to adhere and seal bleeding arteries and cardiac walls after UV light irradiation. These repairs can withstand up to 290 mm Hg blood pressure, significantly higher than blood pressures in most clinical settings (systolic BP 60–160 mm Hg). Most importantly, the hydrogel can stop high-pressure bleeding from pig carotid arteries with 4~ 5 mm-long incision wounds and from pig hearts with 6 mm diameter cardiac penetration holes. Treated pigs survived after hemostatic treatments with this hydrogel, which is well-tolerated and appears to offer significant clinical advantage as a traumatic wound sealant. Uncontrollable bleeding is a major problem in surgery and after trauma. Here the authors design a photo-Reactive Adhesive that mimics the composition of connective tissue and is able to stop high pressure bleeding within half a minute.
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A strongly Adhesive hemostatic hydrogel for the repair of arterial and heart bleeds
Nature Publishing Group, 2019Co-Authors: Yi Hong, Feifei Zhou, Yujie Hua, Xianzhu Zhang, Dihao Pan, Yiqing Zhang, Deming Jiang, Long Yang, Qiuning LinAbstract:Uncontrollable bleeding is a major problem in surgery and after trauma. Here the authors design a photo-Reactive Adhesive that mimics the composition of connective tissue and is able to stop high pressure bleeding within half a minute
