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Sun Jae Jung - One of the best experts on this subject based on the ideXlab platform.
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association between psychological resilience and cognitive function in older adults effect modification by inflammatory status
GeroScience, 2021Co-Authors: Karestan C. Koenen, Kristen Nishimi, Sun Jae Jung, Ga Bin Lee, Lori B Chibnik, Hyeon Chang KimAbstract:To examine the association between psychological resilience and cognitive function and investigate the role of acute inflammation as an effect modifier. Total 7535 people from the Cardiovascular and Metabolic Disease Etiology Research Center (CMERC), aged ≥ 50 years and residing in areas near Seoul, South Korea, were included in this cross-sectional analysis. Stressful life events in the past 6 months were gauged by the Life Experience Survey, and current Depression symptoms were analyzed with the Beck Depression Inventory-II. Participants were categorized into the following four groups according to their past experience and Depression status: reference, resilient, Reactive Depression, and vulnerable Depression. Cognitive function was evaluated using the mini-mental state examination (MMSE). The level of high-sensitivity C-Reactive protein (hsCRP) was measured from blood samples. A generalized linear model was used. Upon adjusting for socio-demographic factors, comorbidity, and lifestyle factors, the final model was stratified with the highest quartile of the hsCRP level by sex. Compared to the reference group, the resilient group showed higher MMSE, which was also significant in women (adj-β = 0.280, p-value < 0.001). Vulnerable Depression group showed a significantly lower MMSE (adj-β = − -0.997, p-value 0.002), especially in men. This pattern seemed to be limited to the low hsCRP subgroup. We provided evidence from the largest Korean population used to evaluate the association between psychological resilience and cognition, which was more prominent in low inflammatory status. Psychological resilience was associated with a lower likelihood of cognitive deficit in women. This pattern was modulated by inflammatory status.
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correlates of psychological resilience and risk prospective associations of self reported and relative resilience with connor davidson resilience scale heart rate variability and mental health indices
Brain and behavior, 2021Co-Authors: Karmel W. Choi, Karestan C. Koenen, Sun Jae Jung, Ye Jin Jeon, Ji Su Yang, Jeongho Chae, Hyeon Chang KimAbstract:Background There are several ways to determine psychological resilience. However, the correlation between each measurement is not clear. We explored associations of baseline relative "resilience" and risk with later self-reported trait resilience and other biological/mental health indices. Methods We utilized baseline and follow-up survey data from 500 participants aged 30-64 in the community cohort. Baseline "relative" resilience was defined by: (a) negative life events (NLEs) in the six months before baseline and (b) depressive symptoms at baseline, yielding four groups of individuals: i) "Unexposed and well," "Vulnerable (Depression)," "Reactive (Depression)," and "Resilient." "Trait" resilience at follow-up was self-reported using the Connor-Davidson Resilience Scale (CD-RISC). Associations between relative resilience at baseline, CD-RISC, and heart rate variability (HRV) indices at follow-up were assessed with generalized linear regression models after adjustments. Associations between baseline resilience and subsequent loneliness/Depression indices were also evaluated. Results Overall trait resilience and its subfactors at follow-up showed strong negative associations with "Reactive" at baseline (adj-β for total CD-RISC score: -11.204 (men), -9.472 (women)). However, resilience at baseline was not associated with later HRV, which was compared with the significant positive association observed between CD-RISC and HRV at the same follow-up time point. The "Reactive" exhibited significantly increased depressive symptoms at follow-up. The overall distribution pattern of CD-RISC subfactors differed by baseline resilience status by sex. Conclusions The "relative" resilience based on the absence of Depression despite prior adversity seems to be highly related with trait resilience at follow-up but not with HRV. The sub-factor pattern of CD-RISC was different by sex.
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association between psychological resilience and cognitive function in later life effect modification by inflammatory status
Social Science Research Network, 2020Co-Authors: Karestan C. Koenen, Kristen Nishimi, Sun Jae Jung, Ga Bin Lee, Chibnik Lori, Hyeon Chang KimAbstract:Background: We aimed to examine the association between psychological resilience and cognitive function and investigate the role of acute inflammation as an effect modifier. Methods: Total 7,535 people from the Cardiovascular and Metabolic Disease Etiology Research Center (CMERC), aged ≥50, were included in the analysis. Stressful life events in the past 6 months were gauged by the Life Experience Survey, and current Depression symptoms were analysed with the Beck Depression Inventory-II. Participants were categorised into four groups according to their past experience and Depression status: ‘reference,’ ‘resilient,’ ‘Reactive Depression,’ and ‘vulnerable Depression.’ Cognitive function was evaluated using the Mini-Mental State Examination (MMSE). The level of high-sensitivity C-Reactive protein (hsCRP) and Interleukin-6 were measured from blood samples. A generalised linear regression was performed. Upon adjusting for socio-demographic factors, comorbidity, and lifestyle factors, the final model was stratified with the highest quartile of the hsCRP level by sex. Findings: Compared with the reference group, ‘resilient group’ showed higher MMSE, which was also significant in women (adj-β=0·280, p-value<0·001). ‘Vulnerable Depression’ showed a significant lower MMSE (adj-β=-0·997, p-value 0·002) in especially men. This pattern seemed to be limited to the low hsCRP subgroup. Interpretation: Psychological resilience was associated with a lower likelihood of cognitive deficit in women. This pattern seemed to be modulated by inflammatory status. Funding Statement: This research was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF), funded by the Ministry of Science and ICT (2018R1C1B5083722), and the CMERC cohort study was supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (grant number HI13C0715). Declaration of Interests: The authors declare no competing interests. Ethics Approval Statement: The Institutional Review Board of Yonsei University (YUIRB-4-2013-0661) approved the protocol of this study, and all participants provided written informed consents.
Hyeon Chang Kim - One of the best experts on this subject based on the ideXlab platform.
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association between psychological resilience and cognitive function in older adults effect modification by inflammatory status
GeroScience, 2021Co-Authors: Karestan C. Koenen, Kristen Nishimi, Sun Jae Jung, Ga Bin Lee, Lori B Chibnik, Hyeon Chang KimAbstract:To examine the association between psychological resilience and cognitive function and investigate the role of acute inflammation as an effect modifier. Total 7535 people from the Cardiovascular and Metabolic Disease Etiology Research Center (CMERC), aged ≥ 50 years and residing in areas near Seoul, South Korea, were included in this cross-sectional analysis. Stressful life events in the past 6 months were gauged by the Life Experience Survey, and current Depression symptoms were analyzed with the Beck Depression Inventory-II. Participants were categorized into the following four groups according to their past experience and Depression status: reference, resilient, Reactive Depression, and vulnerable Depression. Cognitive function was evaluated using the mini-mental state examination (MMSE). The level of high-sensitivity C-Reactive protein (hsCRP) was measured from blood samples. A generalized linear model was used. Upon adjusting for socio-demographic factors, comorbidity, and lifestyle factors, the final model was stratified with the highest quartile of the hsCRP level by sex. Compared to the reference group, the resilient group showed higher MMSE, which was also significant in women (adj-β = 0.280, p-value < 0.001). Vulnerable Depression group showed a significantly lower MMSE (adj-β = − -0.997, p-value 0.002), especially in men. This pattern seemed to be limited to the low hsCRP subgroup. We provided evidence from the largest Korean population used to evaluate the association between psychological resilience and cognition, which was more prominent in low inflammatory status. Psychological resilience was associated with a lower likelihood of cognitive deficit in women. This pattern was modulated by inflammatory status.
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correlates of psychological resilience and risk prospective associations of self reported and relative resilience with connor davidson resilience scale heart rate variability and mental health indices
Brain and behavior, 2021Co-Authors: Karmel W. Choi, Karestan C. Koenen, Sun Jae Jung, Ye Jin Jeon, Ji Su Yang, Jeongho Chae, Hyeon Chang KimAbstract:Background There are several ways to determine psychological resilience. However, the correlation between each measurement is not clear. We explored associations of baseline relative "resilience" and risk with later self-reported trait resilience and other biological/mental health indices. Methods We utilized baseline and follow-up survey data from 500 participants aged 30-64 in the community cohort. Baseline "relative" resilience was defined by: (a) negative life events (NLEs) in the six months before baseline and (b) depressive symptoms at baseline, yielding four groups of individuals: i) "Unexposed and well," "Vulnerable (Depression)," "Reactive (Depression)," and "Resilient." "Trait" resilience at follow-up was self-reported using the Connor-Davidson Resilience Scale (CD-RISC). Associations between relative resilience at baseline, CD-RISC, and heart rate variability (HRV) indices at follow-up were assessed with generalized linear regression models after adjustments. Associations between baseline resilience and subsequent loneliness/Depression indices were also evaluated. Results Overall trait resilience and its subfactors at follow-up showed strong negative associations with "Reactive" at baseline (adj-β for total CD-RISC score: -11.204 (men), -9.472 (women)). However, resilience at baseline was not associated with later HRV, which was compared with the significant positive association observed between CD-RISC and HRV at the same follow-up time point. The "Reactive" exhibited significantly increased depressive symptoms at follow-up. The overall distribution pattern of CD-RISC subfactors differed by baseline resilience status by sex. Conclusions The "relative" resilience based on the absence of Depression despite prior adversity seems to be highly related with trait resilience at follow-up but not with HRV. The sub-factor pattern of CD-RISC was different by sex.
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association between psychological resilience and cognitive function in later life effect modification by inflammatory status
Social Science Research Network, 2020Co-Authors: Karestan C. Koenen, Kristen Nishimi, Sun Jae Jung, Ga Bin Lee, Chibnik Lori, Hyeon Chang KimAbstract:Background: We aimed to examine the association between psychological resilience and cognitive function and investigate the role of acute inflammation as an effect modifier. Methods: Total 7,535 people from the Cardiovascular and Metabolic Disease Etiology Research Center (CMERC), aged ≥50, were included in the analysis. Stressful life events in the past 6 months were gauged by the Life Experience Survey, and current Depression symptoms were analysed with the Beck Depression Inventory-II. Participants were categorised into four groups according to their past experience and Depression status: ‘reference,’ ‘resilient,’ ‘Reactive Depression,’ and ‘vulnerable Depression.’ Cognitive function was evaluated using the Mini-Mental State Examination (MMSE). The level of high-sensitivity C-Reactive protein (hsCRP) and Interleukin-6 were measured from blood samples. A generalised linear regression was performed. Upon adjusting for socio-demographic factors, comorbidity, and lifestyle factors, the final model was stratified with the highest quartile of the hsCRP level by sex. Findings: Compared with the reference group, ‘resilient group’ showed higher MMSE, which was also significant in women (adj-β=0·280, p-value<0·001). ‘Vulnerable Depression’ showed a significant lower MMSE (adj-β=-0·997, p-value 0·002) in especially men. This pattern seemed to be limited to the low hsCRP subgroup. Interpretation: Psychological resilience was associated with a lower likelihood of cognitive deficit in women. This pattern seemed to be modulated by inflammatory status. Funding Statement: This research was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF), funded by the Ministry of Science and ICT (2018R1C1B5083722), and the CMERC cohort study was supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (grant number HI13C0715). Declaration of Interests: The authors declare no competing interests. Ethics Approval Statement: The Institutional Review Board of Yonsei University (YUIRB-4-2013-0661) approved the protocol of this study, and all participants provided written informed consents.
Peter Mcguffin - One of the best experts on this subject based on the ideXlab platform.
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the endogenous and Reactive Depression subtypes revisited integrative animal and human studies implicate multiple distinct molecular mechanisms underlying major depressive disorder
BMC Medicine, 2014Co-Authors: Karim Malki, Robert Keers, Maria G Tosto, Anbarasu Lourdusamy, Lucia Carboni, Enrico Domenici, Rudolf Uher, Peter McguffinAbstract:Traditional diagnoses of major depressive disorder (MDD) suggested that the presence or absence of stress prior to onset results in either ‘Reactive’ or ‘endogenous’ subtypes of the disorder, respectively. Several lines of research suggest that the biological underpinnings of ‘Reactive’ or ‘endogenous’ subtypes may also differ, resulting in differential response to treatment. We investigated this hypothesis by comparing the gene-expression profiles of three animal models of ‘Reactive’ and ‘endogenous’ Depression. We then translated these findings to clinical samples using a human post-mortem mRNA study. Affymetrix mouse whole-genome oligonucleotide arrays were used to measure gene expression from hippocampal tissues of 144 mice from the Genome-based Therapeutic Drugs for Depression (GENDEP) project. The study used four inbred mouse strains and two depressogenic ‘stress’ protocols (maternal separation and Unpredictable Chronic Mild Stress) to model ‘Reactive’ Depression. Stress-related mRNA differences in mouse were compared with a parallel mRNA study using Flinders Sensitive and Resistant rat lines as a model of ‘endogenous’ Depression. Convergent genes differentially expressed across the animal studies were used to inform candidate gene selection in a human mRNA post-mortem case control study from the Stanley Brain Consortium. In the mouse ‘Reactive’ model, the expression of 350 genes changed in response to early stresses and 370 in response to late stresses. A minimal genetic overlap (less than 8.8%) was detected in response to both stress protocols, but 30% of these genes (21) were also differentially regulated in the ‘endogenous’ rat study. This overlap is significantly greater than expected by chance. The VAMP-2 gene, differentially expressed across the rodent studies, was also significantly altered in the human study after correcting for multiple testing. Our results suggest that ‘endogenous’ and ‘Reactive’ subtypes of Depression are associated with largely distinct changes in gene-expression. However, they also suggest that the molecular signature of ‘Reactive’ Depression caused by early stressors differs considerably from that of ‘Reactive’ Depression caused by late stressors. A small set of genes was consistently dysregulated across each paradigm and in post-mortem brain tissue of depressed patients suggesting a final common pathway to the disorder. These genes included the VAMP-2 gene, which has previously been associated with Axis-I disorders including MDD, bipolar Depression, schizophrenia and with antidepressant treatment response. We also discuss the implications of our findings for disease classification, personalized medicine and case-control studies of MDD.
Rudolf Uher - One of the best experts on this subject based on the ideXlab platform.
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the endogenous and Reactive Depression subtypes revisited integrative animal and human studies implicate multiple distinct molecular mechanisms underlying major depressive disorder
BMC Medicine, 2014Co-Authors: Karim Malki, Robert Keers, Maria G Tosto, Anbarasu Lourdusamy, Lucia Carboni, Enrico Domenici, Rudolf Uher, Peter McguffinAbstract:Traditional diagnoses of major depressive disorder (MDD) suggested that the presence or absence of stress prior to onset results in either ‘Reactive’ or ‘endogenous’ subtypes of the disorder, respectively. Several lines of research suggest that the biological underpinnings of ‘Reactive’ or ‘endogenous’ subtypes may also differ, resulting in differential response to treatment. We investigated this hypothesis by comparing the gene-expression profiles of three animal models of ‘Reactive’ and ‘endogenous’ Depression. We then translated these findings to clinical samples using a human post-mortem mRNA study. Affymetrix mouse whole-genome oligonucleotide arrays were used to measure gene expression from hippocampal tissues of 144 mice from the Genome-based Therapeutic Drugs for Depression (GENDEP) project. The study used four inbred mouse strains and two depressogenic ‘stress’ protocols (maternal separation and Unpredictable Chronic Mild Stress) to model ‘Reactive’ Depression. Stress-related mRNA differences in mouse were compared with a parallel mRNA study using Flinders Sensitive and Resistant rat lines as a model of ‘endogenous’ Depression. Convergent genes differentially expressed across the animal studies were used to inform candidate gene selection in a human mRNA post-mortem case control study from the Stanley Brain Consortium. In the mouse ‘Reactive’ model, the expression of 350 genes changed in response to early stresses and 370 in response to late stresses. A minimal genetic overlap (less than 8.8%) was detected in response to both stress protocols, but 30% of these genes (21) were also differentially regulated in the ‘endogenous’ rat study. This overlap is significantly greater than expected by chance. The VAMP-2 gene, differentially expressed across the rodent studies, was also significantly altered in the human study after correcting for multiple testing. Our results suggest that ‘endogenous’ and ‘Reactive’ subtypes of Depression are associated with largely distinct changes in gene-expression. However, they also suggest that the molecular signature of ‘Reactive’ Depression caused by early stressors differs considerably from that of ‘Reactive’ Depression caused by late stressors. A small set of genes was consistently dysregulated across each paradigm and in post-mortem brain tissue of depressed patients suggesting a final common pathway to the disorder. These genes included the VAMP-2 gene, which has previously been associated with Axis-I disorders including MDD, bipolar Depression, schizophrenia and with antidepressant treatment response. We also discuss the implications of our findings for disease classification, personalized medicine and case-control studies of MDD.
Maria G Tosto - One of the best experts on this subject based on the ideXlab platform.
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the endogenous and Reactive Depression subtypes revisited integrative animal and human studies implicate multiple distinct molecular mechanisms underlying major depressive disorder
BMC Medicine, 2014Co-Authors: Karim Malki, Robert Keers, Maria G Tosto, Anbarasu Lourdusamy, Lucia Carboni, Enrico Domenici, Rudolf Uher, Peter McguffinAbstract:Traditional diagnoses of major depressive disorder (MDD) suggested that the presence or absence of stress prior to onset results in either ‘Reactive’ or ‘endogenous’ subtypes of the disorder, respectively. Several lines of research suggest that the biological underpinnings of ‘Reactive’ or ‘endogenous’ subtypes may also differ, resulting in differential response to treatment. We investigated this hypothesis by comparing the gene-expression profiles of three animal models of ‘Reactive’ and ‘endogenous’ Depression. We then translated these findings to clinical samples using a human post-mortem mRNA study. Affymetrix mouse whole-genome oligonucleotide arrays were used to measure gene expression from hippocampal tissues of 144 mice from the Genome-based Therapeutic Drugs for Depression (GENDEP) project. The study used four inbred mouse strains and two depressogenic ‘stress’ protocols (maternal separation and Unpredictable Chronic Mild Stress) to model ‘Reactive’ Depression. Stress-related mRNA differences in mouse were compared with a parallel mRNA study using Flinders Sensitive and Resistant rat lines as a model of ‘endogenous’ Depression. Convergent genes differentially expressed across the animal studies were used to inform candidate gene selection in a human mRNA post-mortem case control study from the Stanley Brain Consortium. In the mouse ‘Reactive’ model, the expression of 350 genes changed in response to early stresses and 370 in response to late stresses. A minimal genetic overlap (less than 8.8%) was detected in response to both stress protocols, but 30% of these genes (21) were also differentially regulated in the ‘endogenous’ rat study. This overlap is significantly greater than expected by chance. The VAMP-2 gene, differentially expressed across the rodent studies, was also significantly altered in the human study after correcting for multiple testing. Our results suggest that ‘endogenous’ and ‘Reactive’ subtypes of Depression are associated with largely distinct changes in gene-expression. However, they also suggest that the molecular signature of ‘Reactive’ Depression caused by early stressors differs considerably from that of ‘Reactive’ Depression caused by late stressors. A small set of genes was consistently dysregulated across each paradigm and in post-mortem brain tissue of depressed patients suggesting a final common pathway to the disorder. These genes included the VAMP-2 gene, which has previously been associated with Axis-I disorders including MDD, bipolar Depression, schizophrenia and with antidepressant treatment response. We also discuss the implications of our findings for disease classification, personalized medicine and case-control studies of MDD.
