The Experts below are selected from a list of 8445 Experts worldwide ranked by ideXlab platform
V Weiss - One of the best experts on this subject based on the ideXlab platform.
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A common switch in activation of the response regulators NtrC and PhoB: phosphorylation induces dimerization of the Receiver Modules.
The EMBO journal, 1995Co-Authors: U Fiedler, V WeissAbstract:During signal transduction, response regulators of two-component systems are phosphorylated in a conserved Receiver Module. Phosphorylation induces activation of the non-conserved output domain. We fused various domains of the response regulators NtrC, PhoB or CheB to the DNA binding domain of lambda repressor. Analysis of these hybrid proteins shows that the Receiver Modules of NtrC and PhoB are potential dimerization domains. In the unphosphorylated proteins, the ability of the Receiver Modules to dimerize is masked due to inhibition by their output domains. Inhibition can be relieved in two ways: phosphorylation of the Receiver Module or deletion of the output domain. In contrast, the Receiver Module of CheB lacks this ability for dimerization. We propose a model which groups response regulators into two classes. Common to both classes is the interaction between Receiver and output domain in the unphosphorylated protein. In class I (e.g. NtrC and PhoB), this interaction leads to the inhibition of the Receiver Module. Phosphorylation relieves inhibition, thereby inducing activation via dimerization of the Receiver Modules. In class II (e.g. CheB), the interaction between Receiver and output domain results in inhibition of the output domain. Phosphorylation relieves inhibition, thereby activating the output domain.
Po-jui Chiang - One of the best experts on this subject based on the ideXlab platform.
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ISCAS - Design of High-Speed Optical Receiver Module for 160Gb/s NRZ and 200Gb/s PAM4 Transmissions
2019 IEEE International Symposium on Circuits and Systems (ISCAS), 2019Co-Authors: Jian-yu Lai, Chuan-yu Liao, Jau-ji Jou, Tien-tsorng Shih, Po-jui ChiangAbstract:In this paper, we propose a high-speed optical Receiver Module with four channels. The optical Receiver Module was composed of a four-channel PIN photodiode array and a four-channel linear transimpedance amplifier on a six-layer printed circuit board (PCB). The top and bottom layers of the PCB were used as the high-speed layers. The grounded coplanar waveguide structure was designed on the PCB for high-speed data transmissions. The interface of the optical Receiver Module was designed as the QSFP28 pin definition. According to the eye diagram and bit-error rate measurements, the optical Receiver Module can be achieved 160 Gb/s NRZ and 200 Gb/s PAM4 transmissions over 1 km single mode fiber [1].
G. Berkowitz - One of the best experts on this subject based on the ideXlab platform.
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A 32-channel tunable Receiver Module for wavelength-division multiple-access networks
IEEE Photonics Technology Letters, 1997Co-Authors: F. Tong, G. BerkowitzAbstract:We report the realization of a 32-channel tunable optical Receiver Module for packet-switched multiwavelength computer networks. The tunable Receiver consists of a planar array waveguide grating demultiplexer, photodetector array and followed by selectable Receivers. The channel selection is based on sequential switching of the received optical signals in stages at the analogue level. Typical Receiver sensitivity is -24 dBm at 10/sup -9/, using a 700-Mb/s nonreturn-to-zero (NRZ) pseudorandom binary sequence (PRBS). The channel switching time is /spl sim/40 ns.
T Harada - One of the best experts on this subject based on the ideXlab platform.
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high performance of 10 gb s apd preamplifier optical Receiver Module with compact size
IEEE Photonics Technology Letters, 2003Co-Authors: H Matsuda, A Miura, Y Okamura, H Irie, K Ito, T Toyonaka, H Takahashi, T HaradaAbstract:A 10-Gb/s optical-Receiver Module comprising an InAlAs avalanche photodiode and an SiGe-HBT preamplifier with differential outputs has been developed. The capacity of the newly designed optical-Receiver Module package is about 1 cc and is compact enough to be incorporated into a transceiver or a full-Receiver Module. The performance of the newly designed optical-Receiver Module is excellent for the moderate fiber-length link application. The measured back-to-back minimum sensitivity of -29.5 dBm is achieved with a pseudorandom binary sequence of 2/sup 31/ -1 at a bit error rate of 10/sup -9/.
Stephen C. Winans - One of the best experts on this subject based on the ideXlab platform.
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Pleiotropic phenotypes caused by genetic ablation of the Receiver Module of the Agrobacterium tumefaciens VirA protein.
Journal of bacteriology, 1996Co-Authors: C H Chang, Jun Zhu, Stephen C. WinansAbstract:The VirA protein of Agrobacterium tumefaciens is a transmembrane sensory kinase that phosphorylates the VirG response regulator in response to chemical signals released from plant wound sites. VirA contains both a two-component kinase Module and, at its carboxyl terminus, a Receiver Module. We previously provided evidence that this Receiver Module inhibited the activity of the kinase Module and that inhibition might be neutralized by phosphorylation. In this report, we provide additional evidence for this model by showing that overexpressing the Receiver Module in trans can restore low-level basal activity to a VirA mutant protein lacking the Receiver Module. We also show that ablation of the Receiver Module restores activity to the inactive VirA (delta324-413) mutant, which has a deletion within a region designated the linker Module. This indicates that deletion of the linker Module does not denature the kinase Module, but rather locks the kinase into a phenotypically inactive conformation, and that this inactivity requires the Receiver Module. These data provide genetic evidence that the kinase and Receiver Modules of VirA attain their native conformations autonomously. The Receiver Module also restricts the variety of phenolic compounds that have stimulatory activity, since removal of this Module causes otherwise nonstimulatory phenolic compounds such as 4-hydroxyacetophenone to stimulate vir gene expression.
