The Experts below are selected from a list of 24 Experts worldwide ranked by ideXlab platform
Bernhard Meier - One of the best experts on this subject based on the ideXlab platform.
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frequency distribution of collateral flow and factors influencing collateral channel development functional collateral channel measurement in 450 patients with coronary artery disease
Journal of the American College of Cardiology, 2001Co-Authors: Tilmann Pohl, Christian Seiler, Michael Billinger, Evigna Herren, Kerstin Wustmann, Haresh Mehta, Stephan Windecker, Franz R Eberli, Bernhard MeierAbstract:OBJECTIVES We sought to determine the pathogenetic predictors of collateral channels in a large cohort of patients with coronary artery disease (CAD). BACKGROUND The frequency distribution of collateral flow in patients with CAD is unknown. Only small qualitative studies have investigated which factors influence the development of collateral channels. METHODS In 450 patients with one- to three-Vessel CAD undergoing percutaneous transluminal coronary angioplasty (PTCA), collateral flow was measured. A collateral flow index (CFI; no unit) expressing collateral flow relative to normal anterograde flow was determined using coronary wedge pressure or Doppler measurements through sensor-tipped PTCA guide wires. Frequency distribution analysis of CFI and univariate and multivariate analyses of 32 factors, including gender, age, patient history, cardiovascular risk factors, medication and coronary angiographic data, were performed. RESULTS Two-thirds of the patients had a CFI <0.25 and ∼40% of patients had a CFI <0.15, but only ∼10% of the patients had a recruitable CFI ≥0.4. By univariate analysis, the following were predictors of CFI ≥0.25: high levels of high-density lipoprotein cholesterol, the absence of previous non–Q-wave myocardial infarction, angina pectoris during an exercise test, angiographic indicators of severe CAD and the left circumflex or right coronary artery as the collateral-Receiving Vessel. Percent diameter stenosis of the lesion undergoing PTCA was the only independent predictor of a high CFI. CONCLUSIONS This large clinical study of patients with CAD in whom collateral flow was quantitatively assessed reveals that two-thirds of the patients do not have enough collateral flow to prevent myocardial ischemia during coronary occlusion, and that coronary lesion severity is the only independent pathogenetic variable related to collateral flow.
Ronald W. Rousseau - One of the best experts on this subject based on the ideXlab platform.
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batch and tubular batch crystallization of paracetamol crystal size distribution and polymorph formation
Crystal Growth & Design, 2006Co-Authors: Jose Mendez R Del Rio, Ronald W. RousseauAbstract:The crystallization of paracetamol from ethanol and methanol solutions was used to examine the possibility of using rapid cooling in a tubular flow-through apparatus to manipulate crystal size distribution and morphology. Flow through the tubular portion of the apparatus was laminar, and hence, the device, including a Receiving Vessel, is referred to as a laminar-flow tubular crystallizer (LFTC). Undersaturated solution entered the tubular portion of the LFTC and was rapidly cooled to temperatures far below solubility conditions. Experimental results were also obtained using a typical batch configuration with the same solute and solvents, but with significantly lower cooling rates than in the LFTC. The crystals produced in the flow-through apparatus were of smaller mean size than those obtained from batch crystallizations, and evidence was found that using the rapid-cooling technique could lead to the generation of kinetically stable polymorphs. Moreover, the total run time required to relieve all of the ...
Tilmann Pohl - One of the best experts on this subject based on the ideXlab platform.
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frequency distribution of collateral flow and factors influencing collateral channel development functional collateral channel measurement in 450 patients with coronary artery disease
Journal of the American College of Cardiology, 2001Co-Authors: Tilmann Pohl, Christian Seiler, Michael Billinger, Evigna Herren, Kerstin Wustmann, Haresh Mehta, Stephan Windecker, Franz R Eberli, Bernhard MeierAbstract:OBJECTIVES We sought to determine the pathogenetic predictors of collateral channels in a large cohort of patients with coronary artery disease (CAD). BACKGROUND The frequency distribution of collateral flow in patients with CAD is unknown. Only small qualitative studies have investigated which factors influence the development of collateral channels. METHODS In 450 patients with one- to three-Vessel CAD undergoing percutaneous transluminal coronary angioplasty (PTCA), collateral flow was measured. A collateral flow index (CFI; no unit) expressing collateral flow relative to normal anterograde flow was determined using coronary wedge pressure or Doppler measurements through sensor-tipped PTCA guide wires. Frequency distribution analysis of CFI and univariate and multivariate analyses of 32 factors, including gender, age, patient history, cardiovascular risk factors, medication and coronary angiographic data, were performed. RESULTS Two-thirds of the patients had a CFI <0.25 and ∼40% of patients had a CFI <0.15, but only ∼10% of the patients had a recruitable CFI ≥0.4. By univariate analysis, the following were predictors of CFI ≥0.25: high levels of high-density lipoprotein cholesterol, the absence of previous non–Q-wave myocardial infarction, angina pectoris during an exercise test, angiographic indicators of severe CAD and the left circumflex or right coronary artery as the collateral-Receiving Vessel. Percent diameter stenosis of the lesion undergoing PTCA was the only independent predictor of a high CFI. CONCLUSIONS This large clinical study of patients with CAD in whom collateral flow was quantitatively assessed reveals that two-thirds of the patients do not have enough collateral flow to prevent myocardial ischemia during coronary occlusion, and that coronary lesion severity is the only independent pathogenetic variable related to collateral flow.
Konstantinos G Adamopoulos - One of the best experts on this subject based on the ideXlab platform.
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spray drying of tomato pulp in dehumidified air i the effect on product recovery
Journal of Food Engineering, 2005Co-Authors: Athanasia M Goula, Konstantinos G AdamopoulosAbstract:Abstract This work investigates the performance of a modified spray dryer for tomato powder preparation by spray drying of tomato pulp. A pilot scale spray dryer (Buchi, B-191) with cocurrent operation and a two-fluid nozzle atomizer was employed for the spray drying process. The modification made to the original design consisted in connecting the spray dryer inlet air intake to an absorption air dryer. Samples of tomato pulp with a 14% constant total solids concentration were used. Sixty-four different experiments were conducted keeping constant the feed rate, the feed temperature and the atomizer pressure, and varying the compressed air flow rate, the flow rate of drying rate and the air inlet temperature. Data for the residue remaining on the walls and for the product collected in the Receiving Vessel were gathered. Analysis of experimental data yielded correlations between product recovery and the variable operating conditions. The modified spray drying system was proved advantageous over the standard laboratory spray dryer. Preliminary air dehumidification reduced residue accumulation, allowing the product to be dried at lower air outlet temperatures.
Jose Mendez R Del Rio - One of the best experts on this subject based on the ideXlab platform.
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batch and tubular batch crystallization of paracetamol crystal size distribution and polymorph formation
Crystal Growth & Design, 2006Co-Authors: Jose Mendez R Del Rio, Ronald W. RousseauAbstract:The crystallization of paracetamol from ethanol and methanol solutions was used to examine the possibility of using rapid cooling in a tubular flow-through apparatus to manipulate crystal size distribution and morphology. Flow through the tubular portion of the apparatus was laminar, and hence, the device, including a Receiving Vessel, is referred to as a laminar-flow tubular crystallizer (LFTC). Undersaturated solution entered the tubular portion of the LFTC and was rapidly cooled to temperatures far below solubility conditions. Experimental results were also obtained using a typical batch configuration with the same solute and solvents, but with significantly lower cooling rates than in the LFTC. The crystals produced in the flow-through apparatus were of smaller mean size than those obtained from batch crystallizations, and evidence was found that using the rapid-cooling technique could lead to the generation of kinetically stable polymorphs. Moreover, the total run time required to relieve all of the ...
