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H. Grosse-wilde - One of the best experts on this subject based on the ideXlab platform.
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Fc Receptor Blocking antibodies after active immunization for the treatment of recurrent spontaneous abortion.
Journal of Reproductive Immunology, 1991Co-Authors: U. Kuhn, R. Blasczyk, B. Hojnacki, U. Vögeler, W. Luboldt, E. Passarge, W.m. Fischer, H. Grosse-wildeAbstract:In a prospective study 140 couples who had at least three spontaneous abortions (RSA) were studied for the presence of Fc Receptor Blocking antibodies detected by the erythrocyte antibody rosette inhibition (EAI) assay, for anti-paternal cytotoxic antibodies (APCA), and for mixed lymphocyte culture inhibiting (MLCI) antibodies before and after active immunization with paternal lymphocytes. The comparative analysis revealed the EAI assay to possess a higher sensitivity than the APCA and/or MLCI tests in monitoring the specific immune response after active immunization. The success of pregnancy in EAI positive post-immunization patients was not influenced by the presence or absence of APCA or MLCI. In the light of a successful pregnancy outcome of 85.7% (n = 37) in this study we conclude that the monitoring of Fc Receptor Blocking antibodies is useful in active immunization protocols for RSA patients.
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Fc Receptor Blocking antibodies after active immunization for the treatment of recurrent spontaneous abortion.
Journal of Reproductive Immunology, 1991Co-Authors: U. Kuhn, R. Blasczyk, B. Hojnacki, U. Vögeler, W. Luboldt, E. Passarge, W.m. Fischer, H. Grosse-wildeAbstract:In a prospective study 140 couples who had at least three spontaneous abortions (RSA) were studied for the presence of Fc Receptor Blocking antibodies detected by the erythrocyte antibody rosette inhibition (EAI) assay, for anti-paternal cytotoxic antibodies (APCA), and for mixed lymphocyte culture inhibiting (MLCI) antibodies before and after active immunization with paternal lymphocytes. The comparative analysis revealed the EAI assay to possess a higher sensitivity than the APCA and/or MLCI tests in monitoring the specific immune response after active immunization. The success of pregnancy in EAI positive post-immunization patients was not influenced by the presence or absence of APCA or MLCI. In the light of a successful pregnancy outcome of 85.7% (n = 37) in this study we conclude that the monitoring of Fc Receptor Blocking antibodies is useful in active immunization protocols for RSA patients.
U. Kuhn - One of the best experts on this subject based on the ideXlab platform.
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Fc Receptor Blocking antibodies after active immunization for the treatment of recurrent spontaneous abortion.
Journal of Reproductive Immunology, 1991Co-Authors: U. Kuhn, R. Blasczyk, B. Hojnacki, U. Vögeler, W. Luboldt, E. Passarge, W.m. Fischer, H. Grosse-wildeAbstract:In a prospective study 140 couples who had at least three spontaneous abortions (RSA) were studied for the presence of Fc Receptor Blocking antibodies detected by the erythrocyte antibody rosette inhibition (EAI) assay, for anti-paternal cytotoxic antibodies (APCA), and for mixed lymphocyte culture inhibiting (MLCI) antibodies before and after active immunization with paternal lymphocytes. The comparative analysis revealed the EAI assay to possess a higher sensitivity than the APCA and/or MLCI tests in monitoring the specific immune response after active immunization. The success of pregnancy in EAI positive post-immunization patients was not influenced by the presence or absence of APCA or MLCI. In the light of a successful pregnancy outcome of 85.7% (n = 37) in this study we conclude that the monitoring of Fc Receptor Blocking antibodies is useful in active immunization protocols for RSA patients.
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Fc Receptor Blocking antibodies after active immunization for the treatment of recurrent spontaneous abortion.
Journal of Reproductive Immunology, 1991Co-Authors: U. Kuhn, R. Blasczyk, B. Hojnacki, U. Vögeler, W. Luboldt, E. Passarge, W.m. Fischer, H. Grosse-wildeAbstract:In a prospective study 140 couples who had at least three spontaneous abortions (RSA) were studied for the presence of Fc Receptor Blocking antibodies detected by the erythrocyte antibody rosette inhibition (EAI) assay, for anti-paternal cytotoxic antibodies (APCA), and for mixed lymphocyte culture inhibiting (MLCI) antibodies before and after active immunization with paternal lymphocytes. The comparative analysis revealed the EAI assay to possess a higher sensitivity than the APCA and/or MLCI tests in monitoring the specific immune response after active immunization. The success of pregnancy in EAI positive post-immunization patients was not influenced by the presence or absence of APCA or MLCI. In the light of a successful pregnancy outcome of 85.7% (n = 37) in this study we conclude that the monitoring of Fc Receptor Blocking antibodies is useful in active immunization protocols for RSA patients.
R S Brown - One of the best experts on this subject based on the ideXlab platform.
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Maternal Thyrotropin Receptor Blocking Antibody-Induced Congenital Hypothyroidism in Babies Born to Apparently Normal Mothers
Pediatric Research, 1999Co-Authors: C A Alter, Sadeghi-nejad, P M Martha, B A Rosen, R S BrownAbstract:Maternal Thyrotropin Receptor Blocking Antibody-Induced Congenital Hypothyroidism in Babies Born to Apparently Normal Mothers
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incidence of transient congenital hypothyroidism due to maternal thyrotropin Receptor Blocking antibodies in over one million babies
The Journal of Clinical Endocrinology and Metabolism, 1996Co-Authors: R S Brown, Ronald L Bellisario, Diego Botero, Lawrence Fournier, Cyril A L Abrams, Marilyn L Cowger, Ralph David, Pavel Fort, Robert A RichmanAbstract:To determine the incidence of transient congenital hypothyroidism due to TSH Receptor-Blocking antibodies, we screened dried blood specimens obtained from 788 neonates identified as having possible congenital hypothyroidism (from a total population of 1,614,166 babies) and 121 controls. A RRA was used. The potency of blood spot TSH binding inhibitory activity was compared with the severity of congenital hypothyroidism to assess the possible etiological relationship. Maternal serum was studied to confirm the presence of Blocking antibodies by both RRA and bioassay. Blood spots obtained from 9 infants contained potent TSH Receptor-Blocking activity. Samples from 2 additional babies, studied because of clinical suspicion of the disease, were also positive. Long term outcome was known in 8 of the 11 babies, and all had transient disease. Neonates with TSH Receptor-Blocking activity greater than 132 U/L had a significantly lower T4 level (P < 0.05) and higher TSH (P < 0.005) than those in whom TSH binding-inhi...
W.m. Fischer - One of the best experts on this subject based on the ideXlab platform.
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Fc Receptor Blocking antibodies after active immunization for the treatment of recurrent spontaneous abortion.
Journal of Reproductive Immunology, 1991Co-Authors: U. Kuhn, R. Blasczyk, B. Hojnacki, U. Vögeler, W. Luboldt, E. Passarge, W.m. Fischer, H. Grosse-wildeAbstract:In a prospective study 140 couples who had at least three spontaneous abortions (RSA) were studied for the presence of Fc Receptor Blocking antibodies detected by the erythrocyte antibody rosette inhibition (EAI) assay, for anti-paternal cytotoxic antibodies (APCA), and for mixed lymphocyte culture inhibiting (MLCI) antibodies before and after active immunization with paternal lymphocytes. The comparative analysis revealed the EAI assay to possess a higher sensitivity than the APCA and/or MLCI tests in monitoring the specific immune response after active immunization. The success of pregnancy in EAI positive post-immunization patients was not influenced by the presence or absence of APCA or MLCI. In the light of a successful pregnancy outcome of 85.7% (n = 37) in this study we conclude that the monitoring of Fc Receptor Blocking antibodies is useful in active immunization protocols for RSA patients.
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Fc Receptor Blocking antibodies after active immunization for the treatment of recurrent spontaneous abortion.
Journal of Reproductive Immunology, 1991Co-Authors: U. Kuhn, R. Blasczyk, B. Hojnacki, U. Vögeler, W. Luboldt, E. Passarge, W.m. Fischer, H. Grosse-wildeAbstract:In a prospective study 140 couples who had at least three spontaneous abortions (RSA) were studied for the presence of Fc Receptor Blocking antibodies detected by the erythrocyte antibody rosette inhibition (EAI) assay, for anti-paternal cytotoxic antibodies (APCA), and for mixed lymphocyte culture inhibiting (MLCI) antibodies before and after active immunization with paternal lymphocytes. The comparative analysis revealed the EAI assay to possess a higher sensitivity than the APCA and/or MLCI tests in monitoring the specific immune response after active immunization. The success of pregnancy in EAI positive post-immunization patients was not influenced by the presence or absence of APCA or MLCI. In the light of a successful pregnancy outcome of 85.7% (n = 37) in this study we conclude that the monitoring of Fc Receptor Blocking antibodies is useful in active immunization protocols for RSA patients.
E. Passarge - One of the best experts on this subject based on the ideXlab platform.
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Fc Receptor Blocking antibodies after active immunization for the treatment of recurrent spontaneous abortion.
Journal of Reproductive Immunology, 1991Co-Authors: U. Kuhn, R. Blasczyk, B. Hojnacki, U. Vögeler, W. Luboldt, E. Passarge, W.m. Fischer, H. Grosse-wildeAbstract:In a prospective study 140 couples who had at least three spontaneous abortions (RSA) were studied for the presence of Fc Receptor Blocking antibodies detected by the erythrocyte antibody rosette inhibition (EAI) assay, for anti-paternal cytotoxic antibodies (APCA), and for mixed lymphocyte culture inhibiting (MLCI) antibodies before and after active immunization with paternal lymphocytes. The comparative analysis revealed the EAI assay to possess a higher sensitivity than the APCA and/or MLCI tests in monitoring the specific immune response after active immunization. The success of pregnancy in EAI positive post-immunization patients was not influenced by the presence or absence of APCA or MLCI. In the light of a successful pregnancy outcome of 85.7% (n = 37) in this study we conclude that the monitoring of Fc Receptor Blocking antibodies is useful in active immunization protocols for RSA patients.
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Fc Receptor Blocking antibodies after active immunization for the treatment of recurrent spontaneous abortion.
Journal of Reproductive Immunology, 1991Co-Authors: U. Kuhn, R. Blasczyk, B. Hojnacki, U. Vögeler, W. Luboldt, E. Passarge, W.m. Fischer, H. Grosse-wildeAbstract:In a prospective study 140 couples who had at least three spontaneous abortions (RSA) were studied for the presence of Fc Receptor Blocking antibodies detected by the erythrocyte antibody rosette inhibition (EAI) assay, for anti-paternal cytotoxic antibodies (APCA), and for mixed lymphocyte culture inhibiting (MLCI) antibodies before and after active immunization with paternal lymphocytes. The comparative analysis revealed the EAI assay to possess a higher sensitivity than the APCA and/or MLCI tests in monitoring the specific immune response after active immunization. The success of pregnancy in EAI positive post-immunization patients was not influenced by the presence or absence of APCA or MLCI. In the light of a successful pregnancy outcome of 85.7% (n = 37) in this study we conclude that the monitoring of Fc Receptor Blocking antibodies is useful in active immunization protocols for RSA patients.
