The Experts below are selected from a list of 273 Experts worldwide ranked by ideXlab platform
Masabumi Shibuya - One of the best experts on this subject based on the ideXlab platform.
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Structure and Function of VEGF/VEGF-Receptor System Involved in Angiogenesis
Cell Structure and Function, 2001Co-Authors: Masabumi ShibuyaAbstract:Angiogenesis is an essential biological process not only in embryogenesis but also in the progression of a variety of major diseases such as cancer, diabetes and inflammation. Vascular endothelial growth factor (VEGF) family and its Receptor System has been shown to be the fundamental regulator in the cell signaling of angiogenesis. Other Systems, Angiopoietin-Tie and EphrinB2-Eph4B etc. are also involved in and cooperate with VEGF System to establish the dynamic blood vessel structures. VEGF Receptor belongs to PDGF Receptor super-gene family, and carries seven Ig-domains in the extracellular region and a tyrosine kinase domain in the intracellular region. Three members of VEGF Receptor family, Flt-1, KDR/Flk-1 and Flt-4, have unique characteristics in terms of the signal transduction, and regulate angiogenesis, lymphangiongenesis and vascular permeability. Further studies on VEGF-VEGF Receptor System may significantly facilitate our understanding on the physiological as well as pathological vascular Systems in the body and the development of new strategies to control and suppress the major diseases in humans.
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structure and function of vegf vegf Receptor System involved in angiogenesis
Cell Structure and Function, 2001Co-Authors: Masabumi ShibuyaAbstract:Angiogenesis is an essential biological process not only in embryogenesis but also in the progression of a variety of major diseases such as cancer, diabetes and inflammation. Vascular endothelial growth factor (VEGF) family and its Receptor System has been shown to be the fundamental regulator in the cell signaling of angiogenesis. Other Systems, Angiopoietin-Tie and EphrinB2-Eph4B etc. are also involved in and cooperate with VEGF System to establish the dynamic blood vessel structures. VEGF Receptor belongs to PDGF Receptor super-gene family, and carries seven Ig-domains in the extracellular region and a tyrosine kinase domain in the intracellular region. Three members of VEGF Receptor family, Flt-1, KDR/Flk-1 and Flt-4, have unique characteristics in terms of the signal transduction, and regulate angiogenesis, lymphangiongenesis and vascular permeability. Further studies on VEGF-VEGF Receptor System may significantly facilitate our understanding on the physiological as well as pathological vascular Systems in the body and the development of new strategies to control and suppress the major diseases in humans.
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role of vegf flt Receptor System in normal and tumor angiogenesis
Advances in Cancer Research, 1995Co-Authors: Masabumi ShibuyaAbstract:Publisher Summary This chapter focuses on the role of the vascular endothelial growth factor (VEGF)-Flt Receptor System in normal and tumor angiogeneses. The vascular network in the body is crucial for the development and maintenance of a variety of normal tissues in higher organisms. Vascular formation is important not only for the establishment of stable circular Systems during embryogenesis in vertebrates but also for the rapid and transient angiogenesis under physiological conditions of the adult, such as the formation of the corpus luteum. Angiogenesis is widely known to be associated with various pathological conditions: inflammatory lesions, wound healing, endocrine diseases, particularly diabetes mellitus, and growing tumors in vivo. To understand the mechanisms underlying angiogenesis during pathological conditions, an extensive analysis of the physiological processes of vasculogenesis and angiogenesis at molecular levels is essential. The VEGF-Flt Receptor family System is utilized under normal angiogenic conditions; it appears to be one of the major signal transduction Systems in reciprocal communication between endothelial cells and the surrounding parenchymal cells and is involved in a wide variety of tumor angiogeneses in vivo. VEGF was originally isolated from ascites-generating tumors. The contribution of VEGF to ascites or pleural effusion is different in every patient with tumor.
Xu Tan - One of the best experts on this subject based on the ideXlab platform.
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a combinatorial tir1 afb aux iaa co Receptor System for differential sensing of auxin
Nature Chemical Biology, 2012Co-Authors: Sarah Lee, César Augusto F. De Oliveira, Anthony Ivetac, Wolfgang Brandt, Lynne Armitage, Laura B. Sheard, Xu Tan, Luz Irina Calderon A VillalobosAbstract:The plant hormone auxin regulates virtually every aspect of plant growth and development. Auxin acts by binding the F-box protein transport inhibitor response 1 (TIR1) and promotes the degradation of the AUXIN/INDOLE-3-ACETIC ACID (Aux/IAA) transcriptional repressors. Here we show that efficient auxin binding requires assembly of an auxin co-Receptor complex consisting of TIR1 and an Aux/IAA protein. Heterologous experiments in yeast and quantitative IAA binding assays using purified proteins showed that different combinations of TIR1 and Aux/IAA proteins form co-Receptor complexes with a wide range of auxin-binding affinities. Auxin affinity seems to be largely determined by the Aux/IAA. As there are 6 TIR1/AUXIN SIGNALING F-BOX proteins (AFBs) and 29 Aux/IAA proteins in Arabidopsis thaliana, combinatorial interactions may result in many co-Receptors with distinct auxin-sensing properties. We also demonstrate that the AFB5–Aux/IAA co-Receptor selectively binds the auxinic herbicide picloram. This co-Receptor System broadens the effective concentration range of the hormone and may contribute to the complexity of auxin response.
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A combinatorial TIR1/AFB–Aux/IAA co-Receptor System for differential sensing of auxin
Nature chemical biology, 2012Co-Authors: Luz Irina A. Calderón Villalobos, Sarah Lee, César Augusto F. De Oliveira, Anthony Ivetac, Wolfgang Brandt, Lynne Armitage, Laura B. Sheard, Xu Tan, Geraint Parry, Haibin MaoAbstract:The plant hormone auxin regulates virtually every aspect of plant growth and development. Auxin acts by binding the F-box protein transport inhibitor response 1 (TIR1) and promotes the degradation of the AUXIN/INDOLE-3-ACETIC ACID (Aux/IAA) transcriptional repressors. Here we show that efficient auxin binding requires assembly of an auxin co-Receptor complex consisting of TIR1 and an Aux/IAA protein. Heterologous experiments in yeast and quantitative IAA binding assays using purified proteins showed that different combinations of TIR1 and Aux/IAA proteins form co-Receptor complexes with a wide range of auxin-binding affinities. Auxin affinity seems to be largely determined by the Aux/IAA. As there are 6 TIR1/AUXIN SIGNALING F-BOX proteins (AFBs) and 29 Aux/IAA proteins in Arabidopsis thaliana, combinatorial interactions may result in many co-Receptors with distinct auxin-sensing properties. We also demonstrate that the AFB5–Aux/IAA co-Receptor selectively binds the auxinic herbicide picloram. This co-Receptor System broadens the effective concentration range of the hormone and may contribute to the complexity of auxin response.
Luz Irina Calderon A Villalobos - One of the best experts on this subject based on the ideXlab platform.
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a combinatorial tir1 afb aux iaa co Receptor System for differential sensing of auxin
Nature Chemical Biology, 2012Co-Authors: Sarah Lee, César Augusto F. De Oliveira, Anthony Ivetac, Wolfgang Brandt, Lynne Armitage, Laura B. Sheard, Xu Tan, Luz Irina Calderon A VillalobosAbstract:The plant hormone auxin regulates virtually every aspect of plant growth and development. Auxin acts by binding the F-box protein transport inhibitor response 1 (TIR1) and promotes the degradation of the AUXIN/INDOLE-3-ACETIC ACID (Aux/IAA) transcriptional repressors. Here we show that efficient auxin binding requires assembly of an auxin co-Receptor complex consisting of TIR1 and an Aux/IAA protein. Heterologous experiments in yeast and quantitative IAA binding assays using purified proteins showed that different combinations of TIR1 and Aux/IAA proteins form co-Receptor complexes with a wide range of auxin-binding affinities. Auxin affinity seems to be largely determined by the Aux/IAA. As there are 6 TIR1/AUXIN SIGNALING F-BOX proteins (AFBs) and 29 Aux/IAA proteins in Arabidopsis thaliana, combinatorial interactions may result in many co-Receptors with distinct auxin-sensing properties. We also demonstrate that the AFB5–Aux/IAA co-Receptor selectively binds the auxinic herbicide picloram. This co-Receptor System broadens the effective concentration range of the hormone and may contribute to the complexity of auxin response.
Georg Breier - One of the best experts on this subject based on the ideXlab platform.
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Functions of the VEGF/VEGF Receptor System in the vascular System.
Seminars in Thrombosis and Hemostasis, 2000Co-Authors: Georg BreierAbstract:The vascular endothelial growth factor (VEGF)/VEGF Receptor System plays a central regulatory role in physiological and pathological angiogenesis. During embryogenesis, the VEGF/VEGF Receptor System is critically involved in the formation of the vascular System by regulating both the growth and the survival of blood vessels. In the vasculature of the adult organism, the high-affinity signaling VEGF Receptor-2 (VEGFR-2) is downregulated but is reinduced during transient phases of physiological angiogenesis. Moreover, a variety of pathological conditions are associated with the upregulation of VEGF and the VEGF Receptors. VEGF stimulates angiogenesis and the survival of endothelial cells in tumors, thereby enabling tumor expansion and metastasis. VEGF is also upregulated in ischemic diseases, such as coronary heart disease or stroke, and is thought to stimulate the--often insufficient--compensatory formation of blood vessels. The implication of VEGF in these pathological processes has opened up promising new therapeutic strategies. In malignancies, attempts are made to inhibit VEGF-mediated signaling and angiogenesis. In ischemic disease, the exogenous application of VEGF may enhance the formation of collaterals. However, considering the complexity of the regulatory pathways involved in the formation of new blood vessels under physiological conditions, a treatment relying on VEGF as the sole angiogenic factor may be insufficient, and the combination with other factors may improve the functionality of newly formed blood vessels and the efficacy of therapeutic angiogenesis.
Haibin Mao - One of the best experts on this subject based on the ideXlab platform.
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A combinatorial TIR1/AFB–Aux/IAA co-Receptor System for differential sensing of auxin
Nature chemical biology, 2012Co-Authors: Luz Irina A. Calderón Villalobos, Sarah Lee, César Augusto F. De Oliveira, Anthony Ivetac, Wolfgang Brandt, Lynne Armitage, Laura B. Sheard, Xu Tan, Geraint Parry, Haibin MaoAbstract:The plant hormone auxin regulates virtually every aspect of plant growth and development. Auxin acts by binding the F-box protein transport inhibitor response 1 (TIR1) and promotes the degradation of the AUXIN/INDOLE-3-ACETIC ACID (Aux/IAA) transcriptional repressors. Here we show that efficient auxin binding requires assembly of an auxin co-Receptor complex consisting of TIR1 and an Aux/IAA protein. Heterologous experiments in yeast and quantitative IAA binding assays using purified proteins showed that different combinations of TIR1 and Aux/IAA proteins form co-Receptor complexes with a wide range of auxin-binding affinities. Auxin affinity seems to be largely determined by the Aux/IAA. As there are 6 TIR1/AUXIN SIGNALING F-BOX proteins (AFBs) and 29 Aux/IAA proteins in Arabidopsis thaliana, combinatorial interactions may result in many co-Receptors with distinct auxin-sensing properties. We also demonstrate that the AFB5–Aux/IAA co-Receptor selectively binds the auxinic herbicide picloram. This co-Receptor System broadens the effective concentration range of the hormone and may contribute to the complexity of auxin response.
