The Experts below are selected from a list of 12318 Experts worldwide ranked by ideXlab platform
Stephen J. Moss - One of the best experts on this subject based on the ideXlab platform.
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gabaa Receptor Trafficking and its role in the dynamic modulation of neuronal inhibition
Nature Reviews Neuroscience, 2008Co-Authors: Tija C Jacob, Stephen J. Moss, Rachel JurdAbstract:γ-Aminobutyric acid type A (GABAA) Receptors mediate the majority of fast synaptic inhibition in the mammalian brain, controlling activity both at the network and cellular level. The diverse functions of GABA in the central nervous system are matched not just by the heterogeneity of GABAA Receptors, but also the complex Trafficking mechanisms and protein-protein interactions that generate and maintain appropriate Receptor cell surface localization. In this review, we discuss recent progress in our understanding of the dynamic regulation of GABAA Receptor composition, Trafficking to and from the neuronal surface, and lateral movement of Receptors between synaptic and extrasynaptic locations. Finally, we highlight a number of neurological disorders, including epilepsy and schizophrenia, in which alterations in GABAA Receptor Trafficking occur.
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modulation of gabaa Receptor activity by phosphorylation and Receptor Trafficking implications for the efficacy of synaptic inhibition
Current Opinion in Neurobiology, 2003Co-Authors: Josef T. Kittler, Stephen J. MossAbstract:Fast synaptic inhibition in the brain is largely mediated by GABAA Receptors. These ligand-gated ion channels are crucial in the control of cell and network activity. Therefore, modulating their function or cell surface stability will have major consequences for neuronal excitation. It has become clear that the stability and activity of GABAA Receptors at synapses can be dynamically modulated by Receptor Trafficking and phosphorylation. Here, we discuss these regulatory mechanisms, and their consequences for the efficacy of GABAA Receptor mediated synaptic inhibition.
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Neurotransmitter Receptor Trafficking and the regulation of synaptic strength.
Traffic, 2001Co-Authors: Josef T. Kittler, Stephen J. MossAbstract:Modulation of the strength of synapses is thought to be one of the mechanisms that underlies learning and memory and is also likely to be important in processes of neuropathology and drug tolerance. This review focuses on the emerging role of postsynaptic neurotransmitter Receptor Trafficking as an essential mechanism underlying the dynamic regulation of synaptic strength.
Alexis Brice - One of the best experts on this subject based on the ideXlab platform.
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a regulated interaction with the uim protein eps15 implicates parkin in egf Receptor Trafficking and pi 3 k akt signalling
Nature Cell Biology, 2006Co-Authors: Lara Fallon, Catherine M L Belanger, Amadou T Corera, Maria Kontogiannea, Elsa Reganklapisz, Jarno Voortman, Michael Haber, Genevieve Rouleau, Thorhildur Thorarinsdottir, Alexis BriceAbstract:A regulated interaction with the UIM protein Eps15 implicates parkin in EGF Receptor Trafficking and PI(3)K–Akt signalling
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A regulated interaction with the UIM protein Eps15 implicates parkin in EGF Receptor Trafficking and PI(3)K–Akt signalling
Nature Cell Biology, 2006Co-Authors: Lara Fallon, Catherine M L Belanger, Amadou T Corera, Maria Kontogiannea, Jarno Voortman, Michael Haber, Genevieve Rouleau, Thorhildur Thorarinsdottir, Elsa Regan-klapisz, Alexis BriceAbstract:A regulated interaction with the UIM protein Eps15 implicates parkin in EGF Receptor Trafficking and PI(3)K–Akt signalling
Robert C Malenka - One of the best experts on this subject based on the ideXlab platform.
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presynaptic neurexin 3 alternative splicing trans synaptically controls postsynaptic ampa Receptor Trafficking
Cell, 2013Co-Authors: Jason Aoto, Robert C Malenka, David C Martinelli, Katsuhiko Tabuchi, Thomas C SudhofAbstract:Summary Neurexins are essential presynaptic cell adhesion molecules that are linked to schizophrenia and autism and are subject to extensive alternative splicing. Here, we used a genetic approach to test the physiological significance of neurexin alternative splicing. We generated knockin mice in which alternatively spliced sequence #4 (SS4) of neuexin-3 is constitutively included but can be selectively excised by cre-recombination. SS4 of neurexin-3 was chosen because it is highly regulated and controls neurexin binding to neuroligins, LRRTMs, and other ligands. Unexpectedly, constitutive inclusion of SS4 in presynaptic neurexin-3 decreased postsynaptic AMPA, but not NMDA Receptor levels, and enhanced postsynaptic AMPA Receptor endocytosis. Moreover, constitutive inclusion of SS4 in presynaptic neurexin-3 abrogated postsynaptic AMPA Receptor recruitment during NMDA Receptor-dependent LTP. These phenotypes were fully rescued by constitutive excision of SS4 in neurexin-3. Thus, alternative splicing of presynaptic neurexin-3 controls postsynaptic AMPA Receptor Trafficking, revealing an unanticipated alternative splicing mechanism for trans -synaptic regulation of synaptic strength and long-term plasticity.
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synaptic plasticity and ampa Receptor Trafficking
Annals of the New York Academy of Sciences, 2003Co-Authors: Robert C MalenkaAbstract:Abstract: Alterations in neuronal activity can elicit long-lasting changes in the strength of synaptic transmission at excitatory synapses and, as a consequence, may underlie many forms of experience-dependent plasticity, including learning and memory. The best-characterized forms of such synaptic plasticity are the long-term depression (LTD) and long-term potentiation (LTP) observed at excitatory synapses in the CA1 region of the hippocampus. It is now well accepted that the Trafficking of AMPA Receptors to and away from the synaptic plasma membrane plays an essential role in both LTP and LTD, respectively. Here we review current models of AMPA Receptor Trafficking and how this Trafficking may be regulated at the molecular level in order to produce the observed changes in synaptic strength. We also review recent work from our lab suggesting that synaptic plasticity in the mesolimbic dopamine system may contribute importantly to the neural adaptations elicited by drugs of abuse.
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ampa Receptor Trafficking and synaptic plasticity
Annual Review of Neuroscience, 2002Co-Authors: Roberto Malinow, Robert C MalenkaAbstract:Activity-dependent changes in synaptic function are believed to underlie the formation of memories. Two prominent examples are long-term potentiation (LTP) and long-term depression (LTD), whose mechanisms have been the subject of considerable scrutiny over the past few decades. Here we review the growing literature that supports a critical role for AMPA Receptor Trafficking in LTP and LTD, focusing on the roles proposed for specific AMPA Receptor subunits and their interacting proteins. While much work remains to understand the molecular basis for synaptic plasticity, recent results on AMPA Receptor Trafficking provide a clear conceptual framework for future studies.
Lara Fallon - One of the best experts on this subject based on the ideXlab platform.
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a regulated interaction with the uim protein eps15 implicates parkin in egf Receptor Trafficking and pi 3 k akt signalling
Nature Cell Biology, 2006Co-Authors: Lara Fallon, Catherine M L Belanger, Amadou T Corera, Maria Kontogiannea, Elsa Reganklapisz, Jarno Voortman, Michael Haber, Genevieve Rouleau, Thorhildur Thorarinsdottir, Alexis BriceAbstract:A regulated interaction with the UIM protein Eps15 implicates parkin in EGF Receptor Trafficking and PI(3)K–Akt signalling
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A regulated interaction with the UIM protein Eps15 implicates parkin in EGF Receptor Trafficking and PI(3)K–Akt signalling
Nature Cell Biology, 2006Co-Authors: Lara Fallon, Catherine M L Belanger, Amadou T Corera, Maria Kontogiannea, Jarno Voortman, Michael Haber, Genevieve Rouleau, Thorhildur Thorarinsdottir, Elsa Regan-klapisz, Alexis BriceAbstract:A regulated interaction with the UIM protein Eps15 implicates parkin in EGF Receptor Trafficking and PI(3)K–Akt signalling
Suzanne R Zukin - One of the best experts on this subject based on the ideXlab platform.
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nmda Receptor Trafficking and targeting implications for synaptic transmission and plasticity
Trends in Neurosciences, 2002Co-Authors: Reed C Carroll, Suzanne R ZukinAbstract:Abstract Dynamic regulation of synaptic efficacy is thought to play a crucial role in formation of neuronal connections and in experience-dependent modification of neural circuitry. The molecular and cellular mechanisms by which synaptic changes are triggered and expressed are the focus of intense interest. This articles reviews recent evidence that NMDA Receptors undergo dynamically regulated targeting and Trafficking, and that the physical transport of NMDA Receptors in and out of the synaptic membrane contributes to several forms of long-lasting synaptic plasticity. The identification of targeting and internalization sequences in NMDA-Receptor subunits has begun the unraveling of some mechanisms that underlie activity-dependent redistribution of NMDA Receptors. Given that NMDA Receptors are widely expressed throughout the CNS, regulation of NMDA-Receptor Trafficking provides a potentially important way to modulate efficacy of synaptic transmission.
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protein kinase c modulates nmda Receptor Trafficking and gating
Nature Neuroscience, 2001Co-Authors: Vytenis Arvydas Skeberdis, Teresa Jover, Sonja Y Grooms, Ricardo C Araneda, Xin Zheng, Michael V L Bennett, Suzanne R ZukinAbstract:Regulation of neuronal N-methyl-D-aspartate Receptors (NMDARs) by protein kinases is critical in synaptic transmission. However, the molecular mechanisms underlying protein kinase C (PKC) potentiation of NMDARs are uncertain. Here we demonstrate that PKC increases NMDA channel opening rate and delivers new NMDA channels to the plasma membrane through regulated exocytosis. PKC induced a rapid delivery of functional NMDARs to the cell surface and increased surface NR1 immunofluorescence in Xenopus oocytes expressing NMDARs. PKC potentiation was inhibited by botulinum neurotoxin A and a dominant negative mutant of soluble NSF-associated protein (SNAP-25), suggesting that Receptor Trafficking occurs via SNARE-dependent exocytosis. In neurons, PKC induced a rapid delivery of functional NMDARs, assessed by electrophysiology, and an increase in NMDAR clusters on the surface of dendrites and dendritic spines, as indicated by immunofluorescence. Thus, PKC regulates NMDAR channel gating and Trafficking in recombinant systems and in neurons, mechanisms that may be relevant to synaptic plasticity.
