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Rainfray Muriel - One of the best experts on this subject based on the ideXlab platform.

  • Drugs Aging
    'Springer Science and Business Media LLC', 2019
    Co-Authors: Guerville F., Roubaud-baudron C., Duc S., Salles N., Rainfray Muriel
    Abstract:

    BACKGROUND: In older patients, the agreement is low between creatinine clearance estimated with the Cockcroft-Gault equation (eCrCl) and glomerular filtration rate estimated with the Chronic Kidney Disease Epidemiology Collaboration equation (eGFRCKD-EPI). The implications of these discrepancies for Drug prescription have so far been assessed only for a few selected molecules. OBJECTIVE: The aim of this study was to investigate the proportion of geriatric patients receiving Drugs with a different Recommended Dose or indication (i.e. an adjustment discrepancy) depending on eCrCl versus eGFRCKD-EPI estimates of kidney function. METHODS: Patients admitted to acute geriatric care units in our university hospital were eligible for inclusion. All Drug classes were studied. We retrospectively determined Recommended prescriptions according to eCrCl and eGFRCKD-EPI. RESULTS: Sixty percent of patients received at least one Drug requiring Dose adjustment and/or received a Drug with a relative contraindication based on their estimated kidney function. Thirty-one percent of patients received at least one Drug with an adjustment discrepancy: 20% received at least one Drug for which the Recommended Dose differed depending on eCrCl versus eGFRCKD-EPI estimates of kidney function, 4% received a Drug with a relative contraindication according to eCrCl but not eGFRCKD-EPI, and 7% received both. Factors independently associated with an adjustment discrepancy were older age and lower weight. Main Drug classes involved were benzodiazepines, anticoagulants, and anti-microbial Drugs. CONCLUSION: In acute geriatric care units, Recommended Drug Dose adjustments are frequently discordant according to the equations used to estimate kidney function, notably for benzodiazepines, anticoagulants, and anti-microbial Drugs. The consequences for treatment efficacy and safety should be investigated

Guerville F. - One of the best experts on this subject based on the ideXlab platform.

  • Drugs Aging
    'Springer Science and Business Media LLC', 2019
    Co-Authors: Guerville F., Roubaud-baudron C., Duc S., Salles N., Rainfray Muriel
    Abstract:

    BACKGROUND: In older patients, the agreement is low between creatinine clearance estimated with the Cockcroft-Gault equation (eCrCl) and glomerular filtration rate estimated with the Chronic Kidney Disease Epidemiology Collaboration equation (eGFRCKD-EPI). The implications of these discrepancies for Drug prescription have so far been assessed only for a few selected molecules. OBJECTIVE: The aim of this study was to investigate the proportion of geriatric patients receiving Drugs with a different Recommended Dose or indication (i.e. an adjustment discrepancy) depending on eCrCl versus eGFRCKD-EPI estimates of kidney function. METHODS: Patients admitted to acute geriatric care units in our university hospital were eligible for inclusion. All Drug classes were studied. We retrospectively determined Recommended prescriptions according to eCrCl and eGFRCKD-EPI. RESULTS: Sixty percent of patients received at least one Drug requiring Dose adjustment and/or received a Drug with a relative contraindication based on their estimated kidney function. Thirty-one percent of patients received at least one Drug with an adjustment discrepancy: 20% received at least one Drug for which the Recommended Dose differed depending on eCrCl versus eGFRCKD-EPI estimates of kidney function, 4% received a Drug with a relative contraindication according to eCrCl but not eGFRCKD-EPI, and 7% received both. Factors independently associated with an adjustment discrepancy were older age and lower weight. Main Drug classes involved were benzodiazepines, anticoagulants, and anti-microbial Drugs. CONCLUSION: In acute geriatric care units, Recommended Drug Dose adjustments are frequently discordant according to the equations used to estimate kidney function, notably for benzodiazepines, anticoagulants, and anti-microbial Drugs. The consequences for treatment efficacy and safety should be investigated

Roubaud-baudron C. - One of the best experts on this subject based on the ideXlab platform.

  • Drugs Aging
    'Springer Science and Business Media LLC', 2019
    Co-Authors: Guerville F., Roubaud-baudron C., Duc S., Salles N., Rainfray Muriel
    Abstract:

    BACKGROUND: In older patients, the agreement is low between creatinine clearance estimated with the Cockcroft-Gault equation (eCrCl) and glomerular filtration rate estimated with the Chronic Kidney Disease Epidemiology Collaboration equation (eGFRCKD-EPI). The implications of these discrepancies for Drug prescription have so far been assessed only for a few selected molecules. OBJECTIVE: The aim of this study was to investigate the proportion of geriatric patients receiving Drugs with a different Recommended Dose or indication (i.e. an adjustment discrepancy) depending on eCrCl versus eGFRCKD-EPI estimates of kidney function. METHODS: Patients admitted to acute geriatric care units in our university hospital were eligible for inclusion. All Drug classes were studied. We retrospectively determined Recommended prescriptions according to eCrCl and eGFRCKD-EPI. RESULTS: Sixty percent of patients received at least one Drug requiring Dose adjustment and/or received a Drug with a relative contraindication based on their estimated kidney function. Thirty-one percent of patients received at least one Drug with an adjustment discrepancy: 20% received at least one Drug for which the Recommended Dose differed depending on eCrCl versus eGFRCKD-EPI estimates of kidney function, 4% received a Drug with a relative contraindication according to eCrCl but not eGFRCKD-EPI, and 7% received both. Factors independently associated with an adjustment discrepancy were older age and lower weight. Main Drug classes involved were benzodiazepines, anticoagulants, and anti-microbial Drugs. CONCLUSION: In acute geriatric care units, Recommended Drug Dose adjustments are frequently discordant according to the equations used to estimate kidney function, notably for benzodiazepines, anticoagulants, and anti-microbial Drugs. The consequences for treatment efficacy and safety should be investigated

Duc S. - One of the best experts on this subject based on the ideXlab platform.

  • Drugs Aging
    'Springer Science and Business Media LLC', 2019
    Co-Authors: Guerville F., Roubaud-baudron C., Duc S., Salles N., Rainfray Muriel
    Abstract:

    BACKGROUND: In older patients, the agreement is low between creatinine clearance estimated with the Cockcroft-Gault equation (eCrCl) and glomerular filtration rate estimated with the Chronic Kidney Disease Epidemiology Collaboration equation (eGFRCKD-EPI). The implications of these discrepancies for Drug prescription have so far been assessed only for a few selected molecules. OBJECTIVE: The aim of this study was to investigate the proportion of geriatric patients receiving Drugs with a different Recommended Dose or indication (i.e. an adjustment discrepancy) depending on eCrCl versus eGFRCKD-EPI estimates of kidney function. METHODS: Patients admitted to acute geriatric care units in our university hospital were eligible for inclusion. All Drug classes were studied. We retrospectively determined Recommended prescriptions according to eCrCl and eGFRCKD-EPI. RESULTS: Sixty percent of patients received at least one Drug requiring Dose adjustment and/or received a Drug with a relative contraindication based on their estimated kidney function. Thirty-one percent of patients received at least one Drug with an adjustment discrepancy: 20% received at least one Drug for which the Recommended Dose differed depending on eCrCl versus eGFRCKD-EPI estimates of kidney function, 4% received a Drug with a relative contraindication according to eCrCl but not eGFRCKD-EPI, and 7% received both. Factors independently associated with an adjustment discrepancy were older age and lower weight. Main Drug classes involved were benzodiazepines, anticoagulants, and anti-microbial Drugs. CONCLUSION: In acute geriatric care units, Recommended Drug Dose adjustments are frequently discordant according to the equations used to estimate kidney function, notably for benzodiazepines, anticoagulants, and anti-microbial Drugs. The consequences for treatment efficacy and safety should be investigated

Salles N. - One of the best experts on this subject based on the ideXlab platform.

  • Drugs Aging
    'Springer Science and Business Media LLC', 2019
    Co-Authors: Guerville F., Roubaud-baudron C., Duc S., Salles N., Rainfray Muriel
    Abstract:

    BACKGROUND: In older patients, the agreement is low between creatinine clearance estimated with the Cockcroft-Gault equation (eCrCl) and glomerular filtration rate estimated with the Chronic Kidney Disease Epidemiology Collaboration equation (eGFRCKD-EPI). The implications of these discrepancies for Drug prescription have so far been assessed only for a few selected molecules. OBJECTIVE: The aim of this study was to investigate the proportion of geriatric patients receiving Drugs with a different Recommended Dose or indication (i.e. an adjustment discrepancy) depending on eCrCl versus eGFRCKD-EPI estimates of kidney function. METHODS: Patients admitted to acute geriatric care units in our university hospital were eligible for inclusion. All Drug classes were studied. We retrospectively determined Recommended prescriptions according to eCrCl and eGFRCKD-EPI. RESULTS: Sixty percent of patients received at least one Drug requiring Dose adjustment and/or received a Drug with a relative contraindication based on their estimated kidney function. Thirty-one percent of patients received at least one Drug with an adjustment discrepancy: 20% received at least one Drug for which the Recommended Dose differed depending on eCrCl versus eGFRCKD-EPI estimates of kidney function, 4% received a Drug with a relative contraindication according to eCrCl but not eGFRCKD-EPI, and 7% received both. Factors independently associated with an adjustment discrepancy were older age and lower weight. Main Drug classes involved were benzodiazepines, anticoagulants, and anti-microbial Drugs. CONCLUSION: In acute geriatric care units, Recommended Drug Dose adjustments are frequently discordant according to the equations used to estimate kidney function, notably for benzodiazepines, anticoagulants, and anti-microbial Drugs. The consequences for treatment efficacy and safety should be investigated