The Experts below are selected from a list of 360 Experts worldwide ranked by ideXlab platform
Alexander M Seifalian - One of the best experts on this subject based on the ideXlab platform.
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the regenerative role of adipose derived stem cells adsc in plastic and Reconstructive Surgery
International Wound Journal, 2017Co-Authors: Naghmeh Naderi, Emman J Combellack, Michelle Griffin, Tina Sedaghati, Muhammad Javed, Michael Findlay, Christopher Glenn Wallace, Afshin Mosahebi, Peter Em Butler, Alexander M SeifalianAbstract:The potential use of stem cell-based therapies for the repair and regeneration of various tissues and organs offers a paradigm shift in plastic and Reconstructive Surgery. The use of either embryonic stem cells (ESC) or induced pluripotent stem cells (iPSC) in clinical situations is limited because of regulations and ethical considerations even though these cells are theoretically highly beneficial. Adult mesenchymal stem cells appear to be an ideal stem cell population for practical regenerative medicine. Among these cells, adipose-derived stem cells (ADSC) have the potential to differentiate the mesenchymal, ectodermal and endodermal lineages and are easy to harvest. Additionally, adipose tissue yields a high number of ADSC per volume of tissue. Based on this background knowledge, the purpose of this review is to summarise and describe the proliferation and differentiation capacities of ADSC together with current preclinical data regarding the use of ADSC as regenerative tools in plastic and Reconstructive Surgery.
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advancing nasal Reconstructive Surgery the application of tissue engineering technology
Journal of Tissue Engineering and Regenerative Medicine, 2012Co-Authors: Adelola O Oseni, Peter Em Butler, Claire Crowley, Mark W Lowdell, Martin A Birchall, Alexander M SeifalianAbstract:Cartilage tissue engineering is a rapidly progressing area of regenerative medicine with advances in cell biology and scaffold engineering constantly being investigated. Many groups are now capable of making neocartilage constructs with some level of morphological, biochemical, and histological likeness to native human cartilage tissues. The application of this useful technology in articular cartilage repair is well described in the literature; however, few studies have evaluated its application in head and neck reconstruction. Although there are many studies on auricular cartilage tissue engineering, there are few studies regarding cartilage tissue engineering for complex nasal reconstruction. This study therefore highlighted the challenges involved with nasal reconstruction, with special focus on nasal cartilage tissue, and examined how advancements made in cartilage tissue engineering research could be applied to improve the clinical outcomes of total nasal Reconstructive Surgery. © 2011 John Wiley & Sons, Ltd.
Christopher P Cannon - One of the best experts on this subject based on the ideXlab platform.
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the effect of preoperative radiotherapy and Reconstructive Surgery on wound complications after resection of extremity soft tissue sarcomas
Annals of Surgical Oncology, 2006Co-Authors: Jennifer F Tseng, Matthew T Ballo, Howard N Langstein, Jeffrey D Wayne, Janice N Cormier, Kelly K Hunt, Barry W Feig, Alan W Yasko, Valerae O Lewis, Christopher P CannonAbstract:Major wound complications (MWCs) are frequent after preoperative radiotherapy (RT) for extremity soft-tissue sarcoma (STS). We examined the rate of MWCs at a single institution with readily available Reconstructive Surgery. The medical records of consecutively treated extremity STS patients treated with preoperative external-beam RT and surgical resection from June 1996 through February 2003 were reviewed. Patients underwent RT (median 50 Gy), followed by resection 4–8 weeks later. Patients believed to be at higher risk for MWC underwent wound closure by the Reconstructive Surgery service (RSS). MWCs included secondary operation, invasive procedure, hospital readmission, or persistent deep packing or dressing changes. A total of 173 patients underwent preoperative RT. Median age was 54 years; 51% were female; 80% had lower extremity STS. Wound closure was performed by the primary surgeon in 91 cases (53%). The RSS performed wound closure in the remaining 82 patients (47%). One or more MWCs occurred in 55 patients (32%). Wound complications were more likely in patients with lower extremity (49/138, 36%) than upper extremity (6/35, 17%) STS (P = 0.03). Among patients with lower-risk wounds closed by the primary surgical team, 29 (32%) experienced MWC, whereas in the higher-risk patients closed by the RSS, MWC occurred in 26 (32%). MWCs are frequent after preoperative RT and occur more commonly in patients with lower extremity tumors. The MWC rate observed in a single-institution setting was comparable to that observed in the preoperative therapy arm of a multicenter Canadian trial. Patients believed to be at higher risk for MWCs undergoing RSS closure have MWC rates comparable to those with lower-risk wounds closed by the primary team.
Peter Albers - One of the best experts on this subject based on the ideXlab platform.
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tissue engineering and Reconstructive Surgery in urology
European Urology, 2007Co-Authors: Peter AlbersAbstract:This review tries to cover not only all fields of tissue engineering (TE) and grafting in urology but also the ethical and legal aspects of the approaches [1]. Each of the topics deserves a review on its own merits. The legal aspects are increasingly important but there is a profound overlap to the political discussion. The clinicians who read European Urology and who are usually not involved in the development of TE approaches are more interested in the outcomes of TE and Reconstructive Surgery using grafts. Moreover, the judgement of the reviewer remains important to get focussed on the overwhelming literature. Unfortunately, the word count restrictions compromise the value of the review in the specific fields (eg, small intestine submucosa [SIS] grafting). In urethral reconstruction, for example, SIS was introduced for bladder and urethral reconstruction >12 yr ago from preclinical studies, but long-term data on follow-up have not been sufficiently reported [2]. From more classical approaches such as endoscopic urethrotomies and buccal mucosa grafting we know that the final judgement of the technique needs a follow-up of >3 yr [3–5]. Therefore, single case reports of an inferior outcome of SIS urethral grafting should not influence the view on this technique in 2007 [6]. Moreover, SIS grafting in children (mostly hypospadias repair) needs to be reviewed differently from the use of SIS in the reconstruction of recurrent strictures due to infection, Surgery, or trauma in mostly elderly patients. In the same context, a review on the stem cell approaches in the treatment of stress urinary incontinence deserves a more detailed judgement
Marie G Gantz - One of the best experts on this subject based on the ideXlab platform.
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pain and activity after vaginal Reconstructive Surgery for pelvic organ prolapse and stress urinary incontinence
American Journal of Obstetrics and Gynecology, 2019Co-Authors: Matthew D Barber, Linda Brubaker, Ingrid Nygaard, Keisha Y Dyer, David R Ellington, Amaanti Sridhar, Marie G GantzAbstract:Background Little is known about short- and long-term pain and functional activity after Surgery for pelvic organ prolapse. Objective The objectives of the study were to describe postoperative pain and functional activity after transvaginal native tissue Reconstructive Surgery with apical suspension and retropubic synthetic midurethral sling and to compare these outcomes between patients receiving 2 common transvaginal prolapse repairs, uterosacral ligament, and sacrospinous ligament vaginal vault suspension. Study Design This planned secondary analysis of a 2 × 2 factorial randomized trial included 374 women randomized to receive uterosacral (n = 188) or sacrospinous (n = 186) vaginal vault suspension to treat both stages 2–4 apical vaginal prolapse and stress urinary incontinence between 2008 and 2013 at 9 medical centers. Participants were also randomized to receive perioperative pelvic muscle therapy or usual care. All patients received transvaginal native tissue repairs and a midurethral sling. Participants completed the Surgical Pain Scales (0–10 numeric rating scales; higher scores = greater pain) and Activity Assessment Scale (0–100; higher score = higher activity) prior to Surgery and at 2 weeks, 4–6 weeks, and 3 months postoperatively. The MOS 36-item Short-Form Health Survey was completed at baseline and 6, 12, and 24 months after Surgery; the bodily pain, physical functioning, and role–physical subscales were used for this analysis (higher scores = less disability). Self-reported pain medication use was also collected. RESULTS Before Surgery, average pain at rest and during normal activity were (adjusted mean ± SE) 2.24 ± 0.23 and 2.76 ± 0.25; both increased slightly from baseline at 2 weeks (+0.65, P = .004, and +0.74, P = .007, respectively) and then decreased below baseline at 3 months (–0.87 and –1.14, respectively, P Conclusion Pain and functional activity improve for up to 2 years after native tissue Reconstructive Surgery with uterosacral or sacrospinous vaginal vault suspension and midurethral sling for stages 2–4 pelvic organ prolapse. On average, immediate postoperative pain is low and improves to below baseline levels by 4–6 weeks.
Jennifer F Tseng - One of the best experts on this subject based on the ideXlab platform.
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the effect of preoperative radiotherapy and Reconstructive Surgery on wound complications after resection of extremity soft tissue sarcomas
Annals of Surgical Oncology, 2006Co-Authors: Jennifer F Tseng, Matthew T Ballo, Howard N Langstein, Jeffrey D Wayne, Janice N Cormier, Kelly K Hunt, Barry W Feig, Alan W Yasko, Valerae O Lewis, Christopher P CannonAbstract:Major wound complications (MWCs) are frequent after preoperative radiotherapy (RT) for extremity soft-tissue sarcoma (STS). We examined the rate of MWCs at a single institution with readily available Reconstructive Surgery. The medical records of consecutively treated extremity STS patients treated with preoperative external-beam RT and surgical resection from June 1996 through February 2003 were reviewed. Patients underwent RT (median 50 Gy), followed by resection 4–8 weeks later. Patients believed to be at higher risk for MWC underwent wound closure by the Reconstructive Surgery service (RSS). MWCs included secondary operation, invasive procedure, hospital readmission, or persistent deep packing or dressing changes. A total of 173 patients underwent preoperative RT. Median age was 54 years; 51% were female; 80% had lower extremity STS. Wound closure was performed by the primary surgeon in 91 cases (53%). The RSS performed wound closure in the remaining 82 patients (47%). One or more MWCs occurred in 55 patients (32%). Wound complications were more likely in patients with lower extremity (49/138, 36%) than upper extremity (6/35, 17%) STS (P = 0.03). Among patients with lower-risk wounds closed by the primary surgical team, 29 (32%) experienced MWC, whereas in the higher-risk patients closed by the RSS, MWC occurred in 26 (32%). MWCs are frequent after preoperative RT and occur more commonly in patients with lower extremity tumors. The MWC rate observed in a single-institution setting was comparable to that observed in the preoperative therapy arm of a multicenter Canadian trial. Patients believed to be at higher risk for MWCs undergoing RSS closure have MWC rates comparable to those with lower-risk wounds closed by the primary team.
