The Experts below are selected from a list of 83544 Experts worldwide ranked by ideXlab platform
Ben Zhong Tang - One of the best experts on this subject based on the ideXlab platform.
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aggregation induced Emission luminogen with deep Red Emission for through skull three photon fluorescence imaging of mouse
ACS Nano, 2017Co-Authors: Yalun Wang, Wei Qin, Anjun Qin, Ben Zhong Tang, Ming Chen, Nuernisha Alifu, Jun QianAbstract:Imaging the brain with high integrity is of great importance to neuroscience and related applications. X-ray computed tomography (CT) and magnetic resonance imaging (MRI) are two clinically used modalities for deep-penetration brain imaging. However, their spatial resolution is quite limited. Two-photon fluorescence microscopic (2PFM) imaging with its femtosecond (fs) excitation wavelength in the traditional near-infraRed (NIR) region (700–1000 nm) is able to realize deep-tissue and high-resolution brain imaging. However, it requires craniotomy and cranial window or skull-thinning techniques due to photon scattering of the excitation light. Herein, based on a type of aggregation-induced Emission luminogen (AIEgen) DCDPP-2TPA with a large three-photon absorption (3PA) cross section at 1550 nm and deep-Red Emission, we realized through-skull three-photon fluorescence microscopic (3PFM) imaging of mouse cerebral vasculature without craniotomy and skull-thinning. Reduced photon scattering of a 1550 nm fs exci...
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functionalized aie nanoparticles with efficient deep Red Emission mitochondrial specificity cancer cell selectivity and multiphoton susceptibility
Chemical Science, 2017Co-Authors: Alexander Nicol, Jun Qian, Wei Qin, Ryan T K Kwok, Jeffrey Mark Burkhartsmeyer, Zhenfeng Zhu, Wenwen Luo, Jacky Wing Yip Lam, Kam Sing Wong, Ben Zhong TangAbstract:Multiphoton microscopy is an exciting tool for biomedical research because it can be used to image single cells in vivo due to its greater penetration depth, lower phototoxicity and higher resolution when compaRed to confocal laser scanning microscopy. This helps researchers understand how certain cells change over time and evaluate the efficacy of different therapies. Herein, we report a new AIE luminogen (AIEgen), abbreviated as TPE-TETRAD, with a favorable absorption and efficient deep-Red Emission in the solid state. TPE-TETRAD possesses a high two-photon absorption cross-section (313 MG at 830 nm) and a rich array of non-linear optical properties including aggregation-induced three-photon luminescence. Biotinylated TPE-TETRAD nanoparticles are also fabricated and applied to stain mitochondria in live cancer cells with high specificity. The purpose of this study is to characterize a novel deep-Red AIEgen and fabricate biotinylated nanoparticles for applications as (1) biocompatible and photostable AIE probes for specific mitochondria imaging and (2) multiphoton imaging probes suitable for two/three-photon fluorescence microscopy.
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a Red emitting mitochondria targeted aie probe as an indicator for membrane potential and mouse sperm activity
Chemical Communications, 2015Co-Authors: Ben Zhong Tang, Na Zhao, Sijie Chen, Yuning HongAbstract:In this work, a Red Emission AIE active mitochondrial probe is developed. It is the first non-self-quenching mitochondria specific probe with membrane potential sensitivity. Its application in sensing the membrane potential differences in mouse sperm cells is demonstrated.
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biocompatible and photostable aie dots with Red Emission for in vivo two photon bioimaging
Scientific Reports, 2015Co-Authors: Dan Wang, Jun Qian, Wei Qin, Anjun Qin, Ben Zhong TangAbstract:Biocompatible and Photostable AIE Dots with Red Emission for In Vivo Two-Photon Bioimaging
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biocompatible and photostable aie dots with Red Emission for in vivo two photon bioimaging
Scientific Reports, 2015Co-Authors: Dan Wang, Jun Qian, Wei Qin, Anjun Qin, Ben Zhong TangAbstract:Bioimaging systems with cytocompatibility, photostability, Red fluorescence, and optical nonlinearity are in great demand. Herein we report such a bioimaging system. Integration of tetraphenylethene (T), triphenylamine (T), and fumaronitrile (F) units yielded adduct TTF with aggregation-induced Emission (AIE). Nanodots of the AIE fluorogen with efficient Red Emission were fabricated by encapsulating TTF with phospholipid. The AIE dots enabled three-dimensional dynamic imaging with high resolution in blood vessels of mouse brain under two-photon excitation.
M G Brik - One of the best experts on this subject based on the ideXlab platform.
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narrow Red Emission band fluoride phosphor knasif6 mn4 for warm white light emitting diodes
ACS Applied Materials & Interfaces, 2016Co-Authors: Ye Jin, Mu-huai Fang, M Grinberg, Sebastian Mahlik, Tadeusz Lesniewski, M G Brik, Guanyu Luo, J G LinAbstract:Red phosphors AMF6:Mn4+ (A = Na, K, Cs, Ba, Rb; M = Si, Ti, Ge) have been widely studied due to the narrow Red Emission bands around 630 nm. The different Emission of the zero-phonon line (ZPL) may affect the color rendering index of white light-emitting diodes (WLED). The primary reason behind the emergence and intensity of ZPL, taking KNaSiF6:Mn4+ as an example, was investigated here. The effects of pressure on crystal structure and luminescence were determined experimentally and theoretically. The increase of band gap, Red shift of Emission spectrum and blue shift of excitation spectrum were observed with higher applied pressure. The angles of ∠FMnF and ∠FMF(M = Si, Ti, Ge) were found clearly distorted from 180° in MF62– octahedron with strong ZPL intensity. The larger distorted SiF62– octahedron, the stronger ZPL intensity. This research provides a new perspective to address the ZPL intensity problem of the hexafluorosilicate phosphors caused by crystal distortion and pressure-dependence of the lumine...
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narrow Red Emission band fluoride phosphor knasif6 mn4 for warm white light emitting diodes
ACS Applied Materials & Interfaces, 2016Co-Authors: Mu-huai Fang, M Grinberg, Sebastian Mahlik, Tadeusz Lesniewski, M G BrikAbstract:Red phosphors AMF6:Mn4+ (A = Na, K, Cs, Ba, Rb; M = Si, Ti, Ge) have been widely studied due to the narrow Red Emission bands around 630 nm. The different Emission of the zero-phonon line (ZPL) may affect the color rendering index of white light-emitting diodes (WLED). The primary reason behind the emergence and intensity of ZPL, taking KNaSiF6:Mn4+ as an example, was investigated here. The effects of pressure on crystal structure and luminescence were determined experimentally and theoretically. The increase of band gap, Red shift of Emission spectrum and blue shift of excitation spectrum were observed with higher applied pressure. The angles of ∠FMnF and ∠FMF(M = Si, Ti, Ge) were found clearly distorted from 180° in MF62– octahedron with strong ZPL intensity. The larger distorted SiF62– octahedron, the stronger ZPL intensity. This research provides a new perspective to address the ZPL intensity problem of the hexafluorosilicate phosphors caused by crystal distortion and pressure-dependence of the lumine...
Mu-huai Fang - One of the best experts on this subject based on the ideXlab platform.
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narrow Red Emission band fluoride phosphor knasif6 mn4 for warm white light emitting diodes
ACS Applied Materials & Interfaces, 2016Co-Authors: Mu-huai Fang, M Grinberg, Sebastian Mahlik, Tadeusz Lesniewski, M G BrikAbstract:Red phosphors AMF6:Mn4+ (A = Na, K, Cs, Ba, Rb; M = Si, Ti, Ge) have been widely studied due to the narrow Red Emission bands around 630 nm. The different Emission of the zero-phonon line (ZPL) may affect the color rendering index of white light-emitting diodes (WLED). The primary reason behind the emergence and intensity of ZPL, taking KNaSiF6:Mn4+ as an example, was investigated here. The effects of pressure on crystal structure and luminescence were determined experimentally and theoretically. The increase of band gap, Red shift of Emission spectrum and blue shift of excitation spectrum were observed with higher applied pressure. The angles of ∠FMnF and ∠FMF(M = Si, Ti, Ge) were found clearly distorted from 180° in MF62– octahedron with strong ZPL intensity. The larger distorted SiF62– octahedron, the stronger ZPL intensity. This research provides a new perspective to address the ZPL intensity problem of the hexafluorosilicate phosphors caused by crystal distortion and pressure-dependence of the lumine...
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narrow Red Emission band fluoride phosphor knasif6 mn4 for warm white light emitting diodes
ACS Applied Materials & Interfaces, 2016Co-Authors: Ye Jin, Mu-huai Fang, M Grinberg, Sebastian Mahlik, Tadeusz Lesniewski, M G Brik, Guanyu Luo, J G LinAbstract:Red phosphors AMF6:Mn4+ (A = Na, K, Cs, Ba, Rb; M = Si, Ti, Ge) have been widely studied due to the narrow Red Emission bands around 630 nm. The different Emission of the zero-phonon line (ZPL) may affect the color rendering index of white light-emitting diodes (WLED). The primary reason behind the emergence and intensity of ZPL, taking KNaSiF6:Mn4+ as an example, was investigated here. The effects of pressure on crystal structure and luminescence were determined experimentally and theoretically. The increase of band gap, Red shift of Emission spectrum and blue shift of excitation spectrum were observed with higher applied pressure. The angles of ∠FMnF and ∠FMF(M = Si, Ti, Ge) were found clearly distorted from 180° in MF62– octahedron with strong ZPL intensity. The larger distorted SiF62– octahedron, the stronger ZPL intensity. This research provides a new perspective to address the ZPL intensity problem of the hexafluorosilicate phosphors caused by crystal distortion and pressure-dependence of the lumine...
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Photoluminescent Evolution Induced by Structural Transformation Through Thermal Treating in the Red Narrow-Band Phosphor K2GeF6:Mn4+
ACS applied materials & interfaces, 2015Co-Authors: Ling Ling Wei, Chun Che Lin, Yi Ying Wang, Mu-huai Fang, Huan Jiao, Ru-shi LiuAbstract:This study exploRed optimal preparation conditions for K2GeF6:Mn4+ Red phosphors by using chemical coprecipitation method. The prepaRed hexagonal P3m1 K2GeF6:Mn4+ exhibited efficient Red Emission, high color purity, good Mn4+ concentration stability, and low thermal quenching. Structural evolution from hexagonal P3m1 to P63mc and then P63mc to cubic Fm3m occurRed after thermal treatment at approximately 400 and 500 °C, respectively. Hexagonal P63mc phase showed an obvious zero phonon line peak at 621 nm, whereas cubic Fm3m phase showed no Red Emission. Yellowish K2GeF6:Mn4+ with both hexagonal P3m1 and P63mc symmetries are promising commercial Red phosphors for white light-emitting diodes.
Jun Qian - One of the best experts on this subject based on the ideXlab platform.
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aggregation induced Emission luminogen with deep Red Emission for through skull three photon fluorescence imaging of mouse
ACS Nano, 2017Co-Authors: Yalun Wang, Wei Qin, Anjun Qin, Ben Zhong Tang, Ming Chen, Nuernisha Alifu, Jun QianAbstract:Imaging the brain with high integrity is of great importance to neuroscience and related applications. X-ray computed tomography (CT) and magnetic resonance imaging (MRI) are two clinically used modalities for deep-penetration brain imaging. However, their spatial resolution is quite limited. Two-photon fluorescence microscopic (2PFM) imaging with its femtosecond (fs) excitation wavelength in the traditional near-infraRed (NIR) region (700–1000 nm) is able to realize deep-tissue and high-resolution brain imaging. However, it requires craniotomy and cranial window or skull-thinning techniques due to photon scattering of the excitation light. Herein, based on a type of aggregation-induced Emission luminogen (AIEgen) DCDPP-2TPA with a large three-photon absorption (3PA) cross section at 1550 nm and deep-Red Emission, we realized through-skull three-photon fluorescence microscopic (3PFM) imaging of mouse cerebral vasculature without craniotomy and skull-thinning. Reduced photon scattering of a 1550 nm fs exci...
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functionalized aie nanoparticles with efficient deep Red Emission mitochondrial specificity cancer cell selectivity and multiphoton susceptibility
Chemical Science, 2017Co-Authors: Alexander Nicol, Jun Qian, Wei Qin, Ryan T K Kwok, Jeffrey Mark Burkhartsmeyer, Zhenfeng Zhu, Wenwen Luo, Jacky Wing Yip Lam, Kam Sing Wong, Ben Zhong TangAbstract:Multiphoton microscopy is an exciting tool for biomedical research because it can be used to image single cells in vivo due to its greater penetration depth, lower phototoxicity and higher resolution when compaRed to confocal laser scanning microscopy. This helps researchers understand how certain cells change over time and evaluate the efficacy of different therapies. Herein, we report a new AIE luminogen (AIEgen), abbreviated as TPE-TETRAD, with a favorable absorption and efficient deep-Red Emission in the solid state. TPE-TETRAD possesses a high two-photon absorption cross-section (313 MG at 830 nm) and a rich array of non-linear optical properties including aggregation-induced three-photon luminescence. Biotinylated TPE-TETRAD nanoparticles are also fabricated and applied to stain mitochondria in live cancer cells with high specificity. The purpose of this study is to characterize a novel deep-Red AIEgen and fabricate biotinylated nanoparticles for applications as (1) biocompatible and photostable AIE probes for specific mitochondria imaging and (2) multiphoton imaging probes suitable for two/three-photon fluorescence microscopy.
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biocompatible and photostable aie dots with Red Emission for in vivo two photon bioimaging
Scientific Reports, 2015Co-Authors: Dan Wang, Jun Qian, Wei Qin, Anjun Qin, Ben Zhong TangAbstract:Biocompatible and Photostable AIE Dots with Red Emission for In Vivo Two-Photon Bioimaging
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biocompatible and photostable aie dots with Red Emission for in vivo two photon bioimaging
Scientific Reports, 2015Co-Authors: Dan Wang, Jun Qian, Wei Qin, Anjun Qin, Ben Zhong TangAbstract:Bioimaging systems with cytocompatibility, photostability, Red fluorescence, and optical nonlinearity are in great demand. Herein we report such a bioimaging system. Integration of tetraphenylethene (T), triphenylamine (T), and fumaronitrile (F) units yielded adduct TTF with aggregation-induced Emission (AIE). Nanodots of the AIE fluorogen with efficient Red Emission were fabricated by encapsulating TTF with phospholipid. The AIE dots enabled three-dimensional dynamic imaging with high resolution in blood vessels of mouse brain under two-photon excitation.
Wei Qin - One of the best experts on this subject based on the ideXlab platform.
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aggregation induced Emission luminogen with deep Red Emission for through skull three photon fluorescence imaging of mouse
ACS Nano, 2017Co-Authors: Yalun Wang, Wei Qin, Anjun Qin, Ben Zhong Tang, Ming Chen, Nuernisha Alifu, Jun QianAbstract:Imaging the brain with high integrity is of great importance to neuroscience and related applications. X-ray computed tomography (CT) and magnetic resonance imaging (MRI) are two clinically used modalities for deep-penetration brain imaging. However, their spatial resolution is quite limited. Two-photon fluorescence microscopic (2PFM) imaging with its femtosecond (fs) excitation wavelength in the traditional near-infraRed (NIR) region (700–1000 nm) is able to realize deep-tissue and high-resolution brain imaging. However, it requires craniotomy and cranial window or skull-thinning techniques due to photon scattering of the excitation light. Herein, based on a type of aggregation-induced Emission luminogen (AIEgen) DCDPP-2TPA with a large three-photon absorption (3PA) cross section at 1550 nm and deep-Red Emission, we realized through-skull three-photon fluorescence microscopic (3PFM) imaging of mouse cerebral vasculature without craniotomy and skull-thinning. Reduced photon scattering of a 1550 nm fs exci...
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functionalized aie nanoparticles with efficient deep Red Emission mitochondrial specificity cancer cell selectivity and multiphoton susceptibility
Chemical Science, 2017Co-Authors: Alexander Nicol, Jun Qian, Wei Qin, Ryan T K Kwok, Jeffrey Mark Burkhartsmeyer, Zhenfeng Zhu, Wenwen Luo, Jacky Wing Yip Lam, Kam Sing Wong, Ben Zhong TangAbstract:Multiphoton microscopy is an exciting tool for biomedical research because it can be used to image single cells in vivo due to its greater penetration depth, lower phototoxicity and higher resolution when compaRed to confocal laser scanning microscopy. This helps researchers understand how certain cells change over time and evaluate the efficacy of different therapies. Herein, we report a new AIE luminogen (AIEgen), abbreviated as TPE-TETRAD, with a favorable absorption and efficient deep-Red Emission in the solid state. TPE-TETRAD possesses a high two-photon absorption cross-section (313 MG at 830 nm) and a rich array of non-linear optical properties including aggregation-induced three-photon luminescence. Biotinylated TPE-TETRAD nanoparticles are also fabricated and applied to stain mitochondria in live cancer cells with high specificity. The purpose of this study is to characterize a novel deep-Red AIEgen and fabricate biotinylated nanoparticles for applications as (1) biocompatible and photostable AIE probes for specific mitochondria imaging and (2) multiphoton imaging probes suitable for two/three-photon fluorescence microscopy.
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biocompatible and photostable aie dots with Red Emission for in vivo two photon bioimaging
Scientific Reports, 2015Co-Authors: Dan Wang, Jun Qian, Wei Qin, Anjun Qin, Ben Zhong TangAbstract:Biocompatible and Photostable AIE Dots with Red Emission for In Vivo Two-Photon Bioimaging
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biocompatible and photostable aie dots with Red Emission for in vivo two photon bioimaging
Scientific Reports, 2015Co-Authors: Dan Wang, Jun Qian, Wei Qin, Anjun Qin, Ben Zhong TangAbstract:Bioimaging systems with cytocompatibility, photostability, Red fluorescence, and optical nonlinearity are in great demand. Herein we report such a bioimaging system. Integration of tetraphenylethene (T), triphenylamine (T), and fumaronitrile (F) units yielded adduct TTF with aggregation-induced Emission (AIE). Nanodots of the AIE fluorogen with efficient Red Emission were fabricated by encapsulating TTF with phospholipid. The AIE dots enabled three-dimensional dynamic imaging with high resolution in blood vessels of mouse brain under two-photon excitation.
