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Denis J. Crankshaw - One of the best experts on this subject based on the ideXlab platform.

  • Effects in Rats of Maternal Exposure to Raspberry Leaf and Its Constituents on the Activity of Cytochrome P450 Enzymes in the Offspring
    International Journal of Toxicology, 2010
    Co-Authors: Emilija Makaji, Alison C. Holloway, Shirley Ho, Denis J. Crankshaw
    Abstract:

    The goal of our study was to determine whether maternal exposure to Red Raspberry Leaf (RRL) and its constituents can permanently alter biotransformation of fluorogenic substrates by cytochrome P450 (CYP) in the livers of male and female offspring. Nulliparous female rats received vehicle, Raspberry Leaf, kaempferol, quercetin, or ellagic acid orally once breeding had been confirmed until parturition. Hepatic microsomes were prepaRed from animals at birth (postnatal day 1 [PND1]), weaning (PND21), PND65, and PND120 to determine the biotransformation of 8 fluorogenic substrates. The pattern of biotransformation of all but 2 of the substrates was gender specific. Maternal consumption of RRL increased biotransformation of 3 substrates by female offspring at PND120 resulting in a more masculine profile. Kaempferol and quercetin had a similar effect to RRL. These results suggest that maternal consumption of either RRL or some of its constituents leads to long-term alterations of CYP activity in female offspring.

  • The Effects of Commercial Preparations of Red Raspberry Leaf on the Contractility of the Rat’s Uterus In Vitro
    Reproductive Sciences, 2010
    Co-Authors: Jing Zheng, Marc J. Pistilli, Alison C. Holloway, Denis J. Crankshaw
    Abstract:

    We investigated the direct effects of various commercially available preparations of Red Raspberry Leaf (RRL) on the in vitro contractility of uteri collected from diethylstilbestrol (DES)-treated nonpregnant (NP) and late pregnant rats. In DES-treated NP rats, RRL tea and capsule caused weak contractions. Neither preparation affected the ability of oxytocin to initiate contractions; however, both partially inhibited preexisting oxytocin-driven contractions at the highest concentration tested. Red Raspberry Leaf ethanol extract had little effect on contractility. Pretreatment with tea did not alter the ability of oxytocin to initiate contractions. In pregnant animals Red Raspberry Leaf tea had variable effects on preexisting oxytocin-induced contractions, sometimes augmenting oxytocin’s effect and sometimes causing augmentation followed by inhibition. We conclude that the biological activity of RRL varies depending on the herbal preparation used and pregnancy status. These results do not support the hypothesis that RRL augments labor by a direct effect on uterine contractility.

  • the effects of commercial preparations of Red Raspberry Leaf on the contractility of the rat s uterus in vitro
    Reproductive Sciences, 2010
    Co-Authors: Jing Zheng, Marc J. Pistilli, Alison C. Holloway, Denis J. Crankshaw
    Abstract:

    We investigated the direct effects of various commercially available preparations of Red Raspberry Leaf (RRL) on the in vitro contractility of uteri collected from diethylstilbestrol (DES)-treated nonpregnant (NP) and late pregnant rats. In DES-treated NP rats, RRL tea and capsule caused weak contractions. Neither preparation affected the ability of oxytocin to initiate contractions; however, both partially inhibited preexisting oxytocin-driven contractions at the highest concentration tested. Red Raspberry Leaf ethanol extract had little effect on contractility. Pretreatment with tea did not alter the ability of oxytocin to initiate contractions. In pregnant animals Red Raspberry Leaf tea had variable effects on preexisting oxytocin-induced contractions, sometimes augmenting oxytocin's effect and sometimes causing augmentation followed by inhibition. We conclude that the biological activity of RRL varies depending on the herbal preparation used and pregnancy status. These results do not support the hypothesis that RRL augments labor by a direct effect on uterine contractility.

Jing Zheng - One of the best experts on this subject based on the ideXlab platform.

  • The Effects of Commercial Preparations of Red Raspberry Leaf on the Contractility of the Rat’s Uterus In Vitro
    Reproductive Sciences, 2010
    Co-Authors: Jing Zheng, Marc J. Pistilli, Alison C. Holloway, Denis J. Crankshaw
    Abstract:

    We investigated the direct effects of various commercially available preparations of Red Raspberry Leaf (RRL) on the in vitro contractility of uteri collected from diethylstilbestrol (DES)-treated nonpregnant (NP) and late pregnant rats. In DES-treated NP rats, RRL tea and capsule caused weak contractions. Neither preparation affected the ability of oxytocin to initiate contractions; however, both partially inhibited preexisting oxytocin-driven contractions at the highest concentration tested. Red Raspberry Leaf ethanol extract had little effect on contractility. Pretreatment with tea did not alter the ability of oxytocin to initiate contractions. In pregnant animals Red Raspberry Leaf tea had variable effects on preexisting oxytocin-induced contractions, sometimes augmenting oxytocin’s effect and sometimes causing augmentation followed by inhibition. We conclude that the biological activity of RRL varies depending on the herbal preparation used and pregnancy status. These results do not support the hypothesis that RRL augments labor by a direct effect on uterine contractility.

  • the effects of commercial preparations of Red Raspberry Leaf on the contractility of the rat s uterus in vitro
    Reproductive Sciences, 2010
    Co-Authors: Jing Zheng, Marc J. Pistilli, Alison C. Holloway, Denis J. Crankshaw
    Abstract:

    We investigated the direct effects of various commercially available preparations of Red Raspberry Leaf (RRL) on the in vitro contractility of uteri collected from diethylstilbestrol (DES)-treated nonpregnant (NP) and late pregnant rats. In DES-treated NP rats, RRL tea and capsule caused weak contractions. Neither preparation affected the ability of oxytocin to initiate contractions; however, both partially inhibited preexisting oxytocin-driven contractions at the highest concentration tested. Red Raspberry Leaf ethanol extract had little effect on contractility. Pretreatment with tea did not alter the ability of oxytocin to initiate contractions. In pregnant animals Red Raspberry Leaf tea had variable effects on preexisting oxytocin-induced contractions, sometimes augmenting oxytocin's effect and sometimes causing augmentation followed by inhibition. We conclude that the biological activity of RRL varies depending on the herbal preparation used and pregnancy status. These results do not support the hypothesis that RRL augments labor by a direct effect on uterine contractility.

Alison C. Holloway - One of the best experts on this subject based on the ideXlab platform.

  • Effects in Rats of Maternal Exposure to Raspberry Leaf and Its Constituents on the Activity of Cytochrome P450 Enzymes in the Offspring
    International Journal of Toxicology, 2010
    Co-Authors: Emilija Makaji, Alison C. Holloway, Shirley Ho, Denis J. Crankshaw
    Abstract:

    The goal of our study was to determine whether maternal exposure to Red Raspberry Leaf (RRL) and its constituents can permanently alter biotransformation of fluorogenic substrates by cytochrome P450 (CYP) in the livers of male and female offspring. Nulliparous female rats received vehicle, Raspberry Leaf, kaempferol, quercetin, or ellagic acid orally once breeding had been confirmed until parturition. Hepatic microsomes were prepaRed from animals at birth (postnatal day 1 [PND1]), weaning (PND21), PND65, and PND120 to determine the biotransformation of 8 fluorogenic substrates. The pattern of biotransformation of all but 2 of the substrates was gender specific. Maternal consumption of RRL increased biotransformation of 3 substrates by female offspring at PND120 resulting in a more masculine profile. Kaempferol and quercetin had a similar effect to RRL. These results suggest that maternal consumption of either RRL or some of its constituents leads to long-term alterations of CYP activity in female offspring.

  • The Effects of Commercial Preparations of Red Raspberry Leaf on the Contractility of the Rat’s Uterus In Vitro
    Reproductive Sciences, 2010
    Co-Authors: Jing Zheng, Marc J. Pistilli, Alison C. Holloway, Denis J. Crankshaw
    Abstract:

    We investigated the direct effects of various commercially available preparations of Red Raspberry Leaf (RRL) on the in vitro contractility of uteri collected from diethylstilbestrol (DES)-treated nonpregnant (NP) and late pregnant rats. In DES-treated NP rats, RRL tea and capsule caused weak contractions. Neither preparation affected the ability of oxytocin to initiate contractions; however, both partially inhibited preexisting oxytocin-driven contractions at the highest concentration tested. Red Raspberry Leaf ethanol extract had little effect on contractility. Pretreatment with tea did not alter the ability of oxytocin to initiate contractions. In pregnant animals Red Raspberry Leaf tea had variable effects on preexisting oxytocin-induced contractions, sometimes augmenting oxytocin’s effect and sometimes causing augmentation followed by inhibition. We conclude that the biological activity of RRL varies depending on the herbal preparation used and pregnancy status. These results do not support the hypothesis that RRL augments labor by a direct effect on uterine contractility.

  • the effects of commercial preparations of Red Raspberry Leaf on the contractility of the rat s uterus in vitro
    Reproductive Sciences, 2010
    Co-Authors: Jing Zheng, Marc J. Pistilli, Alison C. Holloway, Denis J. Crankshaw
    Abstract:

    We investigated the direct effects of various commercially available preparations of Red Raspberry Leaf (RRL) on the in vitro contractility of uteri collected from diethylstilbestrol (DES)-treated nonpregnant (NP) and late pregnant rats. In DES-treated NP rats, RRL tea and capsule caused weak contractions. Neither preparation affected the ability of oxytocin to initiate contractions; however, both partially inhibited preexisting oxytocin-driven contractions at the highest concentration tested. Red Raspberry Leaf ethanol extract had little effect on contractility. Pretreatment with tea did not alter the ability of oxytocin to initiate contractions. In pregnant animals Red Raspberry Leaf tea had variable effects on preexisting oxytocin-induced contractions, sometimes augmenting oxytocin's effect and sometimes causing augmentation followed by inhibition. We conclude that the biological activity of RRL varies depending on the herbal preparation used and pregnancy status. These results do not support the hypothesis that RRL augments labor by a direct effect on uterine contractility.

Marc J. Pistilli - One of the best experts on this subject based on the ideXlab platform.

  • The Effects of Commercial Preparations of Red Raspberry Leaf on the Contractility of the Rat’s Uterus In Vitro
    Reproductive Sciences, 2010
    Co-Authors: Jing Zheng, Marc J. Pistilli, Alison C. Holloway, Denis J. Crankshaw
    Abstract:

    We investigated the direct effects of various commercially available preparations of Red Raspberry Leaf (RRL) on the in vitro contractility of uteri collected from diethylstilbestrol (DES)-treated nonpregnant (NP) and late pregnant rats. In DES-treated NP rats, RRL tea and capsule caused weak contractions. Neither preparation affected the ability of oxytocin to initiate contractions; however, both partially inhibited preexisting oxytocin-driven contractions at the highest concentration tested. Red Raspberry Leaf ethanol extract had little effect on contractility. Pretreatment with tea did not alter the ability of oxytocin to initiate contractions. In pregnant animals Red Raspberry Leaf tea had variable effects on preexisting oxytocin-induced contractions, sometimes augmenting oxytocin’s effect and sometimes causing augmentation followed by inhibition. We conclude that the biological activity of RRL varies depending on the herbal preparation used and pregnancy status. These results do not support the hypothesis that RRL augments labor by a direct effect on uterine contractility.

  • the effects of commercial preparations of Red Raspberry Leaf on the contractility of the rat s uterus in vitro
    Reproductive Sciences, 2010
    Co-Authors: Jing Zheng, Marc J. Pistilli, Alison C. Holloway, Denis J. Crankshaw
    Abstract:

    We investigated the direct effects of various commercially available preparations of Red Raspberry Leaf (RRL) on the in vitro contractility of uteri collected from diethylstilbestrol (DES)-treated nonpregnant (NP) and late pregnant rats. In DES-treated NP rats, RRL tea and capsule caused weak contractions. Neither preparation affected the ability of oxytocin to initiate contractions; however, both partially inhibited preexisting oxytocin-driven contractions at the highest concentration tested. Red Raspberry Leaf ethanol extract had little effect on contractility. Pretreatment with tea did not alter the ability of oxytocin to initiate contractions. In pregnant animals Red Raspberry Leaf tea had variable effects on preexisting oxytocin-induced contractions, sometimes augmenting oxytocin's effect and sometimes causing augmentation followed by inhibition. We conclude that the biological activity of RRL varies depending on the herbal preparation used and pregnancy status. These results do not support the hypothesis that RRL augments labor by a direct effect on uterine contractility.

Ribo Deng - One of the best experts on this subject based on the ideXlab platform.

  • a simple room temperature extraction method for 14carbon labeled Red Raspberry Leaf tissues
    Hortscience, 1993
    Co-Authors: Ribo Deng, Danielle J Donnelly
    Abstract:

    Labeled ( 14 C) compounds were recoveRed from tissue disks taken from 14 CO 2 -fed leaves of 1-year-old greenhouse-grown plants and 1-month-old ex vitro transplants of Red Raspberry (Rubus idaeus L.) by hot (boiling in 80% ethanol immediately after 14 C exposure), delayed-hot (boiling in 80% ethanol after a 2- to 3-day ethanol soak), and room-temperature (RT) (2- to 3-day soak in 80% ethanol) extraction methods. The RT extraction method was simple but as effective for extracting 14 C-labeled compounds from Red Raspberry Leaf tissues as hot and delayed-hot extraction methods

  • A Simple, Room-temperature Extraction Method for
    1993
    Co-Authors: Ribo Deng, Danielle Donnelly
    Abstract:

    Labeled ('"C) compounds were recoveRed from tissue disks taken from 14 CO2-fed leaves of l-year-old greenhouse-grown plants and l-month-old ex vitro transplants of Red Raspberry (Rubus idaeus L.) by hot (boiling in 80% ethanol immediately after 14 C exposure), delayed-hot (boiling in 80% ethanol after a 2- to 3-day ethanol soak), and room- temperature (RT) (2-to 3-day soak in 80% ethanol) extraction methods. The RT extraction method was simple but as effective for extracting 14 C-labeled compounds from Red Raspberry Leaf tissues as hot and delayed-hot extraction methods.