The Experts below are selected from a list of 996 Experts worldwide ranked by ideXlab platform
Keitaro Hashimoto - One of the best experts on this subject based on the ideXlab platform.
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effects of dofetilide a class iii antiarrhythmic drug on various ventricular Arrhythmias in dogs
Journal of Cardiovascular Pharmacology, 1996Co-Authors: Jianguang Chen, Yixue Xue, Koji Eto, Keitaro HashimotoAbstract:Dofetilide, a new class III antiarrhythmic agent, was tested in various kinds of canine ventricular Arrhythmias to compare its effects with those of other class III agents. Ventricular Arrhythmia models used were induced by two-stage coronary ligation, digitalis, epinephrine, coronary ligation and reperfusion, and programmed electrical stimulation (PES). Dofetilide (100 micrograms/kg intravenously) did not suppress automaticity Arrhythmias induced by two-stage coronary ligation and epinephrine or the coronary ligation and reperfusion Arrhythmias, but suppressed the Reentry Arrhythmia induced by PES in dogs with old myocardial infarction (MI). This effect was associated with a prolongation of QT interval. Dofetilide also showed antiarrhythmic effect in some dogs with digitalis Arrhythmia. Dofetilide increased QT interval and showed negative chronotropic effect like that of other class III drugs, but was different in antiarrhythmic profiles from those of other class III agents such as D-sotalol, E-4031, and MS-551 in that it did not prevent the occurrence of ventricular fibrillation (VF) immediately after coronary reperfusion and had some antiarrhythmic effects on digitalis Arrhythmia.
Jianguang Chen - One of the best experts on this subject based on the ideXlab platform.
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effects of dofetilide a class iii antiarrhythmic drug on various ventricular Arrhythmias in dogs
Journal of Cardiovascular Pharmacology, 1996Co-Authors: Jianguang Chen, Yixue Xue, Koji Eto, Keitaro HashimotoAbstract:Dofetilide, a new class III antiarrhythmic agent, was tested in various kinds of canine ventricular Arrhythmias to compare its effects with those of other class III agents. Ventricular Arrhythmia models used were induced by two-stage coronary ligation, digitalis, epinephrine, coronary ligation and reperfusion, and programmed electrical stimulation (PES). Dofetilide (100 micrograms/kg intravenously) did not suppress automaticity Arrhythmias induced by two-stage coronary ligation and epinephrine or the coronary ligation and reperfusion Arrhythmias, but suppressed the Reentry Arrhythmia induced by PES in dogs with old myocardial infarction (MI). This effect was associated with a prolongation of QT interval. Dofetilide also showed antiarrhythmic effect in some dogs with digitalis Arrhythmia. Dofetilide increased QT interval and showed negative chronotropic effect like that of other class III drugs, but was different in antiarrhythmic profiles from those of other class III agents such as D-sotalol, E-4031, and MS-551 in that it did not prevent the occurrence of ventricular fibrillation (VF) immediately after coronary reperfusion and had some antiarrhythmic effects on digitalis Arrhythmia.
Yixue Xue - One of the best experts on this subject based on the ideXlab platform.
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effects of dofetilide a class iii antiarrhythmic drug on various ventricular Arrhythmias in dogs
Journal of Cardiovascular Pharmacology, 1996Co-Authors: Jianguang Chen, Yixue Xue, Koji Eto, Keitaro HashimotoAbstract:Dofetilide, a new class III antiarrhythmic agent, was tested in various kinds of canine ventricular Arrhythmias to compare its effects with those of other class III agents. Ventricular Arrhythmia models used were induced by two-stage coronary ligation, digitalis, epinephrine, coronary ligation and reperfusion, and programmed electrical stimulation (PES). Dofetilide (100 micrograms/kg intravenously) did not suppress automaticity Arrhythmias induced by two-stage coronary ligation and epinephrine or the coronary ligation and reperfusion Arrhythmias, but suppressed the Reentry Arrhythmia induced by PES in dogs with old myocardial infarction (MI). This effect was associated with a prolongation of QT interval. Dofetilide also showed antiarrhythmic effect in some dogs with digitalis Arrhythmia. Dofetilide increased QT interval and showed negative chronotropic effect like that of other class III drugs, but was different in antiarrhythmic profiles from those of other class III agents such as D-sotalol, E-4031, and MS-551 in that it did not prevent the occurrence of ventricular fibrillation (VF) immediately after coronary reperfusion and had some antiarrhythmic effects on digitalis Arrhythmia.
Koji Eto - One of the best experts on this subject based on the ideXlab platform.
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effects of dofetilide a class iii antiarrhythmic drug on various ventricular Arrhythmias in dogs
Journal of Cardiovascular Pharmacology, 1996Co-Authors: Jianguang Chen, Yixue Xue, Koji Eto, Keitaro HashimotoAbstract:Dofetilide, a new class III antiarrhythmic agent, was tested in various kinds of canine ventricular Arrhythmias to compare its effects with those of other class III agents. Ventricular Arrhythmia models used were induced by two-stage coronary ligation, digitalis, epinephrine, coronary ligation and reperfusion, and programmed electrical stimulation (PES). Dofetilide (100 micrograms/kg intravenously) did not suppress automaticity Arrhythmias induced by two-stage coronary ligation and epinephrine or the coronary ligation and reperfusion Arrhythmias, but suppressed the Reentry Arrhythmia induced by PES in dogs with old myocardial infarction (MI). This effect was associated with a prolongation of QT interval. Dofetilide also showed antiarrhythmic effect in some dogs with digitalis Arrhythmia. Dofetilide increased QT interval and showed negative chronotropic effect like that of other class III drugs, but was different in antiarrhythmic profiles from those of other class III agents such as D-sotalol, E-4031, and MS-551 in that it did not prevent the occurrence of ventricular fibrillation (VF) immediately after coronary reperfusion and had some antiarrhythmic effects on digitalis Arrhythmia.
Heather S Duffy - One of the best experts on this subject based on the ideXlab platform.
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abstract 14385 c src tyrosine kinase mediates the effect of mitochondrial oxidative stress on gap junctional remodeling and ventricular tachycardia
Circulation, 2011Co-Authors: Ali A Sovari, Euymyoung Jeong, Elena Dolmatova, Alex Y Tan, Shadi Zandieh, Man Liu, Gu Lianzhi, Divya Arasu, Marcelo G Bonini, Heather S DuffyAbstract:Introduction: Reactive oxygen species (ROS) are thought to play a central role in the genesis of Arrhythmia. Mitochondria are the major source of cardiac ROS. Studies suggest ROS activates c-Src tyrosine kinase, which reduces Cx43 at the gap junctions by competing with Cx43 for binding to Zonula Occludence-1. We sought to determine the role of mitochondria oxidative stress in the genesis of ventricular Arrhythmia in a manganese superoxide dismutase (MnSOD) knock out mouse model. We hypothesized that excess ROS in this model would activate c-Src and reduce Cx43 levels and that inhibition of c-Src would prevent Cx43 remodeling and the risk of Arrhythmia. Method: Wild type and MnSOD+/- mice with and without treatment with the c-Src inhibitor PP1 (1.5 mg/kg IP three times/week x 2 weeks) were studied. Western blotting and immunohistochemistry staining for Cx43 were performed. Mitochondrial ROS was measured by confocal microscopy and flow cytometry from isolated cardiomyocytes using mitoSOX red. In-vivo epicardial mapping was performed using a 30-channel bipolar electrode array with 1 mm resolution. Results: MnSOD+/- myocytes showed a 66% increase in the level of mitochondrial ROS compared to the control (by mitoSOX, P Conclusion: Mitochondrial oxidative stress is associated with increased risk of ventricular Arrhythmia and a significant reduction in Cx43 at the gap junctions, providing the impaired conduction substrate for Reentry Arrhythmia. c-Src tyrosine kinase seems to mediate the effect of mitochondrial ROS on Cx43 and may be an effective antiarrhythmic target in oxidative stress states.