The Experts below are selected from a list of 30 Experts worldwide ranked by ideXlab platform
Anna Spagnoli - One of the best experts on this subject based on the ideXlab platform.
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role of mesenchymal stem cells in Regenerative Medicine Application to bone and cartilage repair
Expert Opinion on Biological Therapy, 2008Co-Authors: Froilan Graneromolto, Jared A Weis, Lara Longobardi, Anna SpagnoliAbstract:Background: Mesenchymal stem cells (MSC) are multipotent cells with the ability to differentiate into mesenchyme-derived cells including osteoblasts and chondrocytes. Objective: To provide an overview and expert opinion on the in vivo ability of MSC to home into tissues, their Regenerative properties and potential Applications for cell-based therapies to treat bone and cartilage disorders. Methods: Data sources including the PubMed database, abstract booklets and conference proceedings were searched for publications pertinent to MSC and their properties with emphasis on the in vivo studies and clinical use in cartilage and bone regeneration and repair. The search included the most current information possible. Conclusion: MSC can migrate to injured tissues and some of their reparative properties are mediated by paracrine mechanisms including their immunomodulatory actions. MSC possess a critical potential in Regenerative Medicine for the treatment of skeletal diseases, such as osteoarthritis or fracture h...
Froilan Graneromolto - One of the best experts on this subject based on the ideXlab platform.
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role of mesenchymal stem cells in Regenerative Medicine Application to bone and cartilage repair
Expert Opinion on Biological Therapy, 2008Co-Authors: Froilan Graneromolto, Jared A Weis, Lara Longobardi, Anna SpagnoliAbstract:Background: Mesenchymal stem cells (MSC) are multipotent cells with the ability to differentiate into mesenchyme-derived cells including osteoblasts and chondrocytes. Objective: To provide an overview and expert opinion on the in vivo ability of MSC to home into tissues, their Regenerative properties and potential Applications for cell-based therapies to treat bone and cartilage disorders. Methods: Data sources including the PubMed database, abstract booklets and conference proceedings were searched for publications pertinent to MSC and their properties with emphasis on the in vivo studies and clinical use in cartilage and bone regeneration and repair. The search included the most current information possible. Conclusion: MSC can migrate to injured tissues and some of their reparative properties are mediated by paracrine mechanisms including their immunomodulatory actions. MSC possess a critical potential in Regenerative Medicine for the treatment of skeletal diseases, such as osteoarthritis or fracture h...
Lara Longobardi - One of the best experts on this subject based on the ideXlab platform.
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role of mesenchymal stem cells in Regenerative Medicine Application to bone and cartilage repair
Expert Opinion on Biological Therapy, 2008Co-Authors: Froilan Graneromolto, Jared A Weis, Lara Longobardi, Anna SpagnoliAbstract:Background: Mesenchymal stem cells (MSC) are multipotent cells with the ability to differentiate into mesenchyme-derived cells including osteoblasts and chondrocytes. Objective: To provide an overview and expert opinion on the in vivo ability of MSC to home into tissues, their Regenerative properties and potential Applications for cell-based therapies to treat bone and cartilage disorders. Methods: Data sources including the PubMed database, abstract booklets and conference proceedings were searched for publications pertinent to MSC and their properties with emphasis on the in vivo studies and clinical use in cartilage and bone regeneration and repair. The search included the most current information possible. Conclusion: MSC can migrate to injured tissues and some of their reparative properties are mediated by paracrine mechanisms including their immunomodulatory actions. MSC possess a critical potential in Regenerative Medicine for the treatment of skeletal diseases, such as osteoarthritis or fracture h...
Jared A Weis - One of the best experts on this subject based on the ideXlab platform.
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role of mesenchymal stem cells in Regenerative Medicine Application to bone and cartilage repair
Expert Opinion on Biological Therapy, 2008Co-Authors: Froilan Graneromolto, Jared A Weis, Lara Longobardi, Anna SpagnoliAbstract:Background: Mesenchymal stem cells (MSC) are multipotent cells with the ability to differentiate into mesenchyme-derived cells including osteoblasts and chondrocytes. Objective: To provide an overview and expert opinion on the in vivo ability of MSC to home into tissues, their Regenerative properties and potential Applications for cell-based therapies to treat bone and cartilage disorders. Methods: Data sources including the PubMed database, abstract booklets and conference proceedings were searched for publications pertinent to MSC and their properties with emphasis on the in vivo studies and clinical use in cartilage and bone regeneration and repair. The search included the most current information possible. Conclusion: MSC can migrate to injured tissues and some of their reparative properties are mediated by paracrine mechanisms including their immunomodulatory actions. MSC possess a critical potential in Regenerative Medicine for the treatment of skeletal diseases, such as osteoarthritis or fracture h...
Giancarlo Logroscino - One of the best experts on this subject based on the ideXlab platform.
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Bone substitutes in orthopaedic surgery: from basic science to clinical practice
Journal of Materials Science: Materials in Medicine, 2014Co-Authors: V. Campana, Enrico Pagano, C. Cicione, G. Salonna, W. Lattanzi, Gianluca Milano, Marina Barba, Giancarlo LogroscinoAbstract:Bone substitutes are being increasingly used in surgery as over two millions bone grafting procedures are performed worldwide per year. Autografts still represent the gold standard for bone substitution, though the morbidity and the inherent limited availability are the main limitations. Allografts, i.e. banked bone, are osteoconductive and weakly osteoinductive, though there are still concerns about the residual infective risks, costs and donor availability issues. As an alternative, xenograft substitutes are cheap, but their use provided contrasting results, so far. Ceramic-based synthetic bone substitutes are alternatively based on hydroxyapatite (HA) and tricalcium phosphates, and are widely used in the clinical practice. Indeed, despite being completely resorbable and weaker than cortical bone, they have exhaustively proved to be effective. Biomimetic HAs are the evolution of traditional HA and contains ions (carbonates, Si, Sr, Fl, Mg) that mimic natural HA (biomimetic HA). Injectable cements represent another evolution, enabling mininvasive techniques. Bone morphogenetic proteins (namely BMP2 and 7) are the only bone inducing growth factors approved for human use in spine surgery and for the treatment of tibial nonunion. Demineralized bone matrix and platelet rich plasma did not prove to be effective and their use as bone substitutes remains controversial. Experimental cell-based approaches are considered the best suitable emerging strategies in several Regenerative Medicine Application, including bone regeneration. In some cases, cells have been used as bioactive vehicles delivering osteoinductive genes locally to achieve bone regeneration. In particular, mesenchymal stem cells have been widely exploited for this purpose, being multipotent cells capable of efficient osteogenic potential. Here we intend to review and update the alternative available techniques used for bone fusion, along with some hints on the advancements achieved through the experimental research in this field.