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Roberta Tasso - One of the best experts on this subject based on the ideXlab platform.

  • Circulating healing (CH) cells expressing BST2 are functionally activated by the injury-regulated systemic factor HGFA.
    Stem cell research & therapy, 2018
    Co-Authors: Claudia Lo Sicco, Daniele Reverberi, Federico Villa, Ulrich Pfeffer, Rodolfo Quarto, Ranieri Cancedda, Roberta Tasso
    Abstract:

    Restoration of damaged tissues through the activation of endogenous progenitors is an attractive therapeutic option. A deep evaluation of the intrinsic stem/progenitor cell properties as well as the reciprocal interactions with injured environments is of critical importance. Here, we show that bone marrow stromal cell antigen 2 (BST2) allows the isolation of a population of circulating progenitors, the circulating healing (CH) cells, characterized by a distinctive core signature. The bone marrow (BM) origin of BST2pos CH cells has been strengthened by the co-expression of leptin receptor, the hallmark of a subpopulation of BM-skeletal stem cells. BST2pos CH cells retained the capacity to (i) respond to injury signals generated by a bone fracture, (ii) modify the expression of cell motility genes following damage, and (iii) react to hepatocyte growth factor-activator (HGFA), an injury-Related Stimulus sufficient to induce their transition into GALERT, a state in which cells are functionally activated and participate in tissue repair. Taken together, these results could pave the way for the identification of new strategies to enhance and potentiate endogenous regenerative mechanisms for future therapies.

  • Circulating healing (CH) cells expressing BST2 are functionally activated by the injury-regulated systemic factor HGFA
    Stem Cell Research & Therapy, 2018
    Co-Authors: Claudia Lo Sicco, Daniele Reverberi, Federico Villa, Ulrich Pfeffer, Rodolfo Quarto, Ranieri Cancedda, Roberta Tasso
    Abstract:

    Background Restoration of damaged tissues through the activation of endogenous progenitors is an attractive therapeutic option. A deep evaluation of the intrinsic stem/progenitor cell properties as well as the reciprocal interactions with injured environments is of critical importance. Methods Here, we show that bone marrow stromal cell antigen 2 (BST2) allows the isolation of a population of circulating progenitors, the circulating healing (CH) cells, characterized by a distinctive core signature. The bone marrow (BM) origin of BST2^pos CH cells has been strengthened by the co-expression of leptin receptor, the hallmark of a subpopulation of BM-skeletal stem cells. Results BST2^pos CH cells retained the capacity to (i) respond to injury signals generated by a bone fracture, (ii) modify the expression of cell motility genes following damage, and (iii) react to hepatocyte growth factor-activator (HGFA), an injury-Related Stimulus sufficient to induce their transition into G_ALERT, a state in which cells are functionally activated and participate in tissue repair. Conclusions Taken together, these results could pave the way for the identification of new strategies to enhance and potentiate endogenous regenerative mechanisms for future therapies.

Claudia Lo Sicco - One of the best experts on this subject based on the ideXlab platform.

  • Circulating healing (CH) cells expressing BST2 are functionally activated by the injury-regulated systemic factor HGFA.
    Stem cell research & therapy, 2018
    Co-Authors: Claudia Lo Sicco, Daniele Reverberi, Federico Villa, Ulrich Pfeffer, Rodolfo Quarto, Ranieri Cancedda, Roberta Tasso
    Abstract:

    Restoration of damaged tissues through the activation of endogenous progenitors is an attractive therapeutic option. A deep evaluation of the intrinsic stem/progenitor cell properties as well as the reciprocal interactions with injured environments is of critical importance. Here, we show that bone marrow stromal cell antigen 2 (BST2) allows the isolation of a population of circulating progenitors, the circulating healing (CH) cells, characterized by a distinctive core signature. The bone marrow (BM) origin of BST2pos CH cells has been strengthened by the co-expression of leptin receptor, the hallmark of a subpopulation of BM-skeletal stem cells. BST2pos CH cells retained the capacity to (i) respond to injury signals generated by a bone fracture, (ii) modify the expression of cell motility genes following damage, and (iii) react to hepatocyte growth factor-activator (HGFA), an injury-Related Stimulus sufficient to induce their transition into GALERT, a state in which cells are functionally activated and participate in tissue repair. Taken together, these results could pave the way for the identification of new strategies to enhance and potentiate endogenous regenerative mechanisms for future therapies.

  • Circulating healing (CH) cells expressing BST2 are functionally activated by the injury-regulated systemic factor HGFA
    Stem Cell Research & Therapy, 2018
    Co-Authors: Claudia Lo Sicco, Daniele Reverberi, Federico Villa, Ulrich Pfeffer, Rodolfo Quarto, Ranieri Cancedda, Roberta Tasso
    Abstract:

    Background Restoration of damaged tissues through the activation of endogenous progenitors is an attractive therapeutic option. A deep evaluation of the intrinsic stem/progenitor cell properties as well as the reciprocal interactions with injured environments is of critical importance. Methods Here, we show that bone marrow stromal cell antigen 2 (BST2) allows the isolation of a population of circulating progenitors, the circulating healing (CH) cells, characterized by a distinctive core signature. The bone marrow (BM) origin of BST2^pos CH cells has been strengthened by the co-expression of leptin receptor, the hallmark of a subpopulation of BM-skeletal stem cells. Results BST2^pos CH cells retained the capacity to (i) respond to injury signals generated by a bone fracture, (ii) modify the expression of cell motility genes following damage, and (iii) react to hepatocyte growth factor-activator (HGFA), an injury-Related Stimulus sufficient to induce their transition into G_ALERT, a state in which cells are functionally activated and participate in tissue repair. Conclusions Taken together, these results could pave the way for the identification of new strategies to enhance and potentiate endogenous regenerative mechanisms for future therapies.

Monicque M. Lorist - One of the best experts on this subject based on the ideXlab platform.

  • Caffeine Boosts Preparatory Attention for Reward-Related Stimulus Information.
    Journal of cognitive neuroscience, 2020
    Co-Authors: Berry Van Den Berg, Marlon De Jong, Marty G. Woldorff, Monicque M. Lorist
    Abstract:

    The intake of caffeine and the prospect of reward have both been associated with increased arousal, enhanced attention, and improved behavioral performance on cognitive tasks, but how they interact...

  • Caffeine boosts preparatory attention for reward-Related Stimulus information
    2019
    Co-Authors: Berry Van Den Berg, Marlon De Jong, Marty G. Woldorff, Monicque M. Lorist
    Abstract:

    Abstract Both the intake of caffeine-containing substances and the prospect of reward for performing a cognitive task have been associated with improved behavioral performance. To investigate the possible common and interactive influences of caffeine and reward-prospect on preparatory attention, we tested 24 participants during a 2-session experiment in which they performed a cued-reward color-word Stroop task. On each trial, participants were presented with a cue to inform them whether they had to prepare for presentation of a Stroop Stimulus and whether they could receive a reward if they performed well on that trial. Prior to each session, participants received either coffee with caffeine (3 mg/kg bodyweight) or with placebo (3 mg/kg bodyweight lactose). In addition to behavioral measures, electroencephalography (EEG) measures of electrical brain activity were recorded. Results showed that both the intake of caffeine and the prospect of reward improved speed and accuracy, with the effects of caffeine and reward-prospect being additive on performance. Neurally, reward-prospect resulted in an enlarged contingent negative variation (CNV) and reduced posterior alpha power (indicating increased cortical activity), both hallmark neural markers for preparatory attention. Moreover, the CNV enhancement for reward-prospect trials was considerably more pronounced in the caffeine condition as compared to the placebo condition. These results thus suggest that caffeine intake boosts preparatory attention for task-relevant information, especially when performance on that task can lead to reward.

Ranieri Cancedda - One of the best experts on this subject based on the ideXlab platform.

  • Circulating healing (CH) cells expressing BST2 are functionally activated by the injury-regulated systemic factor HGFA.
    Stem cell research & therapy, 2018
    Co-Authors: Claudia Lo Sicco, Daniele Reverberi, Federico Villa, Ulrich Pfeffer, Rodolfo Quarto, Ranieri Cancedda, Roberta Tasso
    Abstract:

    Restoration of damaged tissues through the activation of endogenous progenitors is an attractive therapeutic option. A deep evaluation of the intrinsic stem/progenitor cell properties as well as the reciprocal interactions with injured environments is of critical importance. Here, we show that bone marrow stromal cell antigen 2 (BST2) allows the isolation of a population of circulating progenitors, the circulating healing (CH) cells, characterized by a distinctive core signature. The bone marrow (BM) origin of BST2pos CH cells has been strengthened by the co-expression of leptin receptor, the hallmark of a subpopulation of BM-skeletal stem cells. BST2pos CH cells retained the capacity to (i) respond to injury signals generated by a bone fracture, (ii) modify the expression of cell motility genes following damage, and (iii) react to hepatocyte growth factor-activator (HGFA), an injury-Related Stimulus sufficient to induce their transition into GALERT, a state in which cells are functionally activated and participate in tissue repair. Taken together, these results could pave the way for the identification of new strategies to enhance and potentiate endogenous regenerative mechanisms for future therapies.

  • Circulating healing (CH) cells expressing BST2 are functionally activated by the injury-regulated systemic factor HGFA
    Stem Cell Research & Therapy, 2018
    Co-Authors: Claudia Lo Sicco, Daniele Reverberi, Federico Villa, Ulrich Pfeffer, Rodolfo Quarto, Ranieri Cancedda, Roberta Tasso
    Abstract:

    Background Restoration of damaged tissues through the activation of endogenous progenitors is an attractive therapeutic option. A deep evaluation of the intrinsic stem/progenitor cell properties as well as the reciprocal interactions with injured environments is of critical importance. Methods Here, we show that bone marrow stromal cell antigen 2 (BST2) allows the isolation of a population of circulating progenitors, the circulating healing (CH) cells, characterized by a distinctive core signature. The bone marrow (BM) origin of BST2^pos CH cells has been strengthened by the co-expression of leptin receptor, the hallmark of a subpopulation of BM-skeletal stem cells. Results BST2^pos CH cells retained the capacity to (i) respond to injury signals generated by a bone fracture, (ii) modify the expression of cell motility genes following damage, and (iii) react to hepatocyte growth factor-activator (HGFA), an injury-Related Stimulus sufficient to induce their transition into G_ALERT, a state in which cells are functionally activated and participate in tissue repair. Conclusions Taken together, these results could pave the way for the identification of new strategies to enhance and potentiate endogenous regenerative mechanisms for future therapies.

Rodolfo Quarto - One of the best experts on this subject based on the ideXlab platform.

  • Circulating healing (CH) cells expressing BST2 are functionally activated by the injury-regulated systemic factor HGFA.
    Stem cell research & therapy, 2018
    Co-Authors: Claudia Lo Sicco, Daniele Reverberi, Federico Villa, Ulrich Pfeffer, Rodolfo Quarto, Ranieri Cancedda, Roberta Tasso
    Abstract:

    Restoration of damaged tissues through the activation of endogenous progenitors is an attractive therapeutic option. A deep evaluation of the intrinsic stem/progenitor cell properties as well as the reciprocal interactions with injured environments is of critical importance. Here, we show that bone marrow stromal cell antigen 2 (BST2) allows the isolation of a population of circulating progenitors, the circulating healing (CH) cells, characterized by a distinctive core signature. The bone marrow (BM) origin of BST2pos CH cells has been strengthened by the co-expression of leptin receptor, the hallmark of a subpopulation of BM-skeletal stem cells. BST2pos CH cells retained the capacity to (i) respond to injury signals generated by a bone fracture, (ii) modify the expression of cell motility genes following damage, and (iii) react to hepatocyte growth factor-activator (HGFA), an injury-Related Stimulus sufficient to induce their transition into GALERT, a state in which cells are functionally activated and participate in tissue repair. Taken together, these results could pave the way for the identification of new strategies to enhance and potentiate endogenous regenerative mechanisms for future therapies.

  • Circulating healing (CH) cells expressing BST2 are functionally activated by the injury-regulated systemic factor HGFA
    Stem Cell Research & Therapy, 2018
    Co-Authors: Claudia Lo Sicco, Daniele Reverberi, Federico Villa, Ulrich Pfeffer, Rodolfo Quarto, Ranieri Cancedda, Roberta Tasso
    Abstract:

    Background Restoration of damaged tissues through the activation of endogenous progenitors is an attractive therapeutic option. A deep evaluation of the intrinsic stem/progenitor cell properties as well as the reciprocal interactions with injured environments is of critical importance. Methods Here, we show that bone marrow stromal cell antigen 2 (BST2) allows the isolation of a population of circulating progenitors, the circulating healing (CH) cells, characterized by a distinctive core signature. The bone marrow (BM) origin of BST2^pos CH cells has been strengthened by the co-expression of leptin receptor, the hallmark of a subpopulation of BM-skeletal stem cells. Results BST2^pos CH cells retained the capacity to (i) respond to injury signals generated by a bone fracture, (ii) modify the expression of cell motility genes following damage, and (iii) react to hepatocyte growth factor-activator (HGFA), an injury-Related Stimulus sufficient to induce their transition into G_ALERT, a state in which cells are functionally activated and participate in tissue repair. Conclusions Taken together, these results could pave the way for the identification of new strategies to enhance and potentiate endogenous regenerative mechanisms for future therapies.