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Mingxi Qiao - One of the best experts on this subject based on the ideXlab platform.

  • sustained Release Coating of tablets with eudragit rs rl using a novel electrostatic dry powder Coating process
    International Journal of Pharmaceutics, 2010
    Co-Authors: Liqiang Zhang, Mingxi Qiao, Yanfeng Luo, Tyler Shawn Stephenson, Jesse Zhu
    Abstract:

    The objectives of this study were to develop an electrostatic dry powder Coating process for sustained Coating tablets with Eudragit(®) RS/RL and to investigate the effects of various factors and operating conditions on the Coating process and drug Release profile. A liquid plasticizer (triethyl citrate) was sprayed onto the surface of the tablets followed by spraying Coating powder by an electrostatic spray gun. The powder coated tablets were cured at elevated temperature for a film formation. Liquid plasticizer played important roles in lowering down the glass transition temperature (T(g)) of the Coating polymer and increasing the surface electrical conduction of tablet cores. Electrostatic assisted Coating deposition was confirmed by the fact that higher Coating level was obtained with electrical charging than the ones without it. The micrographs of scanning electron microscopy (SEM) of coated tablets showed that the film formation mainly occurred during the curing step. Higher curing temperature and longer curing time help enhance the film formation. The in vitro drug Release profiles indicated that curing time, temperature, Coating level and ratio of Eudragit(®) RS/RL were the main factors affecting the sustained Release profile. The electrostatic dry powder Coating process has been demonstrated to be an alternative for tablet sustained Release Coating with Eudragit(®) RS and RL.

  • Sustained Release Coating of tablets with Eudragit(®) RS/RL using a novel electrostatic dry powder Coating process.
    International journal of pharmaceutics, 2010
    Co-Authors: Mingxi Qiao, Liqiang Zhang, Yanfeng Luo, Tyler Shawn Stephenson, Jesse Zhu
    Abstract:

    The objectives of this study were to develop an electrostatic dry powder Coating process for sustained Coating tablets with Eudragit(®) RS/RL and to investigate the effects of various factors and operating conditions on the Coating process and drug Release profile. A liquid plasticizer (triethyl citrate) was sprayed onto the surface of the tablets followed by spraying Coating powder by an electrostatic spray gun. The powder coated tablets were cured at elevated temperature for a film formation. Liquid plasticizer played important roles in lowering down the glass transition temperature (T(g)) of the Coating polymer and increasing the surface electrical conduction of tablet cores. Electrostatic assisted Coating deposition was confirmed by the fact that higher Coating level was obtained with electrical charging than the ones without it. The micrographs of scanning electron microscopy (SEM) of coated tablets showed that the film formation mainly occurred during the curing step. Higher curing temperature and longer curing time help enhance the film formation. The in vitro drug Release profiles indicated that curing time, temperature, Coating level and ratio of Eudragit(®) RS/RL were the main factors affecting the sustained Release profile. The electrostatic dry powder Coating process has been demonstrated to be an alternative for tablet sustained Release Coating with Eudragit(®) RS and RL.

  • A novel electrostatic dry powder Coating process for pharmaceutical dosage forms: Immediate Release Coatings for tablets
    European Journal of Pharmaceutics and Biopharmaceutics, 2010
    Co-Authors: Mingxi Qiao, Jesse Zhu, Yingliang Ma, Liqiang Zhang, Kwok Chow
    Abstract:

    An electrostatic dry powder Coating process for pharmaceutical solid dosage forms was developed for the first time by electrostatic dry powder Coating in a pan coater system. Two immediate Release Coating compositions with Opadry® AMB and Eudragit® EPO were successfully applied using this process. A liquid plasticizer was sprayed onto the surface of the tablet cores to increase the conductivity of tablet cores to enhance particle deposition, electrical resistivity reduced from greater than 1×1013Ωm to less than 1×109Ωm, and to lower the glass transition temperature (Tg) of the Coating polymer for film forming in the pan coater. The application of liquid plasticizer was followed by spraying charged Coating particles using an electrostatic charging gun to enhance the uniform deposition on tablet surface. The Coating particles were coalesced into a thin film by curing at an acceptable processing temperature as formation was confirmed by SEM micrographs. The results also show that the optimized dry powder Coating process produces tablets with smooth surface, good Coating uniformity and Release profile that are comparable to that of the tablet cores. The data also suggest that this novel electrostatic dry powder Coating technique is an alternative to aqueous- or solvent-based Coating process for pharmaceutical products. © 2010.

Jesse Zhu - One of the best experts on this subject based on the ideXlab platform.

  • sustained Release Coating of tablets with eudragit rs rl using a novel electrostatic dry powder Coating process
    International Journal of Pharmaceutics, 2010
    Co-Authors: Liqiang Zhang, Mingxi Qiao, Yanfeng Luo, Tyler Shawn Stephenson, Jesse Zhu
    Abstract:

    The objectives of this study were to develop an electrostatic dry powder Coating process for sustained Coating tablets with Eudragit(®) RS/RL and to investigate the effects of various factors and operating conditions on the Coating process and drug Release profile. A liquid plasticizer (triethyl citrate) was sprayed onto the surface of the tablets followed by spraying Coating powder by an electrostatic spray gun. The powder coated tablets were cured at elevated temperature for a film formation. Liquid plasticizer played important roles in lowering down the glass transition temperature (T(g)) of the Coating polymer and increasing the surface electrical conduction of tablet cores. Electrostatic assisted Coating deposition was confirmed by the fact that higher Coating level was obtained with electrical charging than the ones without it. The micrographs of scanning electron microscopy (SEM) of coated tablets showed that the film formation mainly occurred during the curing step. Higher curing temperature and longer curing time help enhance the film formation. The in vitro drug Release profiles indicated that curing time, temperature, Coating level and ratio of Eudragit(®) RS/RL were the main factors affecting the sustained Release profile. The electrostatic dry powder Coating process has been demonstrated to be an alternative for tablet sustained Release Coating with Eudragit(®) RS and RL.

  • Sustained Release Coating of tablets with Eudragit(®) RS/RL using a novel electrostatic dry powder Coating process.
    International journal of pharmaceutics, 2010
    Co-Authors: Mingxi Qiao, Liqiang Zhang, Yanfeng Luo, Tyler Shawn Stephenson, Jesse Zhu
    Abstract:

    The objectives of this study were to develop an electrostatic dry powder Coating process for sustained Coating tablets with Eudragit(®) RS/RL and to investigate the effects of various factors and operating conditions on the Coating process and drug Release profile. A liquid plasticizer (triethyl citrate) was sprayed onto the surface of the tablets followed by spraying Coating powder by an electrostatic spray gun. The powder coated tablets were cured at elevated temperature for a film formation. Liquid plasticizer played important roles in lowering down the glass transition temperature (T(g)) of the Coating polymer and increasing the surface electrical conduction of tablet cores. Electrostatic assisted Coating deposition was confirmed by the fact that higher Coating level was obtained with electrical charging than the ones without it. The micrographs of scanning electron microscopy (SEM) of coated tablets showed that the film formation mainly occurred during the curing step. Higher curing temperature and longer curing time help enhance the film formation. The in vitro drug Release profiles indicated that curing time, temperature, Coating level and ratio of Eudragit(®) RS/RL were the main factors affecting the sustained Release profile. The electrostatic dry powder Coating process has been demonstrated to be an alternative for tablet sustained Release Coating with Eudragit(®) RS and RL.

  • A novel electrostatic dry powder Coating process for pharmaceutical dosage forms: Immediate Release Coatings for tablets
    European Journal of Pharmaceutics and Biopharmaceutics, 2010
    Co-Authors: Mingxi Qiao, Jesse Zhu, Yingliang Ma, Liqiang Zhang, Kwok Chow
    Abstract:

    An electrostatic dry powder Coating process for pharmaceutical solid dosage forms was developed for the first time by electrostatic dry powder Coating in a pan coater system. Two immediate Release Coating compositions with Opadry® AMB and Eudragit® EPO were successfully applied using this process. A liquid plasticizer was sprayed onto the surface of the tablet cores to increase the conductivity of tablet cores to enhance particle deposition, electrical resistivity reduced from greater than 1×1013Ωm to less than 1×109Ωm, and to lower the glass transition temperature (Tg) of the Coating polymer for film forming in the pan coater. The application of liquid plasticizer was followed by spraying charged Coating particles using an electrostatic charging gun to enhance the uniform deposition on tablet surface. The Coating particles were coalesced into a thin film by curing at an acceptable processing temperature as formation was confirmed by SEM micrographs. The results also show that the optimized dry powder Coating process produces tablets with smooth surface, good Coating uniformity and Release profile that are comparable to that of the tablet cores. The data also suggest that this novel electrostatic dry powder Coating technique is an alternative to aqueous- or solvent-based Coating process for pharmaceutical products. © 2010.

Liqiang Zhang - One of the best experts on this subject based on the ideXlab platform.

  • sustained Release Coating of tablets with eudragit rs rl using a novel electrostatic dry powder Coating process
    International Journal of Pharmaceutics, 2010
    Co-Authors: Liqiang Zhang, Mingxi Qiao, Yanfeng Luo, Tyler Shawn Stephenson, Jesse Zhu
    Abstract:

    The objectives of this study were to develop an electrostatic dry powder Coating process for sustained Coating tablets with Eudragit(®) RS/RL and to investigate the effects of various factors and operating conditions on the Coating process and drug Release profile. A liquid plasticizer (triethyl citrate) was sprayed onto the surface of the tablets followed by spraying Coating powder by an electrostatic spray gun. The powder coated tablets were cured at elevated temperature for a film formation. Liquid plasticizer played important roles in lowering down the glass transition temperature (T(g)) of the Coating polymer and increasing the surface electrical conduction of tablet cores. Electrostatic assisted Coating deposition was confirmed by the fact that higher Coating level was obtained with electrical charging than the ones without it. The micrographs of scanning electron microscopy (SEM) of coated tablets showed that the film formation mainly occurred during the curing step. Higher curing temperature and longer curing time help enhance the film formation. The in vitro drug Release profiles indicated that curing time, temperature, Coating level and ratio of Eudragit(®) RS/RL were the main factors affecting the sustained Release profile. The electrostatic dry powder Coating process has been demonstrated to be an alternative for tablet sustained Release Coating with Eudragit(®) RS and RL.

  • Sustained Release Coating of tablets with Eudragit(®) RS/RL using a novel electrostatic dry powder Coating process.
    International journal of pharmaceutics, 2010
    Co-Authors: Mingxi Qiao, Liqiang Zhang, Yanfeng Luo, Tyler Shawn Stephenson, Jesse Zhu
    Abstract:

    The objectives of this study were to develop an electrostatic dry powder Coating process for sustained Coating tablets with Eudragit(®) RS/RL and to investigate the effects of various factors and operating conditions on the Coating process and drug Release profile. A liquid plasticizer (triethyl citrate) was sprayed onto the surface of the tablets followed by spraying Coating powder by an electrostatic spray gun. The powder coated tablets were cured at elevated temperature for a film formation. Liquid plasticizer played important roles in lowering down the glass transition temperature (T(g)) of the Coating polymer and increasing the surface electrical conduction of tablet cores. Electrostatic assisted Coating deposition was confirmed by the fact that higher Coating level was obtained with electrical charging than the ones without it. The micrographs of scanning electron microscopy (SEM) of coated tablets showed that the film formation mainly occurred during the curing step. Higher curing temperature and longer curing time help enhance the film formation. The in vitro drug Release profiles indicated that curing time, temperature, Coating level and ratio of Eudragit(®) RS/RL were the main factors affecting the sustained Release profile. The electrostatic dry powder Coating process has been demonstrated to be an alternative for tablet sustained Release Coating with Eudragit(®) RS and RL.

  • A novel electrostatic dry powder Coating process for pharmaceutical dosage forms: Immediate Release Coatings for tablets
    European Journal of Pharmaceutics and Biopharmaceutics, 2010
    Co-Authors: Mingxi Qiao, Jesse Zhu, Yingliang Ma, Liqiang Zhang, Kwok Chow
    Abstract:

    An electrostatic dry powder Coating process for pharmaceutical solid dosage forms was developed for the first time by electrostatic dry powder Coating in a pan coater system. Two immediate Release Coating compositions with Opadry® AMB and Eudragit® EPO were successfully applied using this process. A liquid plasticizer was sprayed onto the surface of the tablet cores to increase the conductivity of tablet cores to enhance particle deposition, electrical resistivity reduced from greater than 1×1013Ωm to less than 1×109Ωm, and to lower the glass transition temperature (Tg) of the Coating polymer for film forming in the pan coater. The application of liquid plasticizer was followed by spraying charged Coating particles using an electrostatic charging gun to enhance the uniform deposition on tablet surface. The Coating particles were coalesced into a thin film by curing at an acceptable processing temperature as formation was confirmed by SEM micrographs. The results also show that the optimized dry powder Coating process produces tablets with smooth surface, good Coating uniformity and Release profile that are comparable to that of the tablet cores. The data also suggest that this novel electrostatic dry powder Coating technique is an alternative to aqueous- or solvent-based Coating process for pharmaceutical products. © 2010.

Robert J Levy - One of the best experts on this subject based on the ideXlab platform.

Clare J Stracha - One of the best experts on this subject based on the ideXlab platform.

  • evaluating the effect of Coating equipment on tablet film quality using terahertz pulsed imaging
    European Journal of Pharmaceutics and Biopharmaceutics, 2013
    Co-Authors: Miriam Haase, Kaisa Naelapaa, Keith C Gordo, M Peppe, Jukka Rantane, Clare J Stracha
    Abstract:

    Abstract In this study, terahertz pulsed imaging (TPI) was employed to investigate the effect of the Coating equipment (fluid bed and drum coater) on the structure of the applied film Coating and subsequent dissolution behaviour. Six tablets from every batch coated with the same delayed Release Coating formulation under recommended process conditions (provided by the Coating polymer supplier) were mapped individually to evaluate the effect of Coating device on critical Coating characteristics (Coating thickness, surface morphology and density). Although the traditional Coating quality parameter (weight gain) indicated no differences between both batches, TPI analysis revealed a lower mean Coating thickness (CT) for tablets coated in the drum coater compared to fluid bed coated tablets (p