The Experts below are selected from a list of 108 Experts worldwide ranked by ideXlab platform
Heini Murer - One of the best experts on this subject based on the ideXlab platform.
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Comprehensive Physiology - Renal Excretion and Tubular Transport of Organic Anions and Cations
Comprehensive Physiology, 2011Co-Authors: Françoise Roch-ramel, Kamel Besseghir, Heini MurerAbstract:The sections in this article are: 1 Organic Anions 1.1 Introduction 1.2 Renal Excretion and Tubular Transport of Organic Anions 1.3 Mechanisms Involved in Tubular Transport of Organic Anions 1.4 Conclusions on the Renal Transport of Organic Anions 2 Organic Cations 2.1 Introduction 2.2 Renal Excretion and Tubular Transport of Organic Cations 2.3 Mechanisms Involved in Tubular Transport of Organic Cations 3 General Conclusions
Wang Jiping - One of the best experts on this subject based on the ideXlab platform.
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Organic anion and cation transporters are possibly involved in Renal Excretion of entecavir in rats.
Life sciences, 2011Co-Authors: Chen Yanxiao, Xu Ruijuan, Yang Jin, Chen Lei, Wang Qian, Yin Xuefen, Tang Hong, Zhang Xueying, Andrew K Davey, Wang JipingAbstract:The purpose of the present study was to investigate the roles of transporters in the Renal Excretion of entecavir. We analyzed the effect of probenecid, cimetidine, sulfobromophthalein sodium (BSP), verapamil, inhibitors of organic anion transporter (OAT), organic cation transporter (OCT), multidrug resistance-associated protein 2 (MRP2) and P-glycoprotein respectively, on the Excretion of entecavir. The area under plasma concentration-time curve (AUC), body clearance, and Renal clearance of entecavir was examined in each group. After intravenous coadministration with entecavir in conscious rats, cimetidine, probenecid, BSP and verapamil significantly increased the AUC of entecavir by 40.07%, 48.78%, 37.49%, and 54.58%, and reduced the body clearance by 27.14%, 31.69%, 29.79%, and 42.17%, respectively. Then the effects of these inhibitors on the Renal clearance of entecavir in unconscious rats were studied. Coadministration of cimetidine and probenecid increased the steady plasma concentration of entecavir by 127.61% and 169.46%, reduced the Renal clearance by 50.47% and 67.76%, and decreased the Excretion ratio by 44.81% and 64.16% compared to initial values. However, the effects of BSP and verapamil were slight. Cimetidine and probenecid also increased the concentration of entecavir in kidney from 34.00±0.80ng/mL to 55.19±4.92ng/mL and 49.92±1.53ng/mL, while the concentration of entecavir in kidney from BSP and verapamil groups was 30.96±0.81ng/mL and 35.72±7.30ng/mL, respectively. These results suggest that cimetidine and probenecid inhibit the Renal Excretion of entecavir in rats, which indicates the most likely involvement of organic anion and cation transporters in the Renal Excretion of entecavir. Copyright © 2011 Elsevier Inc. All rights reserved.
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Organic anion and cation transporters are possibly involved in Renal Excretion of entecavir in rats
Life Sciences, 2011Co-Authors: Chen Yanxiao, Xu Ruijuan, Yang Jin, Chen Lei, Wang Qian, Yin Xuefen, Tang Hong, Zhang Xueying, Andrew K Davey, Wang JipingAbstract:Abstract Aims The purpose of the present study was to investigate the roles of transporters in the Renal Excretion of entecavir. Main methods We analyzed the effect of probenecid, cimetidine, sulfobromophthalein sodium (BSP), verapamil, inhibitors of organic anion transporter (OAT), organic cation transporter (OCT), multidrug resistance-associated protein 2 (MRP2) and P-glycoprotein respectively, on the Excretion of entecavir. The area under plasma concentration–time curve (AUC), body clearance, and Renal clearance of entecavir was examined in each group. Key findings After intravenous coadministration with entecavir in conscious rats, cimetidine, probenecid, BSP and verapamil significantly increased the AUC of entecavir by 40.07%, 48.78%, 37.49%, and 54.58%, and reduced the body clearance by 27.14%, 31.69%, 29.79%, and 42.17%, respectively. Then the effects of these inhibitors on the Renal clearance of entecavir in unconscious rats were studied. Coadministration of cimetidine and probenecid increased the steady plasma concentration of entecavir by 127.61% and 169.46%, reduced the Renal clearance by 50.47% and 67.76%, and decreased the Excretion ratio by 44.81% and 64.16% compared to initial values. However, the effects of BSP and verapamil were slight. Cimetidine and probenecid also increased the concentration of entecavir in kidney from 34.00 ± 0.80 ng/mL to 55.19 ± 4.92 ng/mL and 49.92 ± 1.53 ng/mL, while the concentration of entecavir in kidney from BSP and verapamil groups was 30.96 ± 0.81 ng/mL and 35.72 ± 7.30 ng/mL, respectively. Significance These results suggest that cimetidine and probenecid inhibit the Renal Excretion of entecavir in rats, which indicates the most likely involvement of organic anion and cation transporters in the Renal Excretion of entecavir.
Françoise Roch-ramel - One of the best experts on this subject based on the ideXlab platform.
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Comprehensive Physiology - Renal Excretion and Tubular Transport of Organic Anions and Cations
Comprehensive Physiology, 2011Co-Authors: Françoise Roch-ramel, Kamel Besseghir, Heini MurerAbstract:The sections in this article are: 1 Organic Anions 1.1 Introduction 1.2 Renal Excretion and Tubular Transport of Organic Anions 1.3 Mechanisms Involved in Tubular Transport of Organic Anions 1.4 Conclusions on the Renal Transport of Organic Anions 2 Organic Cations 2.1 Introduction 2.2 Renal Excretion and Tubular Transport of Organic Cations 2.3 Mechanisms Involved in Tubular Transport of Organic Cations 3 General Conclusions
Chen Yanxiao - One of the best experts on this subject based on the ideXlab platform.
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Organic anion and cation transporters are possibly involved in Renal Excretion of entecavir in rats.
Life sciences, 2011Co-Authors: Chen Yanxiao, Xu Ruijuan, Yang Jin, Chen Lei, Wang Qian, Yin Xuefen, Tang Hong, Zhang Xueying, Andrew K Davey, Wang JipingAbstract:The purpose of the present study was to investigate the roles of transporters in the Renal Excretion of entecavir. We analyzed the effect of probenecid, cimetidine, sulfobromophthalein sodium (BSP), verapamil, inhibitors of organic anion transporter (OAT), organic cation transporter (OCT), multidrug resistance-associated protein 2 (MRP2) and P-glycoprotein respectively, on the Excretion of entecavir. The area under plasma concentration-time curve (AUC), body clearance, and Renal clearance of entecavir was examined in each group. After intravenous coadministration with entecavir in conscious rats, cimetidine, probenecid, BSP and verapamil significantly increased the AUC of entecavir by 40.07%, 48.78%, 37.49%, and 54.58%, and reduced the body clearance by 27.14%, 31.69%, 29.79%, and 42.17%, respectively. Then the effects of these inhibitors on the Renal clearance of entecavir in unconscious rats were studied. Coadministration of cimetidine and probenecid increased the steady plasma concentration of entecavir by 127.61% and 169.46%, reduced the Renal clearance by 50.47% and 67.76%, and decreased the Excretion ratio by 44.81% and 64.16% compared to initial values. However, the effects of BSP and verapamil were slight. Cimetidine and probenecid also increased the concentration of entecavir in kidney from 34.00±0.80ng/mL to 55.19±4.92ng/mL and 49.92±1.53ng/mL, while the concentration of entecavir in kidney from BSP and verapamil groups was 30.96±0.81ng/mL and 35.72±7.30ng/mL, respectively. These results suggest that cimetidine and probenecid inhibit the Renal Excretion of entecavir in rats, which indicates the most likely involvement of organic anion and cation transporters in the Renal Excretion of entecavir. Copyright © 2011 Elsevier Inc. All rights reserved.
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Organic anion and cation transporters are possibly involved in Renal Excretion of entecavir in rats
Life Sciences, 2011Co-Authors: Chen Yanxiao, Xu Ruijuan, Yang Jin, Chen Lei, Wang Qian, Yin Xuefen, Tang Hong, Zhang Xueying, Andrew K Davey, Wang JipingAbstract:Abstract Aims The purpose of the present study was to investigate the roles of transporters in the Renal Excretion of entecavir. Main methods We analyzed the effect of probenecid, cimetidine, sulfobromophthalein sodium (BSP), verapamil, inhibitors of organic anion transporter (OAT), organic cation transporter (OCT), multidrug resistance-associated protein 2 (MRP2) and P-glycoprotein respectively, on the Excretion of entecavir. The area under plasma concentration–time curve (AUC), body clearance, and Renal clearance of entecavir was examined in each group. Key findings After intravenous coadministration with entecavir in conscious rats, cimetidine, probenecid, BSP and verapamil significantly increased the AUC of entecavir by 40.07%, 48.78%, 37.49%, and 54.58%, and reduced the body clearance by 27.14%, 31.69%, 29.79%, and 42.17%, respectively. Then the effects of these inhibitors on the Renal clearance of entecavir in unconscious rats were studied. Coadministration of cimetidine and probenecid increased the steady plasma concentration of entecavir by 127.61% and 169.46%, reduced the Renal clearance by 50.47% and 67.76%, and decreased the Excretion ratio by 44.81% and 64.16% compared to initial values. However, the effects of BSP and verapamil were slight. Cimetidine and probenecid also increased the concentration of entecavir in kidney from 34.00 ± 0.80 ng/mL to 55.19 ± 4.92 ng/mL and 49.92 ± 1.53 ng/mL, while the concentration of entecavir in kidney from BSP and verapamil groups was 30.96 ± 0.81 ng/mL and 35.72 ± 7.30 ng/mL, respectively. Significance These results suggest that cimetidine and probenecid inhibit the Renal Excretion of entecavir in rats, which indicates the most likely involvement of organic anion and cation transporters in the Renal Excretion of entecavir.
Yutaka Sekine - One of the best experts on this subject based on the ideXlab platform.
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Renal Excretion Mechanism of Sparfloxacin
Drug Metabolism and Pharmacokinetics, 1991Co-Authors: Toshikazu Yamaguchi, Makiko Yokogawa, Yutaka SekineAbstract:The Renal Excretion mechanism of sparfloxacin (5-amino-1-cyclopropyl-7-(cis-3, 5-dimethyl-1-piperazinyl)-6, 8-difluoro-1, 4-dihydro-4-oxoquinoline-3-carboxylic acid) was studied in rats by using the stop -flow method and the Renal clearance method. The results were as follows :1. Sparfloxacin was scarecely secreted from the proximal tubules of the nephrons, but it was reabsorbed at the distal tubules.2. Fifty-five percent of sparfloxacin present in the plasma were filtered from the glomerulus of the nephrons, and a half of that present in the filtrate was reabsorbed at the distal tubules and a residual half was excreted in urine.3. The Renal handling of sparfloxacin differs from those of other quinolones that show tubular secretion, resulting in the prolonged plasma elimination half-life of sparfloxacin.
