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Alp Sener - One of the best experts on this subject based on the ideXlab platform.
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Hydrogen sulphide and the kidney: Important roles in Renal Physiology and pathogenesis and treatment of kidney injury and disease
Nitric Oxide - Biology and Chemistry, 2015Co-Authors: Ian Lobb, G. Aboalsamh, Eggers Sönke, Alp SenerAbstract:The kidney is an essential mammalian organ that serves to filter toxins and metabolic by-products out of the blood, which are then excreted through urine. Hydrogen sulphide (H2S) is a recently characterized, endogenous gaseous molecule with important physiological roles. Many interesting roles continue to be identified for H2S related specifically to the kidney. The current review discusses how production and action of H2S influences normal Physiology of the kidney. We investigate as well the many roles H2S plays in the pathogenesis and treatment of kidney injury and disease, such as chronic kidney disease (CKD), ureteral obstruction (UO), hyperhomocysteinaemia (HHcy), drug-induced nephrotoxicity (DIN) and Renal ischaemia reperfusion injury (IRI). We suggest that H2S plays a complex and essential role in the normal function of the kidney and dysregulation of H2S production can directly or indirectly contribute to the pathogenesis of Renal disease and injury. Also, H2S could be a promising potential therapeutic treatment to decrease the severity of several Renal diseases. Further research will identify increasingly important and complex roles for H2S in Renal Physiology and how H2S can be effectively utilized to improve clinical outcomes of Renal disease.
Elizabeth S. Montemayor - One of the best experts on this subject based on the ideXlab platform.
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Teaching Renal Physiology to the Millennial Student: the University of the Philippines Manila Experience
Medical Science Educator, 2020Co-Authors: Francisco E. Anacleto, Dolores D. Bonzon, Melissa A. Dator, Elizabeth S. MontemayorAbstract:Objectives To compare the conventional style from a multi-modal approach in the teaching of Renal Physiology among University of the Philippines-College of Medicine (UPCM) first-year medical students in terms of their attitudes and rating scale. Methods We conducted an exploratory sequential mixed methods design using an online survey employing a likert scale followed by a focus group discussion of medical students taking the excretory module from 2016 to 2019. Abbreviated plenary live lectures, online videos embedded in a learning management system, patient contact experience ward work, role-playing, and quiz shows are used to integrate the lessons being taught. Results One-hundred sixty-one respondents out of 185 medical students answered the online survey. We identified that the 67.8% of students found web-facilitated videos extremely effective in understanding Renal Physiology. Among the online videos, voice-over powerpoint format was proven to be most helpful. Students disclosed that the overall scheme was generally positive and it proved to be enjoyable and provided great learning experiences. Conclusion Applied to a class of millennial students, the pilot flight of the redesigned program attempted to engage the audience in such a way that they would not only memorize the topics by rote, they would be able to understand the topics so they could then correlate them to a real-world, clinical, or a laboratory setting following a multi-modal representation.
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Teaching Renal Physiology to the Millennial Student: the University of the Philippines Manila Experience
Medical Science Educator, 2020Co-Authors: Francisco E. Anacleto, Dolores D. Bonzon, Melissa A. Dator, Elizabeth S. MontemayorAbstract:To compare the conventional style from a multi-modal approach in the teaching of Renal Physiology among University of the Philippines-College of Medicine (UPCM) first-year medical students in terms of their attitudes and rating scale. We conducted an exploratory sequential mixed methods design using an online survey employing a likert scale followed by a focus group discussion of medical students taking the excretory module from 2016 to 2019. Abbreviated plenary live lectures, online videos embedded in a learning management system, patient contact experience ward work, role-playing, and quiz shows are used to integrate the lessons being taught. One-hundred sixty-one respondents out of 185 medical students answered the online survey. We identified that the 67.8% of students found web-facilitated videos extremely effective in understanding Renal Physiology. Among the online videos, voice-over powerpoint format was proven to be most helpful. Students disclosed that the overall scheme was generally positive and it proved to be enjoyable and provided great learning experiences. Applied to a class of millennial students, the pilot flight of the redesigned program attempted to engage the audience in such a way that they would not only memorize the topics by rote, they would be able to understand the topics so they could then correlate them to a real-world, clinical, or a laboratory setting following a multi-modal representation.
Samuel E. Trujillo - One of the best experts on this subject based on the ideXlab platform.
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Effect of flipped classroom methodology on the student performance of gastrointestinal and Renal Physiology entrants and repeaters
BMC Medical Education, 2020Co-Authors: Julio C. Sánchez, Diego F. López-zapata, Óscar A. Pinzón, Andrés M. García, Martha D. Morales, Samuel E. TrujilloAbstract:Abstract Background Physiology is a subject that is considered difficult; it is associated with academic failure and causes high levels of stress and anxiety in students. Methods This study compared the effectiveness of a traditional lecture-based methodology with that of a flipped classroom scheme focusing on cooperative ludic learning among gastrointestinal and Renal Physiology students. Two groups were subjected to these two different methods to teach gastrointestinal and Renal Physiology content divided into 14 topics. Additionally, two subgroups were identified in each group: entrants and repeaters. There were no differences in age or gender between the subgroups. Results Levels of self-perceived stress (measured by the SISCO scale), biological stress (measured by awakening salivary cortisol levels), and anxiety (measured by the Zung scale) were high in all of the students; the cortisol levels increased in the entrants and some of the scores in SISCO scale increased in the repeaters, throughout the study. The self-reported study time was longer in the students subjected to the flipped classroom-based method. The final exam results were better only in the new students facing the flipped methodology, but not in the repeaters, who scored lower on the final evaluation. The quantitative and qualitative assessments completed by the participants regarding the different aspects of the flipped-classroom-based methodology were favorable; however, the participants believed that traditional lectures should be maintained for specific topics. Conclusions A methodology based on flipped teaching was an effective strategy to improve academic performance ingastrointestinal and Renal Physiology, but only in new students.
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Effect of flipped classroom methodology on the student performance of gastrointestinal and Renal Physiology entrants and repeaters.
BMC medical education, 2020Co-Authors: Julio C. Sánchez, Diego F. López-zapata, Óscar A. Pinzón, Andrés M. García, Martha D. Morales, Samuel E. TrujilloAbstract:Physiology is a subject that is considered difficult; it is associated with academic failure and causes high levels of stress and anxiety in students. This study compared the effectiveness of a traditional lecture-based methodology with that of a flipped classroom scheme focusing on cooperative ludic learning among gastrointestinal and Renal Physiology students. Two groups were subjected to these two different methods to teach gastrointestinal and Renal Physiology content divided into 14 topics. Additionally, two subgroups were identified in each group: entrants and repeaters. There were no differences in age or gender between the subgroups. Levels of self-perceived stress (measured by the SISCO scale), biological stress (measured by awakening salivary cortisol levels), and anxiety (measured by the Zung scale) were high in all of the students; the cortisol levels increased in the entrants and some of the scores in SISCO scale increased in the repeaters, throughout the study. The self-reported study time was longer in the students subjected to the flipped classroom-based method. The final exam results were better only in the new students facing the flipped methodology, but not in the repeaters, who scored lower on the final evaluation. The quantitative and qualitative assessments completed by the participants regarding the different aspects of the flipped-classroom-based methodology were favorable; however, the participants believed that traditional lectures should be maintained for specific topics. A methodology based on flipped teaching was an effective strategy to improve academic performance ingastrointestinal and Renal Physiology, but only in new students.
Ian Lobb - One of the best experts on this subject based on the ideXlab platform.
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Hydrogen sulphide and the kidney: Important roles in Renal Physiology and pathogenesis and treatment of kidney injury and disease
Nitric Oxide - Biology and Chemistry, 2015Co-Authors: Ian Lobb, G. Aboalsamh, Eggers Sönke, Alp SenerAbstract:The kidney is an essential mammalian organ that serves to filter toxins and metabolic by-products out of the blood, which are then excreted through urine. Hydrogen sulphide (H2S) is a recently characterized, endogenous gaseous molecule with important physiological roles. Many interesting roles continue to be identified for H2S related specifically to the kidney. The current review discusses how production and action of H2S influences normal Physiology of the kidney. We investigate as well the many roles H2S plays in the pathogenesis and treatment of kidney injury and disease, such as chronic kidney disease (CKD), ureteral obstruction (UO), hyperhomocysteinaemia (HHcy), drug-induced nephrotoxicity (DIN) and Renal ischaemia reperfusion injury (IRI). We suggest that H2S plays a complex and essential role in the normal function of the kidney and dysregulation of H2S production can directly or indirectly contribute to the pathogenesis of Renal disease and injury. Also, H2S could be a promising potential therapeutic treatment to decrease the severity of several Renal diseases. Further research will identify increasingly important and complex roles for H2S in Renal Physiology and how H2S can be effectively utilized to improve clinical outcomes of Renal disease.
S. R. Thomas - One of the best experts on this subject based on the ideXlab platform.
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Towards a web resource for quantitative Renal Physiology
2005Co-Authors: S. R. Thomas, Harold E. Layton, Anita T. Layton, Peter Harris, Andrew Lonie, Leon C. MooreAbstract:We present a two-pronged project: 1) a Quantitative Kidney DataBase (QKDB), and 2) an interactive website presenting a coherent and comprehensive set of mathematical models covering the major aspects of Renal Physiology. 1. The QKDB will contain the data needed for quantitative evaluation of hypotheses of Renal function, from the cellular, through the epithelial and tubular, to whole organ levels. It will thus put legacy measurements, as well as recent and new data, at the ready disposal of Renal researchers, facilitating comparisons among different species and under various experimental conditions. It will include especially (list to be extended as needed): transport parameters, tubular concentrations and flow rates along the various nephron segments, and anatomical details, in human kidneys, in experimentally studied species, and in model epithelia such as cultured cells and amphibian skin and urinary bladder. 2. The modeling resource, a dynamic website, will be grounded in the experience of the project participants, all of whom are established modelers of kidney Physiology. The site will provide an interactive user interface to a collection of published models at all levels of Renal Physiology, thus enabling non-modelers to interactively exploit the models, altering the key parameters according to hypotheses of their own and visualizing the simulation results, thus permitting quantitative exploration of new hypotheses. The site will include all existing types of models relevant to Renal Physiology, including kinetic models of transporters and channels, transport models of individual cell types, of flat model epithelia (such as bladder and cultured epithelia), and of tubular segments along the nephron, models of the microcirculation, models of tubuloglomerular feedback, and models of inner and outer medulla at various levels of detail. Implementation of the web resource will be facilitated by translation of the models into a common markup language (such as CellML and SBML). There will thus be a modular separation of model descriptions from their numerical solution methods. This two-pronged web resource, by leveraging the efforts of the community of Renal modelers and thus facilitating general access to hypothesis-driven modeling, will enhance the evaluation of new hypotheses in Renal Physiology and the effects of disease-related defects of transport proteins, Renal metabolism, and anatomical features. The development strategy will use, as far as possible, a generic approach so that conversion of this effort for application to other organ systems will be straightforward.
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Web-based tools for quantitative Renal Physiology.
Cellular and molecular biology (Noisy-le-Grand France), 2004Co-Authors: V. Dzodic, S. Hervy, D. Fritsch, H. Khalfallah, M. Thereau, S. R. ThomasAbstract:We present the development strategy and present state of progress on an interactive website project for quantitative Renal Physiology: a) a quantitative kidney database (QKDB), and b) an interactive website presenting mathematical models covering the major aspects of Renal Physiology. QKDB will house data for quantitative evaluation of hypotheses of Renal function, from the cellular, through the epithelial and tubular, to whole organ levels. It will thus facilitate comparisons among different species and under various experimental conditions. It will include especially: transport parameters, tubular concentrations and flow rates along the various nephron segments, and anatomical details, in human kidneys, in experimentally studied species, and in model epithelia, such as cultured cells and amphibian skin and urinary bladder. The modeling resource will provide an interactive user interface to a collection of published models at all levels of Renal Physiology, enabling non-modelers to exploit the models, altering key parameters according to hypotheses of their own and visualizing the simulation results, thus permitting quantitative exploration of new hypotheses. Implementation will be facilitated by translation of the models into a common markup language such as CellML (cell markup language) and SBML (systems biology markup language). There will thus be a modular separation of model descriptions from their numerical solution methods.