The Experts below are selected from a list of 276 Experts worldwide ranked by ideXlab platform
Stephen E Alway - One of the best experts on this subject based on the ideXlab platform.
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vitamin e and c supplementation reduces oxidative stress improves antioxidant enzymes and positive muscle work in chronically loaded muscles of aged rats
Experimental Gerontology, 2010Co-Authors: Michael J Ryan, Holly J Dudash, Megan Docherty, Kenneth B Geronilla, Brent A Baker, Gregory G Haff, Robert G Cutlip, Stephen E AlwayAbstract:Abstract Aging is associated with increased oxidative stress. Muscle levels of oxidative stress are further elevated with exercise. The purpose of this study was to determine if dietary antioxidant supplementation would improve muscle function and cellular markers of oxidative stress in response to chronic Repetitive Loading in aging. The dorsiflexors of the left limb of aged and young adult Fischer 344 Brown × Norway rats were loaded 3 times weekly for 4.5 weeks using 80 maximal stretch–shortening contractions per session. The contra-lateral limb served as the intra-animal control. The rats were randomly assigned to a diet supplemented with Vitamin E and Vitamin C or normal non-supplemented rat chow. Biomarkers of oxidative stress were measured in the tibialis anterior muscle. Repetitive Loading exercise increased maximal isometric force, negative work and positive work in the dorsiflexors of young adult rats. Only positive work increased in the aged animals that were supplemented with Vitamin E and C. Markers of oxidative stress (H2O2, total GSH, GSH/GSSG ratio, malondialdehyde and 8-OHdG) increased in the tibialis anterior muscles from aged and young adult animals with Repetitive Loading, but Vitamin E and C supplements attenuated this increase. MnSOD activity increased with supplementation in the young adult animals. CuZnSOD and catalase activity increased with supplementation in young adult and aged animals and GPx activity increased with exercise in the non-supplemented young adult and aged animals. The increased levels of endogenous antioxidant enzymes after Vitamin E and C supplementation appear to be regulated by post-transcriptional modifications that are affected differently by age, exercise, and supplementation. These data suggest that antioxidant supplementation improves indices of oxidative stress associated with Repetitive Loading exercise and aging and improves the positive work output of muscles in aged rodents.
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Vitamin E and C supplementation reduces oxidative stress, improves antioxidant enzymes and positive muscle work in chronically loaded muscles of aged rats
Experimental gerontology, 2010Co-Authors: Michael J Ryan, Holly J Dudash, Megan Docherty, Kenneth B Geronilla, Brent A Baker, Gregory G Haff, Robert G Cutlip, Stephen E AlwayAbstract:Abstract Aging is associated with increased oxidative stress. Muscle levels of oxidative stress are further elevated with exercise. The purpose of this study was to determine if dietary antioxidant supplementation would improve muscle function and cellular markers of oxidative stress in response to chronic Repetitive Loading in aging. The dorsiflexors of the left limb of aged and young adult Fischer 344 Brown × Norway rats were loaded 3 times weekly for 4.5 weeks using 80 maximal stretch–shortening contractions per session. The contra-lateral limb served as the intra-animal control. The rats were randomly assigned to a diet supplemented with Vitamin E and Vitamin C or normal non-supplemented rat chow. Biomarkers of oxidative stress were measured in the tibialis anterior muscle. Repetitive Loading exercise increased maximal isometric force, negative work and positive work in the dorsiflexors of young adult rats. Only positive work increased in the aged animals that were supplemented with Vitamin E and C. Markers of oxidative stress (H2O2, total GSH, GSH/GSSG ratio, malondialdehyde and 8-OHdG) increased in the tibialis anterior muscles from aged and young adult animals with Repetitive Loading, but Vitamin E and C supplements attenuated this increase. MnSOD activity increased with supplementation in the young adult animals. CuZnSOD and catalase activity increased with supplementation in young adult and aged animals and GPx activity increased with exercise in the non-supplemented young adult and aged animals. The increased levels of endogenous antioxidant enzymes after Vitamin E and C supplementation appear to be regulated by post-transcriptional modifications that are affected differently by age, exercise, and supplementation. These data suggest that antioxidant supplementation improves indices of oxidative stress associated with Repetitive Loading exercise and aging and improves the positive work output of muscles in aged rodents.
Kenneth B Geronilla - One of the best experts on this subject based on the ideXlab platform.
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vitamin e and c supplementation reduces oxidative stress improves antioxidant enzymes and positive muscle work in chronically loaded muscles of aged rats
Experimental Gerontology, 2010Co-Authors: Michael J Ryan, Holly J Dudash, Megan Docherty, Kenneth B Geronilla, Brent A Baker, Gregory G Haff, Robert G Cutlip, Stephen E AlwayAbstract:Abstract Aging is associated with increased oxidative stress. Muscle levels of oxidative stress are further elevated with exercise. The purpose of this study was to determine if dietary antioxidant supplementation would improve muscle function and cellular markers of oxidative stress in response to chronic Repetitive Loading in aging. The dorsiflexors of the left limb of aged and young adult Fischer 344 Brown × Norway rats were loaded 3 times weekly for 4.5 weeks using 80 maximal stretch–shortening contractions per session. The contra-lateral limb served as the intra-animal control. The rats were randomly assigned to a diet supplemented with Vitamin E and Vitamin C or normal non-supplemented rat chow. Biomarkers of oxidative stress were measured in the tibialis anterior muscle. Repetitive Loading exercise increased maximal isometric force, negative work and positive work in the dorsiflexors of young adult rats. Only positive work increased in the aged animals that were supplemented with Vitamin E and C. Markers of oxidative stress (H2O2, total GSH, GSH/GSSG ratio, malondialdehyde and 8-OHdG) increased in the tibialis anterior muscles from aged and young adult animals with Repetitive Loading, but Vitamin E and C supplements attenuated this increase. MnSOD activity increased with supplementation in the young adult animals. CuZnSOD and catalase activity increased with supplementation in young adult and aged animals and GPx activity increased with exercise in the non-supplemented young adult and aged animals. The increased levels of endogenous antioxidant enzymes after Vitamin E and C supplementation appear to be regulated by post-transcriptional modifications that are affected differently by age, exercise, and supplementation. These data suggest that antioxidant supplementation improves indices of oxidative stress associated with Repetitive Loading exercise and aging and improves the positive work output of muscles in aged rodents.
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Vitamin E and C supplementation reduces oxidative stress, improves antioxidant enzymes and positive muscle work in chronically loaded muscles of aged rats
Experimental gerontology, 2010Co-Authors: Michael J Ryan, Holly J Dudash, Megan Docherty, Kenneth B Geronilla, Brent A Baker, Gregory G Haff, Robert G Cutlip, Stephen E AlwayAbstract:Abstract Aging is associated with increased oxidative stress. Muscle levels of oxidative stress are further elevated with exercise. The purpose of this study was to determine if dietary antioxidant supplementation would improve muscle function and cellular markers of oxidative stress in response to chronic Repetitive Loading in aging. The dorsiflexors of the left limb of aged and young adult Fischer 344 Brown × Norway rats were loaded 3 times weekly for 4.5 weeks using 80 maximal stretch–shortening contractions per session. The contra-lateral limb served as the intra-animal control. The rats were randomly assigned to a diet supplemented with Vitamin E and Vitamin C or normal non-supplemented rat chow. Biomarkers of oxidative stress were measured in the tibialis anterior muscle. Repetitive Loading exercise increased maximal isometric force, negative work and positive work in the dorsiflexors of young adult rats. Only positive work increased in the aged animals that were supplemented with Vitamin E and C. Markers of oxidative stress (H2O2, total GSH, GSH/GSSG ratio, malondialdehyde and 8-OHdG) increased in the tibialis anterior muscles from aged and young adult animals with Repetitive Loading, but Vitamin E and C supplements attenuated this increase. MnSOD activity increased with supplementation in the young adult animals. CuZnSOD and catalase activity increased with supplementation in young adult and aged animals and GPx activity increased with exercise in the non-supplemented young adult and aged animals. The increased levels of endogenous antioxidant enzymes after Vitamin E and C supplementation appear to be regulated by post-transcriptional modifications that are affected differently by age, exercise, and supplementation. These data suggest that antioxidant supplementation improves indices of oxidative stress associated with Repetitive Loading exercise and aging and improves the positive work output of muscles in aged rodents.
Robert G Cutlip - One of the best experts on this subject based on the ideXlab platform.
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vitamin e and c supplementation reduces oxidative stress improves antioxidant enzymes and positive muscle work in chronically loaded muscles of aged rats
Experimental Gerontology, 2010Co-Authors: Michael J Ryan, Holly J Dudash, Megan Docherty, Kenneth B Geronilla, Brent A Baker, Gregory G Haff, Robert G Cutlip, Stephen E AlwayAbstract:Abstract Aging is associated with increased oxidative stress. Muscle levels of oxidative stress are further elevated with exercise. The purpose of this study was to determine if dietary antioxidant supplementation would improve muscle function and cellular markers of oxidative stress in response to chronic Repetitive Loading in aging. The dorsiflexors of the left limb of aged and young adult Fischer 344 Brown × Norway rats were loaded 3 times weekly for 4.5 weeks using 80 maximal stretch–shortening contractions per session. The contra-lateral limb served as the intra-animal control. The rats were randomly assigned to a diet supplemented with Vitamin E and Vitamin C or normal non-supplemented rat chow. Biomarkers of oxidative stress were measured in the tibialis anterior muscle. Repetitive Loading exercise increased maximal isometric force, negative work and positive work in the dorsiflexors of young adult rats. Only positive work increased in the aged animals that were supplemented with Vitamin E and C. Markers of oxidative stress (H2O2, total GSH, GSH/GSSG ratio, malondialdehyde and 8-OHdG) increased in the tibialis anterior muscles from aged and young adult animals with Repetitive Loading, but Vitamin E and C supplements attenuated this increase. MnSOD activity increased with supplementation in the young adult animals. CuZnSOD and catalase activity increased with supplementation in young adult and aged animals and GPx activity increased with exercise in the non-supplemented young adult and aged animals. The increased levels of endogenous antioxidant enzymes after Vitamin E and C supplementation appear to be regulated by post-transcriptional modifications that are affected differently by age, exercise, and supplementation. These data suggest that antioxidant supplementation improves indices of oxidative stress associated with Repetitive Loading exercise and aging and improves the positive work output of muscles in aged rodents.
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Vitamin E and C supplementation reduces oxidative stress, improves antioxidant enzymes and positive muscle work in chronically loaded muscles of aged rats
Experimental gerontology, 2010Co-Authors: Michael J Ryan, Holly J Dudash, Megan Docherty, Kenneth B Geronilla, Brent A Baker, Gregory G Haff, Robert G Cutlip, Stephen E AlwayAbstract:Abstract Aging is associated with increased oxidative stress. Muscle levels of oxidative stress are further elevated with exercise. The purpose of this study was to determine if dietary antioxidant supplementation would improve muscle function and cellular markers of oxidative stress in response to chronic Repetitive Loading in aging. The dorsiflexors of the left limb of aged and young adult Fischer 344 Brown × Norway rats were loaded 3 times weekly for 4.5 weeks using 80 maximal stretch–shortening contractions per session. The contra-lateral limb served as the intra-animal control. The rats were randomly assigned to a diet supplemented with Vitamin E and Vitamin C or normal non-supplemented rat chow. Biomarkers of oxidative stress were measured in the tibialis anterior muscle. Repetitive Loading exercise increased maximal isometric force, negative work and positive work in the dorsiflexors of young adult rats. Only positive work increased in the aged animals that were supplemented with Vitamin E and C. Markers of oxidative stress (H2O2, total GSH, GSH/GSSG ratio, malondialdehyde and 8-OHdG) increased in the tibialis anterior muscles from aged and young adult animals with Repetitive Loading, but Vitamin E and C supplements attenuated this increase. MnSOD activity increased with supplementation in the young adult animals. CuZnSOD and catalase activity increased with supplementation in young adult and aged animals and GPx activity increased with exercise in the non-supplemented young adult and aged animals. The increased levels of endogenous antioxidant enzymes after Vitamin E and C supplementation appear to be regulated by post-transcriptional modifications that are affected differently by age, exercise, and supplementation. These data suggest that antioxidant supplementation improves indices of oxidative stress associated with Repetitive Loading exercise and aging and improves the positive work output of muscles in aged rodents.
Michael W. Olson - One of the best experts on this subject based on the ideXlab platform.
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Passive Repetitive Loading of the lumbar tissues influences force output and EMG during maximal efforts
European Journal of Applied Physiology, 2011Co-Authors: Michael W. OlsonAbstract:Loading of the low back tissues induces tension-relaxation in the viscoelastic connective tissues. The extent to which Repetitive Loading influences the muscle activation and subsequent muscle force production has not been fully explored. The purpose of this study was to examine the myoelectric activity of the trunk muscles during maximal flexion and extension exertions before and after a passive trunk flexion–extension protocol. Nineteen subjects performed three trials of maximal efforts in trunk flexion and extension while seated in an upright position. Surface electromyography (EMG) recordings were collected bilaterally from paraspinal (thoracic, TP, lumbar LP), rectus abdominis (RA), and external oblique muscles. A 10-minute passive trunk flexion–extension protocol was used to Repetitively load the lumbar tissues at a rate of 0.17 rad/s, through the subjects’ range of motion. The main findings included a significant reduction in moment output during extension efforts ( p
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Passive Repetitive Loading of the lumbar tissues influences force output and EMG during maximal efforts.
European journal of applied physiology, 2010Co-Authors: Michael W. OlsonAbstract:Loading of the low back tissues induces tension-relaxation in the viscoelastic connective tissues. The extent to which Repetitive Loading influences the muscle activation and subsequent muscle force production has not been fully explored. The purpose of this study was to examine the myoelectric activity of the trunk muscles during maximal flexion and extension exertions before and after a passive trunk flexion–extension protocol. Nineteen subjects performed three trials of maximal efforts in trunk flexion and extension while seated in an upright position. Surface electromyography (EMG) recordings were collected bilaterally from paraspinal (thoracic, TP, lumbar LP), rectus abdominis (RA), and external oblique muscles. A 10-minute passive trunk flexion–extension protocol was used to Repetitively load the lumbar tissues at a rate of 0.17 rad/s, through the subjects’ range of motion. The main findings included a significant reduction in moment output during extension efforts (p < 0.05) with significant reductions in the average EMG from the TP and LP muscles during extension (p < 0.05). In flexion, peak and average EMGs were also significantly reduced (p < 0.05). The results indicate a significant reduction in the ability of the trunk extensors to output force, but this may be due to the increased compliance of the connective tissues rather than modified neuromuscular signals to the paraspinal muscles. However, neuromuscular changes were apparent in the TP and RA muscles suggesting a modified control mechanism was present.
Michael J Ryan - One of the best experts on this subject based on the ideXlab platform.
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vitamin e and c supplementation reduces oxidative stress improves antioxidant enzymes and positive muscle work in chronically loaded muscles of aged rats
Experimental Gerontology, 2010Co-Authors: Michael J Ryan, Holly J Dudash, Megan Docherty, Kenneth B Geronilla, Brent A Baker, Gregory G Haff, Robert G Cutlip, Stephen E AlwayAbstract:Abstract Aging is associated with increased oxidative stress. Muscle levels of oxidative stress are further elevated with exercise. The purpose of this study was to determine if dietary antioxidant supplementation would improve muscle function and cellular markers of oxidative stress in response to chronic Repetitive Loading in aging. The dorsiflexors of the left limb of aged and young adult Fischer 344 Brown × Norway rats were loaded 3 times weekly for 4.5 weeks using 80 maximal stretch–shortening contractions per session. The contra-lateral limb served as the intra-animal control. The rats were randomly assigned to a diet supplemented with Vitamin E and Vitamin C or normal non-supplemented rat chow. Biomarkers of oxidative stress were measured in the tibialis anterior muscle. Repetitive Loading exercise increased maximal isometric force, negative work and positive work in the dorsiflexors of young adult rats. Only positive work increased in the aged animals that were supplemented with Vitamin E and C. Markers of oxidative stress (H2O2, total GSH, GSH/GSSG ratio, malondialdehyde and 8-OHdG) increased in the tibialis anterior muscles from aged and young adult animals with Repetitive Loading, but Vitamin E and C supplements attenuated this increase. MnSOD activity increased with supplementation in the young adult animals. CuZnSOD and catalase activity increased with supplementation in young adult and aged animals and GPx activity increased with exercise in the non-supplemented young adult and aged animals. The increased levels of endogenous antioxidant enzymes after Vitamin E and C supplementation appear to be regulated by post-transcriptional modifications that are affected differently by age, exercise, and supplementation. These data suggest that antioxidant supplementation improves indices of oxidative stress associated with Repetitive Loading exercise and aging and improves the positive work output of muscles in aged rodents.
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Vitamin E and C supplementation reduces oxidative stress, improves antioxidant enzymes and positive muscle work in chronically loaded muscles of aged rats
Experimental gerontology, 2010Co-Authors: Michael J Ryan, Holly J Dudash, Megan Docherty, Kenneth B Geronilla, Brent A Baker, Gregory G Haff, Robert G Cutlip, Stephen E AlwayAbstract:Abstract Aging is associated with increased oxidative stress. Muscle levels of oxidative stress are further elevated with exercise. The purpose of this study was to determine if dietary antioxidant supplementation would improve muscle function and cellular markers of oxidative stress in response to chronic Repetitive Loading in aging. The dorsiflexors of the left limb of aged and young adult Fischer 344 Brown × Norway rats were loaded 3 times weekly for 4.5 weeks using 80 maximal stretch–shortening contractions per session. The contra-lateral limb served as the intra-animal control. The rats were randomly assigned to a diet supplemented with Vitamin E and Vitamin C or normal non-supplemented rat chow. Biomarkers of oxidative stress were measured in the tibialis anterior muscle. Repetitive Loading exercise increased maximal isometric force, negative work and positive work in the dorsiflexors of young adult rats. Only positive work increased in the aged animals that were supplemented with Vitamin E and C. Markers of oxidative stress (H2O2, total GSH, GSH/GSSG ratio, malondialdehyde and 8-OHdG) increased in the tibialis anterior muscles from aged and young adult animals with Repetitive Loading, but Vitamin E and C supplements attenuated this increase. MnSOD activity increased with supplementation in the young adult animals. CuZnSOD and catalase activity increased with supplementation in young adult and aged animals and GPx activity increased with exercise in the non-supplemented young adult and aged animals. The increased levels of endogenous antioxidant enzymes after Vitamin E and C supplementation appear to be regulated by post-transcriptional modifications that are affected differently by age, exercise, and supplementation. These data suggest that antioxidant supplementation improves indices of oxidative stress associated with Repetitive Loading exercise and aging and improves the positive work output of muscles in aged rodents.
