The Experts below are selected from a list of 12045 Experts worldwide ranked by ideXlab platform

Rahal Khaled - One of the best experts on this subject based on the ideXlab platform.

  • Fertility sparing surgery for stage Ic ovarian cancer: An eight case series
    Digital ProScholar Media, 2019
    Co-Authors: Montassar Ghalleb, Hatem Bouzaiene, Sarah Seghaier, Hanen Bouaziz, Monia Hechiche, Riadh Chargui, Rahal Khaled
    Abstract:

    Introduction. One case out of 3 cases of primary ovarian cancer is diagnosed at an early stage. Almost 15% of ovarian cancers are diagnosed in women who are within the range of procreation age, raising the debate on the feasibility of fertility-sparing surgery (FSS) for those tumors. In the case the patient is admitted with stage 1A or 1B in most histologic types, it is still controversial in stage 1C. Results and Discussions. This is an eight-patient-case series. The median age is 27 years old (ranging from 18 to 42). The main clinical manifestation was pelvic pain (87.5%). Four patients (50%) presented with tumor torsion. All patients underwent FSS; five of them (62.5%) had conservative staging, two (25%) underwent salpingooophorectomy and one (12.5%) ovariectomy, type histo + stade Figo. The chemotherapeutic treatment was administered to four patients (50%) following surgery without major side effects. One patient (12.5%) presented a loco regional recurrence that occurred 14 months later. She was treated with combined chemotherapy and radical surgery. One patient out of eight (12.5%) achieved a natural pregnancy after the treatment and another one (12.5%) was submitted to an assisted Reproductive Procedure which did not result in a viable pregnancy. Conclusion. FSS seems to be a suitable approach for stage 1C ovarian cancer. However, more case series and meta-analyses should be conducted

Vida Amid - One of the best experts on this subject based on the ideXlab platform.

Montassar Ghalleb - One of the best experts on this subject based on the ideXlab platform.

  • Fertility sparing surgery for stage Ic ovarian cancer: An eight case series
    Digital ProScholar Media, 2019
    Co-Authors: Montassar Ghalleb, Hatem Bouzaiene, Sarah Seghaier, Hanen Bouaziz, Monia Hechiche, Riadh Chargui, Rahal Khaled
    Abstract:

    Introduction. One case out of 3 cases of primary ovarian cancer is diagnosed at an early stage. Almost 15% of ovarian cancers are diagnosed in women who are within the range of procreation age, raising the debate on the feasibility of fertility-sparing surgery (FSS) for those tumors. In the case the patient is admitted with stage 1A or 1B in most histologic types, it is still controversial in stage 1C. Results and Discussions. This is an eight-patient-case series. The median age is 27 years old (ranging from 18 to 42). The main clinical manifestation was pelvic pain (87.5%). Four patients (50%) presented with tumor torsion. All patients underwent FSS; five of them (62.5%) had conservative staging, two (25%) underwent salpingooophorectomy and one (12.5%) ovariectomy, type histo + stade Figo. The chemotherapeutic treatment was administered to four patients (50%) following surgery without major side effects. One patient (12.5%) presented a loco regional recurrence that occurred 14 months later. She was treated with combined chemotherapy and radical surgery. One patient out of eight (12.5%) achieved a natural pregnancy after the treatment and another one (12.5%) was submitted to an assisted Reproductive Procedure which did not result in a viable pregnancy. Conclusion. FSS seems to be a suitable approach for stage 1C ovarian cancer. However, more case series and meta-analyses should be conducted

Zonis, Raphael Matan. - One of the best experts on this subject based on the ideXlab platform.

  • Development of an automated microfluidic system for the loading and unloading of cryoprotectants from mammalian oocytes
    Massachusetts Institute of Technology, 2020
    Co-Authors: Zonis, Raphael Matan.
    Abstract:

    Thesis: S.M., Massachusetts Institute of Technology, Department of Mechanical Engineering, May, 2020Cataloged from the official PDF of thesis.Includes bibliographical references (pages 98-112).Oocyte cryopreservation is an assistive Reproductive Procedure that has allowed women to overcome infertility and enjoy increased Reproductive freedom. Despite a rapid increase in oocyte cryopreservation cycles over the past seven years, success rates both between and within clinics remain highly heterogeneous, negatively impacting clinical outcomes. This is because the clinical gold standard in oocyte cryopreservation, manual vitrification, is a technically challenging Procedure that's success is strongly dependent on the experience, training, and attentiveness of the operator. In this thesis, the development of an automated platform for the introduction and removal of cryoprotective agents (CPAs) to and from the oocyte is described. By combining microfluidics, automation, and optical measurement systems, the proposed system aims to overcome the challenges inherent to manual vitrification, and improve upon other existing platforms designed to perform these tasks. Development and fabrication of the microfluidic component of this proposed system is described, and is validated through a proof-of-concept experiment. This work marks the first step towards a completely automated vitrification platform, capable of removing the uncertainty in success currently plaguing clinics and their patients.by Raphael Matan Zonis.S.M.S.M. Massachusetts Institute of Technology, Department of Mechanical Engineerin

Ashraf Moini - One of the best experts on this subject based on the ideXlab platform.