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R G Bolte - One of the best experts on this subject based on the ideXlab platform.
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a retrospective review of pediatric patients with epididymitis testicular Torsion and Torsion of testicular appendages
Pediatrics, 1998Co-Authors: H A Kadish, R G BolteAbstract:Study Objective. To compare historical features, physical examination findings, and testicular color Doppler ultrasound in pediatric patients with epididymitis, testicular Torsion, and Torsion of appendix testis. Methods. A retrospective review of patients with the diagnosis of epididymitis, testicular Torsion, or Torsion of appendix testis. Results. Ninety patients were included in the study (64 with epididymitis, 13 with testicular Torsion, and 13 with Torsion of appendix testis). Historical features did not differ among groups except for duration of symptoms. Of 13 patients with testicular Torsion all had a tender testicle and an absent cremasteric reflex. When compared with the testicular Torsion group, fewer patients with epididymitis had a tender testicle (69%) or an absent cremasteric reflex (14%). 62 (97%) patients with epididymitis had a tender epididymis and 43 (67%) had scrotal erythema/edema. By comparison, 3 (23%) and 5 (38%) patients with testicular Torsion had a tender epididymis or scrotal erythema/edema, respectively. Doppler ultrasound showed decreased or absent blood flow in 8 patients, 7 of whom were diagnosed with testicular Torsion. Ten out of 13 patients with testicular Torsion had a salvageable testicle at the time of surgery. Conclusion. The physical examination is helpful in distinguishing among epididymitis, testicular Torsion, and Torsion of appendix testis. Patients presenting with a tender testicle and an absent cremasteric reflex were more likely to have a testicular Torsion rather than epididymitis or Torsion of appendix testis. An absent cremasteric reflex was the most sensitive physical finding for diagnosing testicular Torsion. Color Doppler ultrasound is a useful adjunct in the evaluation of the acute scrotum when physical findings are equivocal.
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A retrospective review of pediatric patients with epididymitis, testicular Torsion, and Torsion of testicular appendages.
Pediatrics, 1998Co-Authors: H A Kadish, R G BolteAbstract:To compare historical features, physical examination findings, and testicular color Doppler ultrasound in pediatric patients with epididymitis, testicular Torsion, and Torsion of appendix testis. A retrospective review of patients with the diagnosis of epididymitis, testicular Torsion, or Torsion of appendix testis. Ninety patients were included in the study (64 with epididymitis, 13 with testicular Torsion, and 13 with Torsion of appendix testis). Historical features did not differ among groups except for duration of symptoms. Of 13 patients with testicular Torsion all had a tender testicle and an absent cremasteric reflex. When compared with the testicular Torsion group, fewer patients with epididymitis had a tender testicle (69%) or an absent cremasteric reflex (14%). 62 (97%) patients with epididymitis had a tender epididymis and 43 (67%) had scrotal erythema/edema. By comparison, 3 (23%) and 5 (38%) patients with testicular Torsion had a tender epididymis or scrotal erythema/edema, respectively. Doppler ultrasound showed decreased or absent blood flow in 8 patients, 7 of whom were diagnosed with testicular Torsion. Ten out of 13 patients with testicular Torsion had a salvageable testicle at the time of surgery. The physical examination is helpful in distinguishing among epididymitis, testicular Torsion, and Torsion of appendix testis. Patients presenting with a tender testicle and an absent cremasteric reflex were more likely to have a testicular Torsion rather than epididymitis or Torsion of appendix testis. An absent cremasteric reflex was the most sensitive physical finding for diagnosing testicular Torsion. Color Doppler ultrasound is a useful adjunct in the evaluation of the acute scrotum when physical findings are equivocal.
Terry T Turner - One of the best experts on this subject based on the ideXlab platform.
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experimental testicular Torsion reperfusion blood flow and subsequent testicular venous plasma testosterone concentrations
Urology, 2005Co-Authors: Terry T Turner, Hyun J Bang, Jeffrey J LysiakAbstract:Abstract Objectives To examine the effect of Torsion on subsequent testicular venous plasma testosterone concentrations (TVT) and to determine the relationship between the TVT values 30 days after Torsion repair and testicular reperfusion immediately after Torsion repair, because testicular Torsion followed by repair induces an ischemia/reperfusion injury of the testis. Methods Adult male rats were subjected to 1 hour of 720° testicular Torsion, a time and degree of Torsion that has been shown to cause severe impairment of spermatogenesis. Testicular microvascular perfusion before Torsion, during Torsion, and 5 minutes after Torsion repair was determined by laser Doppler flowmetry. The animals were evaluated 3 days and 30 days later for microvascular perfusion and TVT. Results Experimental Torsion significantly reduced testicular vascular perfusion. Five minutes after Torsion repair, the mean flow values had returned to approximately 70% of the preTorsion values. Testicular Torsion significantly reduced TVT at both 3 and 30 days after Torsion repair. TVT 30 days after Torsion repair was significantly, but inversely, related to reperfusion values immediately after Torsion repair. Conclusions These results demonstrate that the minimal duration and degree of Torsion known to cause loss of spermatogenesis in the rat also causes a significant reduction in testicular androgen production in the long term. This effect was inversely related to the reperfusion values immediately after Torsion repair. This suggests that reperfusion/oxidative stress may play a role in Leydig cell dysfunction, as well as by acting directly in germ cell apoptosis.
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spermatic cord Torsion loss of spermatogenesis despite return of blood flow
Biology of Reproduction, 1993Co-Authors: Terry T Turner, K J BrownAbstract:Previous work in animal models has recapitulated and refined the clinical observation that longer periods of testicular Torsion are associated within increased damage to the testis. Minimum times of damage-inducing Torsion have not been established, however, nor has it been established to what degree blood flow returns to the testis on examination several hours or days after the Torsion repair. Adult male rats were subjected to 0.5-h or 1.0-h 7200 Torsion and examined for effects on testis weight, histology, and daily sperm production (DSP). None of the parameters examined were affected by 0.5-h, but all were affected by 1.0-h Torsion. In a subsequent experiment, adult rats were subjected to unilateral, I-h, 7200 Torsion, and bilateral testicular blood flow as measured by radiolabeled microsphere distribution was determined during Torsion and 4 h, 24 h, 2 days, 7 days, 15 days, and 30 days after repair of Torsion. Ipsilateral testicular blood flow was reduced 94% during Torsion. Blood flow was not significantly different from control or contralateral values by 4 or 24 h after repair of Torsion. In spite of this return of blood flow, testis weights were significantly reduced by half by 7 days after Torsion repair and spermatogenesis was clearly disrupted upon histological examination 30 days after Torsion repair. Increasing the time of Torsion to 2 or 4 h did not inhibit return of blood flow to the testis as measured 48 h after Torsion repair. Unless the testis is infarcted, testicular blood flow in the rat model returns to normal after Torsion repair. It is speculated that testicular injury occurs at or before initial reperfusion, and experiments are underway to determine specific cell responses to graded periods of Torsion. Contralateral testes were not altered by ipsilateral Torsion.
H A Kadish - One of the best experts on this subject based on the ideXlab platform.
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a retrospective review of pediatric patients with epididymitis testicular Torsion and Torsion of testicular appendages
Pediatrics, 1998Co-Authors: H A Kadish, R G BolteAbstract:Study Objective. To compare historical features, physical examination findings, and testicular color Doppler ultrasound in pediatric patients with epididymitis, testicular Torsion, and Torsion of appendix testis. Methods. A retrospective review of patients with the diagnosis of epididymitis, testicular Torsion, or Torsion of appendix testis. Results. Ninety patients were included in the study (64 with epididymitis, 13 with testicular Torsion, and 13 with Torsion of appendix testis). Historical features did not differ among groups except for duration of symptoms. Of 13 patients with testicular Torsion all had a tender testicle and an absent cremasteric reflex. When compared with the testicular Torsion group, fewer patients with epididymitis had a tender testicle (69%) or an absent cremasteric reflex (14%). 62 (97%) patients with epididymitis had a tender epididymis and 43 (67%) had scrotal erythema/edema. By comparison, 3 (23%) and 5 (38%) patients with testicular Torsion had a tender epididymis or scrotal erythema/edema, respectively. Doppler ultrasound showed decreased or absent blood flow in 8 patients, 7 of whom were diagnosed with testicular Torsion. Ten out of 13 patients with testicular Torsion had a salvageable testicle at the time of surgery. Conclusion. The physical examination is helpful in distinguishing among epididymitis, testicular Torsion, and Torsion of appendix testis. Patients presenting with a tender testicle and an absent cremasteric reflex were more likely to have a testicular Torsion rather than epididymitis or Torsion of appendix testis. An absent cremasteric reflex was the most sensitive physical finding for diagnosing testicular Torsion. Color Doppler ultrasound is a useful adjunct in the evaluation of the acute scrotum when physical findings are equivocal.
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A retrospective review of pediatric patients with epididymitis, testicular Torsion, and Torsion of testicular appendages.
Pediatrics, 1998Co-Authors: H A Kadish, R G BolteAbstract:To compare historical features, physical examination findings, and testicular color Doppler ultrasound in pediatric patients with epididymitis, testicular Torsion, and Torsion of appendix testis. A retrospective review of patients with the diagnosis of epididymitis, testicular Torsion, or Torsion of appendix testis. Ninety patients were included in the study (64 with epididymitis, 13 with testicular Torsion, and 13 with Torsion of appendix testis). Historical features did not differ among groups except for duration of symptoms. Of 13 patients with testicular Torsion all had a tender testicle and an absent cremasteric reflex. When compared with the testicular Torsion group, fewer patients with epididymitis had a tender testicle (69%) or an absent cremasteric reflex (14%). 62 (97%) patients with epididymitis had a tender epididymis and 43 (67%) had scrotal erythema/edema. By comparison, 3 (23%) and 5 (38%) patients with testicular Torsion had a tender epididymis or scrotal erythema/edema, respectively. Doppler ultrasound showed decreased or absent blood flow in 8 patients, 7 of whom were diagnosed with testicular Torsion. Ten out of 13 patients with testicular Torsion had a salvageable testicle at the time of surgery. The physical examination is helpful in distinguishing among epididymitis, testicular Torsion, and Torsion of appendix testis. Patients presenting with a tender testicle and an absent cremasteric reflex were more likely to have a testicular Torsion rather than epididymitis or Torsion of appendix testis. An absent cremasteric reflex was the most sensitive physical finding for diagnosing testicular Torsion. Color Doppler ultrasound is a useful adjunct in the evaluation of the acute scrotum when physical findings are equivocal.
Tarmono Djojodimedjo - One of the best experts on this subject based on the ideXlab platform.
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the effect of dexamethasone on spermatogonium and sertoli cell of ipsilateral testis in unilateral testicular Torsion wistar rat
Indonesian Journal of Urology, 2018Co-Authors: Ferdyan Rachmat Efendi, Johan Renaldo, Tarmono DjojodimedjoAbstract:Objective: To investigate the effect of dexamethasone on spermatogonium and sertoli cell of ipsilateral testis in unilateral testicular Torsion strain wistar rat. Material & Method : Experimental study with post-test only control group design. The present study was conducted on 30 Wistar male rats aged 10 – 12 weeks grouped into 5 groups. Group I was the normal/sham operation group (KN), group II was left testicular Torsion for 4 hours group and followed by manual deTorsion (K1), group III was left testicular Torsion for 10 hours group and followed by manual deTorsion (K2), group IV was left testicular Torsion for 4 hours group and given dexamethasone 10 mg/kg body weight subcutaneously 30 minutes before manual eTorsion (D1), and group V was left testicular Torsion for 10 hours group and given dexamethasone 10 mg/kg body weight subcutaneously 30 minutes before manual deTorsion. All rats had left orchidectomy 4 hours after deTorsion. The number of spermatogonium and sertoli cells were counted in histological seminiferous tubular testis that have obtained Haematoxylin Eosin staining . Data were analyzed by ANNOVA followed by Post Hoc Tukey for spermatogonium and Kruskal Wallis followed by Mann Whitney test for sertoli cell. Differences were considered significant at p <0.05. Results: There was significant difference in the mean number of spermatogonium between K1 & D1 group. Otherwise, there was no significant difference in the mean number of spermatogonium between K2 & D2. There was significant difference in the mean number of Sertoli cells between K1 & D1 group, likewise that between K2 & D2 group . Conclusion: These results suggest that dexamethasone has protective effect in spermatogonium and sertoli cell in testicular Torsion for 4 hours.
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THE EFFECT OF DEXAMETHASONE ON SPERMATOGONIUM AND SERTOLI CELL OF IPSILATERAL TESTIS IN UNILATERAL TESTICULAR Torsion WISTAR RAT
Indonesian Journal of Urology, 2018Co-Authors: Ferdyan Rachmat Efendi, Johan Renaldo, Tarmono DjojodimedjoAbstract:Objective: To investigate the effect of dexamethasone on spermatogonium and sertoli cell of ipsilateral testis in unilateral testicular Torsion strain wistar rat. Material & Method : Experimental study with post-test only control group design. The present study was conducted on 30 Wistar male rats aged 10 – 12 weeks grouped into 5 groups. Group I was the normal/sham operation group (KN), group II was left testicular Torsion for 4 hours group and followed by manual deTorsion (K1), group III was left testicular Torsion for 10 hours group and followed by manual deTorsion (K2), group IV was left testicular Torsion for 4 hours group and given dexamethasone 10 mg/kg body weight subcutaneously 30 minutes before manual eTorsion (D1), and group V was left testicular Torsion for 10 hours group and given dexamethasone 10 mg/kg body weight subcutaneously 30 minutes before manual deTorsion. All rats had left orchidectomy 4 hours after deTorsion. The number of spermatogonium and sertoli cells were counted in histological seminiferous tubular testis that have obtained Haematoxylin Eosin staining . Data were analyzed by ANNOVA followed by Post Hoc Tukey for spermatogonium and Kruskal Wallis followed by Mann Whitney test for sertoli cell. Differences were considered significant at p
Ferdyan Rachmat Efendi - One of the best experts on this subject based on the ideXlab platform.
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the effect of dexamethasone on spermatogonium and sertoli cell of ipsilateral testis in unilateral testicular Torsion wistar rat
Indonesian Journal of Urology, 2018Co-Authors: Ferdyan Rachmat Efendi, Johan Renaldo, Tarmono DjojodimedjoAbstract:Objective: To investigate the effect of dexamethasone on spermatogonium and sertoli cell of ipsilateral testis in unilateral testicular Torsion strain wistar rat. Material & Method : Experimental study with post-test only control group design. The present study was conducted on 30 Wistar male rats aged 10 – 12 weeks grouped into 5 groups. Group I was the normal/sham operation group (KN), group II was left testicular Torsion for 4 hours group and followed by manual deTorsion (K1), group III was left testicular Torsion for 10 hours group and followed by manual deTorsion (K2), group IV was left testicular Torsion for 4 hours group and given dexamethasone 10 mg/kg body weight subcutaneously 30 minutes before manual eTorsion (D1), and group V was left testicular Torsion for 10 hours group and given dexamethasone 10 mg/kg body weight subcutaneously 30 minutes before manual deTorsion. All rats had left orchidectomy 4 hours after deTorsion. The number of spermatogonium and sertoli cells were counted in histological seminiferous tubular testis that have obtained Haematoxylin Eosin staining . Data were analyzed by ANNOVA followed by Post Hoc Tukey for spermatogonium and Kruskal Wallis followed by Mann Whitney test for sertoli cell. Differences were considered significant at p <0.05. Results: There was significant difference in the mean number of spermatogonium between K1 & D1 group. Otherwise, there was no significant difference in the mean number of spermatogonium between K2 & D2. There was significant difference in the mean number of Sertoli cells between K1 & D1 group, likewise that between K2 & D2 group . Conclusion: These results suggest that dexamethasone has protective effect in spermatogonium and sertoli cell in testicular Torsion for 4 hours.
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THE EFFECT OF DEXAMETHASONE ON SPERMATOGONIUM AND SERTOLI CELL OF IPSILATERAL TESTIS IN UNILATERAL TESTICULAR Torsion WISTAR RAT
Indonesian Journal of Urology, 2018Co-Authors: Ferdyan Rachmat Efendi, Johan Renaldo, Tarmono DjojodimedjoAbstract:Objective: To investigate the effect of dexamethasone on spermatogonium and sertoli cell of ipsilateral testis in unilateral testicular Torsion strain wistar rat. Material & Method : Experimental study with post-test only control group design. The present study was conducted on 30 Wistar male rats aged 10 – 12 weeks grouped into 5 groups. Group I was the normal/sham operation group (KN), group II was left testicular Torsion for 4 hours group and followed by manual deTorsion (K1), group III was left testicular Torsion for 10 hours group and followed by manual deTorsion (K2), group IV was left testicular Torsion for 4 hours group and given dexamethasone 10 mg/kg body weight subcutaneously 30 minutes before manual eTorsion (D1), and group V was left testicular Torsion for 10 hours group and given dexamethasone 10 mg/kg body weight subcutaneously 30 minutes before manual deTorsion. All rats had left orchidectomy 4 hours after deTorsion. The number of spermatogonium and sertoli cells were counted in histological seminiferous tubular testis that have obtained Haematoxylin Eosin staining . Data were analyzed by ANNOVA followed by Post Hoc Tukey for spermatogonium and Kruskal Wallis followed by Mann Whitney test for sertoli cell. Differences were considered significant at p
