The Experts below are selected from a list of 300 Experts worldwide ranked by ideXlab platform
Christophe Staub - One of the best experts on this subject based on the ideXlab platform.
-
Anatomy and Physiology of the Male Reproductive System and Potential Targets of Toxicants
Comprehensive Toxicology, 2018Co-Authors: N.h. Ing, L. Johnson, K.o. Curley, T.h. Welsh, Christophe StaubAbstract:Toxicology of Reproductive and Endocrine SystemThis introductory chapter offers a basic overview of male reproduction, specifically the anatomy and physiology of the male Reproductive System. Comprehension of normal anatomy and physiology is necessary to (1) fully understand the severity of toxicant-induced damage to structures and/or functions of the male Reproductive System, (2) design more powerful experiments that analyze potential male Reproductive toxicants, and (3) identify numerous potential targets of toxicants in the male Reproductive System. This chapter begins with an overview of the hypothalamic-pituitary-testicular axis and its interaction with additional components of the male Reproductive System. This is then followed by detailed presentation of the composition of the testis and the interrelationships of the testicular cells, spermatogenesis, the excurrent ducts that carry spermatozoa out of the testis, the accessory sex glands that supply the seminal plasma of semen, the cellular communication within the testis, the Reproductive tract's development, and normal male sexual behavior. The chapter's conclusion emphasizes the foundational importance of the male Reproductive System to desgining, conducting, and interpreting Reproductive toxicology research
-
Anatomy and physiology of the male Reproductive System and potential targets of toxicants
2015Co-Authors: L. Johnson, N.h. Ing, K.o. Curley, J. Graham, T.h. Welsh, Christophe StaubAbstract:This introductory chapter offers a basic overview of male reproduction, specifically the anatomy and physiology of the male Reproductive System. Comprehension of normal anatomy and physiology is necessary to (1) fully understand the severity of toxicant-induced damage to structures and/or functions of the male Reproductive System, (2) design more powerful experiments that analyze potential male Reproductive toxicants, and (3) identify numerous potential targets of toxicants in the male Reproductive System. This chapter begins with an overview of the hypothalamic-pituitary-testicular axis and its interaction with additional components of the male Reproductive System. This is then followed by detailed presentation of the composition of the testis and the interrelationships of the testicular cells, spermatogenesis, the excurrent ducts that carry spermatozoa out of the testis, the accessory sex glands that supply the seminal plasma of semen, the cellular communication within the testis, the Reproductive tract's development, and normal male sexual behavior. The chapter's conclusion emphasizes the foundational importance of the male Reproductive System to desgining, conducting, and interpreting Reproductive toxicology research.
Takayuki Shibamoto - One of the best experts on this subject based on the ideXlab platform.
-
Effect of nanoparticles on the male Reproductive System of mice.
International journal of andrology, 2008Co-Authors: Seiichi Yoshida, Kyoko Hiyoshi, Takamichi Ichinose, Hirohisa Takano, Shigeru Oshio, Isamu Sugawara, Ken Takeda, Takayuki ShibamotoAbstract:The effects of nanoparticles toward on the male Reproductive System of mice were investigated. Three sizes (14, 56 and 95 nm) of carbon black nanoparticles were intratracheally administered (0.1 mg/mouse for 10 times every week) to ICR male mice to investigate their adverse effects on the Reproductive function. The serum testosterone levels were elevated significantly in the 14- and 56-nm carbon nanoparticles-exposed groups. Histological examination showed partial vacuolation of the seminiferous tubules. In addition, the effects of particle number towards the male Reproductive System were investigated. The particle number controlled 14-nm nanoparticles-exposed group (14 N group, which has approximately the same particle number per unit volume as the 56-nm nanoparticles) showed fewer effects than did the 56-nm nanoparticles-exposed groups. These results suggest that carbon nanoparticle-exposure has adverse effects on the mouse male Reproductive function. Furthermore, the effects of nanoparticles on the male Reproductive System depend on particle mass rather than particle number.
N.h. Ing - One of the best experts on this subject based on the ideXlab platform.
-
Anatomy and Physiology of the Male Reproductive System and Potential Targets of Toxicants
Comprehensive Toxicology, 2018Co-Authors: N.h. Ing, L. Johnson, K.o. Curley, T.h. Welsh, Christophe StaubAbstract:Toxicology of Reproductive and Endocrine SystemThis introductory chapter offers a basic overview of male reproduction, specifically the anatomy and physiology of the male Reproductive System. Comprehension of normal anatomy and physiology is necessary to (1) fully understand the severity of toxicant-induced damage to structures and/or functions of the male Reproductive System, (2) design more powerful experiments that analyze potential male Reproductive toxicants, and (3) identify numerous potential targets of toxicants in the male Reproductive System. This chapter begins with an overview of the hypothalamic-pituitary-testicular axis and its interaction with additional components of the male Reproductive System. This is then followed by detailed presentation of the composition of the testis and the interrelationships of the testicular cells, spermatogenesis, the excurrent ducts that carry spermatozoa out of the testis, the accessory sex glands that supply the seminal plasma of semen, the cellular communication within the testis, the Reproductive tract's development, and normal male sexual behavior. The chapter's conclusion emphasizes the foundational importance of the male Reproductive System to desgining, conducting, and interpreting Reproductive toxicology research
-
Anatomy and physiology of the male Reproductive System and potential targets of toxicants
2015Co-Authors: L. Johnson, N.h. Ing, K.o. Curley, J. Graham, T.h. Welsh, Christophe StaubAbstract:This introductory chapter offers a basic overview of male reproduction, specifically the anatomy and physiology of the male Reproductive System. Comprehension of normal anatomy and physiology is necessary to (1) fully understand the severity of toxicant-induced damage to structures and/or functions of the male Reproductive System, (2) design more powerful experiments that analyze potential male Reproductive toxicants, and (3) identify numerous potential targets of toxicants in the male Reproductive System. This chapter begins with an overview of the hypothalamic-pituitary-testicular axis and its interaction with additional components of the male Reproductive System. This is then followed by detailed presentation of the composition of the testis and the interrelationships of the testicular cells, spermatogenesis, the excurrent ducts that carry spermatozoa out of the testis, the accessory sex glands that supply the seminal plasma of semen, the cellular communication within the testis, the Reproductive tract's development, and normal male sexual behavior. The chapter's conclusion emphasizes the foundational importance of the male Reproductive System to desgining, conducting, and interpreting Reproductive toxicology research.
Elisabete Weiderpass - One of the best experts on this subject based on the ideXlab platform.
-
malignant tumors of the female Reproductive System
Safety and health at work, 2012Co-Authors: Elisabete WeiderpassAbstract:This review summarizes the epidemiology of cancer of the female Reproductive System and associated lifestyle factors. It also assesses the available evidence for occupational factors associated with these cancers. Cervical, endometrial, and ovarian cancers are relatively common, and cause significant cancer morbidity and mortality worldwide, whereas vulvar, vaginal, fallopian tube cancers, and choriocarcinomas are very rare. As several lifestyle factors are known to play a major role in the etiology of these cancers, very few published studies have investigated possible relationships with occupational factors. Some occupational exposures have been associated with increased risks of these cancers, but apart from the available evidence on the relationships between asbestos fibers and ovarian cancer, and tetrachloroethylene and cervical cancer, the data is rather scarce. Given the multifactorial nature of cancers of the female Reproductive System, it is of the utmost importance to conduct occupational studies that will gather detailed data on potential individual confounding factors, in particular Reproductive history and other factors that influence the body's hormonal environment, together with information on socio-economic status and lifestyle factors, including physical activity from multiple sources. Studies on the mechanisms of carcinogenesis in the female Reproductive organs are also needed in order to elucidate the possible role of chemical exposures in the development of these cancers.
Seiichi Yoshida - One of the best experts on this subject based on the ideXlab platform.
-
Effect of nanoparticles on the male Reproductive System of mice.
International journal of andrology, 2008Co-Authors: Seiichi Yoshida, Kyoko Hiyoshi, Takamichi Ichinose, Hirohisa Takano, Shigeru Oshio, Isamu Sugawara, Ken Takeda, Takayuki ShibamotoAbstract:The effects of nanoparticles toward on the male Reproductive System of mice were investigated. Three sizes (14, 56 and 95 nm) of carbon black nanoparticles were intratracheally administered (0.1 mg/mouse for 10 times every week) to ICR male mice to investigate their adverse effects on the Reproductive function. The serum testosterone levels were elevated significantly in the 14- and 56-nm carbon nanoparticles-exposed groups. Histological examination showed partial vacuolation of the seminiferous tubules. In addition, the effects of particle number towards the male Reproductive System were investigated. The particle number controlled 14-nm nanoparticles-exposed group (14 N group, which has approximately the same particle number per unit volume as the 56-nm nanoparticles) showed fewer effects than did the 56-nm nanoparticles-exposed groups. These results suggest that carbon nanoparticle-exposure has adverse effects on the mouse male Reproductive function. Furthermore, the effects of nanoparticles on the male Reproductive System depend on particle mass rather than particle number.
