The Experts below are selected from a list of 6225 Experts worldwide ranked by ideXlab platform
Katherine L Kahn - One of the best experts on this subject based on the ideXlab platform.
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reengineering the clinical Research Enterprise to involve more community clinicians
Implementation Science, 2011Co-Authors: Gery W Ryan, Elaine Quiter, Claude Berrebi, Megan K Beckett, Stephanie L Taylor, Harold Alan Pincus, Katherine L KahnAbstract:Background: The National Institutes of Health has called for expansion of practice-based Research to improve the clinical Research Enterprise. Methods: This paper presents a model for the reorganization of clinical Research to foster long-term participation by community clinicians. Based on the literature and interviews with clinicians and other stakeholders, we posited a model, conducted further interviews to test the viability of the model, and further adapted it. Results: We propose a three-dimensional system of checks and balances to support community clinicians using Research support organizations, community outreach, a web-based registry of clinicians and studies, web-based training services, quality audits, and a feedback mechanism for clinicians engaged in Research. Conclusions: The proposed model is designed to offer a systemic mechanism to address current barriers that prevent clinicians from participation in Research. Transparent mechanisms to guarantee the safety of patients and the integrity of the Research Enterprise paired with efficiencies and economies of scale are maintained by centralizing some of the functions. Assigning other responsibilities to more local levels assures flexibility with respect to the size of the clinician networks and the changing needs of Researchers.
Harold Alan Pincus - One of the best experts on this subject based on the ideXlab platform.
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reengineering the clinical Research Enterprise to involve more community clinicians
Implementation Science, 2011Co-Authors: Gery W Ryan, Elaine Quiter, Claude Berrebi, Megan K Beckett, Stephanie L Taylor, Harold Alan Pincus, Katherine L KahnAbstract:Background: The National Institutes of Health has called for expansion of practice-based Research to improve the clinical Research Enterprise. Methods: This paper presents a model for the reorganization of clinical Research to foster long-term participation by community clinicians. Based on the literature and interviews with clinicians and other stakeholders, we posited a model, conducted further interviews to test the viability of the model, and further adapted it. Results: We propose a three-dimensional system of checks and balances to support community clinicians using Research support organizations, community outreach, a web-based registry of clinicians and studies, web-based training services, quality audits, and a feedback mechanism for clinicians engaged in Research. Conclusions: The proposed model is designed to offer a systemic mechanism to address current barriers that prevent clinicians from participation in Research. Transparent mechanisms to guarantee the safety of patients and the integrity of the Research Enterprise paired with efficiencies and economies of scale are maintained by centralizing some of the functions. Assigning other responsibilities to more local levels assures flexibility with respect to the size of the clinician networks and the changing needs of Researchers.
Peter C Johnson - One of the best experts on this subject based on the ideXlab platform.
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reengineering the national clinical and translational Research Enterprise the strategic plan of the national clinical and translational science awards consortium
Academic Medicine, 2010Co-Authors: Steven E Reis, Lars Berglund, Gordon R Bernard, Robert M Califf, Garret A Fitzgerald, Peter C JohnsonAbstract:Advances in human health are dependent on the translation of emerging discoveries in molecular genetics, cellular biology, stem cell Research, and other basic biomedical disciplines into clinically important applications, and on the effective societal deployment of proven applications to clinical practice. Translation of discoveries is a bidirectional process: development of innovative strategies for the prevention, diagnosis, and treatment of human diseases requires that observations from patient-oriented, community-based, and public health Research inform experiments in basic science laboratories. However, the conduct of bidirectional translational Research is becoming more challenging because of the increasing complexities of both the basic and clinical sciences and the regulatory requirements for study conduct and marketing approval. In addition, a myriad of barriers to translational Research have arisen, including the structural organization of traditional academic health centers, academic cultural impediments to collaboration, a shortage of translational investigators, the absence of mechanisms to facilitate translational Research, and inadequate financial support.1 The National Institutes of Health (NIH) catalyzed an effort to overcome these barriers on a national level in 2006 by creating the Clinical and Translational Science Awards (CTSA) program, which aims to develop and support the new discipline of “clinical and translational science.”2–4 During the third year of the program, the National CTSA Consortium embarked on the development and implementation of a comprehensive strategic plan focused on an agenda that is best addressed in a national unified manner through the Consortium rather than at the local level at individual CTSA sites. In this article, we report the process and methods that were used, beginning in 2008, to develop the CTSA Consortium’s strategic plan, which will serve as the roadmap for the reengineering of the national translational Research Enterprise.
Robert M Califf - One of the best experts on this subject based on the ideXlab platform.
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american industry and the u s cardiovascular clinical Research Enterprise an appropriate analogy
Journal of the American College of Cardiology, 2011Co-Authors: Robert M Califf, Robert A HarringtonAbstract:The report by Kim et al. ([1][1]) in this issue of the Journal documents the increasingly widespread phenomenon of the “offshoring” of clinical Research—in this case, clinical trials conducted in foreign countries despite being funded by U.S. taxpayers, administered through grants and
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reengineering the national clinical and translational Research Enterprise the strategic plan of the national clinical and translational science awards consortium
Academic Medicine, 2010Co-Authors: Steven E Reis, Lars Berglund, Gordon R Bernard, Robert M Califf, Garret A Fitzgerald, Peter C JohnsonAbstract:Advances in human health are dependent on the translation of emerging discoveries in molecular genetics, cellular biology, stem cell Research, and other basic biomedical disciplines into clinically important applications, and on the effective societal deployment of proven applications to clinical practice. Translation of discoveries is a bidirectional process: development of innovative strategies for the prevention, diagnosis, and treatment of human diseases requires that observations from patient-oriented, community-based, and public health Research inform experiments in basic science laboratories. However, the conduct of bidirectional translational Research is becoming more challenging because of the increasing complexities of both the basic and clinical sciences and the regulatory requirements for study conduct and marketing approval. In addition, a myriad of barriers to translational Research have arisen, including the structural organization of traditional academic health centers, academic cultural impediments to collaboration, a shortage of translational investigators, the absence of mechanisms to facilitate translational Research, and inadequate financial support.1 The National Institutes of Health (NIH) catalyzed an effort to overcome these barriers on a national level in 2006 by creating the Clinical and Translational Science Awards (CTSA) program, which aims to develop and support the new discipline of “clinical and translational science.”2–4 During the third year of the program, the National CTSA Consortium embarked on the development and implementation of a comprehensive strategic plan focused on an agenda that is best addressed in a national unified manner through the Consortium rather than at the local level at individual CTSA sites. In this article, we report the process and methods that were used, beginning in 2008, to develop the CTSA Consortium’s strategic plan, which will serve as the roadmap for the reengineering of the national translational Research Enterprise.
Nan Lin - One of the best experts on this subject based on the ideXlab platform.
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SOCIAL NETWORKS AND STATUS
Annual Review of Sociology, 1999Co-Authors: Nan LinAbstract:This essay traces the development of the Research Enterprise, known as the social resources theory, which formulated and tested a number of proposi- tions concerning the relationships between embedded resources in social networks and socioeconomic attainment. This Enterprise, seen in the light of social capital, has accumulated a substantial body of Research literature and status attainment supported the proposition that social capital, in terms of both access and mo- bilization of embedded resources, enhances the chances of attaining better statuses. Further, social capital is contingent on initial positions in the social hierarchies as well as on extensity of social ties. The essay concludes with a discussion of remaining critical issues and future Research directions for this Research Enterprise
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Building a Network Theory of Social Capital
Connections, 1999Co-Authors: Nan LinAbstract:In the past two decades, social capital in its various forms and contexts has emerged as one of the most salient concepts in social sciences . While much excitement has been generated, divergent views, perspectives, and expectations have also raised the serious question : is it a fad or does it have enduring qualities that will herald a new intellectual Enterprise? This presentation's purpose is to review social capital as discussed in the literature, identify controversies and debates, consider some critical issues, and propose conceptual and Research strategies in building a theory. I will argue that such a theory and the Research Enterprise must be based on the fundamental understanding that social capital is captured from embedded resources in social networks . Deviations from this understanding in conceptualization and measurement lead to confusion in analyzing causal mechanisms in the macro- and microprocesses. It is precisely these mechanisms and processes, essential for an interactive theory about structure and action, to which social capital promises to make contributions . The paper will begin by exploring the nature of capital and various theories of capital, so that social capital can be properly perceived and located . It will then identify certain controversies which, unless clarified or resolved, will hinder the development of a theory and the Research Enterprise . By considering social capital as assets in networks, the paper will discuss some issues in conceptualizations, measurements, and causal mechanisms (the factors leading to inequality of social capital and the returns following investments in social capital) . A proposed model will follow . The paper will conclude by calling attention to the rise of a new form of social capital, cybernetworks, and briefly suggesting how Research on this topic promises to make important contributions to the Research Enterprise .
