The Experts below are selected from a list of 24 Experts worldwide ranked by ideXlab platform
Joel M Bernstein - One of the best experts on this subject based on the ideXlab platform.
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waldeyer s ring and otitis media the nasopharyngeal tonsil and otitis media
International Journal of Pediatric Otorhinolaryngology, 1999Co-Authors: Joel M BernsteinAbstract:This overview of the relationship between the nasopharyngeal tonsil and otitis media will review three important concepts: (1) Adenoid inflammation leads to inflammatory obstruction of the Eustachian tube; (2) early colonization of the adenoid with the three major bacterial pathogens of otitis media is the most important factor in the early pathogenesis of otitis media; (3) the local immune system in the adenoid particularly specific secretory IgA directed against both viruses and bacterial pathogens are probably genetically controlled and represent the immunological factor in protecting the host against invasion of these agents in the Eustachian tube and middle ear. This overview of the relationship between the adenoid and the development of otitis media emphasizes that nasopharyngeal colonization with the three major middle ear pathogens is among the most important risk factors in the pathogenesis of otitis media. Inasmuch as these pathogens normally reside in the nasopharynges of most healthy children, the factors which trigger development of otitis media need to be carefully evaluated. Among these two triggers are viral infections and upper Respiratory Tract Allergy.
Filiz Sebik - One of the best experts on this subject based on the ideXlab platform.
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eosinophil infiltration of the oesophageal mucosa in patients with pollen Allergy during the season
Clinical & Experimental Allergy, 2005Co-Authors: Kevser Onbasi, Aytul Sin, B Doganavsargil, G F Onder, Serhat Bor, Filiz SebikAbstract:Summary Background The oesophagus is normally devoid of eosinophils. There are some disorders accompanying with eosinophil infiltration. Food Allergy has been reported as a common reason, especially in children but some other studies have also indicated that aeroallergens might have a role in oesophageal eosinophil accumulation. Objective In this study we investigated whether there is any eosinophil recruitment in the oesophagus of pollen-allergic patients who had Respiratory symptoms during the season. Methods Thirty-eight symptomatic patients (allergic rhinitis (AR) with or without asthma) who had sensitization to grass pollen were included in the study during the pollen season. Controls were composed of 25 healthy non-atopics and 24 patients diagnosed as having gastro-oesophageal reflux disease. Reflux was excluded in allergic and non-atopic groups, whereas the presence of Allergy was eliminated in control groups. Gastrointestinal endoscopy was performed in all participants, and biopsy specimens were taken from both the proximal and the distal oesophagus to evaluate eosinophil accumulation. At the same time, blood eosinophil numbers were counted. Results Oesophageal eosinophil accumulation was found in 10 allergic patients (26%) and in five patients (21%) with gastro-oesophageal reflux disease but none of the healthy controls had eosinophils (0%) (P 0.05). Conclusion Our results showed that eosinophil infiltration might be observed in oesophageal tissue of patients with Respiratory Tract Allergy during the symptomatic period. This finding may possibly reflect the systemic and common mucosal aspects of allergic inflammation.
Kevser Onbasi - One of the best experts on this subject based on the ideXlab platform.
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eosinophil infiltration of the oesophageal mucosa in patients with pollen Allergy during the season
Clinical & Experimental Allergy, 2005Co-Authors: Kevser Onbasi, Aytul Sin, B Doganavsargil, G F Onder, Serhat Bor, Filiz SebikAbstract:Summary Background The oesophagus is normally devoid of eosinophils. There are some disorders accompanying with eosinophil infiltration. Food Allergy has been reported as a common reason, especially in children but some other studies have also indicated that aeroallergens might have a role in oesophageal eosinophil accumulation. Objective In this study we investigated whether there is any eosinophil recruitment in the oesophagus of pollen-allergic patients who had Respiratory symptoms during the season. Methods Thirty-eight symptomatic patients (allergic rhinitis (AR) with or without asthma) who had sensitization to grass pollen were included in the study during the pollen season. Controls were composed of 25 healthy non-atopics and 24 patients diagnosed as having gastro-oesophageal reflux disease. Reflux was excluded in allergic and non-atopic groups, whereas the presence of Allergy was eliminated in control groups. Gastrointestinal endoscopy was performed in all participants, and biopsy specimens were taken from both the proximal and the distal oesophagus to evaluate eosinophil accumulation. At the same time, blood eosinophil numbers were counted. Results Oesophageal eosinophil accumulation was found in 10 allergic patients (26%) and in five patients (21%) with gastro-oesophageal reflux disease but none of the healthy controls had eosinophils (0%) (P 0.05). Conclusion Our results showed that eosinophil infiltration might be observed in oesophageal tissue of patients with Respiratory Tract Allergy during the symptomatic period. This finding may possibly reflect the systemic and common mucosal aspects of allergic inflammation.
Serhat Bor - One of the best experts on this subject based on the ideXlab platform.
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eosinophil infiltration of the oesophageal mucosa in patients with pollen Allergy during the season
Clinical & Experimental Allergy, 2005Co-Authors: Kevser Onbasi, Aytul Sin, B Doganavsargil, G F Onder, Serhat Bor, Filiz SebikAbstract:Summary Background The oesophagus is normally devoid of eosinophils. There are some disorders accompanying with eosinophil infiltration. Food Allergy has been reported as a common reason, especially in children but some other studies have also indicated that aeroallergens might have a role in oesophageal eosinophil accumulation. Objective In this study we investigated whether there is any eosinophil recruitment in the oesophagus of pollen-allergic patients who had Respiratory symptoms during the season. Methods Thirty-eight symptomatic patients (allergic rhinitis (AR) with or without asthma) who had sensitization to grass pollen were included in the study during the pollen season. Controls were composed of 25 healthy non-atopics and 24 patients diagnosed as having gastro-oesophageal reflux disease. Reflux was excluded in allergic and non-atopic groups, whereas the presence of Allergy was eliminated in control groups. Gastrointestinal endoscopy was performed in all participants, and biopsy specimens were taken from both the proximal and the distal oesophagus to evaluate eosinophil accumulation. At the same time, blood eosinophil numbers were counted. Results Oesophageal eosinophil accumulation was found in 10 allergic patients (26%) and in five patients (21%) with gastro-oesophageal reflux disease but none of the healthy controls had eosinophils (0%) (P 0.05). Conclusion Our results showed that eosinophil infiltration might be observed in oesophageal tissue of patients with Respiratory Tract Allergy during the symptomatic period. This finding may possibly reflect the systemic and common mucosal aspects of allergic inflammation.
G F Onder - One of the best experts on this subject based on the ideXlab platform.
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eosinophil infiltration of the oesophageal mucosa in patients with pollen Allergy during the season
Clinical & Experimental Allergy, 2005Co-Authors: Kevser Onbasi, Aytul Sin, B Doganavsargil, G F Onder, Serhat Bor, Filiz SebikAbstract:Summary Background The oesophagus is normally devoid of eosinophils. There are some disorders accompanying with eosinophil infiltration. Food Allergy has been reported as a common reason, especially in children but some other studies have also indicated that aeroallergens might have a role in oesophageal eosinophil accumulation. Objective In this study we investigated whether there is any eosinophil recruitment in the oesophagus of pollen-allergic patients who had Respiratory symptoms during the season. Methods Thirty-eight symptomatic patients (allergic rhinitis (AR) with or without asthma) who had sensitization to grass pollen were included in the study during the pollen season. Controls were composed of 25 healthy non-atopics and 24 patients diagnosed as having gastro-oesophageal reflux disease. Reflux was excluded in allergic and non-atopic groups, whereas the presence of Allergy was eliminated in control groups. Gastrointestinal endoscopy was performed in all participants, and biopsy specimens were taken from both the proximal and the distal oesophagus to evaluate eosinophil accumulation. At the same time, blood eosinophil numbers were counted. Results Oesophageal eosinophil accumulation was found in 10 allergic patients (26%) and in five patients (21%) with gastro-oesophageal reflux disease but none of the healthy controls had eosinophils (0%) (P 0.05). Conclusion Our results showed that eosinophil infiltration might be observed in oesophageal tissue of patients with Respiratory Tract Allergy during the symptomatic period. This finding may possibly reflect the systemic and common mucosal aspects of allergic inflammation.