The Experts below are selected from a list of 33 Experts worldwide ranked by ideXlab platform
Y Uno - One of the best experts on this subject based on the ideXlab platform.
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A NOVEL RARE VARIANT R292H IN RTN4R AFFECTS GROWTH CONE FORMATION AND POSSIBLY CONTRIBUTES TO SCHIZOPHRENIA SUSCEPTIBILITY
European Neuropsychopharmacology, 2019Co-Authors: H Kimura, K Ishizuka, C Wang, I Kushima, M Morikawa, Y Uno, Takashi Okada, Toshiya Inanda, Branko Aleksic, Daisuke MoriAbstract:Background RTN4R (Reticulon 4 Receptor) plays an essential role in regulating axonal regeneration and plasticity in the central nervous system through the activation of rho kinase, and is located within chromosome 22q11.2, a region that is known to be a hot-spot for Schizophrenia (SCZ) and Autism Spectrum Disorder (ASD). Recently, rare variants such as Copy Number Variants (CNV) and Single Nucleotide Variants (SNV) have been a focus of research because of their large effect size associated with increased susceptibility to SCZ and ASD and the possibility of elucidating the pathophysiology of mental disorder through functional analysis of the discovered rare variants. Methods In order to discover rare variants with large effect size and to explore their role in the etiopathophysiology of SCZ and ASD, we performed mutation screening of RTN4R coding exons using a sample comprised of 370 SCZ and 192 ASD patients, and association analysis using a large number of unrelated individuals (1716 SCZ, 382 ASD and 4009 controls). Results Through this mutation screening, we discovered four rare (minor allele frequency Discussion This study strengthens the evidence for association between rare variants within RTN4R and SCZ, and may shed light on the molecular mechanisms underlying the neurodevelopmental disorder.
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A novel rare variant R292H in RTN4R affects growth cone formation and possibly contributes to schizophrenia susceptibility
Translational Psychiatry, 2017Co-Authors: H Kimura, Y Fujita, T Kawabata, K Ishizuka, C Wang, Y Iwayama, Y Okahisa, I Kushima, M Morikawa, Y UnoAbstract:Reticulon 4 Receptor (RTN4R) plays an essential role in regulating axonal regeneration and plasticity in the central nervous system through the activation of rho kinase, and is located within chromosome 22q11.2, a region that is known to be a hotspot for schizophrenia (SCZ) and autism spectrum disorder (ASD). Recently, rare variants such as copy-number variants and single-nucleotide variants have been a focus of research because of their large effect size associated with increased susceptibility to SCZ and ASD and the possibility of elucidating the pathophysiology of mental disorder through functional analysis of the discovered rare variants. To discover rare variants with large effect size and to evaluate their role in the etiopathophysiology of SCZ and ASD, we sequenced the RTN4R coding exons with a sample comprising 370 SCZ and 192 ASD patients, and association analysis using a large number of unrelated individuals (1716 SCZ, 382 ASD and 4009 controls). Through this mutation screening, we discovered four rare (minor allele frequency
H Kimura - One of the best experts on this subject based on the ideXlab platform.
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A NOVEL RARE VARIANT R292H IN RTN4R AFFECTS GROWTH CONE FORMATION AND POSSIBLY CONTRIBUTES TO SCHIZOPHRENIA SUSCEPTIBILITY
European Neuropsychopharmacology, 2019Co-Authors: H Kimura, K Ishizuka, C Wang, I Kushima, M Morikawa, Y Uno, Takashi Okada, Toshiya Inanda, Branko Aleksic, Daisuke MoriAbstract:Background RTN4R (Reticulon 4 Receptor) plays an essential role in regulating axonal regeneration and plasticity in the central nervous system through the activation of rho kinase, and is located within chromosome 22q11.2, a region that is known to be a hot-spot for Schizophrenia (SCZ) and Autism Spectrum Disorder (ASD). Recently, rare variants such as Copy Number Variants (CNV) and Single Nucleotide Variants (SNV) have been a focus of research because of their large effect size associated with increased susceptibility to SCZ and ASD and the possibility of elucidating the pathophysiology of mental disorder through functional analysis of the discovered rare variants. Methods In order to discover rare variants with large effect size and to explore their role in the etiopathophysiology of SCZ and ASD, we performed mutation screening of RTN4R coding exons using a sample comprised of 370 SCZ and 192 ASD patients, and association analysis using a large number of unrelated individuals (1716 SCZ, 382 ASD and 4009 controls). Results Through this mutation screening, we discovered four rare (minor allele frequency Discussion This study strengthens the evidence for association between rare variants within RTN4R and SCZ, and may shed light on the molecular mechanisms underlying the neurodevelopmental disorder.
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A novel rare variant R292H in RTN4R affects growth cone formation and possibly contributes to schizophrenia susceptibility
Translational Psychiatry, 2017Co-Authors: H Kimura, Y Fujita, T Kawabata, K Ishizuka, C Wang, Y Iwayama, Y Okahisa, I Kushima, M Morikawa, Y UnoAbstract:Reticulon 4 Receptor (RTN4R) plays an essential role in regulating axonal regeneration and plasticity in the central nervous system through the activation of rho kinase, and is located within chromosome 22q11.2, a region that is known to be a hotspot for schizophrenia (SCZ) and autism spectrum disorder (ASD). Recently, rare variants such as copy-number variants and single-nucleotide variants have been a focus of research because of their large effect size associated with increased susceptibility to SCZ and ASD and the possibility of elucidating the pathophysiology of mental disorder through functional analysis of the discovered rare variants. To discover rare variants with large effect size and to evaluate their role in the etiopathophysiology of SCZ and ASD, we sequenced the RTN4R coding exons with a sample comprising 370 SCZ and 192 ASD patients, and association analysis using a large number of unrelated individuals (1716 SCZ, 382 ASD and 4009 controls). Through this mutation screening, we discovered four rare (minor allele frequency
Daisuke Mori - One of the best experts on this subject based on the ideXlab platform.
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A NOVEL RARE VARIANT R292H IN RTN4R AFFECTS GROWTH CONE FORMATION AND POSSIBLY CONTRIBUTES TO SCHIZOPHRENIA SUSCEPTIBILITY
European Neuropsychopharmacology, 2019Co-Authors: H Kimura, K Ishizuka, C Wang, I Kushima, M Morikawa, Y Uno, Takashi Okada, Toshiya Inanda, Branko Aleksic, Daisuke MoriAbstract:Background RTN4R (Reticulon 4 Receptor) plays an essential role in regulating axonal regeneration and plasticity in the central nervous system through the activation of rho kinase, and is located within chromosome 22q11.2, a region that is known to be a hot-spot for Schizophrenia (SCZ) and Autism Spectrum Disorder (ASD). Recently, rare variants such as Copy Number Variants (CNV) and Single Nucleotide Variants (SNV) have been a focus of research because of their large effect size associated with increased susceptibility to SCZ and ASD and the possibility of elucidating the pathophysiology of mental disorder through functional analysis of the discovered rare variants. Methods In order to discover rare variants with large effect size and to explore their role in the etiopathophysiology of SCZ and ASD, we performed mutation screening of RTN4R coding exons using a sample comprised of 370 SCZ and 192 ASD patients, and association analysis using a large number of unrelated individuals (1716 SCZ, 382 ASD and 4009 controls). Results Through this mutation screening, we discovered four rare (minor allele frequency Discussion This study strengthens the evidence for association between rare variants within RTN4R and SCZ, and may shed light on the molecular mechanisms underlying the neurodevelopmental disorder.
I Kushima - One of the best experts on this subject based on the ideXlab platform.
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A NOVEL RARE VARIANT R292H IN RTN4R AFFECTS GROWTH CONE FORMATION AND POSSIBLY CONTRIBUTES TO SCHIZOPHRENIA SUSCEPTIBILITY
European Neuropsychopharmacology, 2019Co-Authors: H Kimura, K Ishizuka, C Wang, I Kushima, M Morikawa, Y Uno, Takashi Okada, Toshiya Inanda, Branko Aleksic, Daisuke MoriAbstract:Background RTN4R (Reticulon 4 Receptor) plays an essential role in regulating axonal regeneration and plasticity in the central nervous system through the activation of rho kinase, and is located within chromosome 22q11.2, a region that is known to be a hot-spot for Schizophrenia (SCZ) and Autism Spectrum Disorder (ASD). Recently, rare variants such as Copy Number Variants (CNV) and Single Nucleotide Variants (SNV) have been a focus of research because of their large effect size associated with increased susceptibility to SCZ and ASD and the possibility of elucidating the pathophysiology of mental disorder through functional analysis of the discovered rare variants. Methods In order to discover rare variants with large effect size and to explore their role in the etiopathophysiology of SCZ and ASD, we performed mutation screening of RTN4R coding exons using a sample comprised of 370 SCZ and 192 ASD patients, and association analysis using a large number of unrelated individuals (1716 SCZ, 382 ASD and 4009 controls). Results Through this mutation screening, we discovered four rare (minor allele frequency Discussion This study strengthens the evidence for association between rare variants within RTN4R and SCZ, and may shed light on the molecular mechanisms underlying the neurodevelopmental disorder.
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A novel rare variant R292H in RTN4R affects growth cone formation and possibly contributes to schizophrenia susceptibility
Translational Psychiatry, 2017Co-Authors: H Kimura, Y Fujita, T Kawabata, K Ishizuka, C Wang, Y Iwayama, Y Okahisa, I Kushima, M Morikawa, Y UnoAbstract:Reticulon 4 Receptor (RTN4R) plays an essential role in regulating axonal regeneration and plasticity in the central nervous system through the activation of rho kinase, and is located within chromosome 22q11.2, a region that is known to be a hotspot for schizophrenia (SCZ) and autism spectrum disorder (ASD). Recently, rare variants such as copy-number variants and single-nucleotide variants have been a focus of research because of their large effect size associated with increased susceptibility to SCZ and ASD and the possibility of elucidating the pathophysiology of mental disorder through functional analysis of the discovered rare variants. To discover rare variants with large effect size and to evaluate their role in the etiopathophysiology of SCZ and ASD, we sequenced the RTN4R coding exons with a sample comprising 370 SCZ and 192 ASD patients, and association analysis using a large number of unrelated individuals (1716 SCZ, 382 ASD and 4009 controls). Through this mutation screening, we discovered four rare (minor allele frequency
K Ishizuka - One of the best experts on this subject based on the ideXlab platform.
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A NOVEL RARE VARIANT R292H IN RTN4R AFFECTS GROWTH CONE FORMATION AND POSSIBLY CONTRIBUTES TO SCHIZOPHRENIA SUSCEPTIBILITY
European Neuropsychopharmacology, 2019Co-Authors: H Kimura, K Ishizuka, C Wang, I Kushima, M Morikawa, Y Uno, Takashi Okada, Toshiya Inanda, Branko Aleksic, Daisuke MoriAbstract:Background RTN4R (Reticulon 4 Receptor) plays an essential role in regulating axonal regeneration and plasticity in the central nervous system through the activation of rho kinase, and is located within chromosome 22q11.2, a region that is known to be a hot-spot for Schizophrenia (SCZ) and Autism Spectrum Disorder (ASD). Recently, rare variants such as Copy Number Variants (CNV) and Single Nucleotide Variants (SNV) have been a focus of research because of their large effect size associated with increased susceptibility to SCZ and ASD and the possibility of elucidating the pathophysiology of mental disorder through functional analysis of the discovered rare variants. Methods In order to discover rare variants with large effect size and to explore their role in the etiopathophysiology of SCZ and ASD, we performed mutation screening of RTN4R coding exons using a sample comprised of 370 SCZ and 192 ASD patients, and association analysis using a large number of unrelated individuals (1716 SCZ, 382 ASD and 4009 controls). Results Through this mutation screening, we discovered four rare (minor allele frequency Discussion This study strengthens the evidence for association between rare variants within RTN4R and SCZ, and may shed light on the molecular mechanisms underlying the neurodevelopmental disorder.
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A novel rare variant R292H in RTN4R affects growth cone formation and possibly contributes to schizophrenia susceptibility
Translational Psychiatry, 2017Co-Authors: H Kimura, Y Fujita, T Kawabata, K Ishizuka, C Wang, Y Iwayama, Y Okahisa, I Kushima, M Morikawa, Y UnoAbstract:Reticulon 4 Receptor (RTN4R) plays an essential role in regulating axonal regeneration and plasticity in the central nervous system through the activation of rho kinase, and is located within chromosome 22q11.2, a region that is known to be a hotspot for schizophrenia (SCZ) and autism spectrum disorder (ASD). Recently, rare variants such as copy-number variants and single-nucleotide variants have been a focus of research because of their large effect size associated with increased susceptibility to SCZ and ASD and the possibility of elucidating the pathophysiology of mental disorder through functional analysis of the discovered rare variants. To discover rare variants with large effect size and to evaluate their role in the etiopathophysiology of SCZ and ASD, we sequenced the RTN4R coding exons with a sample comprising 370 SCZ and 192 ASD patients, and association analysis using a large number of unrelated individuals (1716 SCZ, 382 ASD and 4009 controls). Through this mutation screening, we discovered four rare (minor allele frequency