The Experts below are selected from a list of 12 Experts worldwide ranked by ideXlab platform
Jerry A Shields - One of the best experts on this subject based on the ideXlab platform.
-
optical coherence tomography of choroidal nevus in 120 patients
Retina-the Journal of Retinal and Vitreous Diseases, 2005Co-Authors: Carol L Shields, Arman Mashayekhi, Miguel A Materin, Caesar Kyle Luo, Brian P Marr, Hakan Demirci, Jerry A ShieldsAbstract:Objective To describe the optical coherence tomography (OCT) findings of choroidal nevi. Methods Retrospective, single-center case series of 120 eyes of 120 consecutive patients with choroidal nevi who were evaluated by OCT. Diagnostic imaging was performed with a Zeiss StratusOCT Model 3000 (Carl Zeiss Ophthalmic Systems, Dublin, CA) using scan acquisition protocols of 6 radial lines and Retinal thickness analysis overlying the nevus. Results The mean patient age was 59 years (median, 60 years; range, 14-87 years). The choroidal nevus was a mean of 5.2 mm in basal dimension and 1.7 mm in thickness and was located a mean of 2.7 mm from the optic disk and 2.5 mm from the foveola. Related Retinal findings by ophthalmoscopic evaluation included overlying Retina Edema (3%), subRetinal fluid (16%), Retinal thinning (0%), drusen (58%), and Retinal pigment epithelium (RPE) detachment (2%). In comparison, related Retinal findings at the site of the nevus by OCT included overlying Retina Edema (15%), subRetinal fluid (26%), Retinal thinning (22%), drusen (41%), and RPE detachment (12%). Furthermore, OCT permitted classification of the overlying Retinal Edema as focal cystoid (3%), diffuse cystoid (8%), coalescent cystoid (3%), and noncystoid Edema (1%). By OCT, the overlying Retina was normal thickness (32%), thinned (22%), or thickened (45%), and photoreceptor loss or attenuation was noted in 51% of cases. Specific OCT findings of the choroidal nevus were limited to its anterior surface with minimal penetration into the mass. These findings included increased thickness of the RPE/choriocapillaris layer (68%) and optical qualities within the anterior portion of the nevus of hyporeflectivity (62%), isoreflectivity (29%), and hyperreflectivity (9%). Hyporeflectivity was observed in 68% of pigmented nevi and 18% of nonpigmented nevi. When comparing OCT with clinical examination, OCT was more sensitive in the detection of related Retinal Edema, subRetinal fluid, Retinal thinning, photoreceptor attenuation, and RPE detachment. Conclusions OCT is a useful diagnostic modality for imaging the Retina overlying a choroidal nevus. Numerous overlying changes such as subRetinal fluid, Retinal Edema, Retinal thinning, and photoreceptor attenuation are visible by OCT.
Robert W Flower - One of the best experts on this subject based on the ideXlab platform.
-
role of vasomotion in control of Retina Edema in diabetic retinopathy quantification of fluid transport through Retinal capillaries
ASME 2008 Summer Bioengineering Conference Parts A and B, 2008Co-Authors: Liang Zhu, Robert W FlowerAbstract:Diabetic retinopathy refers to diabetes-related complications in the Retina, It is a progressive disease and its symptoms in the eyes can vary from non-vision threatening to vision loss, and it can lead to permanent damage to the neuronal Retinal tissue. The irreversible nature of the damage suggests that prevention of diabetes by eliminating risk factors and early screening are the cornerstone of relevant treatment to stop or limit visual damage in those patients.Copyright © 2008 by ASME
Carol L Shields - One of the best experts on this subject based on the ideXlab platform.
-
optical coherence tomography of choroidal nevus in 120 patients
Retina-the Journal of Retinal and Vitreous Diseases, 2005Co-Authors: Carol L Shields, Arman Mashayekhi, Miguel A Materin, Caesar Kyle Luo, Brian P Marr, Hakan Demirci, Jerry A ShieldsAbstract:Objective To describe the optical coherence tomography (OCT) findings of choroidal nevi. Methods Retrospective, single-center case series of 120 eyes of 120 consecutive patients with choroidal nevi who were evaluated by OCT. Diagnostic imaging was performed with a Zeiss StratusOCT Model 3000 (Carl Zeiss Ophthalmic Systems, Dublin, CA) using scan acquisition protocols of 6 radial lines and Retinal thickness analysis overlying the nevus. Results The mean patient age was 59 years (median, 60 years; range, 14-87 years). The choroidal nevus was a mean of 5.2 mm in basal dimension and 1.7 mm in thickness and was located a mean of 2.7 mm from the optic disk and 2.5 mm from the foveola. Related Retinal findings by ophthalmoscopic evaluation included overlying Retina Edema (3%), subRetinal fluid (16%), Retinal thinning (0%), drusen (58%), and Retinal pigment epithelium (RPE) detachment (2%). In comparison, related Retinal findings at the site of the nevus by OCT included overlying Retina Edema (15%), subRetinal fluid (26%), Retinal thinning (22%), drusen (41%), and RPE detachment (12%). Furthermore, OCT permitted classification of the overlying Retinal Edema as focal cystoid (3%), diffuse cystoid (8%), coalescent cystoid (3%), and noncystoid Edema (1%). By OCT, the overlying Retina was normal thickness (32%), thinned (22%), or thickened (45%), and photoreceptor loss or attenuation was noted in 51% of cases. Specific OCT findings of the choroidal nevus were limited to its anterior surface with minimal penetration into the mass. These findings included increased thickness of the RPE/choriocapillaris layer (68%) and optical qualities within the anterior portion of the nevus of hyporeflectivity (62%), isoreflectivity (29%), and hyperreflectivity (9%). Hyporeflectivity was observed in 68% of pigmented nevi and 18% of nonpigmented nevi. When comparing OCT with clinical examination, OCT was more sensitive in the detection of related Retinal Edema, subRetinal fluid, Retinal thinning, photoreceptor attenuation, and RPE detachment. Conclusions OCT is a useful diagnostic modality for imaging the Retina overlying a choroidal nevus. Numerous overlying changes such as subRetinal fluid, Retinal Edema, Retinal thinning, and photoreceptor attenuation are visible by OCT.
Edward P Feener - One of the best experts on this subject based on the ideXlab platform.
-
plasma kallikrein mediates vascular endothelial growth factor induced Retinal dysfunction and thickening
Investigative Ophthalmology & Visual Science, 2016Co-Authors: Allen C Clermont, Nivetha Murugesan, Qunfang Zhou, Takeshi Kita, Peter A Robson, Louise J Rushbrooke, Michael D Evans, Lloyd Paul Aiello, Edward P FeenerAbstract:PURPOSE: Plasma kallikrein is a serine protease and circulating component of inflammation, which exerts clinically significant effects on vasogenic Edema. This study examines the role of plasma kallikrein in VEGF-induced Retinal Edema. METHODS: Intravitreal injections of VEGF and saline vehicle were performed in plasma prekallikrein-deficient (KLKB1-/-) and wild-type (WT) mice, and in both rats and mice receiving a selective plasma kallikrein inhibitor, VA999272. Retinal vascular permeability (RVP) and Retinal thickness were measured by Evans blue permeation and optical coherence tomography, respectively. The Retinal kallikrein kinin system was examined by Western blotting and immunohistochemistry. Retinal neovascularization was investigated in KLKB1-/- and WT mice subjected to oxygen-induced retinopathy. RESULTS: Vascular endothelial growth factor-induced RVP and Retinal thickening were reduced in KLKB1-/- mice by 68% and 47%, respectively, compared to VEGF responses in WT mice. Plasma kallikrein also contributes to TNFα-induced Retinal thickening, which was reduced by 52% in KLKB1-/- mice. Systemic administration of VA999272 reduced VEGF-induced Retinal thickening by 57% (P < 0.001) in mice and 53% (P < 0.001) in rats, compared to vehicle-treated controls. Intravitreal injection of VEGF in WT mice increased plasma prekallikrein in the Retina, which was diffusely distributed throughout the inner and outer Retinal layers. Avascular and neovascular areas induced by oxygen-induced retinopathy were similar in WT and KLKB1-/- mice. CONCLUSIONS: Vascular endothelial growth factor increases extravasation of plasma kallikrein into the Retina, and plasma kallikrein is required for the full effects of VEGF on RVP and Retinal thickening in rodents. Systemic plasma kallikrein inhibition may provide a therapeutic opportunity to treat VEGF-induced Retina Edema.
Arman Mashayekhi - One of the best experts on this subject based on the ideXlab platform.
-
optical coherence tomography of choroidal nevus in 120 patients
Retina-the Journal of Retinal and Vitreous Diseases, 2005Co-Authors: Carol L Shields, Arman Mashayekhi, Miguel A Materin, Caesar Kyle Luo, Brian P Marr, Hakan Demirci, Jerry A ShieldsAbstract:Objective To describe the optical coherence tomography (OCT) findings of choroidal nevi. Methods Retrospective, single-center case series of 120 eyes of 120 consecutive patients with choroidal nevi who were evaluated by OCT. Diagnostic imaging was performed with a Zeiss StratusOCT Model 3000 (Carl Zeiss Ophthalmic Systems, Dublin, CA) using scan acquisition protocols of 6 radial lines and Retinal thickness analysis overlying the nevus. Results The mean patient age was 59 years (median, 60 years; range, 14-87 years). The choroidal nevus was a mean of 5.2 mm in basal dimension and 1.7 mm in thickness and was located a mean of 2.7 mm from the optic disk and 2.5 mm from the foveola. Related Retinal findings by ophthalmoscopic evaluation included overlying Retina Edema (3%), subRetinal fluid (16%), Retinal thinning (0%), drusen (58%), and Retinal pigment epithelium (RPE) detachment (2%). In comparison, related Retinal findings at the site of the nevus by OCT included overlying Retina Edema (15%), subRetinal fluid (26%), Retinal thinning (22%), drusen (41%), and RPE detachment (12%). Furthermore, OCT permitted classification of the overlying Retinal Edema as focal cystoid (3%), diffuse cystoid (8%), coalescent cystoid (3%), and noncystoid Edema (1%). By OCT, the overlying Retina was normal thickness (32%), thinned (22%), or thickened (45%), and photoreceptor loss or attenuation was noted in 51% of cases. Specific OCT findings of the choroidal nevus were limited to its anterior surface with minimal penetration into the mass. These findings included increased thickness of the RPE/choriocapillaris layer (68%) and optical qualities within the anterior portion of the nevus of hyporeflectivity (62%), isoreflectivity (29%), and hyperreflectivity (9%). Hyporeflectivity was observed in 68% of pigmented nevi and 18% of nonpigmented nevi. When comparing OCT with clinical examination, OCT was more sensitive in the detection of related Retinal Edema, subRetinal fluid, Retinal thinning, photoreceptor attenuation, and RPE detachment. Conclusions OCT is a useful diagnostic modality for imaging the Retina overlying a choroidal nevus. Numerous overlying changes such as subRetinal fluid, Retinal Edema, Retinal thinning, and photoreceptor attenuation are visible by OCT.