The Experts below are selected from a list of 246 Experts worldwide ranked by ideXlab platform
R. Van Kooy - One of the best experts on this subject based on the ideXlab platform.
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Retrograde Ejaculation: successful treatment with artificial insemination.
Obstetrics and gynecology, 1992Co-Authors: P. J. Q. Van Der Linden, P. M. Nan, E.r. Te Velde, R. Van KooyAbstract:Retrograde Ejaculation is characterized by aspermia or oligospermia and results from an incompetent bladder neck, often due to a dysfunction of the internal sphincter. In almost 3 years, eight couples who suffered from infertility due to Retrograde Ejaculation were treated with inseminations with spermatozoa gained from the urine. Ovulation was predicted on the basis of blood LH levels. The urine-semen sample was collected in 100 mL of Hepes medium and 5 mL 1% human albumin (pH 7.4). After centrifuging, the remaining sperm pellet was dispersed on a Percoll gradient. After centrifuging and resuspending, followed by two washing procedures with Ham's F-10 and human albumin 1%, the remaining sample was used for intrauterine insemination. Twelve pregnancies were thus achieved; two women became pregnant twice and one three times. The pregnancy rate per cycle was 44.4%. In seven couples, pregnancy was achieved within three cycles. Four pregnancies ended in spontaneous abortion and five ended in the birth of a healthy child; three pregnancies were continuing at the time of writing. Retrograde Ejaculation can be treated successfully with inseminations using spermatozoa obtained from urine. It seems important to collect the urine-semen sample in a buffered medium and to time the insemination on the basis of the LH surge.
P. V. Puntala - One of the best experts on this subject based on the ideXlab platform.
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Successful treatment of infertility due to Retrograde Ejaculation by instillation of serum-containing medium into the bladder. A case report.
International journal of andrology, 1991Co-Authors: J. J. O. Suominen, P. P. Kilkku, E. J. Taina, P. V. PuntalaAbstract:Summary The treatment of infertility caused by Retrograde Ejaculation has often been ineffective. The unphysiological composition of the urine is the main reason complicating the recovery of motile sperm. We describe a case of Retrograde Ejaculation caused by a congenital defect of the internal sphinchter muscle of the urinary bladder. In this case, motile sperm were only recovered if the bladder had been filled previously with artificial culture medium (Ham's F-10) supplemented with the patient's own serum. Two pregnancies followed intrauterine insemination with sperm recovered in this way.
Eberhard Nieschlag - One of the best experts on this subject based on the ideXlab platform.
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Imipramine for successful treatment of Retrograde Ejaculation caused by retroperitoneal surgery.
International journal of andrology, 1999Co-Authors: R. Ochsenkühn, A Kamischke, Eberhard NieschlagAbstract:Retrograde Ejaculation is a known complication following retroperitoneal lymph node dissection. Without further therapy, achieving paternity may be impossible. We evaluated the use of the tricyclic antidepressant imipramine in a new ovarian cycle-dependent dose regime for reversal of Retrograde Ejaculation in 11 patients desiring fertility. Ten patients with retroperitoneal lymph node dissection performed because of testicular cancer, and one with aortic surgery (thromboendarterectomy) were treated in an open, uncontrolled study with imipramine given at a daily oral dose increasing from 25 to 50 mg for 7 days prior to the planned Ejaculation or the expected ovulation of the female partner. In all 11 patients, antegrade Ejaculation could be induced (sperm counts: 3.9-276.0 x 10(6)/mL). Major side-effects were not observed, but half of the patients complained of minor degrees of dizziness, weakness, nausea or sweating during medication. Under treatment, two patients with normal sperm concentrations induced a spontaneous pregnancy. One ICSI cycle each was performed in 2 patients, with successful fertilization, out no pregnancy. In conclusion, temporary oral intake of imipramine is an effective and safe treatment to re-establish antegrade Ejaculation in patients with Retrograde Ejaculation following retroperitoneal surgery, thus providing possibilities for paternity either through intercourse or by assisted fertilization.
Sadao Kamidono - One of the best experts on this subject based on the ideXlab platform.
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Pregnancy by insemination of cryopreserved spermatozoa from a man with Retrograde Ejaculation: a case report.
The Journal of reproductive medicine, 2004Co-Authors: Hiroshi Okada, Kazumasa Goda, Mitsunobu Koshida, Sadao KamidonoAbstract:BACKGROUND: Owing to the prevalence of diabetes mellitus, spinal injuries and aggressive surgical treatment of cancer, the number of younger patients with Retrograde Ejaculation is increasing. Since medical treatment to restore antegrade Ejaculation often fails, several options for accomplishing insemination by these patients, including the use of sperm-rich urine obtained after masturbation and in vitro fertilization with sperm retrieved from the seminal tract, have been reported. We used the least invasive and most inexpensive procedure in a patient/couple with this condition. CASE: A 23-year-old man suffered from Retrograde Ejaculation after a spinal injury. He could achieve erection and engage in sexual intercourse but seldom had an orgasm or the sensation of Ejaculation. We obtained spermatozoa from urine produced after masturbation at home and froze them. We used these frozen-thawed spermatozoa for intrauterine insemination, leading to the term birth of a healthy infant. CONCLUSION: In selected patient/couples, frozen spermatozoa obtained from postmasturbation urine can be used successfully for intrauterine insemination. This minimally invasive and most inexpensive procedure should be tried before planning in vitro fertilization.
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TREATMENT OF PATIENTS WITH Retrograde Ejaculation IN THE ERA OF MODERN ASSISTED REPRODUCTION TECHNOLOGY
The Journal of urology, 1998Co-Authors: Hiroshi Okada, Hitoshi Fujioka, Noboru Tatsumi, Masanori Kanzaki, Yoko Inaba, Masato Fujisawa, Kazuo Gohji, Soichi Arakawa, Sadao KamidonoAbstract:AbstractPurpose: We determined a rational strategy for treatment of patients with Retrograde Ejaculation in the era of modern assisted reproduction technology.Materials and Methods: In 7 consecutive patients medical treatment or retrieval of spermatozoa from the bladder was performed at a male infertility clinic.Results: Antegrade Ejaculation was restored in 3 patients, and spermatozoa were retrieved from the bladder and used for assisted reproduction in 3. Spermatozoa with good oolemma penetrating ability were collected by seminal vesicle massage.Conclusions: Modern assisted reproduction technology is a powerful treatment option for Retrograde Ejaculation when combined with a technique to retrieve spermatozoa of good quality from the bladder.
P. J. Q. Van Der Linden - One of the best experts on this subject based on the ideXlab platform.
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Retrograde Ejaculation: successful treatment with artificial insemination.
Obstetrics and gynecology, 1992Co-Authors: P. J. Q. Van Der Linden, P. M. Nan, E.r. Te Velde, R. Van KooyAbstract:Retrograde Ejaculation is characterized by aspermia or oligospermia and results from an incompetent bladder neck, often due to a dysfunction of the internal sphincter. In almost 3 years, eight couples who suffered from infertility due to Retrograde Ejaculation were treated with inseminations with spermatozoa gained from the urine. Ovulation was predicted on the basis of blood LH levels. The urine-semen sample was collected in 100 mL of Hepes medium and 5 mL 1% human albumin (pH 7.4). After centrifuging, the remaining sperm pellet was dispersed on a Percoll gradient. After centrifuging and resuspending, followed by two washing procedures with Ham's F-10 and human albumin 1%, the remaining sample was used for intrauterine insemination. Twelve pregnancies were thus achieved; two women became pregnant twice and one three times. The pregnancy rate per cycle was 44.4%. In seven couples, pregnancy was achieved within three cycles. Four pregnancies ended in spontaneous abortion and five ended in the birth of a healthy child; three pregnancies were continuing at the time of writing. Retrograde Ejaculation can be treated successfully with inseminations using spermatozoa obtained from urine. It seems important to collect the urine-semen sample in a buffered medium and to time the insemination on the basis of the LH surge.
