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Teruhiko Tamaya - One of the best experts on this subject based on the ideXlab platform.

  • Penetration into and exposure of cefozopran in pelvic Retroperitoneal Space exudate
    Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, 2008
    Co-Authors: Kazuro Ikawa, Hiroshige Mikamo, Norifumi Morikawa, Kayo Ikeda, Teruhiko Tamaya
    Abstract:

    This study aimed to examine the penetration into and exposure of cefozopran in the pelvic Retroperitoneal Space exudate of patients undergoing radical hysterectomy and pelvic lymphadenectomy. Cefozopran (1 g) was administered by 1-h infusion after the end of surgery, and venous blood and exudate samples were obtained 0.5, 1, 1.5, 2, 3, 4, 5, 6, and 8 h thereafter. Drug concentrations in serum and the exudate were determined by a bioassay, analyzed pharmacokinetically, and used for a Monte Carlo simulation with minimum inhibitory concentration (MIC) data. The exudate/serum ratio of the area under the drug concentration-time curve was 0.76 ± 0.19 (mean ± SD), and the simulated concentrations were higher in the exudate than in serum after 2.4 h post-dose. The probability of attaining the pharmacodynamic exposure target (70% of the time above the MIC; i.e., probability of target attainment; PTA) was 94.9% and 100%, respectively, against Escherichia coli and Klebsiella species with 1 g every 12 h; however, 1 g every 8 h was required for a PTA value of 90% or more at an MIC of 8 μg/ml. We consider that these results will help clinicians to better understand the penetration into and exposure of cefozopran in the female genital cavity, while also helping to rationalize the dosage of this agent for gynecologicalsurgery infections.

  • Short communication Pharmacokinetics of miconazole in serum and exudate of pelvic Retroperitoneal Space after radical hysterectomy and pelvic lymphadenectomy
    1998
    Co-Authors: Hiroshige Mikamo, Kunihiko Ito, Kyoko Kawazoe, Yasumasa Sato, Teruhiko Tamaya
    Abstract:

    Due to the increased number of compromised hosts with fungal infections, doctors have recently started prescribing antifungal agents. In the field of gynecology, however, the choice of which drug to use has been difficult. The efficacies of these drugs depend on their antifungal spectra, potencies and concentrations in tissues. The present study was designed to investigate the pharmacokinetics of miconazole in the exudate of the Retroperitoneal Space that is formed after radical hysterectomy and pelvic lymphadenectomy. A total of 600 mg of miconazole was administered to the patients for exactly 60 min using an automatic drip-infusion pump. The parameters of the formulas analyzed by the two-compartment model were determined using the least-squares method, and a simulation curve was made. The maximum drug concentration (Cmax) of miconazole in serum was 6.26 mg:l 1 h after drip infusion commencement and the t1:2 in serum was 8.86 h. The value of the area under the time‐serum concentration curve (AUC) in serum was 19.13 mg:h per l. The Cmax of miconazole in the exudate of the Retroperitoneal Space was 0.13 mg:l 2.48 h after the drip infusion was started. The value of AUC in the exudate was 2.52 mg:h per l. © 1998 Elsevier Science B.V.

  • Pharmacokinetics of miconazole in serum and exudate of pelvic Retroperitoneal Space after radical hysterectomy and pelvic lymphadenectomy
    International journal of antimicrobial agents, 1997
    Co-Authors: Hiroshige Mikamo, Kunihiko Ito, Kyoko Kawazoe, Yasumasa Sato, Teruhiko Tamaya
    Abstract:

    Abstract Due to the increased number of compromised hosts with fungal infections, doctors have recently started prescribing antifungal agents. In the field of gynecology, however, the choice of which drug to use has been difficult. The efficacies of these drugs depend on their antifungal spectra, potencies and concentrations in tissues. The present study was designed to investigate the pharmacokinetics of miconazole in the exudate of the Retroperitoneal Space that is formed after radical hysterectomy and pelvic lymphadenectomy. A total of 600 mg of miconazole was administered to the patients for exactly 60 min using an automatic drip-infusion pump. The parameters of the formulas analyzed by the two-compartment model were determined using the least-squares method, and a simulation curve was made. The maximum drug concentration ( C max ) of miconazole in serum was 6.26 mg/l 1 h after drip infusion commencement and the t 1/2 in serum was 8.86 h. The value of the area under the time–serum concentration curve (AUC) in serum was 19.13 mg/h per l. The C max of miconazole in the exudate of the Retroperitoneal Space was 0.13 mg/l 2.48 h after the drip infusion was started. The value of AUC in the exudate was 2.52 mg/h per l.

  • Pharmacokinetics of Fluconazole in the Serum and Exudate of the Pelvic Retroperitoneal Space after Radical Hysterectomy and Pelvic Lymphadenectomy
    Clinical Drug Investigation, 1995
    Co-Authors: Hiroshige Mikamo, Kunihiko Ito, Kyoko Kawazoe, Koji Izumi, Teruhiko Tamaya
    Abstract:

    The use of systemic antifungal agents has increased in recent years, partly as a result of the increasing incidence of compromised hosts. In gynaecology, the decision of which of these drugs to use has been a difficult one. The efficacies of these drugs depend on their antifungal spectra, potencies and tissue concentrations. This study investigated the pharmacokinetics of fluconazole in the serum and exudate of the Retroperitoneal Space that is formed after radical hysterectomy and pelvic lymphadenectomy. Fluconazole 200mg was administered to study patients for exactly 60 minutes using an automatic drip infusion pump. The parameters of the formulae analysed by the 2-compartment model were determined by the least-squares method, and a simulation curve was made. The maximum drug concentration (Cmax) of fluconazole in serum was 6.2 mg/L at 1.0 hour after beginning the drip infusion. The half-life of fluconazole in serum was very long, i.e. 17.7 hours after the start of the drip infusion. The area under the serum concentration-time curve (AUC) was 140.4 µg/ml·h. The Cmax of fluconazole in the exudate of the Retroperitoneal Space was 4.3 mg/L at 4.7 hours after the start of the drip infusion. The AUC in the exudate was 167.5 µg/ml·h. Fluconazole therefore appears to show considerable potential for attaining satisfactory tissue concentrations in the treatment of systemic fungal infections.

  • Drug concentrations in the pelvic Retroperitoneal Space exudate after the combined administration of cephems and astromicin
    Current Therapeutic Research, 1994
    Co-Authors: Hiroshige Mikano, Kunihiko Ito, Kyoko Kawazoe, Koji Izumi, Yoshitaka Yamada, Teruhiko Tamaya
    Abstract:

    Abstract Cephems and aminoglycosides are frequently used incombination to enhance and widen the antibacterial spectrum. In this study, 200 mg of astromicin (ASTM) in combination with either 2 g of cefotaxime (CTX), 1 g of ceftizoxime (CZX), or 1 g of cefbuperazone (CBPZ) were administered to patients with uterine cervical cancer undergoing radical hysterectomy and pelvic lymphadenectomy. Concentrations of the administered drugs were measured in the exudate of pelvic Retroperitoneal Space and serum. Analysis of these concentrations using a twocompartment model showed that the pharmacokinetic parameters of ASTM, CTX, CZX, and CBPZ after combined administration are similar to those determined after administration of each drug individually. In the exudate of the pelvic Retroperitoneal Space, ASTM was detected at concentrations of 4.9 μg/mL or more, while CTX, CZX, and CBPZ were found at 11.1 μg/mL or higher concentrations. These results show that the combination of these drugs is useful for the treatment of infections in the field of obstetrics and gynecology.

Hiroshige Mikamo - One of the best experts on this subject based on the ideXlab platform.

  • Penetration into and exposure of cefozopran in pelvic Retroperitoneal Space exudate
    Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, 2008
    Co-Authors: Kazuro Ikawa, Hiroshige Mikamo, Norifumi Morikawa, Kayo Ikeda, Teruhiko Tamaya
    Abstract:

    This study aimed to examine the penetration into and exposure of cefozopran in the pelvic Retroperitoneal Space exudate of patients undergoing radical hysterectomy and pelvic lymphadenectomy. Cefozopran (1 g) was administered by 1-h infusion after the end of surgery, and venous blood and exudate samples were obtained 0.5, 1, 1.5, 2, 3, 4, 5, 6, and 8 h thereafter. Drug concentrations in serum and the exudate were determined by a bioassay, analyzed pharmacokinetically, and used for a Monte Carlo simulation with minimum inhibitory concentration (MIC) data. The exudate/serum ratio of the area under the drug concentration-time curve was 0.76 ± 0.19 (mean ± SD), and the simulated concentrations were higher in the exudate than in serum after 2.4 h post-dose. The probability of attaining the pharmacodynamic exposure target (70% of the time above the MIC; i.e., probability of target attainment; PTA) was 94.9% and 100%, respectively, against Escherichia coli and Klebsiella species with 1 g every 12 h; however, 1 g every 8 h was required for a PTA value of 90% or more at an MIC of 8 μg/ml. We consider that these results will help clinicians to better understand the penetration into and exposure of cefozopran in the female genital cavity, while also helping to rationalize the dosage of this agent for gynecologicalsurgery infections.

  • Short communication Pharmacokinetics of miconazole in serum and exudate of pelvic Retroperitoneal Space after radical hysterectomy and pelvic lymphadenectomy
    1998
    Co-Authors: Hiroshige Mikamo, Kunihiko Ito, Kyoko Kawazoe, Yasumasa Sato, Teruhiko Tamaya
    Abstract:

    Due to the increased number of compromised hosts with fungal infections, doctors have recently started prescribing antifungal agents. In the field of gynecology, however, the choice of which drug to use has been difficult. The efficacies of these drugs depend on their antifungal spectra, potencies and concentrations in tissues. The present study was designed to investigate the pharmacokinetics of miconazole in the exudate of the Retroperitoneal Space that is formed after radical hysterectomy and pelvic lymphadenectomy. A total of 600 mg of miconazole was administered to the patients for exactly 60 min using an automatic drip-infusion pump. The parameters of the formulas analyzed by the two-compartment model were determined using the least-squares method, and a simulation curve was made. The maximum drug concentration (Cmax) of miconazole in serum was 6.26 mg:l 1 h after drip infusion commencement and the t1:2 in serum was 8.86 h. The value of the area under the time‐serum concentration curve (AUC) in serum was 19.13 mg:h per l. The Cmax of miconazole in the exudate of the Retroperitoneal Space was 0.13 mg:l 2.48 h after the drip infusion was started. The value of AUC in the exudate was 2.52 mg:h per l. © 1998 Elsevier Science B.V.

  • Pharmacokinetics of miconazole in serum and exudate of pelvic Retroperitoneal Space after radical hysterectomy and pelvic lymphadenectomy
    International journal of antimicrobial agents, 1997
    Co-Authors: Hiroshige Mikamo, Kunihiko Ito, Kyoko Kawazoe, Yasumasa Sato, Teruhiko Tamaya
    Abstract:

    Abstract Due to the increased number of compromised hosts with fungal infections, doctors have recently started prescribing antifungal agents. In the field of gynecology, however, the choice of which drug to use has been difficult. The efficacies of these drugs depend on their antifungal spectra, potencies and concentrations in tissues. The present study was designed to investigate the pharmacokinetics of miconazole in the exudate of the Retroperitoneal Space that is formed after radical hysterectomy and pelvic lymphadenectomy. A total of 600 mg of miconazole was administered to the patients for exactly 60 min using an automatic drip-infusion pump. The parameters of the formulas analyzed by the two-compartment model were determined using the least-squares method, and a simulation curve was made. The maximum drug concentration ( C max ) of miconazole in serum was 6.26 mg/l 1 h after drip infusion commencement and the t 1/2 in serum was 8.86 h. The value of the area under the time–serum concentration curve (AUC) in serum was 19.13 mg/h per l. The C max of miconazole in the exudate of the Retroperitoneal Space was 0.13 mg/l 2.48 h after the drip infusion was started. The value of AUC in the exudate was 2.52 mg/h per l.

  • Pharmacokinetics of Fluconazole in the Serum and Exudate of the Pelvic Retroperitoneal Space after Radical Hysterectomy and Pelvic Lymphadenectomy
    Clinical Drug Investigation, 1995
    Co-Authors: Hiroshige Mikamo, Kunihiko Ito, Kyoko Kawazoe, Koji Izumi, Teruhiko Tamaya
    Abstract:

    The use of systemic antifungal agents has increased in recent years, partly as a result of the increasing incidence of compromised hosts. In gynaecology, the decision of which of these drugs to use has been a difficult one. The efficacies of these drugs depend on their antifungal spectra, potencies and tissue concentrations. This study investigated the pharmacokinetics of fluconazole in the serum and exudate of the Retroperitoneal Space that is formed after radical hysterectomy and pelvic lymphadenectomy. Fluconazole 200mg was administered to study patients for exactly 60 minutes using an automatic drip infusion pump. The parameters of the formulae analysed by the 2-compartment model were determined by the least-squares method, and a simulation curve was made. The maximum drug concentration (Cmax) of fluconazole in serum was 6.2 mg/L at 1.0 hour after beginning the drip infusion. The half-life of fluconazole in serum was very long, i.e. 17.7 hours after the start of the drip infusion. The area under the serum concentration-time curve (AUC) was 140.4 µg/ml·h. The Cmax of fluconazole in the exudate of the Retroperitoneal Space was 4.3 mg/L at 4.7 hours after the start of the drip infusion. The AUC in the exudate was 167.5 µg/ml·h. Fluconazole therefore appears to show considerable potential for attaining satisfactory tissue concentrations in the treatment of systemic fungal infections.

  • Drug Concentrations in the Pelvic Retroperitoneal Space Exudate after the Combined Administration of Cephems and Amikacin
    Drug Investigation, 1992
    Co-Authors: Hiroshige Mikamo, Kunihiko Ito, Koji Izumi, Yoshitaka Yamada, Teruhiko Tamaya
    Abstract:

    Cephems and aminoglycosides are frequently used in combination to enhance and widen the antibacterial spectrum. In this study amikacin in combination with either cefotaxime, cefmenoxime, or cefbuperazone were administered to patients with uterine cervical cancer undergoing radical hysterectomy and pelvic lymphadenectomy. Concentrations of the administered drugs were measured in the exudate of the pelvic Retroperitoneal Space and serum. Analysis of these concentrations using a 2-compartment model shows that the pharmacokinetic parameters of amikacin, cefotaxime, cefmenoxime and cefbuperazone after combined administration are similar to those determined after administration of each drug individually.

Kazuo Kaneko - One of the best experts on this subject based on the ideXlab platform.

  • intraoperative ultrasound visualization of paravertebral anatomy in the Retroperitoneal Space during lateral lumbar spine surgery
    Journal of Neurosurgery, 2019
    Co-Authors: Hidetoshi Nojiri, Kei Miyagawa, Hiroto Yamaguchi, Masato Koike, Yoshiyuki Iwase, Takatoshi Okuda, Kazuo Kaneko
    Abstract:

    OBJECTIVE Lumbar surgery via a lateral approach is a minimally invasive and highly useful procedure. However, care must be taken to avoid its potentially fatal complications of intestinal and vascular injuries. The object of this study was to evaluate the usefulness of intraoperative ultrasound in improving the safety of lateral lumbar spine surgery. METHODS A transvaginal ultrasound probe was inserted into the operative field, and the intestinal tract, kidney, psoas muscle, and vertebral body were identified using B-mode ultrasound. The aorta, vena cava, common iliac vessels, and lumbar arteries and their associated branches were identified using the color Doppler mode. RESULTS The study cohort comprised 100 patients who underwent lateral lumbar spine surgery, 92 via a left-sided approach. The intestinal tract and kidney lateral to the psoas muscle on the anatomical approach pathway were visualized in 36 and 26 patients, respectively. A detachment maneuver displaced the intestinal tract and kidneys in an anteroinferior direction, enabling confirmation of the absence of organ tissues above the psoas. In all patients, the major vessels anterior to the vertebral bodies and the lumbar arteries and associated branches in the psoas on the approach path were clearly visualized in the Doppler mode, and their orientation, location, and positional relationship with regard to the vertebral bodies, intervertebral discs, and psoas were determined. CONCLUSIONS When approaching the lateral side of the lumbar spine in the Retroperitoneal Space, intraoperative ultrasound allows real-time identification of the blood vessels surrounding the lumbar spine, intestinal tract, and kidney in the approach path and improves the safety of surgery without increasing invasiveness.

Michał Tkocz - One of the best experts on this subject based on the ideXlab platform.

Kunihiko Ito - One of the best experts on this subject based on the ideXlab platform.

  • Short communication Pharmacokinetics of miconazole in serum and exudate of pelvic Retroperitoneal Space after radical hysterectomy and pelvic lymphadenectomy
    1998
    Co-Authors: Hiroshige Mikamo, Kunihiko Ito, Kyoko Kawazoe, Yasumasa Sato, Teruhiko Tamaya
    Abstract:

    Due to the increased number of compromised hosts with fungal infections, doctors have recently started prescribing antifungal agents. In the field of gynecology, however, the choice of which drug to use has been difficult. The efficacies of these drugs depend on their antifungal spectra, potencies and concentrations in tissues. The present study was designed to investigate the pharmacokinetics of miconazole in the exudate of the Retroperitoneal Space that is formed after radical hysterectomy and pelvic lymphadenectomy. A total of 600 mg of miconazole was administered to the patients for exactly 60 min using an automatic drip-infusion pump. The parameters of the formulas analyzed by the two-compartment model were determined using the least-squares method, and a simulation curve was made. The maximum drug concentration (Cmax) of miconazole in serum was 6.26 mg:l 1 h after drip infusion commencement and the t1:2 in serum was 8.86 h. The value of the area under the time‐serum concentration curve (AUC) in serum was 19.13 mg:h per l. The Cmax of miconazole in the exudate of the Retroperitoneal Space was 0.13 mg:l 2.48 h after the drip infusion was started. The value of AUC in the exudate was 2.52 mg:h per l. © 1998 Elsevier Science B.V.

  • Pharmacokinetics of miconazole in serum and exudate of pelvic Retroperitoneal Space after radical hysterectomy and pelvic lymphadenectomy
    International journal of antimicrobial agents, 1997
    Co-Authors: Hiroshige Mikamo, Kunihiko Ito, Kyoko Kawazoe, Yasumasa Sato, Teruhiko Tamaya
    Abstract:

    Abstract Due to the increased number of compromised hosts with fungal infections, doctors have recently started prescribing antifungal agents. In the field of gynecology, however, the choice of which drug to use has been difficult. The efficacies of these drugs depend on their antifungal spectra, potencies and concentrations in tissues. The present study was designed to investigate the pharmacokinetics of miconazole in the exudate of the Retroperitoneal Space that is formed after radical hysterectomy and pelvic lymphadenectomy. A total of 600 mg of miconazole was administered to the patients for exactly 60 min using an automatic drip-infusion pump. The parameters of the formulas analyzed by the two-compartment model were determined using the least-squares method, and a simulation curve was made. The maximum drug concentration ( C max ) of miconazole in serum was 6.26 mg/l 1 h after drip infusion commencement and the t 1/2 in serum was 8.86 h. The value of the area under the time–serum concentration curve (AUC) in serum was 19.13 mg/h per l. The C max of miconazole in the exudate of the Retroperitoneal Space was 0.13 mg/l 2.48 h after the drip infusion was started. The value of AUC in the exudate was 2.52 mg/h per l.

  • Pharmacokinetics of Fluconazole in the Serum and Exudate of the Pelvic Retroperitoneal Space after Radical Hysterectomy and Pelvic Lymphadenectomy
    Clinical Drug Investigation, 1995
    Co-Authors: Hiroshige Mikamo, Kunihiko Ito, Kyoko Kawazoe, Koji Izumi, Teruhiko Tamaya
    Abstract:

    The use of systemic antifungal agents has increased in recent years, partly as a result of the increasing incidence of compromised hosts. In gynaecology, the decision of which of these drugs to use has been a difficult one. The efficacies of these drugs depend on their antifungal spectra, potencies and tissue concentrations. This study investigated the pharmacokinetics of fluconazole in the serum and exudate of the Retroperitoneal Space that is formed after radical hysterectomy and pelvic lymphadenectomy. Fluconazole 200mg was administered to study patients for exactly 60 minutes using an automatic drip infusion pump. The parameters of the formulae analysed by the 2-compartment model were determined by the least-squares method, and a simulation curve was made. The maximum drug concentration (Cmax) of fluconazole in serum was 6.2 mg/L at 1.0 hour after beginning the drip infusion. The half-life of fluconazole in serum was very long, i.e. 17.7 hours after the start of the drip infusion. The area under the serum concentration-time curve (AUC) was 140.4 µg/ml·h. The Cmax of fluconazole in the exudate of the Retroperitoneal Space was 4.3 mg/L at 4.7 hours after the start of the drip infusion. The AUC in the exudate was 167.5 µg/ml·h. Fluconazole therefore appears to show considerable potential for attaining satisfactory tissue concentrations in the treatment of systemic fungal infections.

  • Drug concentrations in the pelvic Retroperitoneal Space exudate after the combined administration of cephems and astromicin
    Current Therapeutic Research, 1994
    Co-Authors: Hiroshige Mikano, Kunihiko Ito, Kyoko Kawazoe, Koji Izumi, Yoshitaka Yamada, Teruhiko Tamaya
    Abstract:

    Abstract Cephems and aminoglycosides are frequently used incombination to enhance and widen the antibacterial spectrum. In this study, 200 mg of astromicin (ASTM) in combination with either 2 g of cefotaxime (CTX), 1 g of ceftizoxime (CZX), or 1 g of cefbuperazone (CBPZ) were administered to patients with uterine cervical cancer undergoing radical hysterectomy and pelvic lymphadenectomy. Concentrations of the administered drugs were measured in the exudate of pelvic Retroperitoneal Space and serum. Analysis of these concentrations using a twocompartment model showed that the pharmacokinetic parameters of ASTM, CTX, CZX, and CBPZ after combined administration are similar to those determined after administration of each drug individually. In the exudate of the pelvic Retroperitoneal Space, ASTM was detected at concentrations of 4.9 μg/mL or more, while CTX, CZX, and CBPZ were found at 11.1 μg/mL or higher concentrations. These results show that the combination of these drugs is useful for the treatment of infections in the field of obstetrics and gynecology.

  • Drug Concentrations in the Pelvic Retroperitoneal Space Exudate after the Combined Administration of Cephems and Amikacin
    Drug Investigation, 1992
    Co-Authors: Hiroshige Mikamo, Kunihiko Ito, Koji Izumi, Yoshitaka Yamada, Teruhiko Tamaya
    Abstract:

    Cephems and aminoglycosides are frequently used in combination to enhance and widen the antibacterial spectrum. In this study amikacin in combination with either cefotaxime, cefmenoxime, or cefbuperazone were administered to patients with uterine cervical cancer undergoing radical hysterectomy and pelvic lymphadenectomy. Concentrations of the administered drugs were measured in the exudate of the pelvic Retroperitoneal Space and serum. Analysis of these concentrations using a 2-compartment model shows that the pharmacokinetic parameters of amikacin, cefotaxime, cefmenoxime and cefbuperazone after combined administration are similar to those determined after administration of each drug individually.