The Experts below are selected from a list of 125574 Experts worldwide ranked by ideXlab platform
D R Avery - One of the best experts on this subject based on the ideXlab platform.
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comparison of mineral trioxide aggregate and calcium hydroxide as pulpotomy agents in young permanent teeth apexogenesis
Pediatric Dentistry, 2006Co-Authors: O A Elmeligy, D R AveryAbstract:Purpose: The purpose of this study was to compare mineral trioxide aggregate (MTA) with calcium hydroxide (Ca(OH) 2 ) clinically and radiographically as a pulpotomy agent in immature permanent teeth (apexogenesis). Methods: Fifteen children, each with at least 2 immature permanent teeth requiring pulp- otomy (apexogenesis), were selected for this study. All selected teeth were evenly divided into 2 test groups. In group 1, the conventional Ca(OH) 2 pulpotomy (control) was performed, whereas in group 2, the MTA pulpotomy (experimental) was done. The children were recalled for clinical and radiographic evaluations after 3, 6, and 12 months. Results: The follow-up evaluations Revealed Failure due to pain and swelling detected at 6 and 12 months postoperative evaluations in only 2 teeth treated with Ca(OH) 2 . The remaining 28 teeth appeared to be clinically and radiographically successful 12 months postoperatively. Calcific metamorphosis was a radiographic finding in 2 teeth treated with Ca(OH) 2 and 4 teeth treated with MTA. Conclusions: Mineral trioxide aggregate showed clinical and radiographic success as a pulpotomy agent in immature permanent teeth (apexogenesis) and seems to be a suitable alternative to calcium hydroxide. (Pediatr Dent 2006;28:399-404)
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comparison of apexification with mineral trioxide aggregate and calcium hydroxide
Pediatric Dentistry, 2006Co-Authors: O A Elmeligy, D R AveryAbstract:Purpose: The aim of this study was to compare mineral trioxide aggregate (MTA) with calcium hydroxide (Ca(OH)2) clinically and radiographically as materials used to induce root-end closure in necrotic permanent teeth with immature apices (apexification). Methods: Fifteen children, each with at least 2 necrotic permanent teeth requiring root- end closure (apexification), were selected for this study. All selected teeth were evenly divided into 2 test groups. In group 1, the conventional calcium hydroxide apexification (control) was performed, whereas in group 2, the MTA apexification (experimental) was done. The children were recalled for clinical and radiographic evaluations after 3, 6, and 12 months. Results: The follow-up evaluations Revealed Failure due to persistent periradicular inflam- mation and tenderness to percussion detected at 6 and 12 months postoperative evaluation in only 2 teeth treated with Ca(OH)2. The remaining 13 teeth appeared to be clinically and radiographically successful 12 months postoperatively. None of the MTA-treated teeth showed any clinical or radiographic pathology. Conclusions: Mineral trioxide aggregate showed clinical and radiographic success as a ma- terial used to induce root-end closure and is a suitable replacement for calcium hydroxide for the apexification procedure. (Pediatr Dent 2006;28:248-253)
O A Elmeligy - One of the best experts on this subject based on the ideXlab platform.
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comparison of mineral trioxide aggregate and calcium hydroxide as pulpotomy agents in young permanent teeth apexogenesis
Pediatric Dentistry, 2006Co-Authors: O A Elmeligy, D R AveryAbstract:Purpose: The purpose of this study was to compare mineral trioxide aggregate (MTA) with calcium hydroxide (Ca(OH) 2 ) clinically and radiographically as a pulpotomy agent in immature permanent teeth (apexogenesis). Methods: Fifteen children, each with at least 2 immature permanent teeth requiring pulp- otomy (apexogenesis), were selected for this study. All selected teeth were evenly divided into 2 test groups. In group 1, the conventional Ca(OH) 2 pulpotomy (control) was performed, whereas in group 2, the MTA pulpotomy (experimental) was done. The children were recalled for clinical and radiographic evaluations after 3, 6, and 12 months. Results: The follow-up evaluations Revealed Failure due to pain and swelling detected at 6 and 12 months postoperative evaluations in only 2 teeth treated with Ca(OH) 2 . The remaining 28 teeth appeared to be clinically and radiographically successful 12 months postoperatively. Calcific metamorphosis was a radiographic finding in 2 teeth treated with Ca(OH) 2 and 4 teeth treated with MTA. Conclusions: Mineral trioxide aggregate showed clinical and radiographic success as a pulpotomy agent in immature permanent teeth (apexogenesis) and seems to be a suitable alternative to calcium hydroxide. (Pediatr Dent 2006;28:399-404)
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comparison of apexification with mineral trioxide aggregate and calcium hydroxide
Pediatric Dentistry, 2006Co-Authors: O A Elmeligy, D R AveryAbstract:Purpose: The aim of this study was to compare mineral trioxide aggregate (MTA) with calcium hydroxide (Ca(OH)2) clinically and radiographically as materials used to induce root-end closure in necrotic permanent teeth with immature apices (apexification). Methods: Fifteen children, each with at least 2 necrotic permanent teeth requiring root- end closure (apexification), were selected for this study. All selected teeth were evenly divided into 2 test groups. In group 1, the conventional calcium hydroxide apexification (control) was performed, whereas in group 2, the MTA apexification (experimental) was done. The children were recalled for clinical and radiographic evaluations after 3, 6, and 12 months. Results: The follow-up evaluations Revealed Failure due to persistent periradicular inflam- mation and tenderness to percussion detected at 6 and 12 months postoperative evaluation in only 2 teeth treated with Ca(OH)2. The remaining 13 teeth appeared to be clinically and radiographically successful 12 months postoperatively. None of the MTA-treated teeth showed any clinical or radiographic pathology. Conclusions: Mineral trioxide aggregate showed clinical and radiographic success as a ma- terial used to induce root-end closure and is a suitable replacement for calcium hydroxide for the apexification procedure. (Pediatr Dent 2006;28:248-253)
Omar El Meligy - One of the best experts on this subject based on the ideXlab platform.
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comparison of apexification with mineral trioxide aggregate and calcium hydroxide
Pediatric Dentistry, 2006Co-Authors: Omar El MeligyAbstract:Purpose: The aim of this study was to compare mineral trioxide aggregate (MTA) with calcium hydroxide [Ca(OH)2] clinically and radiographically as materials used to induce root-end closure in necrotic permanent teeth with immature apices (apexification). Methods: Fifteen children, each with at least 2 necrotic permanent teeth requiring root-end closure (apexification), were selected for this study. All selected teeth were evenly divided into 2 test groups. In group 1, the conventional calcium hydroxide apexification (control) was performed, whereas in group 2, the MTA apexification (experimental) was done. The children were recalled for clinical and radiographic evaluations after 3, 6, and 12 months. Results: The follow-up evaluations Revealed Failure due to persistent periradicular inflammation and tenderness to percussion detected at 6 and 12 months postoperative evaluation in only 2 teeth treated with Ca(OH)2. The remaining 13 teeth appeared to be clinically and radiographically successful 12 months postoperatively. None of the MTA-treated teeth showed any clinical or radiographic pathology. Conclusions: Mineral trioxide aggregate showed clinical and radiographic success as a material used to induce root-end closure and is a suitable replacement for calcium hydroxide for the apexification procedure.
Henning Madry - One of the best experts on this subject based on the ideXlab platform.
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microfracture for cartilage repair in the knee a systematic review of the contemporary literature
Knee Surgery Sports Traumatology Arthroscopy, 2020Co-Authors: Patrick Orth, Liang Gao, Henning MadryAbstract:To systematically review and evaluate novel clinical data following microfracture treatment of knee articular cartilage defects. A systematic review was performed by searching PubMed, ScienceDirect, and Cochrane Library databases for clinical trials on microfracture treatment, published between 2013 and 2018. Titles, abstracts, and articles were reviewed, and data concerning patient demographics, study design, pre-, intra-, and postoperative findings were extracted. PRISMA guidelines were applied. The methodological quality of the included studies was analyzed by the modified Coleman Methodology Score (CMS), and aggregate data were generated. Eighteen studies including 1830 defects (1759 patients) were included. Of them, 8 (59% of patients) were cohort studies without a comparison group. Overall study quality was moderate (mean total CMS: 64 points), mainly due to low patient numbers, short follow-up periods, lack of control groups and structural repair tissue evaluation, and inhomogeneity in outcome parameters. Microfracture treatment of full-thickness articular cartilage defects (3.4 ± 2.1 cm2) was performed at 43.4 ± 68.0 months of symptom duration. Postoperative assessment at 79.5 ± 27.2 months Revealed Failure rates of 11–27% within 5 years and 6–32% at 10 years. Imaging analysis was conducted in 10 studies, second-look arthroscopies were reported twice (n = 205 patients) and Revealed well integrated fibrocartilaginous repair tissue. Microfracture provides good function and pain relief at the mid-term and clinically largely satisfying results thereafter. Standardized, high-quality future study designs will better refine optimal indications for microfracture in the context of cartilage repair strategies. This systematic review is based on studies with levels of evidence ranging between I and IV (see results section and Table). Therefore, and according to this journals Instructions for Authors (SYSTEMATIC REVIEWS AND META-ANALYSES are assigned a level of evidence equivalent to the lowest level of evidence used from the manuscripts analysed), level of evidence is IV.
Julan Chao - One of the best experts on this subject based on the ideXlab platform.
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an essential role for the dna breakage repair protein ku80 in programmed dna rearrangements in tetrahymena thermophila
Molecular Biology of the Cell, 2012Co-Authors: Julan ChaoAbstract:Programmed DNA rearrangements are important processes present in many organisms. In the ciliated protozoan Tetrahymena thermophila, DNA rearrangements occur during the sexual conjugation process and lead to the deletion of thousands of specific DNA segments and fragmentation of the chromosomes. In this study, we found that the Ku80 homologue, a conserved component of the nonhomologous end-joining process of DNA repair, was essential for these two processes. During conjugation, TKU80 was highly expressed and localized to the new macronucleus, where DNA rearrangements occur. Homokaryon TKU80-knockout mutants are unable to complete conjugation and produce progeny and are arrested at the two-micronuclei/two-macronuclei stage. Analysis of their DNA Revealed Failure to complete DNA deletion. However, the DNA-cutting step appeared to have occurred, as evidenced by the presence of circularized excised DNA. Moreover, chromosome breakage or de novo telomere addition was affected. The mutant appears to accumulate free DNA ends detectable by terminal deoxynucleotidyl transferase dUTP nick end labeling assays that led to the degradation of most DNA in the developing macronucleus. These findings suggest that Tku80p may serve an end-protective role after DNA cleavage has occurred. Unexpectedly, the large heterochromatin structures that normally associate with DNA rearrangements failed to form without TKU80. Together the results suggest multiple roles for Tku80p and indicate that a Ku-dependent DNA-repair pathway is involved in programmed DNA rearrangements in Tetrahymena.