The Experts below are selected from a list of 9456 Experts worldwide ranked by ideXlab platform
Jong Kil Nam - One of the best experts on this subject based on the ideXlab platform.
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Unilateral synchronous papillary renal neoplasm with Reverse Polarity and clear cell renal cell carcinoma: a case report with KRAS and PIK3CA mutations.
Diagnostic pathology, 2020Co-Authors: Hyun Jung Lee, Dong Hoon Shin, Joon Young Park, So Young Kim, Chung Su Hwang, Jung Hee Lee, Jee Yeon Kim, Mee Young Sol, Jong Kil NamAbstract:The presence of histologically different neoplasms in the same organ is rare in pathologic practice. We report the first case of synchronous clear cell renal cell carcinoma (clear cell RCC) and papillary renal neoplasm with Reverse Polarity (PRNRP) with comprehensive immunohistochemical and molecular characterization using next-generation sequencing (NGS). A 61-year-old man was incidentally found to have a left renal mass on imaging studies performed for workup of left back pain and urine color change for 1 week. A laparoscopic left radical nephrectomy was performed. Gross examination showed lobulated masses measuring 5.6 × 4.0 × 3.3 cm in the upper to mid pole and 1.1 × 1.0 × 1.0 cm in the lower pole. Microscopic findings revealed these to be two different separate masses of clear cell renal cell carcinoma and papillary renal neoplasm with Reverse Polarity. NGS analyses revealed KRAS gene mutation (c.35G > T/p.G12V in exon 2) in the papillary renal neoplasm with Reverse Polarity, with PIK3CA gene mutation restricted to the clear cell renal cell carcinoma (c.1624G > A/p.E542K in exon 10). We report here an extraordinarily rare case of synchronous renal tumors of papillary renal neoplasm with Reverse Polarity and clear cell renal cell carcinoma. We identified simultaneous KRAS and PIK3CA mutations in two different renal masses in the same kidney for the first time. New pathologic assessment with comparative molecular analysis of mutational profiles may be helpful for tumor studies.
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Unilateral synchronous papillary renal neoplasm with Reverse Polarity and clear cell renal cell carcinoma: a case report with KRAS and PIK3CA mutations
2020Co-Authors: Hyun Jung Lee, Dong Hoon Shin, Joon Young Park, So Young Kim, Chung Su Hwang, Jung Hee Lee, Jee Yeon Kim, Mee Young Sol, Jong Kil NamAbstract:Abstract Background: The presence of histologically different neoplasms in the same organ is rare in pathologic practice. We report the first case of synchronous clear cell renal cell carcinoma (clear cell RCC) and papillary renal neoplasm with Reverse Polarity (PRNRP) with comprehensive immunohistochemical and molecular characterization using next-generation sequencing (NGS). Case presentation: A 61-year-old man was incidentally found to have a left renal mass on imaging studies performed for workup of left back pain and urine color change for one week. A laparoscopic left radical nephrectomy was performed. Gross examination showed lobulated masses measuring 5.6 × 4.0 × 3.3 cm in the upper to mid pole and 1.1 × 1.0 × 1.0 cm in the lower pole. Microscopic findings revealed these to be two different separate masses of clear cell renal cell carcinoma and papillary renal neoplasm with Reverse Polarity. NGS analyses revealed KRAS gene mutation (c.35G>T/p.G12V in exon 2) in the papillary renal neoplasm with Reverse Polarity, with PIK3CA gene mutation restricted to the clear cell renal cell carcinoma (c.1624G>A/p.E542K in exon 10).Conclusions: We report here an extraordinarily rare case of synchronous renal tumors of papillary renal neoplasm with Reverse Polarity and clear cell renal cell carcinoma. We identified simultaneous KRAS and PIK3CA mutations in two different renal masses in the same kidney for the first time. New pathologic assessment with comparative molecular analysis of mutational profiles may be helpful for tumor studies.
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Unilateral synchronous papillary renal neoplasm with Reverse Polarity and clear cell renal cell carcinoma: a case report with KRAS and PIK3CA mutations
2020Co-Authors: Hyun Jung Lee, Dong Hoon Shin, Joon Young Park, So Young Kim, Chung Su Hwang, Jung Hee Lee, Jee Yeon Kim, Mee Young Sol, Jong Kil NamAbstract:Abstract BackgroundThe presence of histologically different neoplasms in the same organ is rare in pathologic practice. We report multiple synchronous masses of clear cell renal cell carcinoma and papillary renal neoplasm with Reverse Polarity in the same kidney. Herein, we present the first well-explained case with immunohistochemical findings with next-generation sequencing (NGS) analysis. Case presentationA 61-year-old man was incidentally found to have a left renal mass on imaging studies performed for workup of left back pain and urine color change for one week. A laparoscopic left radical nephrectomy was performed. Gross examination showed lobulated masses in the upper to mid pole measuring 5.6 × 4.0 × 3.3 cm and 1.1 × 1.0 × 1.0 cm in the lower pole. Microscopic findings revealed these to be two different separate masses of clear cell renal cell carcinoma and papillary renal neoplasm with Reverse Polarity. NGS analyses revealed KRAS gene mutation (c.35G>T/p.G12V in exon 2) in the papillary renal neoplasm with Reverse Polarity, with an additional PIK3CA gene mutation restricted to the clear cell renal cell carcinoma (c.1624G>A/p.E542K in exon 10).ConclusionsWe report here an extraordinarily rare case of a patient diagnosed with multiple synchronous renal tumors of papillary renal neoplasm with Reverse Polarity and clear cell renal cell carcinoma. We identified simultaneous KRAS and PIK3CA mutations in two different renal masses in the same kidney for the first time. New pathologic assessment with comparative molecular analysis of mutational profiles may be helpful for tumor studies.
Q. Zhou - One of the best experts on this subject based on the ideXlab platform.
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a synchrotron radiation real time in situ imaging study on the Reverse Polarity effect in cu sn 9zn cu interconnect during liquid solid electromigration
Scripta Materialia, 2013Co-Authors: Mingliang Huang, Zhijie Zhang, Ning Zhao, Q. ZhouAbstract:Synchrotron radiation real-time in situ imaging technology was used to study the interfacial reaction in Cu/Sn–9Zn/Cu interconnect during liquid–solid electromigration. The Reverse Polarity effect, evidenced by the IMC layer at the cathode growing continuously while that at the anode was restrained, resulted from the directional migration of Zn atoms toward the cathode under electron current stressing, which is induced by the positive effective charge number of Zn atoms but not by the back-stress. The severe dissolution of Cu anode was explained theoretically.
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A synchrotron radiation real-time in situ imaging study on the Reverse Polarity effect in Cu/Sn-9Zn/Cu interconnect during liquid-solid electromigration
Scripta Materialia, 2013Co-Authors: Mingliang Huang, Zhijie Zhang, Ning Zhao, Q. ZhouAbstract:Synchrotron radiation real-time in situ imaging technology was used to study the interfacial reaction in Cu/Sn–9Zn/Cu interconnect during liquid–solid electromigration. The Reverse Polarity effect, evidenced by the IMC layer at the cathode growing continuously while that at the anode was restrained, resulted from the directional migration of Zn atoms toward the cathode under electron current stressing, which is induced by the positive effective charge number of Zn atoms but not by the back-stress. The severe dissolution of Cu anode was explained theoretically.
Mingliang Huang - One of the best experts on this subject based on the ideXlab platform.
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in situ study on Reverse Polarity effect in cu sn 9zn ni interconnect undergoing liquid solid electromigration
Journal of Alloys and Compounds, 2015Co-Authors: Mingliang Huang, Ning Zhao, Z J Zhang, Fenfen YangAbstract:Abstract Synchrotron radiation real-time imaging technology was used to in situ study the interfacial reactions in Cu/Sn–9Zn/Ni solder interconnects undergoing liquid–solid electromigration (L–S EM). The Reverse Polarity effect, evidenced by the continuous growth of intermetallic compound (IMC) layer at the cathode and the thinning of the IMC layer at the anode, was resulted from the abnormal directional migration of Zn atoms toward the cathode in electric field. This abnormal migration behavior was induced by the positive effective charge number (Z∗) of Zn atoms, which was calculated to be +0.63 based on the Cu fluxes and the consumption kinetics of the anode Cu. Irrespective of the flowing direction of electrons, the consumption of Cu film was obvious while that of Ni film was limited. The dissolution of anode Cu followed a linear relationship with time while that of cathode Cu followed a parabolic relationship with time. It is more damaging with electrons flowing from the Ni to the Cu than that from the Cu to the Ni. The simulated Zn concentration distributions gave an explanation on the relationship between abnormal migration behavior of Zn atoms and the dissolution of Cu film under electron wind force. The abnormal directional migration of Zn atoms toward the cathode prevented the dissolution of cathode substrate, which is beneficial to improve the EM reliability of micro-bump solder interconnects.
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Reverse Polarity effect in Cu/Sn-9Zn/Ni interconnect under high current density at high temperature
2014 15th International Conference on Electronic Packaging Technology, 2014Co-Authors: Mingliang Huang, Zhijie Zhang, Ning Zhao, Xiaofei FengAbstract:Synchrotron radiation real-time imaging technology was conducted to in situ observe the interfacial reaction in line-type Cu/Sn-9Zn/Ni interconnect under a current density of 2.0 × 104 A/cm2 at 230 °C. The Reverse Polarity effect in Cu/Sn-9Zn/Ni interconnects undergoing L-S EM was verified by the continuous growth of the intermetallic compound (IMC) layer at the cathode while the thinning of that at the anode under both flowing directions of electrons. This provided a clear evidence that Zn atoms migrated from the anode toward the cathode undergoing L-S EM, which is different from the normal diffusion behavior of atoms under the effect of electron current stressing. Since there was no back-stress in L-S EM, it is deduced that the abnormal diffusion behavior of Zn atoms was attributed to the electromigration flux, Jem, being greater than the chemical potential gradient flux, Jchem, during L-S EM under a high current density.
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a synchrotron radiation real time in situ imaging study on the Reverse Polarity effect in cu sn 9zn cu interconnect during liquid solid electromigration
Scripta Materialia, 2013Co-Authors: Mingliang Huang, Zhijie Zhang, Ning Zhao, Q. ZhouAbstract:Synchrotron radiation real-time in situ imaging technology was used to study the interfacial reaction in Cu/Sn–9Zn/Cu interconnect during liquid–solid electromigration. The Reverse Polarity effect, evidenced by the IMC layer at the cathode growing continuously while that at the anode was restrained, resulted from the directional migration of Zn atoms toward the cathode under electron current stressing, which is induced by the positive effective charge number of Zn atoms but not by the back-stress. The severe dissolution of Cu anode was explained theoretically.
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A synchrotron radiation real-time in situ imaging study on the Reverse Polarity effect in Cu/Sn-9Zn/Cu interconnect during liquid-solid electromigration
Scripta Materialia, 2013Co-Authors: Mingliang Huang, Zhijie Zhang, Ning Zhao, Q. ZhouAbstract:Synchrotron radiation real-time in situ imaging technology was used to study the interfacial reaction in Cu/Sn–9Zn/Cu interconnect during liquid–solid electromigration. The Reverse Polarity effect, evidenced by the IMC layer at the cathode growing continuously while that at the anode was restrained, resulted from the directional migration of Zn atoms toward the cathode under electron current stressing, which is induced by the positive effective charge number of Zn atoms but not by the back-stress. The severe dissolution of Cu anode was explained theoretically.
Hyun Jung Lee - One of the best experts on this subject based on the ideXlab platform.
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Unilateral synchronous papillary renal neoplasm with Reverse Polarity and clear cell renal cell carcinoma: a case report with KRAS and PIK3CA mutations.
Diagnostic pathology, 2020Co-Authors: Hyun Jung Lee, Dong Hoon Shin, Joon Young Park, So Young Kim, Chung Su Hwang, Jung Hee Lee, Jee Yeon Kim, Mee Young Sol, Jong Kil NamAbstract:The presence of histologically different neoplasms in the same organ is rare in pathologic practice. We report the first case of synchronous clear cell renal cell carcinoma (clear cell RCC) and papillary renal neoplasm with Reverse Polarity (PRNRP) with comprehensive immunohistochemical and molecular characterization using next-generation sequencing (NGS). A 61-year-old man was incidentally found to have a left renal mass on imaging studies performed for workup of left back pain and urine color change for 1 week. A laparoscopic left radical nephrectomy was performed. Gross examination showed lobulated masses measuring 5.6 × 4.0 × 3.3 cm in the upper to mid pole and 1.1 × 1.0 × 1.0 cm in the lower pole. Microscopic findings revealed these to be two different separate masses of clear cell renal cell carcinoma and papillary renal neoplasm with Reverse Polarity. NGS analyses revealed KRAS gene mutation (c.35G > T/p.G12V in exon 2) in the papillary renal neoplasm with Reverse Polarity, with PIK3CA gene mutation restricted to the clear cell renal cell carcinoma (c.1624G > A/p.E542K in exon 10). We report here an extraordinarily rare case of synchronous renal tumors of papillary renal neoplasm with Reverse Polarity and clear cell renal cell carcinoma. We identified simultaneous KRAS and PIK3CA mutations in two different renal masses in the same kidney for the first time. New pathologic assessment with comparative molecular analysis of mutational profiles may be helpful for tumor studies.
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Unilateral synchronous papillary renal neoplasm with Reverse Polarity and clear cell renal cell carcinoma: a case report with KRAS and PIK3CA mutations
2020Co-Authors: Hyun Jung Lee, Dong Hoon Shin, Joon Young Park, So Young Kim, Chung Su Hwang, Jung Hee Lee, Jee Yeon Kim, Mee Young Sol, Jong Kil NamAbstract:Abstract Background: The presence of histologically different neoplasms in the same organ is rare in pathologic practice. We report the first case of synchronous clear cell renal cell carcinoma (clear cell RCC) and papillary renal neoplasm with Reverse Polarity (PRNRP) with comprehensive immunohistochemical and molecular characterization using next-generation sequencing (NGS). Case presentation: A 61-year-old man was incidentally found to have a left renal mass on imaging studies performed for workup of left back pain and urine color change for one week. A laparoscopic left radical nephrectomy was performed. Gross examination showed lobulated masses measuring 5.6 × 4.0 × 3.3 cm in the upper to mid pole and 1.1 × 1.0 × 1.0 cm in the lower pole. Microscopic findings revealed these to be two different separate masses of clear cell renal cell carcinoma and papillary renal neoplasm with Reverse Polarity. NGS analyses revealed KRAS gene mutation (c.35G>T/p.G12V in exon 2) in the papillary renal neoplasm with Reverse Polarity, with PIK3CA gene mutation restricted to the clear cell renal cell carcinoma (c.1624G>A/p.E542K in exon 10).Conclusions: We report here an extraordinarily rare case of synchronous renal tumors of papillary renal neoplasm with Reverse Polarity and clear cell renal cell carcinoma. We identified simultaneous KRAS and PIK3CA mutations in two different renal masses in the same kidney for the first time. New pathologic assessment with comparative molecular analysis of mutational profiles may be helpful for tumor studies.
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Unilateral synchronous papillary renal neoplasm with Reverse Polarity and clear cell renal cell carcinoma: a case report with KRAS and PIK3CA mutations
2020Co-Authors: Hyun Jung Lee, Dong Hoon Shin, Joon Young Park, So Young Kim, Chung Su Hwang, Jung Hee Lee, Jee Yeon Kim, Mee Young Sol, Jong Kil NamAbstract:Abstract BackgroundThe presence of histologically different neoplasms in the same organ is rare in pathologic practice. We report multiple synchronous masses of clear cell renal cell carcinoma and papillary renal neoplasm with Reverse Polarity in the same kidney. Herein, we present the first well-explained case with immunohistochemical findings with next-generation sequencing (NGS) analysis. Case presentationA 61-year-old man was incidentally found to have a left renal mass on imaging studies performed for workup of left back pain and urine color change for one week. A laparoscopic left radical nephrectomy was performed. Gross examination showed lobulated masses in the upper to mid pole measuring 5.6 × 4.0 × 3.3 cm and 1.1 × 1.0 × 1.0 cm in the lower pole. Microscopic findings revealed these to be two different separate masses of clear cell renal cell carcinoma and papillary renal neoplasm with Reverse Polarity. NGS analyses revealed KRAS gene mutation (c.35G>T/p.G12V in exon 2) in the papillary renal neoplasm with Reverse Polarity, with an additional PIK3CA gene mutation restricted to the clear cell renal cell carcinoma (c.1624G>A/p.E542K in exon 10).ConclusionsWe report here an extraordinarily rare case of a patient diagnosed with multiple synchronous renal tumors of papillary renal neoplasm with Reverse Polarity and clear cell renal cell carcinoma. We identified simultaneous KRAS and PIK3CA mutations in two different renal masses in the same kidney for the first time. New pathologic assessment with comparative molecular analysis of mutational profiles may be helpful for tumor studies.
Ning Zhao - One of the best experts on this subject based on the ideXlab platform.
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in situ study on Reverse Polarity effect in cu sn 9zn ni interconnect undergoing liquid solid electromigration
Journal of Alloys and Compounds, 2015Co-Authors: Mingliang Huang, Ning Zhao, Z J Zhang, Fenfen YangAbstract:Abstract Synchrotron radiation real-time imaging technology was used to in situ study the interfacial reactions in Cu/Sn–9Zn/Ni solder interconnects undergoing liquid–solid electromigration (L–S EM). The Reverse Polarity effect, evidenced by the continuous growth of intermetallic compound (IMC) layer at the cathode and the thinning of the IMC layer at the anode, was resulted from the abnormal directional migration of Zn atoms toward the cathode in electric field. This abnormal migration behavior was induced by the positive effective charge number (Z∗) of Zn atoms, which was calculated to be +0.63 based on the Cu fluxes and the consumption kinetics of the anode Cu. Irrespective of the flowing direction of electrons, the consumption of Cu film was obvious while that of Ni film was limited. The dissolution of anode Cu followed a linear relationship with time while that of cathode Cu followed a parabolic relationship with time. It is more damaging with electrons flowing from the Ni to the Cu than that from the Cu to the Ni. The simulated Zn concentration distributions gave an explanation on the relationship between abnormal migration behavior of Zn atoms and the dissolution of Cu film under electron wind force. The abnormal directional migration of Zn atoms toward the cathode prevented the dissolution of cathode substrate, which is beneficial to improve the EM reliability of micro-bump solder interconnects.
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Reverse Polarity effect in Cu/Sn-9Zn/Ni interconnect under high current density at high temperature
2014 15th International Conference on Electronic Packaging Technology, 2014Co-Authors: Mingliang Huang, Zhijie Zhang, Ning Zhao, Xiaofei FengAbstract:Synchrotron radiation real-time imaging technology was conducted to in situ observe the interfacial reaction in line-type Cu/Sn-9Zn/Ni interconnect under a current density of 2.0 × 104 A/cm2 at 230 °C. The Reverse Polarity effect in Cu/Sn-9Zn/Ni interconnects undergoing L-S EM was verified by the continuous growth of the intermetallic compound (IMC) layer at the cathode while the thinning of that at the anode under both flowing directions of electrons. This provided a clear evidence that Zn atoms migrated from the anode toward the cathode undergoing L-S EM, which is different from the normal diffusion behavior of atoms under the effect of electron current stressing. Since there was no back-stress in L-S EM, it is deduced that the abnormal diffusion behavior of Zn atoms was attributed to the electromigration flux, Jem, being greater than the chemical potential gradient flux, Jchem, during L-S EM under a high current density.
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a synchrotron radiation real time in situ imaging study on the Reverse Polarity effect in cu sn 9zn cu interconnect during liquid solid electromigration
Scripta Materialia, 2013Co-Authors: Mingliang Huang, Zhijie Zhang, Ning Zhao, Q. ZhouAbstract:Synchrotron radiation real-time in situ imaging technology was used to study the interfacial reaction in Cu/Sn–9Zn/Cu interconnect during liquid–solid electromigration. The Reverse Polarity effect, evidenced by the IMC layer at the cathode growing continuously while that at the anode was restrained, resulted from the directional migration of Zn atoms toward the cathode under electron current stressing, which is induced by the positive effective charge number of Zn atoms but not by the back-stress. The severe dissolution of Cu anode was explained theoretically.
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A synchrotron radiation real-time in situ imaging study on the Reverse Polarity effect in Cu/Sn-9Zn/Cu interconnect during liquid-solid electromigration
Scripta Materialia, 2013Co-Authors: Mingliang Huang, Zhijie Zhang, Ning Zhao, Q. ZhouAbstract:Synchrotron radiation real-time in situ imaging technology was used to study the interfacial reaction in Cu/Sn–9Zn/Cu interconnect during liquid–solid electromigration. The Reverse Polarity effect, evidenced by the IMC layer at the cathode growing continuously while that at the anode was restrained, resulted from the directional migration of Zn atoms toward the cathode under electron current stressing, which is induced by the positive effective charge number of Zn atoms but not by the back-stress. The severe dissolution of Cu anode was explained theoretically.