The Experts below are selected from a list of 61443 Experts worldwide ranked by ideXlab platform
Aya Shibai - One of the best experts on this subject based on the ideXlab platform.
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a catch up validation study of an in vitro skin irritation test method using reconstructed human epidermis labcyte epi model24
Journal of Applied Toxicology, 2014Co-Authors: Hajime Kojima, Masakazu Katoh, Shinsuke Shinoda, Tamie Suzuki, Yoshihiro Yamaguchi, Saori Hagiwara, Runa Izumi, Maki Nakamura, Toshihiko Kasahawa, Aya ShibaiAbstract:Three validation studies were conducted by the Japanese Society for Alternatives to Animal Experiments in order to assess the performance of a skin irritation assay using reconstructed human epidermis (RhE) LabCyte EPI-MODEL24 (LabCyte EPI-MODEL24 SIT) developed by the Japan Tissue Engineering Co., Ltd. (J-TEC), and the results of these studies were submitted to the Organisation for Economic Co-operation and Development (OECD) for the creation of a Test Guideline (TG). In the summary Review report from the OECD, the peer Review Panel indicated the need to resolve an issue regarding the misclassification of 1-bromohexane. To this end, a rinsing operation intended to remove exposed chemicals was Reviewed and the standard operating procedure (SOP) revised by J-TEC. Thereafter, in order to confirm general versatility of the revised SOP, a new validation management team was organized by the Japanese Center for the Validation of Alternative Methods (JaCVAM) to undertake a catch-up validation study that would compare the revised assay with similar in vitro skin irritation assays, per OECD TG No. 439 (2010). The catch-up validation and supplementary studies for LabCyte EPI-MODEL24 SIT using the revised SOPs were conducted at three laboratories. These results showed that the revised SOP of LabCyte EPI-MODEL24 SIT conformed more accurately to the classifications for skin irritation under the United Nations Globally Harmonised System of Classification and Labelling of Chemicals (UN GHS), thereby highlighting the importance of an optimized rinsing operation for the removal of exposed chemicals in obtaining consistent results from in vitro skin irritation assays.
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a catch up validation study of an in vitro skin irritation test method using reconstructed human epidermis labcyte epi model24
Journal of Applied Toxicology, 2014Co-Authors: Hajime Kojima, Masakazu Katoh, Shinsuke Shinoda, Tamie Suzuki, Yoshihiro Yamaguchi, Saori Hagiwara, Runa Izumi, Maki Nakamura, Toshihiko Kasahawa, Aya ShibaiAbstract:Three validation studies were conducted by the Japanese Society for Alternatives to Animal Experiments in order to assess the performance of a skin irritation assay using reconstructed human epidermis (RhE) LabCyte EPI-MODEL24 (LabCyte EPI-MODEL24 SIT) developed by the Japan Tissue Engineering Co., Ltd. (J-TEC), and the results of these studies were submitted to the Organisation for Economic Co-operation and Development (OECD) for the creation of a Test Guideline (TG). In the summary Review report from the OECD, the peer Review Panel indicated the need to resolve an issue regarding the misclassification of 1-bromohexane. To this end, a rinsing operation intended to remove exposed chemicals was Reviewed and the standard operating procedure (SOP) revised by J-TEC. Thereafter, in order to confirm general versatility of the revised SOP, a new validation management team was organized by the Japanese Center for the Validation of Alternative Methods (JaCVAM) to undertake a catch-up validation study that would compare the revised assay with similar in vitro skin irritation assays, per OECD TG No. 439 (2010). The catch-up validation and supplementary studies for LabCyte EPI-MODEL24 SIT using the revised SOPs were conducted at three laboratories. These results showed that the revised SOP of LabCyte EPI-MODEL24 SIT conformed more accurately to the classifications for skin irritation under the United Nations Globally Harmonised System of Classification and Labelling of Chemicals (UN GHS), thereby highlighting the importance of an optimized rinsing operation for the removal of exposed chemicals in obtaining consistent results from in vitro skin irritation assays. Copyright © 2013 John Wiley & Sons, Ltd.
Hajime Kojima - One of the best experts on this subject based on the ideXlab platform.
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a catch up validation study of an in vitro skin irritation test method using reconstructed human epidermis labcyte epi model24
Journal of Applied Toxicology, 2014Co-Authors: Hajime Kojima, Masakazu Katoh, Shinsuke Shinoda, Tamie Suzuki, Yoshihiro Yamaguchi, Saori Hagiwara, Runa Izumi, Maki Nakamura, Toshihiko Kasahawa, Aya ShibaiAbstract:Three validation studies were conducted by the Japanese Society for Alternatives to Animal Experiments in order to assess the performance of a skin irritation assay using reconstructed human epidermis (RhE) LabCyte EPI-MODEL24 (LabCyte EPI-MODEL24 SIT) developed by the Japan Tissue Engineering Co., Ltd. (J-TEC), and the results of these studies were submitted to the Organisation for Economic Co-operation and Development (OECD) for the creation of a Test Guideline (TG). In the summary Review report from the OECD, the peer Review Panel indicated the need to resolve an issue regarding the misclassification of 1-bromohexane. To this end, a rinsing operation intended to remove exposed chemicals was Reviewed and the standard operating procedure (SOP) revised by J-TEC. Thereafter, in order to confirm general versatility of the revised SOP, a new validation management team was organized by the Japanese Center for the Validation of Alternative Methods (JaCVAM) to undertake a catch-up validation study that would compare the revised assay with similar in vitro skin irritation assays, per OECD TG No. 439 (2010). The catch-up validation and supplementary studies for LabCyte EPI-MODEL24 SIT using the revised SOPs were conducted at three laboratories. These results showed that the revised SOP of LabCyte EPI-MODEL24 SIT conformed more accurately to the classifications for skin irritation under the United Nations Globally Harmonised System of Classification and Labelling of Chemicals (UN GHS), thereby highlighting the importance of an optimized rinsing operation for the removal of exposed chemicals in obtaining consistent results from in vitro skin irritation assays.
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a catch up validation study of an in vitro skin irritation test method using reconstructed human epidermis labcyte epi model24
Journal of Applied Toxicology, 2014Co-Authors: Hajime Kojima, Masakazu Katoh, Shinsuke Shinoda, Tamie Suzuki, Yoshihiro Yamaguchi, Saori Hagiwara, Runa Izumi, Maki Nakamura, Toshihiko Kasahawa, Aya ShibaiAbstract:Three validation studies were conducted by the Japanese Society for Alternatives to Animal Experiments in order to assess the performance of a skin irritation assay using reconstructed human epidermis (RhE) LabCyte EPI-MODEL24 (LabCyte EPI-MODEL24 SIT) developed by the Japan Tissue Engineering Co., Ltd. (J-TEC), and the results of these studies were submitted to the Organisation for Economic Co-operation and Development (OECD) for the creation of a Test Guideline (TG). In the summary Review report from the OECD, the peer Review Panel indicated the need to resolve an issue regarding the misclassification of 1-bromohexane. To this end, a rinsing operation intended to remove exposed chemicals was Reviewed and the standard operating procedure (SOP) revised by J-TEC. Thereafter, in order to confirm general versatility of the revised SOP, a new validation management team was organized by the Japanese Center for the Validation of Alternative Methods (JaCVAM) to undertake a catch-up validation study that would compare the revised assay with similar in vitro skin irritation assays, per OECD TG No. 439 (2010). The catch-up validation and supplementary studies for LabCyte EPI-MODEL24 SIT using the revised SOPs were conducted at three laboratories. These results showed that the revised SOP of LabCyte EPI-MODEL24 SIT conformed more accurately to the classifications for skin irritation under the United Nations Globally Harmonised System of Classification and Labelling of Chemicals (UN GHS), thereby highlighting the importance of an optimized rinsing operation for the removal of exposed chemicals in obtaining consistent results from in vitro skin irritation assays. Copyright © 2013 John Wiley & Sons, Ltd.
Ramachandran S Vasan - One of the best experts on this subject based on the ideXlab platform.
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a systematic assessment of causes of death after heart failure onset in the community impact of age at death time period and left ventricular systolic dysfunction
Circulation-heart Failure, 2011Co-Authors: Douglas S Lee, Philimon Gona, Irene Albano, Martin G Larson, Emelia J Benjamin, Daniel Levy, William B Kannel, Ramachandran S VasanAbstract:Background—The high mortality rate in patients with heart failure (HF) is influenced by presence of multiple comorbidities. Data are limited on the relative contributions of cardiovascular versus noncardiovascular diseases to death in individuals with HF in the community. Methods and Results—We examined the incidence and predictors of cardiovascular versus noncardiovascular death in participants with HF in the Framingham Heart Study. Underlying, immediate, and contributing causes of death (3 key elements of the World Health Organization classification) were adjudicated by a 3-physician Review Panel. During 1971 to 2004, 1025 participants with HF died (499 men, mean [SD] age at death 79 [11] years), including 463 participants with left ventricular ejection fraction (LVEF) data. Cardiovascular disease was the cause of death in 66.1% overall. Stratified by LVEF, cardiovascular deaths occurred in 44.5% and 69.9% of those with preserved and reduced LVEF, respectively. Presence of reduced LVEF increased the ris...
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a systematic assessment of causes of death after heart failure onset in the community impact of age at death time period and left ventricular systolic dysfunction
Circulation-heart Failure, 2011Co-Authors: Philimon Gona, Irene Albano, Martin G Larson, Emelia J Benjamin, Daniel Levy, William B Kannel, Ramachandran S VasanAbstract:Background —The high mortality in patients with heart failure (HF) is influenced by presence of multiple comorbidities. Data are limited on the relative contributions of cardiovascular versus noncardiovascular diseases to death in individuals with HF in the community. Methods and Results —We examined the incidence and predictors of cardiovascular vs. noncardiovascular death in participants with HF in the Framingham Heart Study. Underlying , immediate and contributing causes of death (3 key elements of the World Health Organization classification) were adjudicated by a 3-physician Review Panel. During 1971-2004, 1025 participants with HF died (499 men, mean [SD] age at death 79 [11] years), including 463 participants with left ventricular ejection fraction (LVEF) data. Cardiovascular disease was the cause of death in 66.1% overall. Stratified by LVEF, cardiovascular deaths occurred in 44.5% and 69.9% of those with preserved and reduced LVEF, respectively. Presence of reduced LVEF increased the risk of cardiovascular death with odds ratios of 3.16 (95%CI 1.73-5.78) in men and 2.39 (95%CI 1.39-4.08) in women. Prior myocardial infarction was associated with increased cardiovascular death in women with HF (odds ratio 1.87, 95%CI; 1.10-3.16), but not in men. The risk of cardiovascular disease death decreased in women (odds ratio post-1980 0.41, 95%CI 0.24-0.69) and men (odds ratio 0.66, 95%CI 0.41-1.07, p=0.095) with HF over time. Infections and kidney disease emerged as key immediate and contributing causes of death, respectively. Conclusions —Individuals with HF in the community often experience cardiovascular death, but noncardiovascular disease also contributes significantly especially among those with preserved LVEF.
Tamie Suzuki - One of the best experts on this subject based on the ideXlab platform.
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a catch up validation study of an in vitro skin irritation test method using reconstructed human epidermis labcyte epi model24
Journal of Applied Toxicology, 2014Co-Authors: Hajime Kojima, Masakazu Katoh, Shinsuke Shinoda, Tamie Suzuki, Yoshihiro Yamaguchi, Saori Hagiwara, Runa Izumi, Maki Nakamura, Toshihiko Kasahawa, Aya ShibaiAbstract:Three validation studies were conducted by the Japanese Society for Alternatives to Animal Experiments in order to assess the performance of a skin irritation assay using reconstructed human epidermis (RhE) LabCyte EPI-MODEL24 (LabCyte EPI-MODEL24 SIT) developed by the Japan Tissue Engineering Co., Ltd. (J-TEC), and the results of these studies were submitted to the Organisation for Economic Co-operation and Development (OECD) for the creation of a Test Guideline (TG). In the summary Review report from the OECD, the peer Review Panel indicated the need to resolve an issue regarding the misclassification of 1-bromohexane. To this end, a rinsing operation intended to remove exposed chemicals was Reviewed and the standard operating procedure (SOP) revised by J-TEC. Thereafter, in order to confirm general versatility of the revised SOP, a new validation management team was organized by the Japanese Center for the Validation of Alternative Methods (JaCVAM) to undertake a catch-up validation study that would compare the revised assay with similar in vitro skin irritation assays, per OECD TG No. 439 (2010). The catch-up validation and supplementary studies for LabCyte EPI-MODEL24 SIT using the revised SOPs were conducted at three laboratories. These results showed that the revised SOP of LabCyte EPI-MODEL24 SIT conformed more accurately to the classifications for skin irritation under the United Nations Globally Harmonised System of Classification and Labelling of Chemicals (UN GHS), thereby highlighting the importance of an optimized rinsing operation for the removal of exposed chemicals in obtaining consistent results from in vitro skin irritation assays.
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a catch up validation study of an in vitro skin irritation test method using reconstructed human epidermis labcyte epi model24
Journal of Applied Toxicology, 2014Co-Authors: Hajime Kojima, Masakazu Katoh, Shinsuke Shinoda, Tamie Suzuki, Yoshihiro Yamaguchi, Saori Hagiwara, Runa Izumi, Maki Nakamura, Toshihiko Kasahawa, Aya ShibaiAbstract:Three validation studies were conducted by the Japanese Society for Alternatives to Animal Experiments in order to assess the performance of a skin irritation assay using reconstructed human epidermis (RhE) LabCyte EPI-MODEL24 (LabCyte EPI-MODEL24 SIT) developed by the Japan Tissue Engineering Co., Ltd. (J-TEC), and the results of these studies were submitted to the Organisation for Economic Co-operation and Development (OECD) for the creation of a Test Guideline (TG). In the summary Review report from the OECD, the peer Review Panel indicated the need to resolve an issue regarding the misclassification of 1-bromohexane. To this end, a rinsing operation intended to remove exposed chemicals was Reviewed and the standard operating procedure (SOP) revised by J-TEC. Thereafter, in order to confirm general versatility of the revised SOP, a new validation management team was organized by the Japanese Center for the Validation of Alternative Methods (JaCVAM) to undertake a catch-up validation study that would compare the revised assay with similar in vitro skin irritation assays, per OECD TG No. 439 (2010). The catch-up validation and supplementary studies for LabCyte EPI-MODEL24 SIT using the revised SOPs were conducted at three laboratories. These results showed that the revised SOP of LabCyte EPI-MODEL24 SIT conformed more accurately to the classifications for skin irritation under the United Nations Globally Harmonised System of Classification and Labelling of Chemicals (UN GHS), thereby highlighting the importance of an optimized rinsing operation for the removal of exposed chemicals in obtaining consistent results from in vitro skin irritation assays. Copyright © 2013 John Wiley & Sons, Ltd.
Maki Nakamura - One of the best experts on this subject based on the ideXlab platform.
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a catch up validation study of an in vitro skin irritation test method using reconstructed human epidermis labcyte epi model24
Journal of Applied Toxicology, 2014Co-Authors: Hajime Kojima, Masakazu Katoh, Shinsuke Shinoda, Tamie Suzuki, Yoshihiro Yamaguchi, Saori Hagiwara, Runa Izumi, Maki Nakamura, Toshihiko Kasahawa, Aya ShibaiAbstract:Three validation studies were conducted by the Japanese Society for Alternatives to Animal Experiments in order to assess the performance of a skin irritation assay using reconstructed human epidermis (RhE) LabCyte EPI-MODEL24 (LabCyte EPI-MODEL24 SIT) developed by the Japan Tissue Engineering Co., Ltd. (J-TEC), and the results of these studies were submitted to the Organisation for Economic Co-operation and Development (OECD) for the creation of a Test Guideline (TG). In the summary Review report from the OECD, the peer Review Panel indicated the need to resolve an issue regarding the misclassification of 1-bromohexane. To this end, a rinsing operation intended to remove exposed chemicals was Reviewed and the standard operating procedure (SOP) revised by J-TEC. Thereafter, in order to confirm general versatility of the revised SOP, a new validation management team was organized by the Japanese Center for the Validation of Alternative Methods (JaCVAM) to undertake a catch-up validation study that would compare the revised assay with similar in vitro skin irritation assays, per OECD TG No. 439 (2010). The catch-up validation and supplementary studies for LabCyte EPI-MODEL24 SIT using the revised SOPs were conducted at three laboratories. These results showed that the revised SOP of LabCyte EPI-MODEL24 SIT conformed more accurately to the classifications for skin irritation under the United Nations Globally Harmonised System of Classification and Labelling of Chemicals (UN GHS), thereby highlighting the importance of an optimized rinsing operation for the removal of exposed chemicals in obtaining consistent results from in vitro skin irritation assays.
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a catch up validation study of an in vitro skin irritation test method using reconstructed human epidermis labcyte epi model24
Journal of Applied Toxicology, 2014Co-Authors: Hajime Kojima, Masakazu Katoh, Shinsuke Shinoda, Tamie Suzuki, Yoshihiro Yamaguchi, Saori Hagiwara, Runa Izumi, Maki Nakamura, Toshihiko Kasahawa, Aya ShibaiAbstract:Three validation studies were conducted by the Japanese Society for Alternatives to Animal Experiments in order to assess the performance of a skin irritation assay using reconstructed human epidermis (RhE) LabCyte EPI-MODEL24 (LabCyte EPI-MODEL24 SIT) developed by the Japan Tissue Engineering Co., Ltd. (J-TEC), and the results of these studies were submitted to the Organisation for Economic Co-operation and Development (OECD) for the creation of a Test Guideline (TG). In the summary Review report from the OECD, the peer Review Panel indicated the need to resolve an issue regarding the misclassification of 1-bromohexane. To this end, a rinsing operation intended to remove exposed chemicals was Reviewed and the standard operating procedure (SOP) revised by J-TEC. Thereafter, in order to confirm general versatility of the revised SOP, a new validation management team was organized by the Japanese Center for the Validation of Alternative Methods (JaCVAM) to undertake a catch-up validation study that would compare the revised assay with similar in vitro skin irritation assays, per OECD TG No. 439 (2010). The catch-up validation and supplementary studies for LabCyte EPI-MODEL24 SIT using the revised SOPs were conducted at three laboratories. These results showed that the revised SOP of LabCyte EPI-MODEL24 SIT conformed more accurately to the classifications for skin irritation under the United Nations Globally Harmonised System of Classification and Labelling of Chemicals (UN GHS), thereby highlighting the importance of an optimized rinsing operation for the removal of exposed chemicals in obtaining consistent results from in vitro skin irritation assays. Copyright © 2013 John Wiley & Sons, Ltd.
