The Experts below are selected from a list of 312 Experts worldwide ranked by ideXlab platform
Ralf G. Dietzgen - One of the best experts on this subject based on the ideXlab platform.
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Molecular characterization of a novel cytorhabdovirus with a unique genomic organization infecting yerba mate (Ilex paraguariensis) in Argentina
Archives of Virology, 2020Co-Authors: Nicolás Bejerman, Ralf G. Dietzgen, Raúl Maximiliano Acevedo, Soledad Breuil, Oscar A. Ruiz, Pedro Sansberro, Claudia Nome, Humberto DebatAbstract:The genome of a novel rhabdovirus was detected in yerba mate ( Ilex paraguariensis St. Hil.). The newly identified virus, tentatively named "yerba mate virus A" (YmVA), has a genome of 14,961 nucleotides. Notably, eight open reading frames were identified in the antigenomic orientation of the negative-sense, single-stranded viral RNA, including two novel accessory genes, in the order 3′-N-P-3-4-M-G-L-8-5′. Sequence comparisons of the encoded proteins as well as phylogenetic analysis suggest that YmVA is a new member of the genus Cytorhabdovirus, family Rhabdoviridae . YmVA's unique genomic organization and phylogenetic relationships indicate that this virus likely represents a distinct evolutionary lineage among the cytorhabdoviruses.
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Molecular characterization of a novel cytorhabdovirus with a unique genomic organization infecting yerba mate (Ilex paraguariensis) in Argentina
2020Co-Authors: Nicolás Bejerman, Ralf G. Dietzgen, Raúl Maximiliano Acevedo, Soledad Breuil, Oscar A. Ruiz, Pedro Sansberro, Claudia Nome, Humberto DebatAbstract:The genome of a novel rhabdovirus was detected in yerba mate (Ilex paraguariensis St. Hil.). The newly identified virus, tentatively named yerba mate virus A (YmVA), has a genome of 14,961 nucleotides. Notably, eight open reading frames were identified in the antigenomic orientation of the negative-sense, single-stranded viral RNA, including two novel accessory genes, in the order 39-N-P-3-4-M-G-L-8-59. Sequence identity of the encoded proteins as well as phylogenetic analysis suggest that YmVA is a new member of the genus Cytorhabdovirus, family Rhabdoviridae. YmVA unique genomic organization and phylogenetic relationships indicate that this virus likely represents a distinct evolutionary lineage within the cytorhabdoviruses.
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ictv virus taxonomy profile Rhabdoviridae
Journal of General Virology, 2018Co-Authors: Peter J Walker, Robert B. Tesh, Hideki Kondo, Ralf G. Dietzgen, Kim R Blasdell, Charles H Calisher, Gael Kurath, Ben Longdon, David M Stone, Noel TordoAbstract:The family Rhabdoviridae comprises viruses with negative-sense (–) single-stranded RNA genomes of 10.8–16.1 kb. Virions are typically enveloped with bullet-shaped or bacilliform morphology but can also be non-enveloped filaments. Rhabdoviruses infect plants and animals including mammals, birds, reptiles and fish, as well as arthropods which serve as single hosts or act as biological vectors for transmission to animals or plants. Rhabdoviruses include important pathogens of humans, livestock, fish and agricultural crops. This is a summary of the International Committee on Taxonomy of Viruses (ICTV) Report on the taxonomy of Rhabdoviridae, which is available at www.ictv.global/report/Rhabdoviridae.
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the family Rhabdoviridae mono and bipartite negative sense rna viruses with diverse genome organization and common evolutionary origins
Virus Research, 2017Co-Authors: Ralf G. Dietzgen, Hideki Kondo, Michael M. Goodin, Gael Kurath, Nikos VasilakisAbstract:The family Rhabdoviridae consists of mostly enveloped, bullet-shaped or bacilliform viruses with a negative-sense, single-stranded RNA genome that infect vertebrates, invertebrates or plants. This ecological diversity is reflected by the diversity and complexity of their genomes. Five canonical structural protein genes are conserved in all rhabdoviruses, but may be overprinted, overlapped or interspersed with several novel and diverse accessory genes. This review gives an overview of the characteristics and diversity of rhabdoviruses, their taxonomic classification, replication mechanism, properties of classical rhabdoviruses such as rabies virus and rhabdoviruses with complex genomes, rhabdoviruses infecting aquatic species, and plant rhabdoviruses with both mono- and bipartite genomes.
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Dichorhavirus: a proposed new genus for Brevipalpus mite-transmitted, nuclear, bacilliform, bipartite, negative-strand RNA plant viruses
Archives of Virology, 2014Co-Authors: Ralf G. Dietzgen, Hideki Kondo, Michael M. Goodin, Jens H. Kuhn, Anna N. Clawson, Juliana Freitas-astúa, Elliott W. Kitajima, Thierry Wetzel, Anna E. WhitfieldAbstract:Orchid fleck virus (OFV) is an unassigned negative-sense, single-stranded (−)ssRNA plant virus that was previously suggested to be included in the family Rhabdoviridae, order Mononegavirales . Although OFV shares some biological characteristics, including nuclear cytopathological effects, gene order, and sequence similarities, with nucleorhabdoviruses, its taxonomic status is unclear because unlike all mononegaviruses, OFV has a segmented genome and its particles are not enveloped. This article analyses the available biological, physico-chemical, and nucleotide sequence evidence that seems to indicate that OFV and several other Brevipalpus mite-transmitted short bacilliform (−)ssRNA viruses are likely related and may be classified taxonomically in novel species in a new free-floating genus Dichorhavirus .
Humberto Debat - One of the best experts on this subject based on the ideXlab platform.
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Molecular characterization of a novel cytorhabdovirus with a unique genomic organization infecting yerba mate (Ilex paraguariensis) in Argentina
Archives of Virology, 2020Co-Authors: Nicolás Bejerman, Ralf G. Dietzgen, Raúl Maximiliano Acevedo, Soledad Breuil, Oscar A. Ruiz, Pedro Sansberro, Claudia Nome, Humberto DebatAbstract:The genome of a novel rhabdovirus was detected in yerba mate ( Ilex paraguariensis St. Hil.). The newly identified virus, tentatively named "yerba mate virus A" (YmVA), has a genome of 14,961 nucleotides. Notably, eight open reading frames were identified in the antigenomic orientation of the negative-sense, single-stranded viral RNA, including two novel accessory genes, in the order 3′-N-P-3-4-M-G-L-8-5′. Sequence comparisons of the encoded proteins as well as phylogenetic analysis suggest that YmVA is a new member of the genus Cytorhabdovirus, family Rhabdoviridae . YmVA's unique genomic organization and phylogenetic relationships indicate that this virus likely represents a distinct evolutionary lineage among the cytorhabdoviruses.
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Molecular characterization of a novel cytorhabdovirus with a unique genomic organization infecting yerba mate (Ilex paraguariensis) in Argentina
2020Co-Authors: Nicolás Bejerman, Ralf G. Dietzgen, Raúl Maximiliano Acevedo, Soledad Breuil, Oscar A. Ruiz, Pedro Sansberro, Claudia Nome, Humberto DebatAbstract:The genome of a novel rhabdovirus was detected in yerba mate (Ilex paraguariensis St. Hil.). The newly identified virus, tentatively named yerba mate virus A (YmVA), has a genome of 14,961 nucleotides. Notably, eight open reading frames were identified in the antigenomic orientation of the negative-sense, single-stranded viral RNA, including two novel accessory genes, in the order 39-N-P-3-4-M-G-L-8-59. Sequence identity of the encoded proteins as well as phylogenetic analysis suggest that YmVA is a new member of the genus Cytorhabdovirus, family Rhabdoviridae. YmVA unique genomic organization and phylogenetic relationships indicate that this virus likely represents a distinct evolutionary lineage within the cytorhabdoviruses.
Robert B. Tesh - One of the best experts on this subject based on the ideXlab platform.
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ictv virus taxonomy profile Rhabdoviridae
Journal of General Virology, 2018Co-Authors: Peter J Walker, Robert B. Tesh, Hideki Kondo, Ralf G. Dietzgen, Kim R Blasdell, Charles H Calisher, Gael Kurath, Ben Longdon, David M Stone, Noel TordoAbstract:The family Rhabdoviridae comprises viruses with negative-sense (–) single-stranded RNA genomes of 10.8–16.1 kb. Virions are typically enveloped with bullet-shaped or bacilliform morphology but can also be non-enveloped filaments. Rhabdoviruses infect plants and animals including mammals, birds, reptiles and fish, as well as arthropods which serve as single hosts or act as biological vectors for transmission to animals or plants. Rhabdoviruses include important pathogens of humans, livestock, fish and agricultural crops. This is a summary of the International Committee on Taxonomy of Viruses (ICTV) Report on the taxonomy of Rhabdoviridae, which is available at www.ictv.global/report/Rhabdoviridae.
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insect specific viruses and their potential impact on arbovirus transmission
Current Opinion in Virology, 2015Co-Authors: Nikos Vasilakis, Robert B. TeshAbstract:Arthropod-borne viruses (arboviruses) are the causative agents of significant morbidity and mortality among humans and animals globally. In the past few years, the widespread adoption of next generation sequencing and metagenomics has led to a new era of virus discovery, where many novel viruses have been documented, exhibiting a restricted host-range in mosquitoes. They represent a wide-range of insect-specific viruses within the families of Bunyaviridae, Flaviviridae, Mesoniviridae, Reoviridae, Rhabdoviridae, Togaviridae, and the newly recognized taxon of Negeviruses. Collectively, their discovery has opened new vistas about the extent of viral diversity and evolution, their influence on vector competence and ability of their insect hosts to transmit human pathogens (e.g. arboviruses), and their potential development as biological control agents or novel vaccine platforms.
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evolution of genome size and complexity in the Rhabdoviridae
PLOS Pathogens, 2015Co-Authors: Peter J Walker, Robert B. Tesh, Kim R Blasdell, Steven G Widen, Thomas G Wood, Hilda Guzman, Edward C Holmes, Cadhla Firth, Prasad N Paradkar, Nikos VasilakisAbstract:RNA viruses exhibit substantial structural, ecological and genomic diversity. However, genome size in RNA viruses is likely limited by a high mutation rate, resulting in the evolution of various mechanisms to increase complexity while minimising genome expansion. Here we conduct a large-scale analysis of the genome sequences of 99 animal rhabdoviruses, including 45 genomes which we determined de novo, to identify patterns of genome expansion and the evolution of genome complexity. All but seven of the rhabdoviruses clustered into 17 well-supported monophyletic groups, of which eight corresponded to established genera, seven were assigned as new genera, and two were taxonomically ambiguous. We show that the acquisition and loss of new genes appears to have been a central theme of rhabdovirus evolution, and has been associated with the appearance of alternative, overlapping and consecutive ORFs within the major structural protein genes, and the insertion and loss of additional ORFs in each gene junction in a clade-specific manner. Changes in the lengths of gene junctions accounted for as much as 48.5% of the variation in genome size from the smallest to the largest genome, and the frequency with which new ORFs were observed increased in the 3’ to 5’ direction along the genome. We also identify several new families of accessory genes encoded in these regions, and show that non-canonical expression strategies involving TURBS-like termination-reinitiation, ribosomal frame-shifts and leaky ribosomal scanning appear to be common. We conclude that rhabdoviruses have an unusual capacity for genomic plasticity that may be linked to their discontinuous transcription strategy from the negative-sense single-stranded RNA genome, and propose a model that accounts for the regular occurrence of genome expansion and contraction throughout the evolution of the Rhabdoviridae.
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two new rhabdoviruses Rhabdoviridae isolated from birds during surveillance for arboviral encephalitis northeastern united states
Emerging Infectious Diseases, 2002Co-Authors: Amelia Travassos P A Da Rosa, Hilda Guzman, Thomas N Mather, Tsutomu Takeda, Chris A Whitehouse, Robert E Shope, Vsevolod L Popov, L Coffey, Tais P Araujo, Robert B. TeshAbstract:Two novel rhabdoviruses were isolated from birds during surveillance for arboviral encephalitis in the northeastern United States. The first, designated Farmington virus, is a tentative new member of the Vesiculovirus genus. The second, designated Rhode Island virus, is unclassified antigenically, but its ultrastructure and size are more similar to those of some of the plant rhabdoviruses. Both viruses infect birds and mice, as well as monkey kidney cells in culture, but their importance for human health is unknown.
Hideki Kondo - One of the best experts on this subject based on the ideXlab platform.
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ictv virus taxonomy profile Rhabdoviridae
Journal of General Virology, 2018Co-Authors: Peter J Walker, Robert B. Tesh, Hideki Kondo, Ralf G. Dietzgen, Kim R Blasdell, Charles H Calisher, Gael Kurath, Ben Longdon, David M Stone, Noel TordoAbstract:The family Rhabdoviridae comprises viruses with negative-sense (–) single-stranded RNA genomes of 10.8–16.1 kb. Virions are typically enveloped with bullet-shaped or bacilliform morphology but can also be non-enveloped filaments. Rhabdoviruses infect plants and animals including mammals, birds, reptiles and fish, as well as arthropods which serve as single hosts or act as biological vectors for transmission to animals or plants. Rhabdoviruses include important pathogens of humans, livestock, fish and agricultural crops. This is a summary of the International Committee on Taxonomy of Viruses (ICTV) Report on the taxonomy of Rhabdoviridae, which is available at www.ictv.global/report/Rhabdoviridae.
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the family Rhabdoviridae mono and bipartite negative sense rna viruses with diverse genome organization and common evolutionary origins
Virus Research, 2017Co-Authors: Ralf G. Dietzgen, Hideki Kondo, Michael M. Goodin, Gael Kurath, Nikos VasilakisAbstract:The family Rhabdoviridae consists of mostly enveloped, bullet-shaped or bacilliform viruses with a negative-sense, single-stranded RNA genome that infect vertebrates, invertebrates or plants. This ecological diversity is reflected by the diversity and complexity of their genomes. Five canonical structural protein genes are conserved in all rhabdoviruses, but may be overprinted, overlapped or interspersed with several novel and diverse accessory genes. This review gives an overview of the characteristics and diversity of rhabdoviruses, their taxonomic classification, replication mechanism, properties of classical rhabdoviruses such as rabies virus and rhabdoviruses with complex genomes, rhabdoviruses infecting aquatic species, and plant rhabdoviruses with both mono- and bipartite genomes.
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transcriptional mapping of the messenger and leader rnas of orchid fleck virus a bisegmented negative strand rna virus
Virology, 2014Co-Authors: Hideki Kondo, Sotaro Chiba, Ida Bagus Andika, Kazuyuki Maruyama, Nobuhiro SuzukiAbstract:Abstract The transcriptional strategy of orchid fleck virus (OFV), which has a two-segmented negative-strand RNA genome and resembles plant nucleorhabdoviruses, remains unexplored. In this study, the transcripts of six genes encoded by OFV RNA1 and RNA2 in the poly(A)-enriched RNA fraction from infected plants were molecularly characterized. All of the OFV mRNAs were initiated at a start sequence 3'-UU-5' with one to three non-viral adenine nucleotides which were added at the 5' end of each mRNA, whereas their 3' termini ended with a 5'-AUUUAAA(U/G)AAAA(A) n -3' sequence. We also identified the presence of polyadenylated short transcripts derived from the 3'-terminal leader regions of both genomic and antigenomic strands, providing the first example of plus- and minus-strand leader RNAs in a segmented minus-strand RNA virus. The similarity in the transcriptional strategy between this bipartite OFV and monopartite rhabdoviruses, especially nucleorhabdoviruses (family Rhabdoviridae ) is additional support for their close relationship.
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Dichorhavirus: a proposed new genus for Brevipalpus mite-transmitted, nuclear, bacilliform, bipartite, negative-strand RNA plant viruses
Archives of Virology, 2014Co-Authors: Ralf G. Dietzgen, Hideki Kondo, Michael M. Goodin, Jens H. Kuhn, Anna N. Clawson, Juliana Freitas-astúa, Elliott W. Kitajima, Thierry Wetzel, Anna E. WhitfieldAbstract:Orchid fleck virus (OFV) is an unassigned negative-sense, single-stranded (−)ssRNA plant virus that was previously suggested to be included in the family Rhabdoviridae, order Mononegavirales . Although OFV shares some biological characteristics, including nuclear cytopathological effects, gene order, and sequence similarities, with nucleorhabdoviruses, its taxonomic status is unclear because unlike all mononegaviruses, OFV has a segmented genome and its particles are not enveloped. This article analyses the available biological, physico-chemical, and nucleotide sequence evidence that seems to indicate that OFV and several other Brevipalpus mite-transmitted short bacilliform (−)ssRNA viruses are likely related and may be classified taxonomically in novel species in a new free-floating genus Dichorhavirus .
Nicolás Bejerman - One of the best experts on this subject based on the ideXlab platform.
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Molecular characterization of a novel cytorhabdovirus with a unique genomic organization infecting yerba mate (Ilex paraguariensis) in Argentina
Archives of Virology, 2020Co-Authors: Nicolás Bejerman, Ralf G. Dietzgen, Raúl Maximiliano Acevedo, Soledad Breuil, Oscar A. Ruiz, Pedro Sansberro, Claudia Nome, Humberto DebatAbstract:The genome of a novel rhabdovirus was detected in yerba mate ( Ilex paraguariensis St. Hil.). The newly identified virus, tentatively named "yerba mate virus A" (YmVA), has a genome of 14,961 nucleotides. Notably, eight open reading frames were identified in the antigenomic orientation of the negative-sense, single-stranded viral RNA, including two novel accessory genes, in the order 3′-N-P-3-4-M-G-L-8-5′. Sequence comparisons of the encoded proteins as well as phylogenetic analysis suggest that YmVA is a new member of the genus Cytorhabdovirus, family Rhabdoviridae . YmVA's unique genomic organization and phylogenetic relationships indicate that this virus likely represents a distinct evolutionary lineage among the cytorhabdoviruses.
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Molecular characterization of a novel cytorhabdovirus with a unique genomic organization infecting yerba mate (Ilex paraguariensis) in Argentina
2020Co-Authors: Nicolás Bejerman, Ralf G. Dietzgen, Raúl Maximiliano Acevedo, Soledad Breuil, Oscar A. Ruiz, Pedro Sansberro, Claudia Nome, Humberto DebatAbstract:The genome of a novel rhabdovirus was detected in yerba mate (Ilex paraguariensis St. Hil.). The newly identified virus, tentatively named yerba mate virus A (YmVA), has a genome of 14,961 nucleotides. Notably, eight open reading frames were identified in the antigenomic orientation of the negative-sense, single-stranded viral RNA, including two novel accessory genes, in the order 39-N-P-3-4-M-G-L-8-59. Sequence identity of the encoded proteins as well as phylogenetic analysis suggest that YmVA is a new member of the genus Cytorhabdovirus, family Rhabdoviridae. YmVA unique genomic organization and phylogenetic relationships indicate that this virus likely represents a distinct evolutionary lineage within the cytorhabdoviruses.
