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Akram Astani - One of the best experts on this subject based on the ideXlab platform.

  • association between abo blood groups and Rhesus Antigen and susceptibility to covid 19 in the yazd hospital
    new microbes and new infections, 2021
    Co-Authors: Emad Behboudi, V Hamidi, F Gholizadeh, E M Grala, Y Ghelmani, M Nakhaie, Javad Charostad, Akram Astani
    Abstract:

    Blood group Antigens are one of the most important Antigens in humans that have an impact on susceptibility to disease and may be used as a prognosis factor in different diseases such as COVID-19. The study aimed to investigate the relationship between ABO blood groups and Rhesus Antigen and susceptibility to COVID-19. The clinical data of 398 subjects were used in the investigation collected from 148 cases vs. 250 controls. This information was obtained from Shahid Sadoughi Hospital of Yazd (IRAN) University. Blood groups and outcomes were assessed using statistical tests for four populations: COV + vs. COV- and COV +/deceased vs. COV +/live. Out of a total of 148 COVID-19 patients, 80 (54/1%) were male, 68 (45/9%) were female. Among these patients, 33 (22/6%) had type A+, 44 (30/1%) had type B+, 13 (8/9%) had type AB+, and 36 (24/7%) had type O+. On the other hand, out of 148 patients, 126 (86/3%) had positive blood types, and 20 (13/7%) had negative blood types. As a result, no significant difference was found in the relationship between ABO blood groups and RH type and susceptibility to COVID-19 (p-value = 0.392 and p-value = 0.847, respectively). Other data showed a significant difference between patients group with other parameters such as age (p-value<0.001) and gender (p-value<0.001). Although in this study there was no association between blood type and RH type with COVID-19, findings of the association between age and gender can confirm the results of previous studies.

Matthias F. Bauer - One of the best experts on this subject based on the ideXlab platform.

  • The molecular basis of the Rhesus Antigen Ew.
    Transfusion, 2004
    Co-Authors: Erwin Strobel, Jean-pierre Cartron, Sabine Hofmann, Matthias F. Bauer
    Abstract:

    w(ISBT designation 004 011) was first described in 1955. It is defined by a specific antibody, but its molecular genetic basis has not yet been resolved. STUDY DESIGN AND METHODS: Two individuals serologically characterized to express the rare Rhesus Antigen E w were analyzed by sequencing of all 10 exons of the RHCE gene. RESULTS: A nucleotide exchange at position 500 (T500A) resulting in a Met167Lys amino acid substitution was found in both individuals. Moreover, we show that an individual carrying the E w Antigen is capable to produce an alloantibody against the wild-type E Antigen. CONCLUSION: The single-point mutation T500A in exon 4 of the RHCE gene is a molecular basis of the rare Rhesus Antigen E w . he Rhesus Antigens represent the most complex blood group system on human RBCs, with at least 48 serologic entities described so far. 1 It is

Peter Agre - One of the best experts on this subject based on the ideXlab platform.

  • A new face of the Rhesus Antigen
    Nature Genetics, 2000
    Co-Authors: Joseph Heitman, Peter Agre
    Abstract:

    The Mep ammonium transporters of Saccharomyces cerevisiae share amino acid sequence identity with the Rh blood group Antigen proteins. A new study shows that the Rhg glycoproteins transport ammonium when heterologously expressed in mep mutant yeast cells, indicating a role for the Rh Antigen complex.

Emad Behboudi - One of the best experts on this subject based on the ideXlab platform.

  • association between abo blood groups and Rhesus Antigen and susceptibility to covid 19 in the yazd hospital
    new microbes and new infections, 2021
    Co-Authors: Emad Behboudi, V Hamidi, F Gholizadeh, E M Grala, Y Ghelmani, M Nakhaie, Javad Charostad, Akram Astani
    Abstract:

    Blood group Antigens are one of the most important Antigens in humans that have an impact on susceptibility to disease and may be used as a prognosis factor in different diseases such as COVID-19. The study aimed to investigate the relationship between ABO blood groups and Rhesus Antigen and susceptibility to COVID-19. The clinical data of 398 subjects were used in the investigation collected from 148 cases vs. 250 controls. This information was obtained from Shahid Sadoughi Hospital of Yazd (IRAN) University. Blood groups and outcomes were assessed using statistical tests for four populations: COV + vs. COV- and COV +/deceased vs. COV +/live. Out of a total of 148 COVID-19 patients, 80 (54/1%) were male, 68 (45/9%) were female. Among these patients, 33 (22/6%) had type A+, 44 (30/1%) had type B+, 13 (8/9%) had type AB+, and 36 (24/7%) had type O+. On the other hand, out of 148 patients, 126 (86/3%) had positive blood types, and 20 (13/7%) had negative blood types. As a result, no significant difference was found in the relationship between ABO blood groups and RH type and susceptibility to COVID-19 (p-value = 0.392 and p-value = 0.847, respectively). Other data showed a significant difference between patients group with other parameters such as age (p-value<0.001) and gender (p-value<0.001). Although in this study there was no association between blood type and RH type with COVID-19, findings of the association between age and gender can confirm the results of previous studies.

Erwin Strobel - One of the best experts on this subject based on the ideXlab platform.

  • The molecular basis of the Rhesus Antigen Ew.
    Transfusion, 2004
    Co-Authors: Erwin Strobel, Jean-pierre Cartron, Sabine Hofmann, Matthias F. Bauer
    Abstract:

    w(ISBT designation 004 011) was first described in 1955. It is defined by a specific antibody, but its molecular genetic basis has not yet been resolved. STUDY DESIGN AND METHODS: Two individuals serologically characterized to express the rare Rhesus Antigen E w were analyzed by sequencing of all 10 exons of the RHCE gene. RESULTS: A nucleotide exchange at position 500 (T500A) resulting in a Met167Lys amino acid substitution was found in both individuals. Moreover, we show that an individual carrying the E w Antigen is capable to produce an alloantibody against the wild-type E Antigen. CONCLUSION: The single-point mutation T500A in exon 4 of the RHCE gene is a molecular basis of the rare Rhesus Antigen E w . he Rhesus Antigens represent the most complex blood group system on human RBCs, with at least 48 serologic entities described so far. 1 It is