The Experts below are selected from a list of 138 Experts worldwide ranked by ideXlab platform
Frank C Arnett - One of the best experts on this subject based on the ideXlab platform.
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accelerated cutaneous Nodulosis during methotrexate therapy in a patient with Rheumatoid arthritis
Journal of The American Academy of Dermatology, 1998Co-Authors: Francis M Williams, Philip R Cohen, Frank C ArnettAbstract:Rheumatoid Nodulosis is characterized by multiple small subcutaneous granulomatous nodules typically located on the elbows in approximately 20% of patients with Rheumatoid arthritis. Accelerated Rheumatoid Nodulosis, especially involving the hands and feet, has recently been reported in patients receiving methotrexate therapy for Rheumatoid arthritis. We describe a woman with seropositive, erosive Rheumatoid arthritis who, on two occasions, developed nonperiarticular subcutaneous nodules and new heart murmurs during methotrexate therapy, while her arthritis remained under good control. The nodules resolved after methotrexate was discontinued and recurred after methotrexate was reintroduced. They again resolved after methotrexate was stopped and colchicine was added. Her DNA oligotyping was positive for HLA-DRB1*0401, a genetic risk factor associated with accelerated Rheumatoid Nodulosis. Cutaneous biopsy specimens revealed palisading granulomas and giant cells consistent with Rheumatoid Nodulosis.
Francis M Williams - One of the best experts on this subject based on the ideXlab platform.
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accelerated cutaneous Nodulosis during methotrexate therapy in a patient with Rheumatoid arthritis
Journal of The American Academy of Dermatology, 1998Co-Authors: Francis M Williams, Philip R Cohen, Frank C ArnettAbstract:Rheumatoid Nodulosis is characterized by multiple small subcutaneous granulomatous nodules typically located on the elbows in approximately 20% of patients with Rheumatoid arthritis. Accelerated Rheumatoid Nodulosis, especially involving the hands and feet, has recently been reported in patients receiving methotrexate therapy for Rheumatoid arthritis. We describe a woman with seropositive, erosive Rheumatoid arthritis who, on two occasions, developed nonperiarticular subcutaneous nodules and new heart murmurs during methotrexate therapy, while her arthritis remained under good control. The nodules resolved after methotrexate was discontinued and recurred after methotrexate was reintroduced. They again resolved after methotrexate was stopped and colchicine was added. Her DNA oligotyping was positive for HLA-DRB1*0401, a genetic risk factor associated with accelerated Rheumatoid Nodulosis. Cutaneous biopsy specimens revealed palisading granulomas and giant cells consistent with Rheumatoid Nodulosis.
Tomoastu Kimura - One of the best experts on this subject based on the ideXlab platform.
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Rheumatoid Nodulosis during methotrexate therapy in a patient with Rheumatoid arthritis
Modern Rheumatology, 2006Co-Authors: Isao Matsushita, Miwa Uzuki, Hiroaki Matsuno, Eiji Sugiyama, Tomoastu KimuraAbstract:We report a 62-year-old man with Rheumatoid arthritis (RA) who developed Nodulosis after methotrexate (MTX) treatment. The epithelioid cells of nodules were positive for matrix metalloproteinases (MMP)-2, MMP-3, MMP-9, and Ki67. The synovial tissues obtained from the same patient were negative for MMP-3, MMP-9, and Ki67. This study demonstrated that MTX-induced nodules are different from synovial tissues in terms of MMP expression, suggesting the presence of different pathologic mechanisms and differential MTX susceptibility.
Nikhil Yawalkar - One of the best experts on this subject based on the ideXlab platform.
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Skin Manifestations of Rheumatoid Arthritis, Juvenile Idiopathic Arthritis, and Spondyloarthritides
Clinical Reviews in Allergy & Immunology, 2017Co-Authors: Carolyn Jean Chua-aguilera, Burkhard Möller, Nikhil YawalkarAbstract:Extra-articular manifestations of Rheumatoid arthritis, juvenile idiopathic arthritis, and various spondyloarthritides including psoriatic arthritis, ankylosing spondylitis, reactive arthritis, and inflammatory bowel disease-associated spondyloarthritis often involve the skin and may occur before or after diagnosis of these rheumatic diseases. Cutaneous manifestations encompass a wide range of reactions that may have a notable negative impact not only on the physical but especially on the emotional and psychosocial well-being of these patients. Several cutaneous manifestations have been related to Rheumatoid arthritis such as subcutaneous nodules including classical Rheumatoid nodules, accelerated Rheumatoid Nodulosis, and Rheumatoid Nodulosis; vascular disorders like Rheumatoid vasculitis, livedo racemosa, and Raynaud’s phenomenon; and neutrophilic and/or granulomatous diseases like pyoderma gangrenosum, Sweet’s syndrome, Rheumatoid neutrophilic dermatitis, interstitial granulomatous dermatitis with arthritis, as well as palisaded neutrophilic and granulomatous dermatitis. In juvenile idiopathic arthritis, the main cutaneous manifestations include an evanescent rash, Rheumatoid nodules, as well as plaque and guttate psoriasis. Plaque psoriasis is also the main skin disease involved in spondyloarthritides. Furthermore, other forms of psoriasis including guttate, inverse, erythrodermic, pustular, and particularly nail psoriasis may also occur. In addition, a variety of drug-induced skin reactions may also appear in these diseases. Early recognition and understanding of these different dermatologic manifestations together with an interdisciplinary approach are often needed to optimize management of these diseases.
Louis P Dehner - One of the best experts on this subject based on the ideXlab platform.
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(Nodulosis) of the Pancreas in an Adult with Long-Standing Rheumatoid Arthritis
2016Co-Authors: Tumefactive Necrobiotic Granulomas, Wolfram F J Riedlinger, Terry C Lairmore, Dennis M Balfe, Louis P DehnerAbstract:The present report documents the occurrence of necrobiotic and hyalinized, palisading granulomas within the pancreas of an adult female with long-standing Rheumatoid arthritis (RA). Because of an elevated serum pancreatic polypeptide (PP) and the presence of mass lesions in the body and tail of the pancreas, an islet cell tumor(s) was strongly sus-pected at the time of surgery. To the best of our knowledge, this case of Rheumatoid Nodulosis in the pancreas would appear to be a unique experience in terms of documentation in the available literature. Case Report The patient, a 46-year-old woman, was diagnosed with RA at the age of 39 years when she initially presented with pain, stiffness, swelling, and ery-thema of both wrists and several interphalangeal joints in both hands. During periods of clinical ex-acerbation, she would develop palpable subcuta-neous nodules principally on the extensor surfaces of the wrists. The serum Rheumatoid factor had been elevated to titers of 1:80
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tumefactive necrobiotic granulomas Nodulosis of the pancreas in an adult with long standing Rheumatoid arthritis
International Journal of Surgical Pathology, 2005Co-Authors: Wolfram F J Riedlinger, Terry C Lairmore, Dennis M Balfe, Louis P DehnerAbstract:Rheumatoid nodules are well-documented clinical and pathologic lesions in patients with seropositive Rheumatoid arthritis (RA). The current report documents the occurrence of Rheumatoid Nodulosis of the pancreas in an adult woman with a 7-year history of seropositive RA who presented with upper abdominal pain and was found to have multiple masses in the body and tail of the pancreas by imaging studies. An elevated serum pancreatic polypeptide (PP) and the development of new lesions in the pancreas prompted a subsequent distal pancreatectomy. The lesions in the pancreas proved to be necrobiotic palisading and hyalinizing granulomas upon pathologic examination. Also, of interest, elevation of serum PP has been observed in patients with RA and other systemic noninfectious and infectious inflammatory disorders in the absence of a pancreatic or intestinal neuroendocrine neoplasm.