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Guglielmo Bonanni - One of the best experts on this subject based on the ideXlab platform.
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sniffin sticks and olfactory system imaging in patients with kallmann syndrome
International Forum of Allergy & Rhinology, 2015Co-Authors: Giancarlo Ottaviano, Valentina Citton, Antonio Agostino Sinisi, Alessandro Salvalaggio, Raffaele Liuzzi, Arianna Derrico, Angela Favaro, Elena Cantone, Bruno Scarpa, Guglielmo BonanniAbstract:Background The relationship between olfactory function, Rhinencephalon and forebrain changes in Kallmann syndrome (KS) have not been adequately investigated. We evaluated a large cohort of male KS patients using Sniffin’ Sticks and MRI in order to study olfactory bulb (OB) volume, olfactory sulcus (OS) depth, cortical thickness close to the OS, and olfactory phenotype. Methods Olfaction was assessed administering Sniffin’ Sticks®, in 38 KS patients and 17 controls (by means of Screening 12 test®). All subjects underwent magnetic resonance imaging (MRI) to study OB volume, sulcus depth, and cortical thickness. Results Compared to controls, KS patients showed smaller OB volume (p<0.0001), reduced sulcus depth (p<0.0001), and thicker cortex in the region close to the OS (p<0.0001). Anosmic KS patients had smaller OB than controls and hyposmic KS patients; there was no difference between hyposmic KS patients and controls. OB volume correlated with Sniffin’ Sticks score (r = 0.64; p < 0.001), OS depth (p<0.0001) and, inversely, with cortical thickness changes (p<0.0001). Sniffin’ Sticks showed an inverse correlation with cortical thickness (r = −0.5; p<0.0001) and a trend toward a statistically significant correlation with OS depth. Conclusion The present study provides further evidence of the strict relationship between olfaction and OB volume. The strong correlation between OB volume and the overlying cortical changes highlights the key role of Rhinencephalon in forebrain embryogenesis.
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Sniffin' Sticks and olfactory system imaging in patients with Kallmann syndrome.
International Forum of Allergy & Rhinology, 2015Co-Authors: Giancarlo Ottaviano, Arianna D'errico, Valentina Citton, Antonio Agostino Sinisi, Alessandro Salvalaggio, Raffaele Liuzzi, Angela Favaro, Elena Cantone, Bruno Scarpa, Guglielmo BonanniAbstract:Background The relationship between olfactory function, Rhinencephalon and forebrain changes in Kallmann syndrome (KS) have not been adequately investigated. We evaluated a large cohort of male KS patients using Sniffin’ Sticks and MRI in order to study olfactory bulb (OB) volume, olfactory sulcus (OS) depth, cortical thickness close to the OS, and olfactory phenotype. Methods Olfaction was assessed administering Sniffin’ Sticks®, in 38 KS patients and 17 controls (by means of Screening 12 test®). All subjects underwent magnetic resonance imaging (MRI) to study OB volume, sulcus depth, and cortical thickness. Results Compared to controls, KS patients showed smaller OB volume (p
Giancarlo Ottaviano - One of the best experts on this subject based on the ideXlab platform.
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sniffin sticks and olfactory system imaging in patients with kallmann syndrome
International Forum of Allergy & Rhinology, 2015Co-Authors: Giancarlo Ottaviano, Valentina Citton, Antonio Agostino Sinisi, Alessandro Salvalaggio, Raffaele Liuzzi, Arianna Derrico, Angela Favaro, Elena Cantone, Bruno Scarpa, Guglielmo BonanniAbstract:Background The relationship between olfactory function, Rhinencephalon and forebrain changes in Kallmann syndrome (KS) have not been adequately investigated. We evaluated a large cohort of male KS patients using Sniffin’ Sticks and MRI in order to study olfactory bulb (OB) volume, olfactory sulcus (OS) depth, cortical thickness close to the OS, and olfactory phenotype. Methods Olfaction was assessed administering Sniffin’ Sticks®, in 38 KS patients and 17 controls (by means of Screening 12 test®). All subjects underwent magnetic resonance imaging (MRI) to study OB volume, sulcus depth, and cortical thickness. Results Compared to controls, KS patients showed smaller OB volume (p<0.0001), reduced sulcus depth (p<0.0001), and thicker cortex in the region close to the OS (p<0.0001). Anosmic KS patients had smaller OB than controls and hyposmic KS patients; there was no difference between hyposmic KS patients and controls. OB volume correlated with Sniffin’ Sticks score (r = 0.64; p < 0.001), OS depth (p<0.0001) and, inversely, with cortical thickness changes (p<0.0001). Sniffin’ Sticks showed an inverse correlation with cortical thickness (r = −0.5; p<0.0001) and a trend toward a statistically significant correlation with OS depth. Conclusion The present study provides further evidence of the strict relationship between olfaction and OB volume. The strong correlation between OB volume and the overlying cortical changes highlights the key role of Rhinencephalon in forebrain embryogenesis.
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Sniffin' Sticks and olfactory system imaging in patients with Kallmann syndrome.
International Forum of Allergy & Rhinology, 2015Co-Authors: Giancarlo Ottaviano, Arianna D'errico, Valentina Citton, Antonio Agostino Sinisi, Alessandro Salvalaggio, Raffaele Liuzzi, Angela Favaro, Elena Cantone, Bruno Scarpa, Guglielmo BonanniAbstract:Background The relationship between olfactory function, Rhinencephalon and forebrain changes in Kallmann syndrome (KS) have not been adequately investigated. We evaluated a large cohort of male KS patients using Sniffin’ Sticks and MRI in order to study olfactory bulb (OB) volume, olfactory sulcus (OS) depth, cortical thickness close to the OS, and olfactory phenotype. Methods Olfaction was assessed administering Sniffin’ Sticks®, in 38 KS patients and 17 controls (by means of Screening 12 test®). All subjects underwent magnetic resonance imaging (MRI) to study OB volume, sulcus depth, and cortical thickness. Results Compared to controls, KS patients showed smaller OB volume (p
Laura Silveira-moriyama - One of the best experts on this subject based on the ideXlab platform.
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The Hitchhiker’s guide to the Rhinencephalon
Arquivos de neuro-psiquiatria, 2016Co-Authors: Laura Silveira-moriyama, Philip Glass, Suraj Rajan, Rafael Carvalho, Fabiano Reis, Carlos A. A. Penatti, Valeria MuioAbstract:Pathology of the Rhinencephalon has been a subject of interest in the fields of neurodegenerative diseases, trauma, epilepsy and other neurological conditions. Most of what is known about the human Rhinencephalon comes from comparative anatomy studies in other mammals and histological studies in primates. Functional imaging studies can provide new and important insight into the function of the Rhinencephalon in humans but have limited spatial resolution, limiting its contribution to the study of the anatomy of the human Rhinencephalon. In this study we aim to provide a brief and objective review of the anatomy of this important and often overlooked area of the nervous system.
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The Hitchhiker's guide to the Rhinencephalon Um guia prático sobre a anatomia do rinencéfalo
2016Co-Authors: Laura Silveira-moriyama, Suraj Rajan, Rafael Carvalho, Fabiano Reis, Philip George Glass, Valeria MuioAbstract:absTracT Pathology of the Rhinencephalon has been a subject of interest in the fields of neurodegenerative diseases, trauma, epilepsy and other neurological conditions. Most of what is known about the human Rhinencephalon comes from comparative anatomy studies in other mammals and histological studies in primates. Functional imaging studies can provide new and important insight into the function of the Rhinencephalon in humans but have limited spatial resolution, limiting its contribution to the study of the anatomy of the human Rhinencephalon. In this study we aim to provide a brief and objective review of the anatomy of this important and often overlooked area of the nervous system.Keywords: olfactory cortex; anatomy; neuroanatomy. resumo As patologias do rinencefalo tem sido assunto de interesse para os estudiosos das doencas neurodegenerativas, do traumatismo cranio-encefalico, epilepsia e outras doencas neurologicas. A maior parte do conhecimento sobre a anatomia do rinencefalo vem de estudos de anatomia comparativa com outros mamiferos e estudos histologicos em primatas. Estudos de imagem funcional, apesar de proporcionarem informacoes uteis e interessantes a respeito do funcionamento do rinencefalo em humanos, sofrem de resolucao espacial limitada, e portanto contribuem de maneira restrita ao estudo dos limites das areas anatomicas. Neste artigo buscamos proporcionar ao neurologista e neurocientista interessado uma revisao pratica e objetiva da anatomia desta area importante e muitas vezes esquecida do sistema nervoso.Palavras-chave: cortex olfatorio; anatomia; neuroanatomia.
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Regional differences in the severity of Lewy body pathology across the olfactory cortex.
Neuroscience letters, 2009Co-Authors: Laura Silveira-moriyama, Andrew J Lees, Ann E. Kingsbury, H Ayling, Janice L. Holton, Aviva Petrie, William Sterlacci, Werner Poewe, Hans Maier, Tamas ReveszAbstract:We studied α-synuclein pathology in the Rhinencephalon of ten cases of Parkinson's disease (PD) and twelve neurologically normal controls, of which seven had incidental Lewy bodies in the substantia nigra at autopsy and five had no pathological evidence of neurological disease. In all PD and incidental Lewy bodies cases, α-synuclein pathology was found in all five subregions of the primary olfactory cortex that were sampled, and amongst them the pathology was significantly more severe in the temporal division of the piriform cortex than in the frontal division of the piriform cortex, olfactory tubercle or anterior portions of the entorhinal cortex. The orbitofrontal cortex, which is an area of projection from the primary olfactory cortex, was affected in some cases but overall the α-synuclein pathology was less severe in this area than in the primary olfactory cortex. Because different areas of the Rhinencephalon are likely to play different roles in olfaction and our data indicate a differential involvement by α-synuclein deposition of structures implicated in smell, future prospective studies investigating the pathophysiological basis of hyposmia in PD should consider to examine the areas of primary olfactory cortex separately.
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Hyposmia in G2019S LRRK2-related parkinsonism Clinical and pathologic data
Neurology, 2008Co-Authors: Laura Silveira-moriyama, Leonor Correia Guedes, Ann E. Kingsbury, H Ayling, Karen Shaw, Egberto Reis Barbosa, Vincenzo Bonifati, Niall Quinn, Patrick M. Abou-sleiman, Nicholas W. WoodAbstract:Background: Mutations in PARK8 (LRRK2) are associated with autosomal dominant parkinsonism and Parkinson disease (PD). Hyposmia is present in at least 80% of patients with PD and an accumulation of alpha-synuclein (alpha-syn) is seen in the olfactory pathways. In this study we have clinically examined olfaction and pathologically examined the Rhinencephalon in individuals carrying the G2019S LRRK2 mutation.Methods: The University of Pennsylvania Smell Test (UPSIT) was used to evaluate the sense of smell in 19 parkinsonian and two asymptomatic carriers of the G2019S mutation and compared with groups of patients with PD and healthy controls. Postmortem examination of alpha-syn accumulation in the Rhinencephalon was also carried out in four parkinsonian carriers of the G2019S mutation.Results: The mean UPSIT score in G2019S parkinsonian carriers was lower than that in healthy controls (p 0.999). Smell tests in two asymptomatic carriers of the G2019S mutation were in the normal range. Postmortem studies of the olfactory pathways in one of the patients who had been clinically tested, and found to have hyposmia, and three other cases with the G2019S mutation, revealed alpha-syn deposition in the olfactory pathways in all cases.Conclusions: Odor identification is diminished in LRRK2G2019S mutation parkinsonism but the asymptomatic carriers of the mutation had normal olfaction. We found alpha-syn accumulation with Lewy bodies in the Rhinencephalon in all four cases examined pathologically.
Bruno Scarpa - One of the best experts on this subject based on the ideXlab platform.
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sniffin sticks and olfactory system imaging in patients with kallmann syndrome
International Forum of Allergy & Rhinology, 2015Co-Authors: Giancarlo Ottaviano, Valentina Citton, Antonio Agostino Sinisi, Alessandro Salvalaggio, Raffaele Liuzzi, Arianna Derrico, Angela Favaro, Elena Cantone, Bruno Scarpa, Guglielmo BonanniAbstract:Background The relationship between olfactory function, Rhinencephalon and forebrain changes in Kallmann syndrome (KS) have not been adequately investigated. We evaluated a large cohort of male KS patients using Sniffin’ Sticks and MRI in order to study olfactory bulb (OB) volume, olfactory sulcus (OS) depth, cortical thickness close to the OS, and olfactory phenotype. Methods Olfaction was assessed administering Sniffin’ Sticks®, in 38 KS patients and 17 controls (by means of Screening 12 test®). All subjects underwent magnetic resonance imaging (MRI) to study OB volume, sulcus depth, and cortical thickness. Results Compared to controls, KS patients showed smaller OB volume (p<0.0001), reduced sulcus depth (p<0.0001), and thicker cortex in the region close to the OS (p<0.0001). Anosmic KS patients had smaller OB than controls and hyposmic KS patients; there was no difference between hyposmic KS patients and controls. OB volume correlated with Sniffin’ Sticks score (r = 0.64; p < 0.001), OS depth (p<0.0001) and, inversely, with cortical thickness changes (p<0.0001). Sniffin’ Sticks showed an inverse correlation with cortical thickness (r = −0.5; p<0.0001) and a trend toward a statistically significant correlation with OS depth. Conclusion The present study provides further evidence of the strict relationship between olfaction and OB volume. The strong correlation between OB volume and the overlying cortical changes highlights the key role of Rhinencephalon in forebrain embryogenesis.
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Sniffin' Sticks and olfactory system imaging in patients with Kallmann syndrome.
International Forum of Allergy & Rhinology, 2015Co-Authors: Giancarlo Ottaviano, Arianna D'errico, Valentina Citton, Antonio Agostino Sinisi, Alessandro Salvalaggio, Raffaele Liuzzi, Angela Favaro, Elena Cantone, Bruno Scarpa, Guglielmo BonanniAbstract:Background The relationship between olfactory function, Rhinencephalon and forebrain changes in Kallmann syndrome (KS) have not been adequately investigated. We evaluated a large cohort of male KS patients using Sniffin’ Sticks and MRI in order to study olfactory bulb (OB) volume, olfactory sulcus (OS) depth, cortical thickness close to the OS, and olfactory phenotype. Methods Olfaction was assessed administering Sniffin’ Sticks®, in 38 KS patients and 17 controls (by means of Screening 12 test®). All subjects underwent magnetic resonance imaging (MRI) to study OB volume, sulcus depth, and cortical thickness. Results Compared to controls, KS patients showed smaller OB volume (p
Elena Cantone - One of the best experts on this subject based on the ideXlab platform.
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sniffin sticks and olfactory system imaging in patients with kallmann syndrome
International Forum of Allergy & Rhinology, 2015Co-Authors: Giancarlo Ottaviano, Valentina Citton, Antonio Agostino Sinisi, Alessandro Salvalaggio, Raffaele Liuzzi, Arianna Derrico, Angela Favaro, Elena Cantone, Bruno Scarpa, Guglielmo BonanniAbstract:Background The relationship between olfactory function, Rhinencephalon and forebrain changes in Kallmann syndrome (KS) have not been adequately investigated. We evaluated a large cohort of male KS patients using Sniffin’ Sticks and MRI in order to study olfactory bulb (OB) volume, olfactory sulcus (OS) depth, cortical thickness close to the OS, and olfactory phenotype. Methods Olfaction was assessed administering Sniffin’ Sticks®, in 38 KS patients and 17 controls (by means of Screening 12 test®). All subjects underwent magnetic resonance imaging (MRI) to study OB volume, sulcus depth, and cortical thickness. Results Compared to controls, KS patients showed smaller OB volume (p<0.0001), reduced sulcus depth (p<0.0001), and thicker cortex in the region close to the OS (p<0.0001). Anosmic KS patients had smaller OB than controls and hyposmic KS patients; there was no difference between hyposmic KS patients and controls. OB volume correlated with Sniffin’ Sticks score (r = 0.64; p < 0.001), OS depth (p<0.0001) and, inversely, with cortical thickness changes (p<0.0001). Sniffin’ Sticks showed an inverse correlation with cortical thickness (r = −0.5; p<0.0001) and a trend toward a statistically significant correlation with OS depth. Conclusion The present study provides further evidence of the strict relationship between olfaction and OB volume. The strong correlation between OB volume and the overlying cortical changes highlights the key role of Rhinencephalon in forebrain embryogenesis.
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Sniffin' Sticks and olfactory system imaging in patients with Kallmann syndrome.
International Forum of Allergy & Rhinology, 2015Co-Authors: Giancarlo Ottaviano, Arianna D'errico, Valentina Citton, Antonio Agostino Sinisi, Alessandro Salvalaggio, Raffaele Liuzzi, Angela Favaro, Elena Cantone, Bruno Scarpa, Guglielmo BonanniAbstract:Background The relationship between olfactory function, Rhinencephalon and forebrain changes in Kallmann syndrome (KS) have not been adequately investigated. We evaluated a large cohort of male KS patients using Sniffin’ Sticks and MRI in order to study olfactory bulb (OB) volume, olfactory sulcus (OS) depth, cortical thickness close to the OS, and olfactory phenotype. Methods Olfaction was assessed administering Sniffin’ Sticks®, in 38 KS patients and 17 controls (by means of Screening 12 test®). All subjects underwent magnetic resonance imaging (MRI) to study OB volume, sulcus depth, and cortical thickness. Results Compared to controls, KS patients showed smaller OB volume (p