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Clercx Cécile - One of the best experts on this subject based on the ideXlab platform.
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Traitement chirurgical de l'aspergillose nasale chez le chien par rhynotomie combinée avec une infusion d'énilconazole
2006Co-Authors: Claeys Stéphanie, Lefebvre J.-b., Schuller S., Hamaide Annick, Clercx CécileAbstract:OBJECTIVES: To evaluate the effectiveness of rhinotomy and surgical debridement associated with topical administration of 2 per cent enilconazole and oral itraconazole in dogs with severe or recurrent sinonasal aspergillosis. METHODS: A standard rhinotomy was performed on seven dogs. In the initial study, the bone flap was left attached cranially and replaced at the end of the procedure. In the main study group, the bone flap was discarded. Nasal passages were debrided and irrigated with enilconazole solution for one hour. Oral itraconazole was administered to four dogs for one month postoperatively. Follow-up Rhinoscopy was performed in all dogs. RESULTS: All three dogs in the initial study had recurrence of the disease and two dogs had a second surgery to remove the flap. The main study group included four dogs in which the flap was initially removed, and the two dogs from the initial study that required a second surgery. At follow-up Rhinoscopy, five dogs were free of aspergillus but had bacterial or inflammatory rhinitis and one dog had a small aspergilloma but was subsequently asymptomatic. Telephone follow-up revealed that four dogs were asymptomatic, one dog had intermittent sneezing and serous nasal discharge, and one dog had intermittent epistaxis. CLINICAL SIGNIFICANCE: Rhinotomy with removal of the flap combined with one-hour infusion of 2 per cent enilconazole and oral itraconazole resulted in satisfactory outcome in dogs with severe or recurrent aspergillosis.Peer reviewe
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Traitement chirurgical de l'aspergillose nasale chez le chien par rhynotomie combinée avec une infusion d'énilconazole
'Wiley', 2006Co-Authors: Claeys Stéphanie, Lefebvre J.-b., Schuller S., Hamaide Annick, Clercx CécileAbstract:peer reviewedaudience: researcher, professional, studentOBJECTIVES: To evaluate the effectiveness of rhinotomy and surgical debridement associated with topical administration of 2 per cent enilconazole and oral itraconazole in dogs with severe or recurrent sinonasal aspergillosis. METHODS: A standard rhinotomy was performed on seven dogs. In the initial study, the bone flap was left attached cranially and replaced at the end of the procedure. In the main study group, the bone flap was discarded. Nasal passages were debrided and irrigated with enilconazole solution for one hour. Oral itraconazole was administered to four dogs for one month postoperatively. Follow-up Rhinoscopy was performed in all dogs. RESULTS: All three dogs in the initial study had recurrence of the disease and two dogs had a second surgery to remove the flap. The main study group included four dogs in which the flap was initially removed, and the two dogs from the initial study that required a second surgery. At follow-up Rhinoscopy, five dogs were free of aspergillus but had bacterial or inflammatory rhinitis and one dog had a small aspergilloma but was subsequently asymptomatic. Telephone follow-up revealed that four dogs were asymptomatic, one dog had intermittent sneezing and serous nasal discharge, and one dog had intermittent epistaxis. CLINICAL SIGNIFICANCE: Rhinotomy with removal of the flap combined with one-hour infusion of 2 per cent enilconazole and oral itraconazole resulted in satisfactory outcome in dogs with severe or recurrent aspergillosis
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Diagnosis of pharyngeal disorders in dogs: a retrospective study of 67 cases
2006Co-Authors: Billen Frédéric, Day M. J., Clercx CécileAbstract:OBJECTIVES: To assess the frequency distribution of pharyngeal disorders and to compare clinical signs in diseases of the different pharyngeal areas. To review the investigation methods. METHODS: Medical records of 67 dogs presenting with abnormalities of the pharyngeal area were retrospectively reviewed and classified according to the anatomic area involved, i.e. the nasopharyngeal, oropharyngeal and laryngopharyngeal areas. Clinical signs, endoscopic findings and results of additional sampling were reviewed. RESULTS: Nasopharyngeal disorders were most frequently encountered (49 per cent), with choanal masses being the most frequent diagnosis (24 of 33), followed by laryngopharyngeal disorders (37.5 per cent) and oropharyngeal disorders (10.5 per cent). A rare condition, stenosis of the intrapharyngeal opening, was classified separately (3 per cent). An overall good correlation between matched cytology and histopathology samples was found. In all categories of diseases, clinical signs related to both the upper respiratory and digestive tracts were reported. CLINICAL SIGNIFICANCE: Pharyngeal disorders are more frequently localised in the nasopharyngeal area and include essentially choanal masses. The use of a flexible endoscope for retrograde Rhinoscopy is essential for adequate investigation of the proximal nasopharyngeal area. Clinical signs do not allow differentiation of the pharyngeal disorder within the different pharyngeal areas.Peer reviewe
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Nasal aspergillosis associated with an impacted canine tooth in a Belgian shepherd dog
2003Co-Authors: Saunders J., Clercx Cécile, Zonderland J.l., Taeymans O.Abstract:A 9-month-old Belgian shepherd dog was evaluated for chronic nasal discharge. Oral examination revealed the absence of the left upper canine tooth. Radiographs showed impaction of this tooth into the left nasal cavity with caudal displacement of the tooth root. Rhinoscopy demonstrated the presence of fungal colonies. The impacted tooth was surgically removed and the nasal cavity flushed with enilconazole 1%. No recurrence was observed during a follow-up period of two years.Peer reviewe
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Nasal aspergillosis associated with an impacted canine tooth in a Belgian shepherd dog
UGent, 2003Co-Authors: Saunders J., Clercx Cécile, Zonderland J.l., Taeymans O.Abstract:peer reviewedaudience: researcher, professionalA 9-month-old Belgian shepherd dog was evaluated for chronic nasal discharge. Oral examination revealed the absence of the left upper canine tooth. Radiographs showed impaction of this tooth into the left nasal cavity with caudal displacement of the tooth root. Rhinoscopy demonstrated the presence of fungal colonies. The impacted tooth was surgically removed and the nasal cavity flushed with enilconazole 1%. No recurrence was observed during a follow-up period of two years
Claeys Stéphanie - One of the best experts on this subject based on the ideXlab platform.
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Traitement chirurgical de l'aspergillose nasale chez le chien par rhynotomie combinée avec une infusion d'énilconazole
2006Co-Authors: Claeys Stéphanie, Lefebvre J.-b., Schuller S., Hamaide Annick, Clercx CécileAbstract:OBJECTIVES: To evaluate the effectiveness of rhinotomy and surgical debridement associated with topical administration of 2 per cent enilconazole and oral itraconazole in dogs with severe or recurrent sinonasal aspergillosis. METHODS: A standard rhinotomy was performed on seven dogs. In the initial study, the bone flap was left attached cranially and replaced at the end of the procedure. In the main study group, the bone flap was discarded. Nasal passages were debrided and irrigated with enilconazole solution for one hour. Oral itraconazole was administered to four dogs for one month postoperatively. Follow-up Rhinoscopy was performed in all dogs. RESULTS: All three dogs in the initial study had recurrence of the disease and two dogs had a second surgery to remove the flap. The main study group included four dogs in which the flap was initially removed, and the two dogs from the initial study that required a second surgery. At follow-up Rhinoscopy, five dogs were free of aspergillus but had bacterial or inflammatory rhinitis and one dog had a small aspergilloma but was subsequently asymptomatic. Telephone follow-up revealed that four dogs were asymptomatic, one dog had intermittent sneezing and serous nasal discharge, and one dog had intermittent epistaxis. CLINICAL SIGNIFICANCE: Rhinotomy with removal of the flap combined with one-hour infusion of 2 per cent enilconazole and oral itraconazole resulted in satisfactory outcome in dogs with severe or recurrent aspergillosis.Peer reviewe
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Traitement chirurgical de l'aspergillose nasale chez le chien par rhynotomie combinée avec une infusion d'énilconazole
'Wiley', 2006Co-Authors: Claeys Stéphanie, Lefebvre J.-b., Schuller S., Hamaide Annick, Clercx CécileAbstract:peer reviewedaudience: researcher, professional, studentOBJECTIVES: To evaluate the effectiveness of rhinotomy and surgical debridement associated with topical administration of 2 per cent enilconazole and oral itraconazole in dogs with severe or recurrent sinonasal aspergillosis. METHODS: A standard rhinotomy was performed on seven dogs. In the initial study, the bone flap was left attached cranially and replaced at the end of the procedure. In the main study group, the bone flap was discarded. Nasal passages were debrided and irrigated with enilconazole solution for one hour. Oral itraconazole was administered to four dogs for one month postoperatively. Follow-up Rhinoscopy was performed in all dogs. RESULTS: All three dogs in the initial study had recurrence of the disease and two dogs had a second surgery to remove the flap. The main study group included four dogs in which the flap was initially removed, and the two dogs from the initial study that required a second surgery. At follow-up Rhinoscopy, five dogs were free of aspergillus but had bacterial or inflammatory rhinitis and one dog had a small aspergilloma but was subsequently asymptomatic. Telephone follow-up revealed that four dogs were asymptomatic, one dog had intermittent sneezing and serous nasal discharge, and one dog had intermittent epistaxis. CLINICAL SIGNIFICANCE: Rhinotomy with removal of the flap combined with one-hour infusion of 2 per cent enilconazole and oral itraconazole resulted in satisfactory outcome in dogs with severe or recurrent aspergillosis
A Aycicek - One of the best experts on this subject based on the ideXlab platform.
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evaluating the relationship between nasal obstruction and mean platelet volume by using acoustic rhinometry in patients with septum deviation
Rhinology, 2013Co-Authors: Sena Ulu, M S Ulu, A Bucak, O K Kahveci, F Yucedag, A AycicekAbstract:BACKGROUND Nasal airway obstruction is a common cause of upper airway obstruction. It is associated strongly with obstructive and hypoxic manifestations. Mean platelet volume (MPV) levels increase in hypoxic conditions. MPV is one of the platelet activation indices which re!ects the platelet production rate. We aimed to evaluate the relationship between MPV levels and nasal septal deviation (NSD) by using acoustics rhinometry in patients with septum deviation. METHODS We performed a retrospective study of 51 patients with NSD and 58 healthy age matched subjects as control group. The diagnosis of patients with NSD was based on anterior Rhinoscopy, endoscopic nasal examination and acoustics rhinometry. All the patients underwent Cottle- or Killian-type septoplasty under general anesthesia. Blood samples were collected before nasal septoplasty. RESULTS MPV and platelet distribution width (PDW) levels were significantly higher and mean platelet count was lower in patients with NSD than the control group. A negative correlation was found between MPV, NDVol2 (volume2 of non-deviated side of the nose) and TNDVol (total volume of non-deviated side of the nose) values. CONCLUSION MPV values increase in patients with NSD. Moreover, this increase was found in relation with the severity of obstruction.
Nicolas Granger - One of the best experts on this subject based on the ideXlab platform.
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Methods of olfactory ensheathing cell harvesting from the olfactory mucosa in dogs
2019Co-Authors: Daisuke Ito, Darren Carwardine, Jon Prager, Liang Fong Wong, Masato Kitagawa, Nick Jeffery, Nicolas GrangerAbstract:Olfactory ensheathing cells are thought to support regeneration and remyelination of damaged axons when transplanted into spinal cord injuries. Following transplantation, improved locomotion has been detected in many laboratory models and in dogs with naturally-occurring spinal cord injury; safety trials in humans have also been completed. For widespread clinical implementation, it will be necessary to derive large numbers of these cells from an accessible and, preferably, autologous, source making olfactory mucosa a good candidate. Here, we compared the yield of olfactory ensheathing cells from the olfactory mucosa using 3 different techniques: rhinotomy, frontal sinus keyhole approach and Rhinoscopy. From canine clinical cases with spinal cord injury, 27 biopsies were obtained by rhinotomy, 7 by a keyhole approach and 1 with Rhinoscopy. Biopsy via Rhinoscopy was also tested in 13 cadavers and 7 living normal dogs. After 21 days of cell culture, the proportions and populations of p75-positive (presumed to be olfactory ensheathing) cells obtained by the keyhole approach and Rhinoscopy were similar (~4.5 x 106 p75-positive cells; ~70% of the total cell population), but fewer were obtained by frontal sinus rhinotomy. Cerebrospinal fluid rhinorrhea was observed in one dog and emphysema in 3 dogs following rhinotomy. Blepharitis occurred in one dog after the keyhole approach. All three biopsy methods appear to be safe for harvesting a suitable number of olfactory ensheathing cells from the olfactory mucosa for transplantation within the spinal cord but each technique has specific advantages and drawbacks.
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Summary of Cell Proportion and Phenotypic Characteristics in Cultures Obtained by Rhinotomy (n = 27), Keyhole approach (n = 7) and Rhinoscopy (Cadaver n = 12, Living dog n = 7) at 21 Days In Vitro.
2019Co-Authors: Daisuke Ito, Darren Carwardine, Jon Prager, Liang Fong Wong, Masato Kitagawa, Nick Jeffery, Nicolas GrangerAbstract:Summary of Cell Proportion and Phenotypic Characteristics in Cultures Obtained by Rhinotomy (n = 27), Keyhole approach (n = 7) and Rhinoscopy (Cadaver n = 12, Living dog n = 7) at 21 Days In Vitro.
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Summary of Estimated Cell Population and Phenotypic Characteristics in Cultures Obtained by Rhinotomy (n = 27), Keyhole approach (n = 7) and Rhinoscopy (Cadaver n = 12, Living dog n = 7) at 21 Days In Vitro.
2019Co-Authors: Daisuke Ito, Darren Carwardine, Jon Prager, Liang Fong Wong, Masato Kitagawa, Nick Jeffery, Nicolas GrangerAbstract:Summary of Estimated Cell Population and Phenotypic Characteristics in Cultures Obtained by Rhinotomy (n = 27), Keyhole approach (n = 7) and Rhinoscopy (Cadaver n = 12, Living dog n = 7) at 21 Days In Vitro.
Schuller S. - One of the best experts on this subject based on the ideXlab platform.
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Traitement chirurgical de l'aspergillose nasale chez le chien par rhynotomie combinée avec une infusion d'énilconazole
2006Co-Authors: Claeys Stéphanie, Lefebvre J.-b., Schuller S., Hamaide Annick, Clercx CécileAbstract:OBJECTIVES: To evaluate the effectiveness of rhinotomy and surgical debridement associated with topical administration of 2 per cent enilconazole and oral itraconazole in dogs with severe or recurrent sinonasal aspergillosis. METHODS: A standard rhinotomy was performed on seven dogs. In the initial study, the bone flap was left attached cranially and replaced at the end of the procedure. In the main study group, the bone flap was discarded. Nasal passages were debrided and irrigated with enilconazole solution for one hour. Oral itraconazole was administered to four dogs for one month postoperatively. Follow-up Rhinoscopy was performed in all dogs. RESULTS: All three dogs in the initial study had recurrence of the disease and two dogs had a second surgery to remove the flap. The main study group included four dogs in which the flap was initially removed, and the two dogs from the initial study that required a second surgery. At follow-up Rhinoscopy, five dogs were free of aspergillus but had bacterial or inflammatory rhinitis and one dog had a small aspergilloma but was subsequently asymptomatic. Telephone follow-up revealed that four dogs were asymptomatic, one dog had intermittent sneezing and serous nasal discharge, and one dog had intermittent epistaxis. CLINICAL SIGNIFICANCE: Rhinotomy with removal of the flap combined with one-hour infusion of 2 per cent enilconazole and oral itraconazole resulted in satisfactory outcome in dogs with severe or recurrent aspergillosis.Peer reviewe
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Traitement chirurgical de l'aspergillose nasale chez le chien par rhynotomie combinée avec une infusion d'énilconazole
'Wiley', 2006Co-Authors: Claeys Stéphanie, Lefebvre J.-b., Schuller S., Hamaide Annick, Clercx CécileAbstract:peer reviewedaudience: researcher, professional, studentOBJECTIVES: To evaluate the effectiveness of rhinotomy and surgical debridement associated with topical administration of 2 per cent enilconazole and oral itraconazole in dogs with severe or recurrent sinonasal aspergillosis. METHODS: A standard rhinotomy was performed on seven dogs. In the initial study, the bone flap was left attached cranially and replaced at the end of the procedure. In the main study group, the bone flap was discarded. Nasal passages were debrided and irrigated with enilconazole solution for one hour. Oral itraconazole was administered to four dogs for one month postoperatively. Follow-up Rhinoscopy was performed in all dogs. RESULTS: All three dogs in the initial study had recurrence of the disease and two dogs had a second surgery to remove the flap. The main study group included four dogs in which the flap was initially removed, and the two dogs from the initial study that required a second surgery. At follow-up Rhinoscopy, five dogs were free of aspergillus but had bacterial or inflammatory rhinitis and one dog had a small aspergilloma but was subsequently asymptomatic. Telephone follow-up revealed that four dogs were asymptomatic, one dog had intermittent sneezing and serous nasal discharge, and one dog had intermittent epistaxis. CLINICAL SIGNIFICANCE: Rhinotomy with removal of the flap combined with one-hour infusion of 2 per cent enilconazole and oral itraconazole resulted in satisfactory outcome in dogs with severe or recurrent aspergillosis
