The Experts below are selected from a list of 1755 Experts worldwide ranked by ideXlab platform
Zengming Man - One of the best experts on this subject based on the ideXlab platform.
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synthesis of 5 iodo 1 2 3 4 tetrahydropyridines by Rhodium catalyzed tandem nucleophilic attacks involving 1 sulfonyl 1 2 3 triazoles and iodides
Organic Letters, 2016Co-Authors: Zengming Man, Yinping Shi, Haican Dai, Dongdong YangAbstract:Sodium iodide is used for the first time as a nucleophile to trap an α-imino Rhodium Carbene, which triggers a tandem process involving intermolecular nucleophilic attack and intramolecular SN2 reaction. A series of 5-iodo-1,2,3,4-tetrahydropyridines are obtained in high yield, and the synthetic utility of the products is demonstrated in cross-coupling reactions and the construction of biorelated polycyclic compounds.
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Rhodium catalyzed synthesis of 4 bromo 1 2 dihydroisoquinolines access to bromonium ylides by the intramolecular reaction of a benzyl bromide and an α imino Carbene
Angewandte Chemie, 2016Co-Authors: Yinping Shi, Zengming Man, Wanli Cheng, Dongdong YangAbstract:Highly functionalized 4-bromo-1,2-dihydroisoquinolines were synthesized from readily available 4-(2-(bromomethyl)phenyl)-1-sulfonyl-1,2,3-triazoles. A bromonium ylide is proposed as the key intermediate, which can be formed by the intramolecular nucleophilic attack of the benzyl bromide on the α-imino Rhodium Carbene formed in the presence of the Rhodium catalyst.
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Synthesis of 5‑Iodo-1,2,3,4-tetrahydropyridines by Rhodium-Catalyzed Tandem Nucleophilic Attacks Involving 1‑Sulfonyl-1,2,3-triazoles and Iodides
2016Co-Authors: Zengming Man, Yinping Shi, Haican Dai, Dongdong YangAbstract:Sodium iodide is used for the first time as a nucleophile to trap an α-imino Rhodium Carbene, which triggers a tandem process involving intermolecular nucleophilic attack and intramolecular SN2 reaction. A series of 5-iodo-1,2,3,4-tetrahydropyridines are obtained in high yield, and the synthetic utility of the products is demonstrated in cross-coupling reactions and the construction of biorelated polycyclic compounds
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synthesis of β amino α β unsaturated ketone derivatives via sequential Rhodium catalyzed sulfur ylide formation rearrangement
Journal of Organic Chemistry, 2015Co-Authors: Zengming Man, Yinping ShiAbstract:In the presence of a Rh(II) catalyst and β-(methylthio)-α,β-unsaturated ketones, 1-sulfonyl-1,2,3-triazoles can be converted into functionalized β-amino-α,β-unsaturated ketones via formation of α-imino Rhodium Carbene/sulfur ylide and subsequent rearrangement. The products decompose to useful 2-methylthiopyrrole derivatives conveniently in high yield.
Mei-hua Shen - One of the best experts on this subject based on the ideXlab platform.
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an efficient approach to 1 2 3 trisubstituted indole via Rhodium catalyzed Carbene c sp 3 h bond insertion
Organic and Biomolecular Chemistry, 2015Co-Authors: Mei-hua Shen, Zhi-hong Jia, Yingpeng Pan, Xintao Ren, Ping ZhangAbstract:A method for convenient synthesis of N-alkyl-2-aryl-indole-3-carbaldehyde has been described. A variety of highly valuable indolyl aldehydes have been prepared through this method. Electron donating groups on both aromatic rings (anilinyl and benzyl) facilitate the formation of the desired products. A benzylic C–H insertion by Rhodium Carbene is the key step for this transformation.
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one pot protocol to functionalized benzopyrrolizidine catalyzed successively by rh2 oac 4 and cu otf 2 a transition metal lewis acid catalysis relay
Organic Letters, 2015Co-Authors: Huadong Xu, Hao Zhou, Ke Xu, Mei-hua ShenAbstract:4-N-Allylarylpropylamino-1-sulfonyl triazoles are converted to structurally unique benzopyrrolizidinyl sulfonamides in a one-pot operation. Intramolecular capture of Rhodium Carbene with arylamino nitrogen gives rise to the formation of an ammonium ylide immediate. A [2,3]- or [1,2]-rearrangement occurs to give a 2-allylpyrrolidinyl-2-carbimine intermediate which undergoes Cu(OTf)2 catalyzed aza-Friedel–Crafts cyclization to finish a highly functionalized tricyclic system decorated with a synthetically difficult quaternary carbon center, a sulfonamide group, and an allyl segment.
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One-Pot Protocol to Functionalized Benzopyrrolizidine Catalyzed Successively by Rh2(OAc)4 and Cu(OTf)2: A Transition Metal–Lewis Acid Catalysis Relay
2015Co-Authors: Zhi-hong Jia, Hao Zhou, Mei-hua ShenAbstract:4-N-Allylarylpropylamino-1-sulfonyl triazoles are converted to structurally unique benzopyrrolizidinyl sulfonamides in a one-pot operation. Intramolecular capture of Rhodium Carbene with arylamino nitrogen gives rise to the formation of an ammonium ylide immediate. A [2,3]- or [1,2]-rearrangement occurs to give a 2-allylpyrrolidinyl-2-carbimine intermediate which undergoes Cu(OTf)2 catalyzed aza-Friedel–Crafts cyclization to finish a highly functionalized tricyclic system decorated with a synthetically difficult quaternary carbon center, a sulfonamide group, and an allyl segment
Dongdong Yang - One of the best experts on this subject based on the ideXlab platform.
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synthesis of 5 iodo 1 2 3 4 tetrahydropyridines by Rhodium catalyzed tandem nucleophilic attacks involving 1 sulfonyl 1 2 3 triazoles and iodides
Organic Letters, 2016Co-Authors: Zengming Man, Yinping Shi, Haican Dai, Dongdong YangAbstract:Sodium iodide is used for the first time as a nucleophile to trap an α-imino Rhodium Carbene, which triggers a tandem process involving intermolecular nucleophilic attack and intramolecular SN2 reaction. A series of 5-iodo-1,2,3,4-tetrahydropyridines are obtained in high yield, and the synthetic utility of the products is demonstrated in cross-coupling reactions and the construction of biorelated polycyclic compounds.
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Rhodium catalyzed synthesis of 4 bromo 1 2 dihydroisoquinolines access to bromonium ylides by the intramolecular reaction of a benzyl bromide and an α imino Carbene
Angewandte Chemie, 2016Co-Authors: Yinping Shi, Zengming Man, Wanli Cheng, Dongdong YangAbstract:Highly functionalized 4-bromo-1,2-dihydroisoquinolines were synthesized from readily available 4-(2-(bromomethyl)phenyl)-1-sulfonyl-1,2,3-triazoles. A bromonium ylide is proposed as the key intermediate, which can be formed by the intramolecular nucleophilic attack of the benzyl bromide on the α-imino Rhodium Carbene formed in the presence of the Rhodium catalyst.
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Synthesis of 5‑Iodo-1,2,3,4-tetrahydropyridines by Rhodium-Catalyzed Tandem Nucleophilic Attacks Involving 1‑Sulfonyl-1,2,3-triazoles and Iodides
2016Co-Authors: Zengming Man, Yinping Shi, Haican Dai, Dongdong YangAbstract:Sodium iodide is used for the first time as a nucleophile to trap an α-imino Rhodium Carbene, which triggers a tandem process involving intermolecular nucleophilic attack and intramolecular SN2 reaction. A series of 5-iodo-1,2,3,4-tetrahydropyridines are obtained in high yield, and the synthetic utility of the products is demonstrated in cross-coupling reactions and the construction of biorelated polycyclic compounds
Yinping Shi - One of the best experts on this subject based on the ideXlab platform.
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synthesis of 5 iodo 1 2 3 4 tetrahydropyridines by Rhodium catalyzed tandem nucleophilic attacks involving 1 sulfonyl 1 2 3 triazoles and iodides
Organic Letters, 2016Co-Authors: Zengming Man, Yinping Shi, Haican Dai, Dongdong YangAbstract:Sodium iodide is used for the first time as a nucleophile to trap an α-imino Rhodium Carbene, which triggers a tandem process involving intermolecular nucleophilic attack and intramolecular SN2 reaction. A series of 5-iodo-1,2,3,4-tetrahydropyridines are obtained in high yield, and the synthetic utility of the products is demonstrated in cross-coupling reactions and the construction of biorelated polycyclic compounds.
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Rhodium catalyzed synthesis of 4 bromo 1 2 dihydroisoquinolines access to bromonium ylides by the intramolecular reaction of a benzyl bromide and an α imino Carbene
Angewandte Chemie, 2016Co-Authors: Yinping Shi, Zengming Man, Wanli Cheng, Dongdong YangAbstract:Highly functionalized 4-bromo-1,2-dihydroisoquinolines were synthesized from readily available 4-(2-(bromomethyl)phenyl)-1-sulfonyl-1,2,3-triazoles. A bromonium ylide is proposed as the key intermediate, which can be formed by the intramolecular nucleophilic attack of the benzyl bromide on the α-imino Rhodium Carbene formed in the presence of the Rhodium catalyst.
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Synthesis of 5‑Iodo-1,2,3,4-tetrahydropyridines by Rhodium-Catalyzed Tandem Nucleophilic Attacks Involving 1‑Sulfonyl-1,2,3-triazoles and Iodides
2016Co-Authors: Zengming Man, Yinping Shi, Haican Dai, Dongdong YangAbstract:Sodium iodide is used for the first time as a nucleophile to trap an α-imino Rhodium Carbene, which triggers a tandem process involving intermolecular nucleophilic attack and intramolecular SN2 reaction. A series of 5-iodo-1,2,3,4-tetrahydropyridines are obtained in high yield, and the synthetic utility of the products is demonstrated in cross-coupling reactions and the construction of biorelated polycyclic compounds
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synthesis of β amino α β unsaturated ketone derivatives via sequential Rhodium catalyzed sulfur ylide formation rearrangement
Journal of Organic Chemistry, 2015Co-Authors: Zengming Man, Yinping ShiAbstract:In the presence of a Rh(II) catalyst and β-(methylthio)-α,β-unsaturated ketones, 1-sulfonyl-1,2,3-triazoles can be converted into functionalized β-amino-α,β-unsaturated ketones via formation of α-imino Rhodium Carbene/sulfur ylide and subsequent rearrangement. The products decompose to useful 2-methylthiopyrrole derivatives conveniently in high yield.
Min Shi - One of the best experts on this subject based on the ideXlab platform.
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recent advances in the synthesis of heterocycles and related substances based on α imino Rhodium Carbene complexes derived from n sulfonyl 1 2 3 triazoles
Chemistry: A European Journal, 2016Co-Authors: Yu Jiang, Run Sun, Xiangying Tang, Min ShiAbstract:In recent years, α-imino Rhodium Carbene complexes derived by ring-opening of N-sulfonyl-1,2,3-triazoles have attracted much attention from organic chemists. Many transformations of these species have been reported that involve, in most cases, nucleophilic attack at the Carbene center of the α-imino Rhodium Carbene, facilitating the synthesis of a wide range of novel and useful compounds, particularly heterocycles. This Minireview mainly focuses on advances in the transformation of N-sulfonyl-1,2,3-triazoles during the past two years.