The Experts below are selected from a list of 318 Experts worldwide ranked by ideXlab platform

K A Rogovin - One of the best experts on this subject based on the ideXlab platform.

  • long term dynamics of fecal corticosterone in male great gerbils Rhombomys Opimus licht effects of environment and social demography
    Physiological and Biochemical Zoology, 2008
    Co-Authors: K A Rogovin, I E Kolosova, Jan A Randall, M P Moshkin
    Abstract:

    Abstract We examined the relationship among seasonal characteristics of climate, food, and population demography (social structure) and fecal corticosterone (CORT) concentrations over 6 yr in adult males of an arid‐adapted species, the great gerbil (Rhombomys Opimus Licht., Gerbillidae, Rodentia), as a measure of chronic stress in high, low, and recovering population densities. Results showed yearly differences in the seasonal means of CORT, with the highest concentrations in the year of the highest population density. Analysis of year‐specific relationships revealed a positive correlation between mean CORT and total precipitation in January and February and a negative correlation with precipitation in March. In the beginning of spring, when gerbils were in maximum reproductive effort, CORT correlated positively with the saturation of burrow systems and with the number of adult females with an adult male. A linear stepwise regression of CORT in individual males in spring seasons of all 6 yr combined after...

  • Long‐Term Dynamics of Fecal Corticosterone in Male Great Gerbils (Rhombomys Opimus Licht.): Effects of Environment and Social Demography
    Physiological and biochemical zoology : PBZ, 2008
    Co-Authors: K A Rogovin, Jan A Randall, Irina Kolosova, M P Moshkin
    Abstract:

    Abstract We examined the relationship among seasonal characteristics of climate, food, and population demography (social structure) and fecal corticosterone (CORT) concentrations over 6 yr in adult males of an arid‐adapted species, the great gerbil (Rhombomys Opimus Licht., Gerbillidae, Rodentia), as a measure of chronic stress in high, low, and recovering population densities. Results showed yearly differences in the seasonal means of CORT, with the highest concentrations in the year of the highest population density. Analysis of year‐specific relationships revealed a positive correlation between mean CORT and total precipitation in January and February and a negative correlation with precipitation in March. In the beginning of spring, when gerbils were in maximum reproductive effort, CORT correlated positively with the saturation of burrow systems and with the number of adult females with an adult male. A linear stepwise regression of CORT in individual males in spring seasons of all 6 yr combined after...

  • Social influences on the morpho-physiological characteristics of young males in groups of great gerbils Rhombomys Opimus in a high density population: a case study
    2006
    Co-Authors: K A Rogovin, A J Randall, Y N Vasilieva, M P Moshkin
    Abstract:

    In a non-breeding, high density population of great gerbil (Rhombomys Opimus Licht) (Bukhara region, Uzbekistan) we studied the dependence of stress and sex hormone concentrations, size of the mid-ventral gland and body mass of young males on presence of adult gerbils (≥1 year old) in social groups. Corticosterone and testosterone in fecal samples collected in the field from young males in fall 1999 were analyzed by non-invasive radioimmunoassay. Gerbil groups with adults were larger in size than groups without adults, so the effect of adults on juveniles can not be considered independently from the group size effect per se. Presence of adults positively affected concentration of fecal corticosterone and suppressed maturation of juvenile males estimated by the smaller size of the mid-ventral gland as an androgen-dependent organ, but at the same time accelerated their growth. Thus a naturally occurring social environment can influence development of morpho-physiological characteristics of young males.

  • Flexible social structure of a desert rodent, Rhombomys Opimus: philopatry, kinship, and ecological constraints
    Behavioral Ecology, 2005
    Co-Authors: Jan A Randall, K A Rogovin, Patricia G. Parker, John A. Eimes
    Abstract:

    We tested hypotheses based on philopatry, kinship, and ecological constraints to explain sociality in a semifossorial desert rodent, the great gerbil, Rhombomys Opimus. Data were collected in the field in Uzbekistan in the spring and fall of 1996 and 1998–2004. Population densities fluctuated dramatically with high turnover in both males and females to reveal that dispersal and social structure were density dependent. Fewer gerbils dispersed at higher densities and members of family groups dispersed together. A majority of females lived in groups at high densities, but as population densities declined, proportionally more females were solitary. DNA analysis revealed that group-living females were genetically similar, whereas solitary females visited by the same male, as well as adult males and females in the same family group, were usually not genetically similar. Reproductive success as measured by the number of emergent pups and survival of juveniles during the summer drought was not related to group size or whether females were philopatric. A majority of females in family groups reproduced, and all females engaged in cooperative behaviors. We accepted three hypotheses to explain fluctuations in group formation in the great gerbil: variation in food abundance and distribution, habitat saturation, and kinship. We conclude that great gerbils are facultatively social. Flexible social behavior may be adaptive in unpredictable desert conditions. Females live solitarily under conditions of limited food and high mortality that disrupt social behavior and group formation and share territories with female kin under favorable conditions for survival and reproduction when kin groups can be maintained. Males adjust to the distribution of females. Key words: desert, gerbil, philopatry, Rhombomys Opimus, social. [Behav Ecol]

  • PREDATION ON A SOCIAL DESERT RODENT, Rhombomys Opimus: EFFECT OF GROUP SIZE, COMPOSITION, AND LOCATION
    Journal of Mammalogy, 2004
    Co-Authors: K A Rogovin, Jan A Randall, Irina Kolosova, M P Moshkin
    Abstract:

    Predation can provide both positive and negative effects on formation of social groups in rodents. On the basis of observational data of predation by the desert monitor lizard (Varanus griseus caspius) on the great gerbil (Rhombomys Opimus), a social rodent of desert Central Asia, we predicted that in a year after a peak in prey density, when the abundance of terrestrial predators is still high, the group mode of life of a prey species might become disadvantageous. Social groups could advertise themselves and attract predators. We therefore hypothesized that the probability of predation would be higher for gerbils in outlying social groups than in groups closely associated with each other, in larger compared with smaller groups, and in groups with an active adult male compared with solitary females with no resident male. We also analyzed whether the survival of gerbils and the stress levels in adult and juvenile males were related to frequency of visits by monitor lizards at gerbil colonies (isolated systems of burrows used by gerbil groups of any size), distance between colonies, and size of social groups. We found that frequency of visits by the monitor lizard depended on distance to the nearest neighboring colony. The more distant the gerbil colony, the more visits by the lizard and the lower the survival of juveniles. We also found a positive correlation between concentration of fecal corticosterone in young males and frequency of monitor lizard visits at colonies. This pattern was not as pronounced in adult males. Results did not support the hypothesis that larger groups would have higher predation because frequency of predator visits, distances to the nearest occupied colonies, and survival of juveniles did not correlate significantly with the size of family groups. There was no difference in survival of juveniles in colonies occupied by single females compared with colonies in which an adult male was present. These results suggest that there is a possible trade-off between competing strategies of antipredator behavior and that factors other than predation are influencing gerbil survival.

Jan A Randall - One of the best experts on this subject based on the ideXlab platform.

  • long term dynamics of fecal corticosterone in male great gerbils Rhombomys Opimus licht effects of environment and social demography
    Physiological and Biochemical Zoology, 2008
    Co-Authors: K A Rogovin, I E Kolosova, Jan A Randall, M P Moshkin
    Abstract:

    Abstract We examined the relationship among seasonal characteristics of climate, food, and population demography (social structure) and fecal corticosterone (CORT) concentrations over 6 yr in adult males of an arid‐adapted species, the great gerbil (Rhombomys Opimus Licht., Gerbillidae, Rodentia), as a measure of chronic stress in high, low, and recovering population densities. Results showed yearly differences in the seasonal means of CORT, with the highest concentrations in the year of the highest population density. Analysis of year‐specific relationships revealed a positive correlation between mean CORT and total precipitation in January and February and a negative correlation with precipitation in March. In the beginning of spring, when gerbils were in maximum reproductive effort, CORT correlated positively with the saturation of burrow systems and with the number of adult females with an adult male. A linear stepwise regression of CORT in individual males in spring seasons of all 6 yr combined after...

  • Long‐Term Dynamics of Fecal Corticosterone in Male Great Gerbils (Rhombomys Opimus Licht.): Effects of Environment and Social Demography
    Physiological and biochemical zoology : PBZ, 2008
    Co-Authors: K A Rogovin, Jan A Randall, Irina Kolosova, M P Moshkin
    Abstract:

    Abstract We examined the relationship among seasonal characteristics of climate, food, and population demography (social structure) and fecal corticosterone (CORT) concentrations over 6 yr in adult males of an arid‐adapted species, the great gerbil (Rhombomys Opimus Licht., Gerbillidae, Rodentia), as a measure of chronic stress in high, low, and recovering population densities. Results showed yearly differences in the seasonal means of CORT, with the highest concentrations in the year of the highest population density. Analysis of year‐specific relationships revealed a positive correlation between mean CORT and total precipitation in January and February and a negative correlation with precipitation in March. In the beginning of spring, when gerbils were in maximum reproductive effort, CORT correlated positively with the saturation of burrow systems and with the number of adult females with an adult male. A linear stepwise regression of CORT in individual males in spring seasons of all 6 yr combined after...

  • Flexible social structure of a desert rodent, Rhombomys Opimus: philopatry, kinship, and ecological constraints
    Behavioral Ecology, 2005
    Co-Authors: Jan A Randall, K A Rogovin, Patricia G. Parker, John A. Eimes
    Abstract:

    We tested hypotheses based on philopatry, kinship, and ecological constraints to explain sociality in a semifossorial desert rodent, the great gerbil, Rhombomys Opimus. Data were collected in the field in Uzbekistan in the spring and fall of 1996 and 1998–2004. Population densities fluctuated dramatically with high turnover in both males and females to reveal that dispersal and social structure were density dependent. Fewer gerbils dispersed at higher densities and members of family groups dispersed together. A majority of females lived in groups at high densities, but as population densities declined, proportionally more females were solitary. DNA analysis revealed that group-living females were genetically similar, whereas solitary females visited by the same male, as well as adult males and females in the same family group, were usually not genetically similar. Reproductive success as measured by the number of emergent pups and survival of juveniles during the summer drought was not related to group size or whether females were philopatric. A majority of females in family groups reproduced, and all females engaged in cooperative behaviors. We accepted three hypotheses to explain fluctuations in group formation in the great gerbil: variation in food abundance and distribution, habitat saturation, and kinship. We conclude that great gerbils are facultatively social. Flexible social behavior may be adaptive in unpredictable desert conditions. Females live solitarily under conditions of limited food and high mortality that disrupt social behavior and group formation and share territories with female kin under favorable conditions for survival and reproduction when kin groups can be maintained. Males adjust to the distribution of females. Key words: desert, gerbil, philopatry, Rhombomys Opimus, social. [Behav Ecol]

  • PREDATION ON A SOCIAL DESERT RODENT, Rhombomys Opimus: EFFECT OF GROUP SIZE, COMPOSITION, AND LOCATION
    Journal of Mammalogy, 2004
    Co-Authors: K A Rogovin, Jan A Randall, Irina Kolosova, M P Moshkin
    Abstract:

    Predation can provide both positive and negative effects on formation of social groups in rodents. On the basis of observational data of predation by the desert monitor lizard (Varanus griseus caspius) on the great gerbil (Rhombomys Opimus), a social rodent of desert Central Asia, we predicted that in a year after a peak in prey density, when the abundance of terrestrial predators is still high, the group mode of life of a prey species might become disadvantageous. Social groups could advertise themselves and attract predators. We therefore hypothesized that the probability of predation would be higher for gerbils in outlying social groups than in groups closely associated with each other, in larger compared with smaller groups, and in groups with an active adult male compared with solitary females with no resident male. We also analyzed whether the survival of gerbils and the stress levels in adult and juvenile males were related to frequency of visits by monitor lizards at gerbil colonies (isolated systems of burrows used by gerbil groups of any size), distance between colonies, and size of social groups. We found that frequency of visits by the monitor lizard depended on distance to the nearest neighboring colony. The more distant the gerbil colony, the more visits by the lizard and the lower the survival of juveniles. We also found a positive correlation between concentration of fecal corticosterone in young males and frequency of monitor lizard visits at colonies. This pattern was not as pronounced in adult males. Results did not support the hypothesis that larger groups would have higher predation because frequency of predator visits, distances to the nearest occupied colonies, and survival of juveniles did not correlate significantly with the size of family groups. There was no difference in survival of juveniles in colonies occupied by single females compared with colonies in which an adult male was present. These results suggest that there is a possible trade-off between competing strategies of antipredator behavior and that factors other than predation are influencing gerbil survival.

  • Social correlates of stress in adult males of the great gerbil, Rhombomys Opimus, in years of high and low population densities.
    Hormones and behavior, 2003
    Co-Authors: K.onstantin Rogovin, Jan A Randall, Irina Kolosova, Mikhail Moshkin
    Abstract:

    The great gerbil, Rhombomys Opimus, is the most social species in the Gerbillinae. The social structure consists of family groups that occupy isolated systems of burrows consisting of one breeding male, from one to seven females, and juveniles. During a year of peak density and one of density decline, we studied the influence of group size, group composition, local density, and distance to the nearest groups on fecal corticosterone and testosterone concentrations in breeding males. We also examined the relationship of hormone concentrations to the survival of males during the summer drought between the spring and the fall. We found that males differed in concentrations of steroid hormones. Concentrations of testosterone were lower whereas those of corticosterone tended to be higher in a year of high population densities compared with higher testosterone and lower corticosterone in a year with a lower density. This finding suggests that stress may be greater in higher densities because of increased social contact. Stepwise regression analysis revealed a positive and significant influence of the number of adult females in a family group on concentrations of fecal corticosterone and testosterone in adult males. Concentrations of corticosterone were also significantly higher in males that disappeared from family groups between the spring and the fall compared with males still alive in family groups in the fall. There was no change in concentrations of testosterone. These results suggest that social interactions within large family groups may be an important source of stress for adult males.

M P Moshkin - One of the best experts on this subject based on the ideXlab platform.

  • long term dynamics of fecal corticosterone in male great gerbils Rhombomys Opimus licht effects of environment and social demography
    Physiological and Biochemical Zoology, 2008
    Co-Authors: K A Rogovin, I E Kolosova, Jan A Randall, M P Moshkin
    Abstract:

    Abstract We examined the relationship among seasonal characteristics of climate, food, and population demography (social structure) and fecal corticosterone (CORT) concentrations over 6 yr in adult males of an arid‐adapted species, the great gerbil (Rhombomys Opimus Licht., Gerbillidae, Rodentia), as a measure of chronic stress in high, low, and recovering population densities. Results showed yearly differences in the seasonal means of CORT, with the highest concentrations in the year of the highest population density. Analysis of year‐specific relationships revealed a positive correlation between mean CORT and total precipitation in January and February and a negative correlation with precipitation in March. In the beginning of spring, when gerbils were in maximum reproductive effort, CORT correlated positively with the saturation of burrow systems and with the number of adult females with an adult male. A linear stepwise regression of CORT in individual males in spring seasons of all 6 yr combined after...

  • Long‐Term Dynamics of Fecal Corticosterone in Male Great Gerbils (Rhombomys Opimus Licht.): Effects of Environment and Social Demography
    Physiological and biochemical zoology : PBZ, 2008
    Co-Authors: K A Rogovin, Jan A Randall, Irina Kolosova, M P Moshkin
    Abstract:

    Abstract We examined the relationship among seasonal characteristics of climate, food, and population demography (social structure) and fecal corticosterone (CORT) concentrations over 6 yr in adult males of an arid‐adapted species, the great gerbil (Rhombomys Opimus Licht., Gerbillidae, Rodentia), as a measure of chronic stress in high, low, and recovering population densities. Results showed yearly differences in the seasonal means of CORT, with the highest concentrations in the year of the highest population density. Analysis of year‐specific relationships revealed a positive correlation between mean CORT and total precipitation in January and February and a negative correlation with precipitation in March. In the beginning of spring, when gerbils were in maximum reproductive effort, CORT correlated positively with the saturation of burrow systems and with the number of adult females with an adult male. A linear stepwise regression of CORT in individual males in spring seasons of all 6 yr combined after...

  • Social influences on the morpho-physiological characteristics of young males in groups of great gerbils Rhombomys Opimus in a high density population: a case study
    2006
    Co-Authors: K A Rogovin, A J Randall, Y N Vasilieva, M P Moshkin
    Abstract:

    In a non-breeding, high density population of great gerbil (Rhombomys Opimus Licht) (Bukhara region, Uzbekistan) we studied the dependence of stress and sex hormone concentrations, size of the mid-ventral gland and body mass of young males on presence of adult gerbils (≥1 year old) in social groups. Corticosterone and testosterone in fecal samples collected in the field from young males in fall 1999 were analyzed by non-invasive radioimmunoassay. Gerbil groups with adults were larger in size than groups without adults, so the effect of adults on juveniles can not be considered independently from the group size effect per se. Presence of adults positively affected concentration of fecal corticosterone and suppressed maturation of juvenile males estimated by the smaller size of the mid-ventral gland as an androgen-dependent organ, but at the same time accelerated their growth. Thus a naturally occurring social environment can influence development of morpho-physiological characteristics of young males.

  • PREDATION ON A SOCIAL DESERT RODENT, Rhombomys Opimus: EFFECT OF GROUP SIZE, COMPOSITION, AND LOCATION
    Journal of Mammalogy, 2004
    Co-Authors: K A Rogovin, Jan A Randall, Irina Kolosova, M P Moshkin
    Abstract:

    Predation can provide both positive and negative effects on formation of social groups in rodents. On the basis of observational data of predation by the desert monitor lizard (Varanus griseus caspius) on the great gerbil (Rhombomys Opimus), a social rodent of desert Central Asia, we predicted that in a year after a peak in prey density, when the abundance of terrestrial predators is still high, the group mode of life of a prey species might become disadvantageous. Social groups could advertise themselves and attract predators. We therefore hypothesized that the probability of predation would be higher for gerbils in outlying social groups than in groups closely associated with each other, in larger compared with smaller groups, and in groups with an active adult male compared with solitary females with no resident male. We also analyzed whether the survival of gerbils and the stress levels in adult and juvenile males were related to frequency of visits by monitor lizards at gerbil colonies (isolated systems of burrows used by gerbil groups of any size), distance between colonies, and size of social groups. We found that frequency of visits by the monitor lizard depended on distance to the nearest neighboring colony. The more distant the gerbil colony, the more visits by the lizard and the lower the survival of juveniles. We also found a positive correlation between concentration of fecal corticosterone in young males and frequency of monitor lizard visits at colonies. This pattern was not as pronounced in adult males. Results did not support the hypothesis that larger groups would have higher predation because frequency of predator visits, distances to the nearest occupied colonies, and survival of juveniles did not correlate significantly with the size of family groups. There was no difference in survival of juveniles in colonies occupied by single females compared with colonies in which an adult male was present. These results suggest that there is a possible trade-off between competing strategies of antipredator behavior and that factors other than predation are influencing gerbil survival.

Yujiang Zhang - One of the best experts on this subject based on the ideXlab platform.

  • Dynamics of Yersinia pestis and Its Antibody Response in Great Gerbils (Rhombomys Opimus) by Subcutaneous Infection
    2016
    Co-Authors: Yujiang Zhang, Qiguo Wang, Azhati Rehemu, Xinhui Wang, Weiwei Meng, Xiang Dai, Tao Luo, Abulimiti Maituohuti, Yujun Cui, Rong Guo
    Abstract:

    Background: Rhombomys Opimus (great gerbil) is a reservoir of Yersinia pestis in the natural plague foci of Central Asia. Great gerbils are highly resistant to Y. pestis infection. The coevolution of great gerbils and Y. pestis is believed to play an important role in the plague epidemics in Central Asia plague foci. However, the dynamics of Y. pestis infection and the corresponding antibody response in great gerbils have not been evaluated. In this report, animal experiments were employed to investigate the bacterial load in both the liver and spleen of infected great gerbils. The dynamics of the antibody response to the F1 capsule antigen of Y. pestis was also determined. Methodology: Captured great gerbils that tested negative for both anti-F1 antibodies and bacterial isolation were infected subcutaneously with different doses (105 to 1011 CFU) of a Y. pestis strain isolated from a live great gerbil during routine plague surveillance in the Junggar Basin, Xinjiang, China. The clinical manifestations, changes in body weight, anal temperature, and gross anatomy of the infected animals were observed. The blood cell count, bacterial load, and anti-F1 antibody titers were determined at different time points after infection using a blood analyzer, plate counts, and an indirect hemagglutination assay, respectively. Conclusions/Significance: The dynamics of bacterial load and the anti-F1 antibody concentration in great gerbils are highly variable among individuals. The Y. pestis infection in great gerbils could persist as long as 15 days. They act as a

  • transmission efficiency of the plague pathogen y pestis by the flea xenopsylla skrjabini to mice and great gerbils
    Parasites & Vectors, 2015
    Co-Authors: Yujiang Zhang, Qiguo Wang, Hongjian Chen, Kemei Wu, Azhati Rehemu, Xiaotao Yu, Ruifu Yang, Xinhui Wang, Weiwei Meng, Yajun Song
    Abstract:

    Background Plague, a zoonotic disease caused by Yersinia pestis, is characterized by its ability to persist in the plague natural foci. Junggar Basin plague focus was recently identified in China, with Rhombomys Opimus (great gerbils) and Xenopsylla skrjabini as the main reservoir and vector for plague. No transmission efficiency data of X. skrjabini for Y. pestis is available till now.

  • Study on the spatial distribution and related risks of Rhombomys Opimus, based on the ecological niche modeling in Junggar Basin, Xinjiang
    Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi, 2014
    Co-Authors: Mei Wang, Qiguo Wang, Tao Luo, Jian Zhao, Ti Azha, Yujiang Zhang
    Abstract:

    Objective In order to understand the distribution of the host animals in Junggar Basin,this study intended to map the spatial distribution and identifying the risk of Rhombomys Opimus in the framework of ecological niche theory based on the "3S" technology.Methods Data on Rhombomys Opimus was obtained through a series of field surveys.Environmental variables were achieved through data from Remote Sensing.Maxent modeling was built to map the potential distribution of Rhombomys Opimus,with its risks identified.Results The prediction model showed ideal accuracy,with the AUC value as 0.968.Probability of Maximum Youden Index was defined as the threshold being used.The sensitivity and specificity showed as 91.4％ and 63.3％,respectively.The accuracy was 73.8％,and the Kappa coefficient was 0.495.The positive predictive value was 59.7％.The negative predictive value was 92.6％.The predicted high risk area was 37 304 km2,with 6.2％ in the whole area,distributed in 18 counties,including Changji Hui Autonomous Prefecture,Urumqi,Karamay and so on.The number of people under high risk would come about 120 000,scattering in the areas of 261 square kilometers.Conclusion It was feasible to predict the potential distribution of Rhombomys Opimus based on the ecological niche theory as well as environmental variables derived from data through remote sensing.More specific high-risk areas could be identified under this technique so as to guide the monitoring programs. Key words: Plague foci;  Ecological niche modeling;  Geographical information system

  • Dynamics of Yersinia pestis and its antibody response in great gerbils (Rhombomys Opimus) by subcutaneous infection.
    PloS one, 2012
    Co-Authors: Yujiang Zhang, Qiguo Wang, Azhati Rehemu, Xinhui Wang, Weiwei Meng, Xiang Dai, Tao Luo, Abulimiti Maituohuti, Yujun Cui, Rong Guo
    Abstract:

    Background Rhombomys Opimus (great gerbil) is a reservoir of Yersinia pestis in the natural plague foci of Central Asia. Great gerbils are highly resistant to Y. pestis infection. The coevolution of great gerbils and Y. pestis is believed to play an important role in the plague epidemics in Central Asia plague foci. However, the dynamics of Y. pestis infection and the corresponding antibody response in great gerbils have not been evaluated. In this report, animal experiments were employed to investigate the bacterial load in both the liver and spleen of infected great gerbils. The dynamics of the antibody response to the F1 capsule antigen of Y. pestis was also determined. Methodology Captured great gerbils that tested negative for both anti-F1 antibodies and bacterial isolation were infected subcutaneously with different doses (105 to 1011 CFU) of a Y. pestis strain isolated from a live great gerbil during routine plague surveillance in the Junggar Basin, Xinjiang, China. The clinical manifestations, changes in body weight, anal temperature, and gross anatomy of the infected animals were observed. The blood cell count, bacterial load, and anti-F1 antibody titers were determined at different time points after infection using a blood analyzer, plate counts, and an indirect hemagglutination assay, respectively. Conclusions/Significance The dynamics of bacterial load and the anti-F1 antibody concentration in great gerbils are highly variable among individuals. The Y. pestis infection in great gerbils could persist as long as 15 days. They act as an appropriate reservoir for plague in the Junggar Basin, which is part of the natural plague foci in Central Asia. The dynamics of the Y. pestis susceptibility of great gerbil will improve the understanding of its variable resistance, which would facilitate the development of more effective countermeasures for controlling plague epidemics in this focus.

  • Genome analysis of Yersinia pestis from Junggar Basin
    Chinese journal of microbiology and immunology, 2008
    Co-Authors: Xinhui Wang, Weiwei Meng, Xiang Dai, Burenmind, Rong Guo, Yujiang Zhang
    Abstract:

    Objective To compare different fragment profiles of Yersinia pestis isolated from Rhombomys Opimus plague natural focus in the Junggar Basin for determining their genomovars newly found in China.Methods Chromosomal DNA of Yersinia pestis Was extracted with routine method.DFR analysis was performed as reported previously.Results The different fragment profiles of Yersinia pestis from Rhombomys Opimus plague natural focus is absence of DFR01,04,06,07,10,13 and DFR 15-18.It is a novel genomovar of Yersinia pestis in China,which is different from Yersinia pestis from the other plague natural foci.Conclusion The genomovar of Yersinia pestis from Rhombomys Opimus plague natural focus in the Junggar Basin is a novel one in China. Key words: Yersinia pestis; Different fragment region; Junggar Basin

Rong Guo - One of the best experts on this subject based on the ideXlab platform.

  • Dynamics of Yersinia pestis and Its Antibody Response in Great Gerbils (Rhombomys Opimus) by Subcutaneous Infection
    2016
    Co-Authors: Yujiang Zhang, Qiguo Wang, Azhati Rehemu, Xinhui Wang, Weiwei Meng, Xiang Dai, Tao Luo, Abulimiti Maituohuti, Yujun Cui, Rong Guo
    Abstract:

    Background: Rhombomys Opimus (great gerbil) is a reservoir of Yersinia pestis in the natural plague foci of Central Asia. Great gerbils are highly resistant to Y. pestis infection. The coevolution of great gerbils and Y. pestis is believed to play an important role in the plague epidemics in Central Asia plague foci. However, the dynamics of Y. pestis infection and the corresponding antibody response in great gerbils have not been evaluated. In this report, animal experiments were employed to investigate the bacterial load in both the liver and spleen of infected great gerbils. The dynamics of the antibody response to the F1 capsule antigen of Y. pestis was also determined. Methodology: Captured great gerbils that tested negative for both anti-F1 antibodies and bacterial isolation were infected subcutaneously with different doses (105 to 1011 CFU) of a Y. pestis strain isolated from a live great gerbil during routine plague surveillance in the Junggar Basin, Xinjiang, China. The clinical manifestations, changes in body weight, anal temperature, and gross anatomy of the infected animals were observed. The blood cell count, bacterial load, and anti-F1 antibody titers were determined at different time points after infection using a blood analyzer, plate counts, and an indirect hemagglutination assay, respectively. Conclusions/Significance: The dynamics of bacterial load and the anti-F1 antibody concentration in great gerbils are highly variable among individuals. The Y. pestis infection in great gerbils could persist as long as 15 days. They act as a

  • Dynamics of Yersinia pestis and its antibody response in great gerbils (Rhombomys Opimus) by subcutaneous infection.
    PloS one, 2012
    Co-Authors: Yujiang Zhang, Qiguo Wang, Azhati Rehemu, Xinhui Wang, Weiwei Meng, Xiang Dai, Tao Luo, Abulimiti Maituohuti, Yujun Cui, Rong Guo
    Abstract:

    Background Rhombomys Opimus (great gerbil) is a reservoir of Yersinia pestis in the natural plague foci of Central Asia. Great gerbils are highly resistant to Y. pestis infection. The coevolution of great gerbils and Y. pestis is believed to play an important role in the plague epidemics in Central Asia plague foci. However, the dynamics of Y. pestis infection and the corresponding antibody response in great gerbils have not been evaluated. In this report, animal experiments were employed to investigate the bacterial load in both the liver and spleen of infected great gerbils. The dynamics of the antibody response to the F1 capsule antigen of Y. pestis was also determined. Methodology Captured great gerbils that tested negative for both anti-F1 antibodies and bacterial isolation were infected subcutaneously with different doses (105 to 1011 CFU) of a Y. pestis strain isolated from a live great gerbil during routine plague surveillance in the Junggar Basin, Xinjiang, China. The clinical manifestations, changes in body weight, anal temperature, and gross anatomy of the infected animals were observed. The blood cell count, bacterial load, and anti-F1 antibody titers were determined at different time points after infection using a blood analyzer, plate counts, and an indirect hemagglutination assay, respectively. Conclusions/Significance The dynamics of bacterial load and the anti-F1 antibody concentration in great gerbils are highly variable among individuals. The Y. pestis infection in great gerbils could persist as long as 15 days. They act as an appropriate reservoir for plague in the Junggar Basin, which is part of the natural plague foci in Central Asia. The dynamics of the Y. pestis susceptibility of great gerbil will improve the understanding of its variable resistance, which would facilitate the development of more effective countermeasures for controlling plague epidemics in this focus.

  • Genome analysis of Yersinia pestis from Junggar Basin
    Chinese journal of microbiology and immunology, 2008
    Co-Authors: Xinhui Wang, Weiwei Meng, Xiang Dai, Burenmind, Rong Guo, Yujiang Zhang
    Abstract:

    Objective To compare different fragment profiles of Yersinia pestis isolated from Rhombomys Opimus plague natural focus in the Junggar Basin for determining their genomovars newly found in China.Methods Chromosomal DNA of Yersinia pestis Was extracted with routine method.DFR analysis was performed as reported previously.Results The different fragment profiles of Yersinia pestis from Rhombomys Opimus plague natural focus is absence of DFR01,04,06,07,10,13 and DFR 15-18.It is a novel genomovar of Yersinia pestis in China,which is different from Yersinia pestis from the other plague natural foci.Conclusion The genomovar of Yersinia pestis from Rhombomys Opimus plague natural focus in the Junggar Basin is a novel one in China. Key words: Yersinia pestis; Different fragment region; Junggar Basin