The Experts below are selected from a list of 66 Experts worldwide ranked by ideXlab platform
Erwin Chargaff - One of the best experts on this subject based on the ideXlab platform.
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Relation of Ribonucleic Acid to the photosynthetic apparatus in Euglena gracilis.
Biochimica et Biophysica Acta, 2003Co-Authors: George Brawerman, Erwin ChargaffAbstract:Abstract The Ribonucleic Acids of green and etiolated Euglena gracilis cells show small but definite differences in their nucleotide distribution. The green organisms have a higher proportion of adenylic and uridylic Acids and a lower content of cytidylic and guanylic Acids. Permanently bleached cells resemble the etiolated organisms in their Ribonucleic Acid composition. The differences in the Ribonucleic Acids of the green and etiolated oragnisms are probably related to the differenced in structure and metabolism of the two types of cells. Two additional nucleotides are present in small amounts in the Ribonucleic Acid of Euglena gracilis. One of them is probably identical with a nucleotide recently found in the Ribonucleic Acids from other organisms and the second one is unknown.
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Changse in protein and Ribonucleic Acid during the formation of chloroplasts in Euglena gracilis
Biochimica et Biophysica Acta, 2003Co-Authors: George Brawerman, Erwin ChargaffAbstract:Abstract Etiolated Euglena gracilis cells can form chloroplasts in the absence of growth and without the net synthesis of protein and Ribonucleic Acid. During this process, approximately 17% of the cellular proteins appear in the chlorplasts fraction. Only the supernatant fraction shows a significant decrease, and it is tentatively concluded that the chloroplastic proteins originate in the latter fraction. The Ribonucleic Acid distribution in the cell is little changed. The development of chloroplasts appears to be linked with a stimulation of the uptake of adenine by the Ribonucleic Acid and of leucine by the protein. These stimulations are apparent in all fractions of the cells. It is concluded that no preferential synthesis of protein and RNA occurs in the chloroplasts during their final development. The formation of specific Ribonucleic Acid molecules during the process is indicated.
George Brawerman - One of the best experts on this subject based on the ideXlab platform.
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Relation of Ribonucleic Acid to the photosynthetic apparatus in Euglena gracilis.
Biochimica et Biophysica Acta, 2003Co-Authors: George Brawerman, Erwin ChargaffAbstract:Abstract The Ribonucleic Acids of green and etiolated Euglena gracilis cells show small but definite differences in their nucleotide distribution. The green organisms have a higher proportion of adenylic and uridylic Acids and a lower content of cytidylic and guanylic Acids. Permanently bleached cells resemble the etiolated organisms in their Ribonucleic Acid composition. The differences in the Ribonucleic Acids of the green and etiolated oragnisms are probably related to the differenced in structure and metabolism of the two types of cells. Two additional nucleotides are present in small amounts in the Ribonucleic Acid of Euglena gracilis. One of them is probably identical with a nucleotide recently found in the Ribonucleic Acids from other organisms and the second one is unknown.
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Changse in protein and Ribonucleic Acid during the formation of chloroplasts in Euglena gracilis
Biochimica et Biophysica Acta, 2003Co-Authors: George Brawerman, Erwin ChargaffAbstract:Abstract Etiolated Euglena gracilis cells can form chloroplasts in the absence of growth and without the net synthesis of protein and Ribonucleic Acid. During this process, approximately 17% of the cellular proteins appear in the chlorplasts fraction. Only the supernatant fraction shows a significant decrease, and it is tentatively concluded that the chloroplastic proteins originate in the latter fraction. The Ribonucleic Acid distribution in the cell is little changed. The development of chloroplasts appears to be linked with a stimulation of the uptake of adenine by the Ribonucleic Acid and of leucine by the protein. These stimulations are apparent in all fractions of the cells. It is concluded that no preferential synthesis of protein and RNA occurs in the chloroplasts during their final development. The formation of specific Ribonucleic Acid molecules during the process is indicated.
Pål Øian - One of the best experts on this subject based on the ideXlab platform.
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Mutations in mitochondrial transfer Ribonucleic Acid genes in preeclampsia.
American Journal of Obstetrics and Gynecology, 1996Co-Authors: Terese Folgerø, Norunn Storbakk, Torberg Torbergsen, Pål ØianAbstract:Abstract OBJECTIVE: We investigated whether maternally inherited mitochondrial deoxyRibonucleic Acid mutations could be associated with preeclampsia because mendelian models fail to explain all the aspects of inheritance in preeclampsia. STUDY DESIGN: In two families with a high occurrence of preeclampsia and eclampsia the 22 mitochondrial transfer Ribonucleic Acid genes were sequenced in eight and three women, respectively. RESULTS: An A-to-G mutation in transfer Ribonucleic Acid leu [UUR] at nucleotide 3243 was found in one family, and in the other there was an A-to-G mutation at nucleotide 12308 in transfer Ribonucleic Acid leu [CUN]. Mutations of mitochondrial transfer Ribonucleic Acid genes are generally considered to have systemic consequences, which might explain the multiorgan involvement seen in preeclampsia. CONCLUSION: We report for the first time mutations in mitochondrial transfer Ribonucleic Acid genes in two families with a high occurrence of preeclampsia and eclampsia. Mitochondrial dysfunction caused by point mutations of mitochondrial deoxyRibonucleic Acid is maternally inherited, but in the case of mutations of nuclear genes mitochondrial dysfunction can be inherited as an autosomal recessive or dominant trait. (AM J OBSTET GYNECOL 1996;174:1626-30.)
Terese Folgerø - One of the best experts on this subject based on the ideXlab platform.
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Mutations in mitochondrial transfer Ribonucleic Acid genes in preeclampsia.
American Journal of Obstetrics and Gynecology, 1996Co-Authors: Terese Folgerø, Norunn Storbakk, Torberg Torbergsen, Pål ØianAbstract:Abstract OBJECTIVE: We investigated whether maternally inherited mitochondrial deoxyRibonucleic Acid mutations could be associated with preeclampsia because mendelian models fail to explain all the aspects of inheritance in preeclampsia. STUDY DESIGN: In two families with a high occurrence of preeclampsia and eclampsia the 22 mitochondrial transfer Ribonucleic Acid genes were sequenced in eight and three women, respectively. RESULTS: An A-to-G mutation in transfer Ribonucleic Acid leu [UUR] at nucleotide 3243 was found in one family, and in the other there was an A-to-G mutation at nucleotide 12308 in transfer Ribonucleic Acid leu [CUN]. Mutations of mitochondrial transfer Ribonucleic Acid genes are generally considered to have systemic consequences, which might explain the multiorgan involvement seen in preeclampsia. CONCLUSION: We report for the first time mutations in mitochondrial transfer Ribonucleic Acid genes in two families with a high occurrence of preeclampsia and eclampsia. Mitochondrial dysfunction caused by point mutations of mitochondrial deoxyRibonucleic Acid is maternally inherited, but in the case of mutations of nuclear genes mitochondrial dysfunction can be inherited as an autosomal recessive or dominant trait. (AM J OBSTET GYNECOL 1996;174:1626-30.)
Norunn Storbakk - One of the best experts on this subject based on the ideXlab platform.
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Mutations in mitochondrial transfer Ribonucleic Acid genes in preeclampsia.
American Journal of Obstetrics and Gynecology, 1996Co-Authors: Terese Folgerø, Norunn Storbakk, Torberg Torbergsen, Pål ØianAbstract:Abstract OBJECTIVE: We investigated whether maternally inherited mitochondrial deoxyRibonucleic Acid mutations could be associated with preeclampsia because mendelian models fail to explain all the aspects of inheritance in preeclampsia. STUDY DESIGN: In two families with a high occurrence of preeclampsia and eclampsia the 22 mitochondrial transfer Ribonucleic Acid genes were sequenced in eight and three women, respectively. RESULTS: An A-to-G mutation in transfer Ribonucleic Acid leu [UUR] at nucleotide 3243 was found in one family, and in the other there was an A-to-G mutation at nucleotide 12308 in transfer Ribonucleic Acid leu [CUN]. Mutations of mitochondrial transfer Ribonucleic Acid genes are generally considered to have systemic consequences, which might explain the multiorgan involvement seen in preeclampsia. CONCLUSION: We report for the first time mutations in mitochondrial transfer Ribonucleic Acid genes in two families with a high occurrence of preeclampsia and eclampsia. Mitochondrial dysfunction caused by point mutations of mitochondrial deoxyRibonucleic Acid is maternally inherited, but in the case of mutations of nuclear genes mitochondrial dysfunction can be inherited as an autosomal recessive or dominant trait. (AM J OBSTET GYNECOL 1996;174:1626-30.)
