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Tamara Alempijevic - One of the best experts on this subject based on the ideXlab platform.
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Noninvasive assessment of portal hypertension in patients with alcoholic cirrhosis.
The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology, 2012Co-Authors: Tamara Alempijevic, Rada Jesic, Aleksandra Sokic Milutinovic, Biljana Milicic, Ana Balovic, Dragan Popovic, Miodrag KrsticAbstract:BACKGROUND/AIMS Portal hypertension and development of esophageal varices is one of the major complications of Liver cirrhosis. The aim of our study was to evaluate the possibility of the presence of esophageal varices and their size using biochemical and ultrasonography parameters in patients with alcoholic Liver cirrhosis. MATERIAL AND METHODS We included in our study 86 patients (74 males, mean age 55±7) with alcoholic Liver cirrhosis. The control group consisted of 102 patients with cirrhosis of other etiologies. All patients underwent a complete biochemical workup, upper digestive endoscopy and ultrasonography examination. The Right Liver Lobe diameter/albumin and platelet count/spleen diameter ratios were calculated. The correlation of the calculated ratios with the presence and degree of esophageal varices in patients with Liver cirrhosis was also determined. RESULTS The mean value of Right Liver Lobe diameter-albumin ratio was 6.15±1.77, and statistically significantly differed from values determined in the control group (4.97±1.68). The mean platelet count-spleen diameter ratio was 972.5±599.0 in alcoholic Liver cirrhosis and 1055.9±821.3 in controls (p>0.05). In patients with alcoholic Liver cirrhosis, none of the analyzed noninvasive markers was shown to be a good predictor of the presence and size of esophageal varices. CONCLUSIONS Despite the important role of noninvasive markers in providing information pertinent to determination of esophageal varices in patients with Liver cirrhosis, these markers have limited relevance in patients with alcoholic cirrhosis.
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Right Liver Lobe/albumin ratio: contribution to non-invasive assessment of portal hypertension.
World journal of gastroenterology, 2007Co-Authors: Tamara Alempijevic, Vladislava Bulat, Srdjan Djuranovic, Nada Kovacevic, Rada Jesic, D. Tomic, Slobodan Krstic, Miodrag KrsticAbstract:Right Liver Lobe/albumin ratio: Contribution to non-invasive assessment of portal hypertension
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Right Liver Lobe albumin ratio contribution to non invasive assessment of portal hypertension
World Journal of Gastroenterology, 2007Co-Authors: Tamara Alempijevic, Vladislava Bulat, Srdjan Djuranovic, Nada Kovacevic, Rada Jesic, D. Tomic, Slobodan Krstic, Miodrag KrsticAbstract:Right Liver Lobe/albumin ratio: Contribution to non-invasive assessment of portal hypertension
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Noninvasive assessment of oesophageal varices presence and size in patients with Liver cirrhosis using Right Liver Lobe/serum albumin concentration
Vojnosanitetski pregled, 2007Co-Authors: Tamara Alempijevic, Vladislava Bulat, Srdjan Djuranovic, Nada Kovacevic, Rada Jesic, D. Tomic, Miodrag KrsticAbstract:Background/Aim. Liver cirrhosis is a chronic, progressive disease and it is usually accompanied by portal hypertension. The development of oesophageal varices (OV) is one of the major complications of portal hypertension. Cirrhotic patients should be screened for the presence of OV when portal hypertension is diagnosed. In order to reduce the increasing burden that endoscopy units have to bear, some studies have attempted to identify parameters for noninvasive prediction of OV presence. The aim of our study was to evaluate the value of biochemical and ultrasonography parameters for prediction of OV presence. Methods. This study included 58 cirrhotic patients who underwent a complete biochemical workup, ultrasonography examination and upper digestive endoscopy. Right Liver Lobe diameter/albumin ratio was calculated and its correlation to the presence and degree of OV, and Child-Pugh score of Liver cirrhosis explored. Results. The mean age of the patients included in the study was 53.07±13.09 years; 40 were males and 18 females. In the Child-Pugh class A were 53.4% patients, class B 39.7%, whereas 6.9% were in the class C. In 24.1% of the patients no OV were identified by upper digestive endoscopy, 19% had OV grade I, 34.5% grade II, 20.7% grade III, and 1.7% OV grade IV. The mean value of the Right Liver Lobe diameter/ albumin ratio was 5.43±1.79 (range of 2.76−11.44). Statistically significant correlation (p < 0.01) was confirm by Spearman's test between OV grade and calculated index (ρ = 0.441). Conclusion. The Right Liver Lobe diameter/albumin ratio is a noninvasive parameter which provides an accurate information pertinent to the determination of OV presence and their grading in patients with Liver cirrhosis. .
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Right Liver Lobe diameter:albumin ratio: a new non-invasive parameter for prediction of oesophageal varices in patients with Liver cirrhosis (preliminary report)
Gut, 2007Co-Authors: Tamara Alempijevic, Nada KovacevicAbstract:Portal hypertension commonly accompanies Liver cirrhosis, and development of oesophageal varices is among the major complications of portal hypertension. Patients with cirrhosis should be screened for the presence of oesophageal varices when portal hypertension is diagnosed. To reduce the increasing burden of endoscopy units, some studies have attempted to identify parameters for non-invasive prediction of the presence of oesophageal varices. We read with great interest the article by Giannini et al ( Gut 2003; 52 :1200–5). Besides the confirmation of proposed platelet count:spleen diameter ratio in predicting the presence of oesophageal varices in patients with Liver cirrhosis, we introduced a new measurement for predicting oesophageal varices. Our preliminary study included 58 patients with cirrhosis who underwent a complete biochemical investigation, upper digestive endoscopy and ultrasonographic examination. Right Liver Lobe diameter:albumin ratio has been calculated and correlated with the presence and grade of oesophageal varices. All patients gave their written consent, …
Miodrag Krstic - One of the best experts on this subject based on the ideXlab platform.
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Noninvasive assessment of portal hypertension in patients with alcoholic cirrhosis.
The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology, 2012Co-Authors: Tamara Alempijevic, Rada Jesic, Aleksandra Sokic Milutinovic, Biljana Milicic, Ana Balovic, Dragan Popovic, Miodrag KrsticAbstract:BACKGROUND/AIMS Portal hypertension and development of esophageal varices is one of the major complications of Liver cirrhosis. The aim of our study was to evaluate the possibility of the presence of esophageal varices and their size using biochemical and ultrasonography parameters in patients with alcoholic Liver cirrhosis. MATERIAL AND METHODS We included in our study 86 patients (74 males, mean age 55±7) with alcoholic Liver cirrhosis. The control group consisted of 102 patients with cirrhosis of other etiologies. All patients underwent a complete biochemical workup, upper digestive endoscopy and ultrasonography examination. The Right Liver Lobe diameter/albumin and platelet count/spleen diameter ratios were calculated. The correlation of the calculated ratios with the presence and degree of esophageal varices in patients with Liver cirrhosis was also determined. RESULTS The mean value of Right Liver Lobe diameter-albumin ratio was 6.15±1.77, and statistically significantly differed from values determined in the control group (4.97±1.68). The mean platelet count-spleen diameter ratio was 972.5±599.0 in alcoholic Liver cirrhosis and 1055.9±821.3 in controls (p>0.05). In patients with alcoholic Liver cirrhosis, none of the analyzed noninvasive markers was shown to be a good predictor of the presence and size of esophageal varices. CONCLUSIONS Despite the important role of noninvasive markers in providing information pertinent to determination of esophageal varices in patients with Liver cirrhosis, these markers have limited relevance in patients with alcoholic cirrhosis.
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Right Liver Lobe/albumin ratio: contribution to non-invasive assessment of portal hypertension.
World journal of gastroenterology, 2007Co-Authors: Tamara Alempijevic, Vladislava Bulat, Srdjan Djuranovic, Nada Kovacevic, Rada Jesic, D. Tomic, Slobodan Krstic, Miodrag KrsticAbstract:Right Liver Lobe/albumin ratio: Contribution to non-invasive assessment of portal hypertension
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Right Liver Lobe albumin ratio contribution to non invasive assessment of portal hypertension
World Journal of Gastroenterology, 2007Co-Authors: Tamara Alempijevic, Vladislava Bulat, Srdjan Djuranovic, Nada Kovacevic, Rada Jesic, D. Tomic, Slobodan Krstic, Miodrag KrsticAbstract:Right Liver Lobe/albumin ratio: Contribution to non-invasive assessment of portal hypertension
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Noninvasive assessment of oesophageal varices presence and size in patients with Liver cirrhosis using Right Liver Lobe/serum albumin concentration
Vojnosanitetski pregled, 2007Co-Authors: Tamara Alempijevic, Vladislava Bulat, Srdjan Djuranovic, Nada Kovacevic, Rada Jesic, D. Tomic, Miodrag KrsticAbstract:Background/Aim. Liver cirrhosis is a chronic, progressive disease and it is usually accompanied by portal hypertension. The development of oesophageal varices (OV) is one of the major complications of portal hypertension. Cirrhotic patients should be screened for the presence of OV when portal hypertension is diagnosed. In order to reduce the increasing burden that endoscopy units have to bear, some studies have attempted to identify parameters for noninvasive prediction of OV presence. The aim of our study was to evaluate the value of biochemical and ultrasonography parameters for prediction of OV presence. Methods. This study included 58 cirrhotic patients who underwent a complete biochemical workup, ultrasonography examination and upper digestive endoscopy. Right Liver Lobe diameter/albumin ratio was calculated and its correlation to the presence and degree of OV, and Child-Pugh score of Liver cirrhosis explored. Results. The mean age of the patients included in the study was 53.07±13.09 years; 40 were males and 18 females. In the Child-Pugh class A were 53.4% patients, class B 39.7%, whereas 6.9% were in the class C. In 24.1% of the patients no OV were identified by upper digestive endoscopy, 19% had OV grade I, 34.5% grade II, 20.7% grade III, and 1.7% OV grade IV. The mean value of the Right Liver Lobe diameter/ albumin ratio was 5.43±1.79 (range of 2.76−11.44). Statistically significant correlation (p < 0.01) was confirm by Spearman's test between OV grade and calculated index (ρ = 0.441). Conclusion. The Right Liver Lobe diameter/albumin ratio is a noninvasive parameter which provides an accurate information pertinent to the determination of OV presence and their grading in patients with Liver cirrhosis. .
Nada Kovacevic - One of the best experts on this subject based on the ideXlab platform.
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Right Liver Lobe/albumin ratio: contribution to non-invasive assessment of portal hypertension.
World journal of gastroenterology, 2007Co-Authors: Tamara Alempijevic, Vladislava Bulat, Srdjan Djuranovic, Nada Kovacevic, Rada Jesic, D. Tomic, Slobodan Krstic, Miodrag KrsticAbstract:Right Liver Lobe/albumin ratio: Contribution to non-invasive assessment of portal hypertension
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Right Liver Lobe albumin ratio contribution to non invasive assessment of portal hypertension
World Journal of Gastroenterology, 2007Co-Authors: Tamara Alempijevic, Vladislava Bulat, Srdjan Djuranovic, Nada Kovacevic, Rada Jesic, D. Tomic, Slobodan Krstic, Miodrag KrsticAbstract:Right Liver Lobe/albumin ratio: Contribution to non-invasive assessment of portal hypertension
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Noninvasive assessment of oesophageal varices presence and size in patients with Liver cirrhosis using Right Liver Lobe/serum albumin concentration
Vojnosanitetski pregled, 2007Co-Authors: Tamara Alempijevic, Vladislava Bulat, Srdjan Djuranovic, Nada Kovacevic, Rada Jesic, D. Tomic, Miodrag KrsticAbstract:Background/Aim. Liver cirrhosis is a chronic, progressive disease and it is usually accompanied by portal hypertension. The development of oesophageal varices (OV) is one of the major complications of portal hypertension. Cirrhotic patients should be screened for the presence of OV when portal hypertension is diagnosed. In order to reduce the increasing burden that endoscopy units have to bear, some studies have attempted to identify parameters for noninvasive prediction of OV presence. The aim of our study was to evaluate the value of biochemical and ultrasonography parameters for prediction of OV presence. Methods. This study included 58 cirrhotic patients who underwent a complete biochemical workup, ultrasonography examination and upper digestive endoscopy. Right Liver Lobe diameter/albumin ratio was calculated and its correlation to the presence and degree of OV, and Child-Pugh score of Liver cirrhosis explored. Results. The mean age of the patients included in the study was 53.07±13.09 years; 40 were males and 18 females. In the Child-Pugh class A were 53.4% patients, class B 39.7%, whereas 6.9% were in the class C. In 24.1% of the patients no OV were identified by upper digestive endoscopy, 19% had OV grade I, 34.5% grade II, 20.7% grade III, and 1.7% OV grade IV. The mean value of the Right Liver Lobe diameter/ albumin ratio was 5.43±1.79 (range of 2.76−11.44). Statistically significant correlation (p < 0.01) was confirm by Spearman's test between OV grade and calculated index (ρ = 0.441). Conclusion. The Right Liver Lobe diameter/albumin ratio is a noninvasive parameter which provides an accurate information pertinent to the determination of OV presence and their grading in patients with Liver cirrhosis. .
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Right Liver Lobe diameter:albumin ratio: a new non-invasive parameter for prediction of oesophageal varices in patients with Liver cirrhosis (preliminary report)
Gut, 2007Co-Authors: Tamara Alempijevic, Nada KovacevicAbstract:Portal hypertension commonly accompanies Liver cirrhosis, and development of oesophageal varices is among the major complications of portal hypertension. Patients with cirrhosis should be screened for the presence of oesophageal varices when portal hypertension is diagnosed. To reduce the increasing burden of endoscopy units, some studies have attempted to identify parameters for non-invasive prediction of the presence of oesophageal varices. We read with great interest the article by Giannini et al ( Gut 2003; 52 :1200–5). Besides the confirmation of proposed platelet count:spleen diameter ratio in predicting the presence of oesophageal varices in patients with Liver cirrhosis, we introduced a new measurement for predicting oesophageal varices. Our preliminary study included 58 patients with cirrhosis who underwent a complete biochemical investigation, upper digestive endoscopy and ultrasonographic examination. Right Liver Lobe diameter:albumin ratio has been calculated and correlated with the presence and grade of oesophageal varices. All patients gave their written consent, …
Zhi-jia Fang - One of the best experts on this subject based on the ideXlab platform.
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Quantitative assessment of the presence and severity of cirrhosis in patients with hepatitis B using Right Liver Lobe volume and spleen size measured at magnetic resonance imaging.
PloS one, 2014Co-Authors: Xiao-li Chen, Tian-wu Chen, Xiao-ming Zhang, Nan-lin Zeng, Dan Wang, Zhi-jia FangAbstract:Objective To determine whether Right Liver Lobe volume (RV) and spleen size measured utilizing magnetic resonance (MR) imaging could identify the presence and severity of cirrhosis in patients with hepatitis B. Methods Two hundred and five consecutive patients with clinically confirmed diagnosis of cirrhosis due to hepatitis B and 40 healthy control individuals were enrolled in this study and underwent abdominal triphasic enhanced scans using MR imaging. Spleen maximal width (W), thickness (T) and length (L), together with RV and spleen volume (SV), were measured utilizing MR imaging. Spleen multidimensional index (SI) was obtained by multiplying previously acquired parameters W×T×L. Then statistical assessment was performed to evaluate the ability of these parameters, including RV, SV, RV/SV and SI, to identify the presence of cirrhosis and define Child-Pugh class of this disease. Results SV and SI tended to increase (r = 0.557 and 0.622, respectively; all P
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quantitative assessment of the presence and severity of cirrhosis in patients with hepatitis b using Right Liver Lobe volume and spleen size measured at magnetic resonance imaging
PLOS ONE, 2014Co-Authors: Xiao-li Chen, Tian-wu Chen, Xiao-ming Zhang, Nan-lin Zeng, Dan Wang, Zhi-jia Fang, Jia Chen, Jun Liu, Jing RenAbstract:Objective To determine whether Right Liver Lobe volume (RV) and spleen size measured utilizing magnetic resonance (MR) imaging could identify the presence and severity of cirrhosis in patients with hepatitis B. Methods Two hundred and five consecutive patients with clinically confirmed diagnosis of cirrhosis due to hepatitis B and 40 healthy control individuals were enrolled in this study and underwent abdominal triphasic enhanced scans using MR imaging. Spleen maximal width (W), thickness (T) and length (L), together with RV and spleen volume (SV), were measured utilizing MR imaging. Spleen multidimensional index (SI) was obtained by multiplying previously acquired parameters W×T×L. Then statistical assessment was performed to evaluate the ability of these parameters, including RV, SV, RV/SV and SI, to identify the presence of cirrhosis and define Child-Pugh class of this disease. Results SV and SI tended to increase (r = 0.557 and 0.622, respectively; all P<0.001), and RV and RV/SV tended to decrease (r = −0.749 and −0.699, respectively; all P<0.001) with increasing Child-Pugh class of cirrhosis. All the parameters, including RV, SV, RV/SV and SI, might be the indicators used to discriminate the patients with Liver cirrhosis from the control group, and to distinguish these patients between Child-Pugh class A and B, between B and C, and between A and C (area under receiver operating characteristic curve [AUC] = 0.609–0.975, all P<0.05). Among these parameters, RV/SV was the best noninvasive factor for the discrimination of Liver cirrhosis between Child-Pugh class A and B (AUC = 0.725), between A and C (AUC = 0.975), and between B and C (AUC = 0.876), while SI was the best variable to distinguish the cirrhosis patients from the control group (AUC = 0.960, P<0.05). Conclusion RV/SV should be used to identify the severity of cirrhosis, while SI can be recommended to determine the presence of this disease.
Xiao-li Chen - One of the best experts on this subject based on the ideXlab platform.
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Quantitative assessment of the presence and severity of cirrhosis in patients with hepatitis B using Right Liver Lobe volume and spleen size measured at magnetic resonance imaging.
PloS one, 2014Co-Authors: Xiao-li Chen, Tian-wu Chen, Xiao-ming Zhang, Nan-lin Zeng, Dan Wang, Zhi-jia FangAbstract:Objective To determine whether Right Liver Lobe volume (RV) and spleen size measured utilizing magnetic resonance (MR) imaging could identify the presence and severity of cirrhosis in patients with hepatitis B. Methods Two hundred and five consecutive patients with clinically confirmed diagnosis of cirrhosis due to hepatitis B and 40 healthy control individuals were enrolled in this study and underwent abdominal triphasic enhanced scans using MR imaging. Spleen maximal width (W), thickness (T) and length (L), together with RV and spleen volume (SV), were measured utilizing MR imaging. Spleen multidimensional index (SI) was obtained by multiplying previously acquired parameters W×T×L. Then statistical assessment was performed to evaluate the ability of these parameters, including RV, SV, RV/SV and SI, to identify the presence of cirrhosis and define Child-Pugh class of this disease. Results SV and SI tended to increase (r = 0.557 and 0.622, respectively; all P
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quantitative assessment of the presence and severity of cirrhosis in patients with hepatitis b using Right Liver Lobe volume and spleen size measured at magnetic resonance imaging
PLOS ONE, 2014Co-Authors: Xiao-li Chen, Tian-wu Chen, Xiao-ming Zhang, Nan-lin Zeng, Dan Wang, Zhi-jia Fang, Jia Chen, Jun Liu, Jing RenAbstract:Objective To determine whether Right Liver Lobe volume (RV) and spleen size measured utilizing magnetic resonance (MR) imaging could identify the presence and severity of cirrhosis in patients with hepatitis B. Methods Two hundred and five consecutive patients with clinically confirmed diagnosis of cirrhosis due to hepatitis B and 40 healthy control individuals were enrolled in this study and underwent abdominal triphasic enhanced scans using MR imaging. Spleen maximal width (W), thickness (T) and length (L), together with RV and spleen volume (SV), were measured utilizing MR imaging. Spleen multidimensional index (SI) was obtained by multiplying previously acquired parameters W×T×L. Then statistical assessment was performed to evaluate the ability of these parameters, including RV, SV, RV/SV and SI, to identify the presence of cirrhosis and define Child-Pugh class of this disease. Results SV and SI tended to increase (r = 0.557 and 0.622, respectively; all P<0.001), and RV and RV/SV tended to decrease (r = −0.749 and −0.699, respectively; all P<0.001) with increasing Child-Pugh class of cirrhosis. All the parameters, including RV, SV, RV/SV and SI, might be the indicators used to discriminate the patients with Liver cirrhosis from the control group, and to distinguish these patients between Child-Pugh class A and B, between B and C, and between A and C (area under receiver operating characteristic curve [AUC] = 0.609–0.975, all P<0.05). Among these parameters, RV/SV was the best noninvasive factor for the discrimination of Liver cirrhosis between Child-Pugh class A and B (AUC = 0.725), between A and C (AUC = 0.975), and between B and C (AUC = 0.876), while SI was the best variable to distinguish the cirrhosis patients from the control group (AUC = 0.960, P<0.05). Conclusion RV/SV should be used to identify the severity of cirrhosis, while SI can be recommended to determine the presence of this disease.
