The Experts below are selected from a list of 6852 Experts worldwide ranked by ideXlab platform
Andrew Huff - One of the best experts on this subject based on the ideXlab platform.
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United States Coast Guard Integrated Risk Assessment Process. Volume 1
1998Co-Authors: William H. Jones, Vernon Guthrie, David Walker, Thomas Zanin, Andrew HuffAbstract:Abstract : Due to the new challenges (e.g., government downsizing, increased system complexity, ever changing high Risk operations) faced by the Coast Guard, the Coast Guard Research and Development Center (RDC) was requested to explore the possibility of applying system safety concepts, including the use of Risk analysis and enhancement of inspection procedures, to improve Coast Guard operations and facility safety. The Coast Guard RDC teamed with JBF Associates, Inc. (JBFA), a consulting firm specializing in hazard and Risk analysis/management, to develop a Risk based loss prevention program. The initial focus was on developing one portion of the Risk based loss prevention program, a Risk Assessment Process. This report discusses the development, validation, and end product (the Integrated Risk Assessment IRA Process) of this effort. Effective implementation of the IRA Process provides the Coast Guard with Risk based information for: (1) controlling and reducing loss exposure, (2) making Risk based decisions, and (3) using limited resources more efficiently. The IRA Process proved to be an effective and efficient Risk Assessment tool for various types of vessels and their operations, as well as shore facilities and their operations.
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United States Coast Guard Integrated Risk Assessment Process. Volume 2. Coarse Hazard Analysis of a WMEC-210 Vessel in Support of the Paragon Project and Coarse Hazard Analysis of the Integrated Support Command (ISC) at Seattle, WA
1998Co-Authors: William H. Jones, Vernon Guthrie, David Walker, Thomas Zanin, Andrew HuffAbstract:Abstract : Due to the new challenges (e.g., government downsizing, increased system complexity, ever changing high Risk operations) faced by the Coast Guard, the Coast Guard Research and Development Center (RDC) was requested to explore the possibility of applying system safety concepts, including the use of Risk analysis and enhancement of inspection procedures, to improve Coast Guard operations and facility safety. The Coast Guard RDC teamed with JBF Associates, Inc. (JBFA), a consulting firm specializing in hazard and Risk analysis/management, to develop a Risk based loss prevention program. The initial focus was on developing one portion of the Risk based loss prevention program, a Risk Assessment Process. This report discusses the development, validation, and end product (the Integrated Risk Assessment IRA Process) of this effort. Effective implementation of the IRA Process provides the Coast Guard with Risk based information for: (1) controlling and reducing loss exposure, (2) making Risk based decisions, and (3) using limited resources more efficiently. The IRA Process proved to be an effective and efficient Risk Assessment tool for various types of vessels and their operations, as well as shore facilities and their operations.
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United States Coast Guard Integrated Risk Assessment Process. Volume 3. Detailed Hazard Analysis of WMEC-270 Small Boat Operations, Detailed Hazard Analysis of WLIC-160 Deck Operations, and Risk-Based Safety Survey of a WHEC-378 Vessel
1998Co-Authors: William H. Jones, Vernon Guthrie, David Walker, Thomas Zanin, Andrew HuffAbstract:Abstract : Due to the new challenges (e.g., government downsizing, increased system complexity, ever changing high Risk operations) faced by the Coast Guard, the Coast Guard Research and Development Center (RDC) was requested to explore the possibility of applying system safety concepts, including the use of Risk analysis and enhancement of inspection procedures, to improve Coast Guard operations and facility safety. The Coast Guard RDC teamed with JBF Associates, Inc. (JBFA), a consulting firm specializing in hazard and Risk analysis/management, to develop a Risk based loss prevention program. The initial focus was on developing one portion of the Risk based loss prevention program, a Risk Assessment Process. This report discusses the development, validation, and end product (the Integrated Risk Assessment IRA Process) of this effort. Effective implementation of the IRA Process provides the Coast Guard with Risk based information for: (1) controlling and reducing loss exposure, (2) making Risk based decisions, and (3) using limited resources more efficiently. The IRA Process proved to be an effective and efficient Risk Assessment tool for various types of vessels and their operations, as well as shore facilities and their operations.
F a Hines - One of the best experts on this subject based on the ideXlab platform.
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Food and Drug Administration Risk Assessment—Process and Toxicologic Pathology:
Toxicologic Pathology, 1997Co-Authors: R W Moch, F a HinesAbstract:A general outline of the Risk Assessment Process at the Center for Food Safety and Applied Nutrition (CFSAN) of the Food and Drug Administration based on the toxicologic evaluation of data is described. Examples of recent pathology evaluations are presented to illustrate primarily the pathology review Process at the CFSAN. These examples include the review of data from rodent studies from proposed indirect food additives and data from dog studies submitted in support of an investigational new drug, a short-acting opioid, proposed as an anesthetic in humans.
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Food and Drug Administration Risk Assessment--Process and toxicologic pathology.
Toxicologic pathology, 1997Co-Authors: R W Moch, P N Dua, F a HinesAbstract:A general outline of the Risk Assessment Process at the Center for Food Safety and Applied Nutrition (CFSAN) of the Food and Drug Administration based on the toxicologic evaluation of data is described. Examples of recent pathology evaluations are presented to illustrate primarily the pathology review Process at the CFSAN. These examples include the review of data from rodent studies from proposed indirect food additives and data from dog studies submitted in support of an investigational new drug, a short-acting opioid, proposed as an anesthetic in humans.
Isak S. Pretorius - One of the best experts on this subject based on the ideXlab platform.
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Establishing a Risk-Assessment Process for release of genetically modified wine yeast into the environment
Canadian Journal of Microbiology, 2009Co-Authors: Heidi Schoeman, Gideon M. Wolfaardt, Alfred Botha, Pierre Van Rensburg, Isak S. PretoriusAbstract:The use and release of genetically modified organisms (GMOs) is an issue of intense public concern and, in the case of food and beverages, products containing GMOs or products thereof carry the Risk of consumer rejection. The recent commercialization of 2 GM wine yeasts in the United States and Canada has made research and development of Risk Assessments for GM microorganisms a priority. The purpose of this study was to take a first step in establishing a Risk-Assessment Process for future use and potential release of GM wine yeasts into the environment. The behaviour and spread of a GM wine yeast was monitored in saturated sand columns, saturated sand flow cells, and conventional flow cells. A widely used commercial Saccharomyces cerevisiae wine yeast, VIN13, a VIN13 transgenic strain (LKA1, which carries the LKA1 α-amylase gene of Lipomyces kononenkoae), a soil bacterium (Dyadobacter fermentens), and a nonwine soil-borne yeast (Cryptococcus laurentii) were compared in laboratory-scale microcosm systems ...
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Establishing a Risk-Assessment Process for release of genetically modified wine yeast into the environment
Canadian Journal of Microbiology, 2009Co-Authors: Heidi Schoeman, Pierre Van Rensburg, Gideon M. Wolfaardt, Alfred Botha, Isak S. PretoriusAbstract:The use and release of genetically modified organisms (GMOs) is an issue of intense public concern and, in the case of food and beverages, products containing GMOs or products thereof carry the Risk of consumer rejection. The recent commercialization of 2 GM wine yeasts in the United States and Canada has made research and development of Risk Assessments for GM microorganisms a priority. The purpose of this study was to take a first step in establishing a Risk-Assessment Process for future use and potential release of GM wine yeasts into the environment. The behaviour and spread of a GM wine yeast was monitored in saturated sand columns, saturated sand flow cells, and conventional flow cells. A widely used commercial Saccharomyces cerevisiae wine yeast, VIN13, a VIN13 transgenic strain (LKA1, which carries the LKA1 α-amylase gene of Lipomyces kononenkoae), a soil bacterium (Dyadobacter fermentens), and a nonwine soil-borne yeast (Cryptococcus laurentii) were compared in laboratory-scale microcosm systems designed to monitor microbial mobility behaviour, survival, and attachment to surfaces. It was found that LKA1 cells survived in saturated sand columns, but showed little mobility in the porous matrix, suggesting that the cells attached with high efficiency to sand. There was no significant difference between the mobility patterns of LKA1 and VIN13. All 3 yeasts (VIN13, LKA1, and C. laurentii) were shown to form stable biofilms; the 2 S. cerevisiae strains either had no difference in biofilm density or the LKA1 biofilm was less dense than that of VIN13. When co-inoculated with C. laurentii, LKA1 had no negative influence on the breakthrough of the Cryptococcus yeast in a sand column or on its ability to form biofilms. In addition, LKA1 did not successfully integrate into a stable mixed-biofilm community, nor did it disrupt the biofilm community. Overall, it was concluded that the LKA1 transgenic yeast had the same reproductive success as VIN13 in these 3 microcosms and had no selective advantage over the untransformed parental strain.
William H. Jones - One of the best experts on this subject based on the ideXlab platform.
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United States Coast Guard Integrated Risk Assessment Process. Volume 1
1998Co-Authors: William H. Jones, Vernon Guthrie, David Walker, Thomas Zanin, Andrew HuffAbstract:Abstract : Due to the new challenges (e.g., government downsizing, increased system complexity, ever changing high Risk operations) faced by the Coast Guard, the Coast Guard Research and Development Center (RDC) was requested to explore the possibility of applying system safety concepts, including the use of Risk analysis and enhancement of inspection procedures, to improve Coast Guard operations and facility safety. The Coast Guard RDC teamed with JBF Associates, Inc. (JBFA), a consulting firm specializing in hazard and Risk analysis/management, to develop a Risk based loss prevention program. The initial focus was on developing one portion of the Risk based loss prevention program, a Risk Assessment Process. This report discusses the development, validation, and end product (the Integrated Risk Assessment IRA Process) of this effort. Effective implementation of the IRA Process provides the Coast Guard with Risk based information for: (1) controlling and reducing loss exposure, (2) making Risk based decisions, and (3) using limited resources more efficiently. The IRA Process proved to be an effective and efficient Risk Assessment tool for various types of vessels and their operations, as well as shore facilities and their operations.
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United States Coast Guard Integrated Risk Assessment Process. Volume 2. Coarse Hazard Analysis of a WMEC-210 Vessel in Support of the Paragon Project and Coarse Hazard Analysis of the Integrated Support Command (ISC) at Seattle, WA
1998Co-Authors: William H. Jones, Vernon Guthrie, David Walker, Thomas Zanin, Andrew HuffAbstract:Abstract : Due to the new challenges (e.g., government downsizing, increased system complexity, ever changing high Risk operations) faced by the Coast Guard, the Coast Guard Research and Development Center (RDC) was requested to explore the possibility of applying system safety concepts, including the use of Risk analysis and enhancement of inspection procedures, to improve Coast Guard operations and facility safety. The Coast Guard RDC teamed with JBF Associates, Inc. (JBFA), a consulting firm specializing in hazard and Risk analysis/management, to develop a Risk based loss prevention program. The initial focus was on developing one portion of the Risk based loss prevention program, a Risk Assessment Process. This report discusses the development, validation, and end product (the Integrated Risk Assessment IRA Process) of this effort. Effective implementation of the IRA Process provides the Coast Guard with Risk based information for: (1) controlling and reducing loss exposure, (2) making Risk based decisions, and (3) using limited resources more efficiently. The IRA Process proved to be an effective and efficient Risk Assessment tool for various types of vessels and their operations, as well as shore facilities and their operations.
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United States Coast Guard Integrated Risk Assessment Process. Volume 3. Detailed Hazard Analysis of WMEC-270 Small Boat Operations, Detailed Hazard Analysis of WLIC-160 Deck Operations, and Risk-Based Safety Survey of a WHEC-378 Vessel
1998Co-Authors: William H. Jones, Vernon Guthrie, David Walker, Thomas Zanin, Andrew HuffAbstract:Abstract : Due to the new challenges (e.g., government downsizing, increased system complexity, ever changing high Risk operations) faced by the Coast Guard, the Coast Guard Research and Development Center (RDC) was requested to explore the possibility of applying system safety concepts, including the use of Risk analysis and enhancement of inspection procedures, to improve Coast Guard operations and facility safety. The Coast Guard RDC teamed with JBF Associates, Inc. (JBFA), a consulting firm specializing in hazard and Risk analysis/management, to develop a Risk based loss prevention program. The initial focus was on developing one portion of the Risk based loss prevention program, a Risk Assessment Process. This report discusses the development, validation, and end product (the Integrated Risk Assessment IRA Process) of this effort. Effective implementation of the IRA Process provides the Coast Guard with Risk based information for: (1) controlling and reducing loss exposure, (2) making Risk based decisions, and (3) using limited resources more efficiently. The IRA Process proved to be an effective and efficient Risk Assessment tool for various types of vessels and their operations, as well as shore facilities and their operations.
R W Moch - One of the best experts on this subject based on the ideXlab platform.
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Food and Drug Administration Risk Assessment—Process and Toxicologic Pathology:
Toxicologic Pathology, 1997Co-Authors: R W Moch, F a HinesAbstract:A general outline of the Risk Assessment Process at the Center for Food Safety and Applied Nutrition (CFSAN) of the Food and Drug Administration based on the toxicologic evaluation of data is described. Examples of recent pathology evaluations are presented to illustrate primarily the pathology review Process at the CFSAN. These examples include the review of data from rodent studies from proposed indirect food additives and data from dog studies submitted in support of an investigational new drug, a short-acting opioid, proposed as an anesthetic in humans.
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Food and Drug Administration Risk Assessment--Process and toxicologic pathology.
Toxicologic pathology, 1997Co-Authors: R W Moch, P N Dua, F a HinesAbstract:A general outline of the Risk Assessment Process at the Center for Food Safety and Applied Nutrition (CFSAN) of the Food and Drug Administration based on the toxicologic evaluation of data is described. Examples of recent pathology evaluations are presented to illustrate primarily the pathology review Process at the CFSAN. These examples include the review of data from rodent studies from proposed indirect food additives and data from dog studies submitted in support of an investigational new drug, a short-acting opioid, proposed as an anesthetic in humans.
